Article
Multidisciplinary Sciences
Laura Ducimetiere, Giulia Lucchiari, Gioana Litscher, Marc Nater, Laura Heeb, Nicolas Gonzalo Nunez, Laura Wyss, Dominik Burri, Marijne Vermeer, Julia Gschwend, Andreas E. Moor, Burkhard Becher, Maries van den Broek, Sonia Tugues
Summary: This study found that innate lymphocyte subpopulations cNKs and trILC1s play nonredundant roles in controlling liver metastasis seeding and outgrowth, respectively, and may contribute to developing therapies involving hepatic innate cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Demi Brownlie, Marlena Scharenberg, Jeff E. Mold, Joanna Hard, Eliisa Kekalainen, Marcus Buggert, Son Nguyen, Jennifer N. Wilson, Mamdoh Al-Ameri, Hans-Gustaf Ljunggren, Nicole Marquardt, Jakob Michaelsson
Summary: Recent studies have shown the existence of tissue-resident adaptive-like NK cells in the human lung and blood, which differ from traditional NK cells and exhibit enhanced cytotoxicity towards tumor cells. These cells may represent a novel strategy for targeted therapies against solid tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Martha E. Haugstoyl, Martin Cornillet, Kristina Strand, Natalie Stiglund, Dan Sun, Laurence Lawrence-Archer, Iren D. Hjellestad, Christian Busch, Gunnar Mellgren, Niklas K. Bjorkstrom, Johan Ferno
Summary: Natural killer (NK) cells play an important role in obesity-related inflammation in adipose tissue. However, the phenotype of NK cell subsets in human adipose tissue and their role in metabolic disorders are poorly understood. This study used multicolor flow cytometry to characterize CD56(bright) and CD56(dim) NK cells in blood and adipose tissue of obese individuals, and identified surface proteins enriched on adipose tissue-resident CD56(bright) NK cells. The study provides valuable insights into the identity of NK cells in blood and adipose tissue in relation to obesity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Calum Forrest, Thomas J. G. Chase, Antonia O. Cuff, Dionas Maroulis, Reza Motallebzadeh, Amir Gander, Brian Davidson, Paul Griffiths, Victoria Male, Matthew Reeves
Summary: This study reveals that liver resident natural killer cells have an altered phenotype in individuals infected with cytomegalovirus and exhibit increased anti-viral activity against multiple viruses in vitro. The authors also identify a subset of natural killer cells responsible for controlling cytomegalovirus replication in the liver. These findings suggest that virally induced expansion of tissue resident natural killer cells can reduce the risk of post-transplant viremia.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Jonna Bister, Ylva Crona Guterstam, Benedikt Strunz, Bogdan Dumitrescu, Karin Haij Bhattarai, Volkan Ozenci, Mats Brannstrom, Martin A. Ivarsson, Sebastian Gidlof, Niklas K. Bjorkstrom
Summary: The study found that MAIT cells in the endometrium exhibit a relatively stable immune cell population under different physiological conditions, with validated antimicrobial capabilities. Additionally, MAIT cells showed an activated tissue-resident phenotype, aiding in the defense against pathogens. Moreover, experimental results demonstrated the ability of MAIT cells to respond to sexually transmitted pathogens such as Neisseria gonorrhoeae.
MUCOSAL IMMUNOLOGY
(2021)
Article
Immunology
Katayoun Ayasoufi, Delaney M. Wolf, Shelby L. Namen, Fang Jin, Zachariah P. Tritz, Christian K. Pfaller, Jiaying Zheng, Emma N. Goddery, Cori E. Fain, Lauren R. Gulbicki, Anna L. Borchers, Rachael A. Reesman, Lila T. Yokanovich, Mark A. Maynes, Michael A. Bamkole, Roman H. Khadka, Michael J. Hansen, Long-Jun Wu, Aaron J. Johnson
Summary: The contribution of circulating versus tissue resident memory T cells to clinical neuropathology is not well understood. This study found that tissue resident memory T cells in the brain can induce significant neuroinflammation, neuropathology, and peripheral immunosuppression. Understanding the functions of these cells is crucial in investigating their role in neurodegenerative disorders and long-term complications associated with viral infections.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Thomas J. Connors, Rei Matsumoto, Shivali Verma, Peter A. Szabo, Rebecca Guyer, Joshua Gray, Zicheng Wang, Puspa Thapa, Pranay Dogra, Maya M. L. Poon, Ksenia Rybkina, Marissa C. Bradley, Emma Idzikowski, James Mcnichols, Masaru Kubota, Kalpana Pethe, Yufeng Shen, Mark A. Atkinson, Maigan Brusko, Todd M. Brusko, Andrew J. Yates, Peter A. Sims, Donna L. Farber
Summary: The study found that memory T cells in infants and young children preferentially localized in the intestines and lungs and accumulated more rapidly in mucosal sites, exhibiting distinct functional capacities and stem-like transcriptional profiles. As children grow older, these cells progressively adopt proinflammatory functions and tissue-resident signatures.
Review
Immunology
Ming Z. M. Zheng, Linda M. Wakim
Summary: Tissue-resident memory (Trm) cells in the respiratory tract play a crucial role in local immune responses against infections. Factors influencing the development, longevity, and immune surveillance of Trm cells were discussed, along with vaccination regimes harnessing these cells as new strategies to combat future global pandemics.
MUCOSAL IMMUNOLOGY
(2022)
Article
Immunology
Yun Hsuan Lin, Han G. Duong, Abigail E. Limary, Eleanor S. Kim, Paul Hsu, Shefali A. Patel, William H. Wong, Cynthia S. Indralingam, Yi Chia Liu, Priscilla Yao, Natalie R. Chiang, Taylor R. Anderson, Jocelyn G. Olvera, Amir Ferry, Kennidy K. Takehara, Wenhao Jin, Matthew S. Tsai, Gene W. Yeo, Ananda W. Goldrath, John T. Chang
Summary: Tissue-resident memory CD8+ T (TRM) cells are a subset of memory T cells that are important for controlling infection. TRM cells in the small intestine and colon exhibit heterogeneity in terms of cytokine and granzyme expression, transcriptional and epigenetic regulation, and functional characteristics. The transcription factor Eomes plays a context-specific role in supporting the maintenance of established TRM cells in the small intestine but not in the colon.
Article
Oncology
Demi Brownlie, Andreas von Kries, Giampiero Valenzano, Nicole Wild, Emel Yilmaz, Jesper Safholm, Mamdoh Al-Ameri, Evren Alici, Hans-Gustaf Ljunggren, Igor Schliemann, Ozan Aricak, Felix Haglund de Flon, Jakob Michaelsson, Nicole Marquardt
Summary: Lung cancer is a major cause of cancer-related deaths globally. High-parameter flow cytometry revealed the accumulation of tissue-resident lymphocytes, including trNK cells and CD8(+) T-RM cells, towards the center of human NSCLC. Unlike CD8(+) T-RM cells, trNK cells and ILCs generally expressed low levels of immune checkpoint receptors, and expressed high levels of granzyme, indicating their functional relevance in lung tumors.
Article
Biology
Erin W. Meermeier, Christina L. Zheng, Jessica G. Tran, Shogo Soma, Aneta H. Worley, David Weiss, Robert L. Modlin, Gwendolyn Swarbrick, Elham Karamooz, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, David M. Lewinsohn
Summary: Human lung-resident MAIT cells are polycytotoxic, secrete antimicrobial molecules, express genes associated with persistence, and selectively express cytokine and chemokine-related molecules. These characteristics make MAIT cells early sensors in the defense of the respiratory barrier.
COMMUNICATIONS BIOLOGY
(2022)
Review
Immunology
Elizabeth Rotrosen, Thomas S. Kupper
Summary: Vaccines have been successful in eliminating many childhood diseases but have had less success in controlling certain pathogens due to their ability to mutate. The focus on neutralizing antibodies has proven complicated due to the emergence of escape variants. This review discusses the potential of generating a robust T cell response to provide better protection, particularly against rapidly mutating pathogens, and highlights the importance of tissue resident memory T cells in future vaccination strategies.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Cell Biology
Stephanie van de Wall, Vladimer P. Badovinac, John T. Harty
Summary: This review discusses lung-resident CD8(+) T cells (Trm) generated upon IAV infection, compared to Trm cells in other tissues, addressing major knowledge gaps in the generation and maintenance of IAV-specific lung Trm. The mechanisms contributing to the decline in lung Trm cell numbers are also discussed, highlighting the importance of understanding effector function versus immunopathology for future IAV vaccine design.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2021)
Article
Immunology
Leen Hermans, Sofie Denaeghel, Robert J. J. Jansens, Steffi De Pelsmaeker, Filip Van Nieuwerburgh, Dieter Deforce, Everardo Hegewisch-Solloa, Emily M. Mace, Eric Cox, Bert Devriendt, Herman W. Favoreel
Summary: Two subsets of NK cells are found in the pig liver, one resembling human lrNK cells and the other resembling conventional CD8a(high) NK cells in peripheral blood. The transcriptome analysis reveals that CD8a(dim) lrNK cells exhibit an immature and anti-inflammatory phenotype, while the CD8a(high) NK cells in the liver have an intermediate phenotype expressing liver residency-associated transcripts.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Astrid Hendriks, Malgorzata Ewa Mnich, Bruna Clemente, Ana Rita Cruz, Simona Tavarini, Fabio Bagnoli, Elisabetta Soldaini
Summary: The skin, as an immunocompetent tissue, contains various immune cells and a diverse microbiome. CD4(+) T cells play a crucial role in protecting against Staphylococcus aureus infection, and skin-specific CD4(+) T cells have been identified in response to S. aureus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Min Xu, Sandra Garcia-Aroz, Babak Banan, Xuanchuan Wang, Brian J. Rabe, Fangyu Zhou, Deepak K. Nayak, Zhengyan Zhang, Jianluo Jia, Gundumi A. Upadhya, Pamela T. Manning, Joseph P. Gaut, Yiing Lin, William C. Chapman
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Immunology
Leigh Anne Dageforde, William Muren, Su-Hsin Chang, Neeta Vachharajani, Diane Brockmeier, Jennifer Yu, Blaire Anderson, Surendra Shenoy, Yiing Lin, Adeel Khan, Jason Wellen, William Chapman, Majella Doyle
Article
Immunology
Sytse J. Piersma, Melissa A. Pak-Wittel, Andrea Lin, Beatrice Plougastel-Douglas, Wayne M. Yokoyama
JOURNAL OF IMMUNOLOGY
(2019)
Article
Cell Biology
Jennifer W. Liu, Sytse Piersma, Simon Y. Tang
CONNECTIVE TISSUE RESEARCH
(2020)
Article
Biology
Sytse J. Piersma, Jennifer Poursine-Laurent, Liping Yang, Glen N. Barber, Bijal A. Parikh, Wayne M. Yokoyama
Article
Immunology
Sandra Garcia-Aroz, Min Xu, Ola Ahmed, Joshua Hollingshead, Xuanchuan Wang, Babak Banan, Adeel Khan, Liang- Kang, Zhengyan Zhang, Gundumi Upadhya, Pamela Manning, Yiing Lin, William C. Chapman
Summary: The study investigates the use of antibody-mediated CD47 blockade in improving liver graft function. CD47mAb treatment reduces ischemia/reperfusion injury and enhances liver regeneration.
Article
Surgery
Ola Ahmed, Min Xu, Fangyu Zhou, Alexander N. Wein, Gundumi A. Upadhya, Li Ye, Brian W. Wong, Yiing Lin, Cliona O'Farrelly, William C. Chapman
Summary: Antioxidant defense mechanisms, particularly the NRF2 axis, play a crucial role in oxidative stress responses and ischemic injury. High NRF2 expression in donor livers is associated with improved liver function, suggesting that targeting this axis may be a rational supplemental treatment strategy for rescuing marginal donor livers.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Sytse J. Piersma, Ilija Brizic
Summary: Natural killer (NK) cells are innate lymphoid cells that play a crucial role in controlling tumors and viral infections by producing cytokines and lysing target cells. The activation of NK cells depends on signals received by cytokine receptors and activation and inhibitory receptors recognizing ligands expressed by virus-infected cells. The focus of ongoing research has been on understanding the signals perceived by NK cells and how they integrate to mediate optimal viral control.
Article
Biology
Francisco Victorino, Tarin Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Liping Yang, Sytse J. Piersma, Elvin J. Lauron, Rebecca M. Davidson, Gary Patti, Wayne M. Yokoyama
Summary: NK cells require HIF1 alpha-dependent metabolic functions to suppress Bim expression and sustain cell numbers for an optimal virus response.
Article
Cell Biology
Katy Borner, Sarah A. Teichmann, Ellen M. Quardokus, James C. Gee, Kristen Browne, David Osumi-Sutherland, Bruce W. Herr, Andreas Bueckle, Hrishikesh Paul, Muzlifah Haniffa, Laura Jardine, Amy Bernard, Song-Lin Ding, Jeremy A. Miller, Shin Lin, Marc K. Halushka, Avinash Boppana, Teri A. Longacre, John Hickey, Yiing Lin, M. Todd Valerius, Yongqun He, Gloria Pryhuber, Xin Sun, Marda Jorgensen, Andrea J. Radtke, Clive Wasserfall, Fiona Ginty, Jonhan Ho, Joel Sunshine, Rebecca T. Beuschel, Maigan Brusko, Sujin Lee, Rajeev Malhotra, Sanjay Jain, Griffin Weber
Summary: This Perspective discusses collaborative efforts by 16 international consortia to create a Human Reference Atlas (HRA) that includes three-dimensional representations of anatomy linked to tables naming major anatomical structures, cell types, and biomarkers (ASCT+B), as well as examples demonstrating the practical utility of the HRA.
NATURE CELL BIOLOGY
(2021)
Article
Transplantation
Min Xu, Fangyu Zhou, Ola Ahmed, Lucy Randle, Jun-Kyu Shin, Yuehui Zhu, Gundumi A. Upadhya, Kathleen Byrnes, Brian Wong, Jae-Sung Kim, Yiing Lin, William C. Chapman
Summary: In the context of liver donation after circulatory death, perfusate lactate clearance (LC) during normothermic machine perfusion (NMP) is correlated with the activation level of extracellular signal-regulated kinase, and successful LC is associated with glycogen restoration and bile lactate levels, which can aid in evaluating hypoxic injury of hepatocytes and cholangiocytes during NMP.
TRANSPLANTATION DIRECT
(2021)
Article
Oncology
Zachary L. Skidmorea, Jason Kunisaki, Yiing Lin, Kelsy C. Cotto, Erica K. Barnell, Jasreet Hundal, Kilannin Krysiak, Vincent Magrini, Lee Trani, Jason R. Walker, Robert Fulton, Elizabeth M. Brunt, Christopher A. Miller, Richard K. Wilson, Elaine R. Mardis, Malachi Griffith, William Chapman, Obi L. Griffith
Article
Biology
Shasha Li, Michael D. Bern, Benpeng Miao, Changxu Fan, Xiaoyun Xing, Takeshi Inoue, Sytse J. Piersma, Ting Wang, Marco Colonna, Tomohiro Kurosaki, Wayne M. Yokoyama
Summary: Bach2 is a transcription repressor that plays important roles in the development of NK cells. It shows specific expression patterns in different developmental stages and in different organs and tissues. Deficiency of Bach2 leads to increased proportions of terminally differentiated NK cells with increased production of enzymes and cytokines, and enhanced control of tumor metastasis by NK cells.
Article
Biochemistry & Molecular Biology
Xiaonan Fu, Li Sun, Runze Dong, Jane Y. Chen, Runglawan Silakit, Logan F. Condon, Yiing Lin, Shin Lin, Richard D. Palmiter, Liangcai Gu
Summary: This study introduces a stamping method for fabricating polony gels, reducing the cost and time of barcode sequencing, and developing a single-cell spatial transcriptomic assay. This method offers high resolution and RNA capture efficiency for mapping and analyzing cell-cell communication in tissues.
Article
Biology
Yashvardhan Jain, Leah L. L. Godwin, Yingnan Ju, Naveksha Sood, Ellen M. M. Quardokus, Andreas Bueckle, Teri Longacre, Aaron Horning, Yiing Lin, Edward D. D. Esplin, John W. W. Hickey, Michael P. P. Snyder, Nathan Heath Patterson, Jeffrey M. M. Spraggins, Katy Borner
Summary: The Human BioMolecular Atlas Program (HuBMAP) aims to create a Human Reference Atlas (HRA) for the healthy adult body at the cellular level. To achieve this, accurate and efficient machine-learning algorithms are needed for the segmentation of functional tissue units (FTUs). A Kaggle competition was organized to develop such algorithms and the winning algorithm, Tom, outperformed others in an expanded study. Tom has been implemented in the HuBMAP infrastructure for large-scale kidney FTU segmentation, showcasing the value of Kaggle competitions in advancing research.
COMMUNICATIONS BIOLOGY
(2023)
