Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis

HumanRELAhaploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration

(2017) Yousef R. Badran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome

(2016) Xixi Zhang et al.   Cell Reports

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

(2015) Vangelis Kondylis et al.   CANCER CELL

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Loss of Epithelial RelA Results in Deregulated Intestinal Proliferative/Apoptotic Homeostasis and Susceptibility to Inflammation

(2014) K. A. Steinbrecher et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Roles of Lung Epithelium in Neutrophil Recruitment During Pneumococcal Pneumonia

(2013) Kazuko Yamamoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Control of Life-or-Death Decisions by RIP1 Kinase

(2013) Dana E Christofferson et al.   Annual Review of Physiology

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Type I Alveolar Epithelial Cells Mount Innate Immune Responses during Pneumococcal Pneumonia

(2012) K. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Earliest Innate Immune Responses Require Macrophage RelA during Pneumococcal Pneumonia

(2011) Lynnelle A. Pittet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Repression of gene expression by unphosphorylated NF- B p65 through epigenetic mechanisms

(2008) J. Dong et al.   GENES & DEVELOPMENT

Genetic Delineation of the Pathways Mediated by Bid and JNK in Tumor Necrosis Factor-α-induced Liver Injury in Adult and Embryonic Mice

(2008) Hong-Min Ni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY