The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production

Th17 cell differentiation proceeds independently of IRF8

(2016) Dane M Newman et al.   IMMUNOLOGY AND CELL BIOLOGY

Relevance of Interferon Regulatory Factor-8 Expression in Myeloid–Tumor Interactions

(2016) Scott I. Abrams et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Identification of early myeloid progenitors as immunosuppressive cells

(2016) Shiming Pu et al.   Scientific Reports

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production

(2015) A. Yanez et al.   BLOOD

Regulation of myelopoiesis by the transcription factor IRF8

(2015) Tomohiko Tamura et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

(2015) Stefano Ugel et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional regulation of myeloid-derived suppressor cells

(2015) Thomas Condamine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy

(2014) Michelle N. Messmer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

(2014) Sebastian Carotta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation

(2014) Hongsheng Wang et al.   JOURNAL OF IMMUNOLOGY

Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients

(2014) W.-C. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

(2014) Daisuke Kurotaki et al.   Nature Communications

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

(2013) Ryo Yamamoto et al.   CELL

Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-derived Suppressor Cells and Contributes to Their Persistence in Cancer

(2013) Xiaolin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

Antitumor Effect of Paclitaxel Is Mediated by Inhibition of Myeloid-Derived Suppressor Cells and Chronic Inflammation in the Spontaneous Melanoma Model

(2013) A. Sevko et al.   JOURNAL OF IMMUNOLOGY

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell-Dependent Antitumor Immunity

(2010) J. Vincent et al.   CANCER RESEARCH

Interferon regulatory factor-8 modulates the development of tumour-induced CD11b+Gr-1+ myeloid cells

(2010) Trina J. Stewart et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias

(2009) Jessica Koenigsmann et al.   BLOOD

Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b+Gr-1+ Myeloid Cells

(2009) T. J. Stewart et al.   JOURNAL OF IMMUNOLOGY