Article
Immunology
C. Lingblom, K. Andersson, C. Wenneras
Summary: The study reveals that suppressive eosinophils expressing CD16 can inhibit T cell activity by releasing Galectin-10, forming synapses with T cells and extruding cell membrane-bound Galectin-10-containing traps. This new function of eosinophils sheds light on their role in immune regulation beyond antibacterial defense.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Li Zhou, Xuemin He, Peihong Cai, Ting Li, Rongdong Peng, Junlong Dang, Yue Li, Haicheng Li, Feng Huang, Guojun Shi, Chichu Xie, Yan Lu, Yanming Chen
Summary: The study found that TGF-beta-induced Tregs could ameliorate the development of T1D and preserve beta cell function in a mouse model. The preventive effect was associated with the inhibition of Tc1 cell function and rebalancing the Treg/Tc1 cell ratio. The underlying mechanisms involved the combinatorial actions of mTOR and TCF1 mediated by TGF-beta.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Priyanka Chauhan, Shuxian Hu, Wen S. Sheng, James R. Lokensgard
Summary: Regulatory T-cells (Tregs) play critical roles in controlling cytotoxic T-cell responses against microglial cells and suppressing the production of tumor necrosis factor and interferon. Tregs can also reduce MHC-1 expression on microglial cells and decrease the production of interleukin-6.
Article
Biochemistry & Molecular Biology
Eduardo Valli, Tomas Dalotto-Moreno, Helena A. Sterle, Santiago P. Mendez-Huergo, Maria A. Paulazo, Silvia I. Garcia, Carlos J. Pirola, Alicia J. Klecha, Gabriel A. Rabinovich, Graciela A. Cremaschi
Summary: Hypothyroidism affects immunity and the role of the HPT axis in immunoregulation is not well understood. This study investigated the regulatory role of HPT axis components in hypothyroid-related immunosuppression. Tg-Trh mice showed increased T-cell proliferation and Th1 cytokine release. Hypothyroid mice had increased frequency of regulatory T cells (Tregs), while Tg-Trh mice did not. Galectin-1 (Gal-1), expressed by Tregs, was found to be involved in immunosuppression in hypothyroid conditions.
Article
Multidisciplinary Sciences
Melba Munoz, Ahmed N. Hegazy, Tobias M. Brunner, Vivien Holecska, Roman M. Marek, Anja Froehlich, Max Loehning
Summary: Th2 cells lacking T-bet exhibit strong immunomodulatory potential by suppressing antigen-specific CD8(+) T cell responses via IL-10. These cells protect mice against virus-induced type 1 diabetes and hinder effector and cytotoxic CD8(+) T cell development by downregulating dendritic cell activation. IL-10-secreting Th2 cells could potentially be used as a therapeutic approach for T cell-mediated inflammatory disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sofie Albinsson, Christine Lingblom, Leif Johansson, Helen Larsson, Christine Wenneras
Summary: CD16+ eosinophils and galectin-10-containing extracellular vesicles were found in the esophageal mucosa of patients with active eosinophilic esophagitis. They disappeared after successful treatment but remained in non-responders. Eosinophilic esophagitis is a T-cell-driven allergic condition characterized by eosinophil infiltration.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Oncology
Nobuhiko Imahashi, Rafet Basar, Yuefan Huang, Fang Wang, Natalia Baran, Pinaki Prosad Banerjee, Junjun Lu, Ana Karen Nunez Cortes, Nadima Uprety, Emily Ensley, Luis Muniz-Feliciano, Tamara J. Laskowski, Judy S. Moyes, May Daher, Mayela Mendt, Lucila N. Kerbauy, Mayra Shanley, Li Li, Francesca Lorraine Wei Inng Lim, Hila Shaim, Ye Li, Marina Konopleva, Michael Green, Jennifer Wargo, Elizabeth J. Shpall, Ken Chen, Katayoun Rezvani
Summary: This study shows that activated B cells suppress T-cell responses through metabolic competition, including increased oxygen consumption and glucose deprivation. These findings provide new insights into immunometabolism and its potential implications for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Alejandro J. Cagnoni, Maria Laura Giribaldi, Ada G. Blidner, Anabela M. Cutine, Sabrina G. Gatto, Rosa M. Morales, Mariana Salatino, Martin C. Abba, Diego O. Croci, Karina V. Marino, Gabriel A. Rabinovich
Summary: Colorectal cancer is a common malignancy with limited response to immunotherapy, prompting the need for new biomarkers and therapeutic targets. Gal-1, as an endogenous glycan-binding protein, has been found to influence the activity of CD8(+) regulatory T cells in CRC, suggesting a potential immunotherapeutic approach for this disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jinghai Yan, Shiguang Huang, Fangli Lu
Summary: The study revealed that blocking galectin-receptor interactions during acute Trichinella spiralis infection resulted in cardiac dysfunction, exacerbated heart pathology, and increased cardiac fibrosis. This was associated with elevated heart eosinophil recruitment and upregulation of Gal-3, which plays a pivotal role in heart functional damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Article
Cell Biology
Channakeshava Sokke Umeshappa, Patricia Sole, Bas G. J. Surewaard, Jun Yamanouchi, Saswat Mohapatra, Muhammad Myn Uddin, Robert Clarke, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, Yang Yang, Dario A. A. Vignali, Pau Serra, Paul Kubes, Pere Santamaria
Summary: Research shows that in models of liver autoimmunity, antigen-specific regulatory T cells can coordinate the recruitment and programming of neutrophils to generate regulatory neutrophils. These regulatory neutrophils in the liver provide disease protection, transfer disease protection to immunocompromised hosts, and inhibit antigen presentation and autoimmune responses through CRAMP.
Article
Multidisciplinary Sciences
Ousheng Liu, Junji Xu, Fu Wang, Wenwen Jin, Peter Zanvit, Dandan Wang, Nathan Goldberg, Alexander Cain, Nancy Guo, Yichen Han, Andrew Bynum, Guowu Ma, Songlin Wang, Zhangui Tang, Wanjun Chen
Summary: Research has shown that ADSCs can produce IL-33 in response to stimulation, which alleviates autoimmune diseases by promoting the proliferation of regulatory T cells (Tregs). This previously unrecognized immunoregulatory function of ADSCs through IL-33 production may have potential clinical applications.
Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Takahiko Sato, Takahito Chiba, Takeshi Nakahara, Ken Watanabe, Sawako Sakai, Natsuko Noguchi, Mai Noto, Shigeharu Ueki, Michihiro Kono
Summary: This study confirms the occurrence of eosinophil extracellular trap cell death and the pathological role of galectin-10 in bullous pemphigoid. Galectin-10 may contribute to blister formation in bullous pemphigoid by promoting the production of matrix metalloproteinases by keratinocytes and fibroblasts.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Hematology
Jennie Andersson, Julia Cromvik, Madeleine Ingelsten, Christine Lingblom, Kerstin Andersson, Jan-Erik Johansson, Christine Wenneras
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2014)
Article
Dentistry, Oral Surgery & Medicine
Jennie Andersson, Ulf I. Dahlgren
EUROPEAN JOURNAL OF ORAL SCIENCES
(2008)
Article
Dentistry, Oral Surgery & Medicine
Jennie Andersson, Ulf Dahlgren
EUROPEAN JOURNAL OF ORAL SCIENCES
(2011)
Article
Dentistry, Oral Surgery & Medicine
Jennie Andersson, Ulf Dahlgren
EUROPEAN JOURNAL OF ORAL SCIENCES
(2011)
Article
Dentistry, Oral Surgery & Medicine
J. Andersson, U. Dahlgren
JOURNAL OF DENTAL RESEARCH
(2010)
Article
Allergy
Christine Lingblom, Elin Redvall, Kerstin Andersson, Christine Wenneras
Article
Hematology
Christine Wenneras, Alaitz Aranburu, Linda Wass, Anna Grankvist, Anna Staffas, Anastasia Soboli, Inga-Lill Martensson, Linda Fogelstrand, Catharina Lewerin
Summary: In this investigation of 5 patients with malignant B-cell lymphoma and concomitant N. mikurensis infection, it was found that chronic stimulation of B cells may lead to B-cell transformation and lymphoma. In some cases, significant improvement and cessation of lymphoma treatment were observed after elimination of N. mikurensis.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Allergy
C. Lingblom, T. Kappi, H. Bergquist, M. Bove, R. Arkel, R. Saalman, C. Wenneras
Article
Immunology
Anna Grankvist, Lisa Labbe Sandelin, Jennie Andersson, Linda Fryland, Peter Wilhelmsson, Per-Eric Lindgren, Pia Forsberg, Christine Wenneras
EMERGING INFECTIOUS DISEASES
(2015)