Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+T Cells

GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity

(2016) Michael S. Magee et al.   OncoImmunology

Clinical Outcome of HIV Viraemic Controllers and Noncontrollers with Normal CD4 Counts Is Exclusively Determined by Antigen-Specific CD8+ T-Cell-Mediated HIV Suppression

(2015) Yada Tansiri et al.   PLoS One

A Phase I study of AD5-GUCY2C-PADRE in stage I and II colon cancer patients

(2015) Adam Snook et al.   Journal for ImmunoTherapy of Cancer

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer

(2015) Glen P. Marszalowicz et al.   Oncotarget

Selective antigen-specific CD4+T-cell, but not CD8+T- or B-cell, tolerance corrupts cancer immunotherapy

(2014) Adam E. Snook et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor Radiation Therapy Creates Therapeutic Vaccine Responses to the Colorectal Cancer Antigen GUCY2C

(2014) Matthew Witek et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Derivation and Fluidity of Acutely Induced Dysfunctional CD8+ T Cells

(2014) G. Plesa et al.   JOURNAL OF IMMUNOLOGY

Boosting Functional Avidity of CD8+ T Cells by Vaccinia Virus Vaccination Depends on Intrinsic T-Cell MyD88 Expression but Not the Inflammatory Milieu

(2014) Z. Hu et al.   JOURNAL OF VIROLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function

(2014) Maria Hottelet Foley et al.   PLoS One

Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes

(2014) Martha Sedegah et al.   PLoS One

Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine

(2013) O Igoucheva et al.   GENE THERAPY

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

(2013) S. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Next-generation peptide vaccines for advanced cancer

(2012) Akira Yamada et al.   CANCER SCIENCE

Clinical development of IMOJEV®—a recombinant Japanese encephalitis chimeric vaccine (JE-CV)

(2012) Mohan Babu Appaiahgari et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C

(2011) Adam E. Snook et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Electroporation delivery of DNA vaccines: prospects for success

(2011) Niranjan Y Sardesai et al.   CURRENT OPINION IN IMMUNOLOGY

Viral vectors as vaccine platforms: deployment in sight

(2011) Christine S Rollier et al.   CURRENT OPINION IN IMMUNOLOGY

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice

(2011) Michael A. Valentino et al.   JOURNAL OF CLINICAL INVESTIGATION

Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior

(2011) R. Gong et al.   SCIENCE

Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines

(2011) Genevieve M. Weir et al.   Cancers

DNA Vaccines: Developing New Strategies against Cancer

(2010) Daniela Fioretti et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lineage-Specific T-Cell Responses to Cancer Mucosa Antigen Oppose Systemic Metastases without Mucosal Inflammatory Disease

(2009) A. E. Snook et al.   CANCER RESEARCH

Guanylyl Cyclase C–Induced Immunotherapeutic Responses Opposing Tumor Metastases Without Autoimmunity

(2008) Adam E. Snook et al.   JNCI-Journal of the National Cancer Institute

DNA vaccines: ready for prime time?

(2008) Michele A. Kutzler et al.   NATURE REVIEWS GENETICS