Article
Immunology
Kyoung Hwa Lee, Seul Gi Yoo, Yonggeun Cho, Da Eun Kwon, Yeonju La, Sang Hoon Han, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Yu Seun Kim, Yoo Hong Min, June-Won Cheong, Jin Seok Kim, Yong Goo Song
Summary: The study emphasizes the importance of CA-RVs diagnosis in transplant recipients even in the long-term posttransplant period, as well as in non-transplant critically ill patients in the ICU with mechanical ventilation. In both groups, mechanical ventilation was identified as an independent risk factor associated with all-cause in-hospital mortality.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Critical Care Medicine
Giacomo Grasselli, Vittorio Scaravilli, Davide Mangioni, Luigia Scudeller, Laura Alagna, Michele Bartoletti, Giacomo Bellani, Emanuela Biagioni, Paolo Bonfanti, Nicola Bottino, Irene Coloretti, Salvatore Lucio Cutuli, Gennaro De Pascale, Daniela Ferlicca, Gabriele Fior, Andrea Forastieri, Marco Franzetti, Massimiliano Greco, Amedeo Guzzardella, Sara Linguadoca, Marianna Meschiari, Antonio Messina, Gianpaola Monti, Paola Morelli, Antonio Muscatello, Simone Redaelli, Flavia Stefanini, Tommaso Tonetti, Massimo Antonelli, Maurizio Cecconi, Giuseppe Foti, Roberto Fumagalli, Massimo Girardis, Marco Ranieri, Pierluigi Viale, Mario Raviglione, Antonio Pesenti, Andrea Gori, Alessandra Bandera
Summary: Critically ill patients with COVID-19 are at high risk for hospital-acquired infections (HAIs), especially ventilator-associated pneumonia (VAP) and bloodstream infections (BSIs) caused by multidrug-resistant organisms. HAIs prolong mechanical ventilation and hospitalization, and those complicated by septic shock nearly double mortality rate.
Article
Infectious Diseases
Alexandra Greco Kinney, Nicole Kovacic Scherrer, Sauradeep Sarkar, Pranav Jain, Sijin Wen, Sarah Hadique
Summary: This study compared the outcomes of severe CAP patients treated with doxycycline versus azithromycin. The results showed no significant differences in in-hospital and 30-day mortality between the two groups. These findings support the inclusion of doxycycline as an alternative treatment regimen in current IDSA recommendations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Paola Cerini, Francesca Rita Meduri, Flaminia Tomassetti, Isabella Polidori, Marta Brugneti, Eleonora Nicolai, Sergio Bernardini, Massimo Pieri, Francesco Broccolo
Summary: The World Health Organization has identified three categories of pathogens based on the need for new antibiotics: critical, high, and medium priority. The prevalence of antibiotic resistant bacteria, such as CPO, MRSA, and VRE, has increased from 2019 to 2022 in both nosocomial and community patients. This highlights the importance of implementing preventive and control measures to reduce the spread of multidrug-resistant pathogens.
Article
Critical Care Medicine
Paul Jaubert, Julien Charpentier, Sarah Benghanem, Alain Cariou, Frederic Pene, Jean-Paul Mira, Mathieu Jozwiak
Summary: This study aimed to investigate whether patients with community-acquired pneumonia caused by pneumococcus develop meningitis and the associated outcomes. The study showed that approximately 16% of patients with severe community-acquired pneumonia caused by pneumococcus and who underwent lumbar puncture were diagnosed with meningitis. Meningitis was more common in patients with pneumococcal bacteremia and was associated with frequent neurological disorders at ICU discharge.
ANNALS OF INTENSIVE CARE
(2023)
Article
Pediatrics
Caizhi Huang, Cong Zhang, Jie Zhang, Lin Zhang, Yi Mo, Liya Mo
Summary: This study investigated the association between Heparin-binding protein (HBP) levels and the development of respiratory failure (RF) and sepsis in critically ill children with severe community-acquired pneumonia (CAP). The results showed that HBP, IL-6, and D-dimer were significant predictors of RF development, with HBP independently associated with RF development. Additionally, HBP was found to be the best indicator for progression to severe sepsis compared to other biomarkers.
FRONTIERS IN PEDIATRICS
(2021)
Article
Critical Care Medicine
G. Umberto Meduri, Mei-Chiung Shih, Lisa Bridges, Thomas J. Martin, Ali El-Solh, Nitin Seam, Anne Davis-Karim, Reba Umberger, Antonio Anzueto, Peruvemba Sriram, Charlie Lan, Marcos I. Restrepo, Juan J. Guardiola, Teresa Buck, David P. Johnson, Anthony Suffredini, W. Andrew Bell, Julia Lin, Lan Zhao, Lauren Uyeda, Lori Nielsen, Grant D. Huang
Summary: Prolonged low-dose methylprednisolone treatment did not significantly improve clinical outcomes in patients with severe community-acquired pneumonia.
INTENSIVE CARE MEDICINE
(2022)
Article
Immunology
Filipa Loureiro Neves, Mariana Nunes Goncalves Afonso Amaral, Sandra Filomena Duraes da Silva, Isabel Maria Melo Silva, Paula Margarida dos Santos Laranjeira, Carla Regina de Jesus Pinto, Artur Augusto Paiva, Andrea Sofia da Silva Dias, Maria Leonor Almeida Carvalho Vieira Coelho
Summary: Immunoparalysis is associated with poorer outcomes in the paediatric intensive care unit (PICU) setting. This study aimed to identify the group of patients with higher chances of immunoparalysis and correlate this status with increased risks of nosocomial infection and adverse clinical parameters. The findings suggest that a reduction in classical monocytes HLA-DR expression with lower frequencies of monocytes producing TNF-alpha and IL-6 during the first week of critical illness may serve as a good marker of immunoparalysis, which is associated with an increased risk of nosocomial infection and deleterious outcomes. The increased frequency of non-classical monocytes in patients with sepsis/septic shock is suggestive of a better prognosis.
Article
Urology & Nephrology
Shahrzad Tehranian, Khaled Shawwa, Erin F. Barreto, Casey M. Clements, Kianoush Kashani
Summary: The use of chloride-rich crystalloids for resuscitation may lead to acute kidney injury, while resuscitation with balanced crystalloids in patients with sepsis-associated community-acquired AKI is associated with higher odds of kidney function recovery.
JOURNAL OF NEPHROLOGY
(2022)
Review
Pediatrics
Abinaya Kannan, Kambagiri Pratyusha, Ruchy Thakur, Manas Ranjan Sahoo, Atul Jindal
Summary: Healthcare-associated infections (HAI) have a direct impact on the survival of children in pediatric intensive care units (PICU), with central line-associated bloodstream infection (CLABSI) being the most common at 25-30%, followed by ventilator-associated pneumonia (VAP) at 20-25%, and other infections like catheter-associated urinary tract infection (CAUTI) at 15% and surgical site infection (SSI) at 11%. HAIs complicate the disease course, especially in critical cases, leading to increased mortality, morbidity, hospital stays, and costs. Recent advances in healthcare practices, including asepsis, hand hygiene, infection surveillance, antibiotic stewardship, and bundled care, have reduced the incidence of HAIs. However, the rise of drug-resistant infections remains a significant threat.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Xiuhua Lu, Zhu Guo, Zhu-Nan Li, Crystal Holiday, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-Ping Tzeng, Anand Kumar, Ian A. York, Timothy M. Uyeki, Terrence Tumpey, James Stevens, Min Z. Levine
Summary: This study analyzed the antibody profiles of patients infected with A(H1N1)pdm09 viruses and found that although some adults produced high levels of antibodies, they still suffered from severe illness or death. The study suggests that narrowly-focused, low-quality antibody responses may contribute to severe lower respiratory tract infection.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Diego Viasus, Lara Nonell, Carlos Restrepo, Fabian Figueroa, Carla Donado-Mazarron, Jordi Carratala
Summary: This study summarizes the reported differentially expressed genes (DEGs) in critically ill septic patients with community-acquired pneumonia (CAP) and investigates their functional implications. The results highlight the complexity of immune responses during CAP.
Article
Medicine, General & Internal
Ahmed E. Abou Warda, Fatma Molham, Heba F. Salem, Gomaa Mostafa-Hedeab, Bashayer F. ALruwaili, Ayman N. Moharram, Mohamed Sebak, Rania M. Sarhan
Summary: This study investigated the incidence of clinical bacterial isolates and their antibiotic resistance burden among critically ill patients in different hospital units. Gram-negative bacteria were the most common pathogens, with a high rate of extended-spectrum beta-lactamase (ESBL) production. Polymyxin B was the most effective antibiotic against Gram-negative bacteria, while vancomycin and linezolid were the most active antibiotics against Gram-positive pathogens.
MEDICINA-LITHUANIA
(2022)
Article
Multidisciplinary Sciences
Weiqing Zhang, Jun Wu, Qiuying Gu, Yanting Gu, Yujin Zhao, Xiaoying Ge, Xiaojing Sun, Jun Lian, Qian Zeng
Summary: Measuring changes in muscle thickness and cross-sectional area using ultrasound can aid in diagnosing ICU-AW, with particular emphasis on the right rectus femoris muscle. Additionally, SOFA and APACHE II scores have good predictive power for ICU-AW on admission day.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Taghreed A. Hafiz, Shahad S. Alghamdi, Murad A. Mubaraki, Shymaa S. M. Alghamdi, Abdulwahab Alothaybi, Esraa Aldawood, Fawziah Alotaibi
Summary: During the COVID-19 pandemic, multidrug-resistant Acinetobacter baumannii respiratory infections were common in adult ICU intubated patients, with a high mortality rate. The majority of patients developed ventilator-associated pneumonia, and a small percentage developed bacteremia. The isolates showed significant antibiotic resistance, with some being pandrug-resistant. Risk factors for death included sepsis, septic shock, VAP, liver diseases, and the use of inappropriate antibiotic therapy. Patients coinfected with COVID-19 had worse outcomes compared to non-COVID-19 patients. The study highlights the importance of surveillance studies in this region to address the threat of MDR-AB.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Letter
Respiratory System
Anna Motos, Alexandre Lopez-Gavin, Jordi Riera, Adrian Ceccato, Laia Fernandez-Barat, Jesus F. Bermejo-Martin, Ricard Ferrer, David de Gonzalo-Calvo, Rosario Menendez, Raquel Perez-Arnal, Dario Garcia-Gasulla, Alejandro Rodriguez, Oscar Penuelas, Jose Angel Lorente, Raquel Almansa, Albert Gabarrus, Judith Marin-Corral, Pilar Ricart, Ferran Roche-Campo, Susana Sancho Chinesta, Lorenzo Socias, Ferran Barbe, Antoni Torres
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Critical Care Medicine
Adrian Ceccato, Raquel Perez-Arnal, Anna Motos, Ferran Barbe, Antoni Torres
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
G. Moreno, M. Ruiz-Botella, I Martin-Loeches, J. Gomez Alvarez, M. Jimenez Herrera, M. Bodi, F. Armestar, A. Marques Parra, A. Estella, S. Trefler, R. Jorge Garcia, J. Murcia Paya, P. Vidal Cortes, E. Diaz, R. Ferrer, A. Albaya-Moreno, L. Socias-Crespi, J. M. Bonell Goytisolo, S. Sancho Chinesta, A. Loza, L. Forcelledo Espina, J. C. Pozo Laderas, M. DeAlba-Aparicio, L. Sanchez Montori, I Vallverdu Perapoch, V Hidalgo, V Fraile Gutierrez, A. M. Casamitjana Ortega, F. Martin Serrano, M. Nieto, M. Blasco Cortes, J. Marin-Corral, J. Sole-Violan, A. Rodriguez
Summary: This study aimed to determine the association between corticosteroid use and ICU mortality in both the whole population and pre-specified clinical phenotypes. The results showed that corticosteroids were not associated with ICU mortality in the overall population, but they may have a protective effect in patients with the highest inflammatory levels.
MEDICINA INTENSIVA
(2023)
Article
Medicine, General & Internal
Ignacio Martin-Loeches, Anna Motos, Rosario Menendez, Albert Gabarrus, Jessica Gonzalez, Laia Fernandez-Barat, Adrian Ceccato, Raquel Perez-Arnal, Dario Garcia-Gasulla, Ricard Ferrer, Jordi Riera, Jose Angel Lorente, Oscar Penuelas, Jesus F. Bermejo-Martin, David de Gonzalo-Calvo, Alejandro Rodriguez, Ferran Barbe, Luciano Aguilera, Rosario Amaya-Villar, Carme Barbera, Jose Barberan, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesus Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalan-Gonzalez, Cristobal Galban, Victor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Diaz, Elena Gallego, Jose Luis Garcia Garmendia, Jose Garnacho-Montero, Jose M. Gomez, Ruth Noemi Jorge Garcia, Ana Loza-Vazquez, Judith Marin-Corral, Amalia Martinez de la Gandara, Ignacio Martinez Varela, Juan Lopez Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Penasco, Pilar Ricart, Luis Urrelo-Cerron, Angel Sanchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Sole-Violan, Luis Tamayo Lomas, Pablo Vidal, Antoni Torres
Summary: Persistent post-COVID-19 symptoms were found in more than two-thirds of patients, with female sex, duration of ICU stay, development of ICUAP, and ARDS identified as independent factors contributing to poor health post-COVID-19. Preventing ICUAP may have beneficial effects on post-COVID-19 recovery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Lluis Servia-Goixart, Juan C. Lopez-Delgado, Teodoro Grau-Carmona, Javier Trujillano-Cabello, M. Luisa Bordeje-Laguna, Esther Mor-Marco, Esther Portugal-Rodriguez, Carol Lorencio-Cardenas, Juan C. Montejo-Gonzalez, Paula Vera-Artazcoz, Laura Macaya-Redin, Juan Francisco Martinez-Carmona, Rayden Iglesias-Rodriguez, Diana Monge-Donaire, Jose L. Flordelis-Lasierra, Beatriz Llorente-Ruiz, Eva M. Menor-Fernandez, Itziar Martinez de Lagran, Juan C. Yebenes-Reyes
Summary: This study aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients. The results showed that factors such as age, organ failure scores, nutritional risk, and the need for parenteral nutrition were associated with mortality. Furthermore, mean calorie and protein intake may also influence outcomes.
CLINICAL NUTRITION ESPEN
(2022)
Letter
Nursing
F. Vela-Cano, D. Ruiz-Sanchez, J. Granado-Solano, A. Garcia-Sanz, M. Ortega-Botias, J. Marin-Corral
ENFERMERIA INTENSIVA
(2022)
Article
Chemistry, Analytical
Alex Gomez-Gomez, Jose Rodriguez-Morato, Noemi Haro, Judith Marin-Corral, Joan Ramon Masclans, Oscar J. Pozo
Summary: Metabolomics, especially untargeted metabolomics, has become the gold standard for biomarker discovery. This study developed a strategy based on derivatization and LC-MS/MS detection for the untargeted determination of carbonyl-containing metabolites. The usefulness of this guided metabolomics approach was demonstrated in the discovery of potential biomarkers for COVID-19 severity.
ANALYTICA CHIMICA ACTA
(2022)
Article
Critical Care Medicine
Luis Felipe Reyes, Alejandro Rodriguez, Alirio Bastidas, Daniela Parra-Tanoux, Yuli Fuentes, Esteban Garcia-Gallo, Gerard Moreno, Gustavo Ospina-Tascon, Gleen Hernandez, Edwin Silva, Ana Maria Diaz, Manuel Jibaja, Magdalena Vera-Alarcon, Emilio Diaz, Maria Bodi, Jordi Sole-Violan, Ricard Ferrer, Antonio Albaya-Moreno, Lorenzo Socias, Angel Estella, Ana Loza-Vazquez, Ruth Jorge-Garcia, Isabel Sancho, Ignacio Martin-Loeches
Summary: This study found a relation between dexamethasone treatment and ICU-acquired respiratory tract infections (ICU-RTI) in patients with COVID-19. Patients treated with dexamethasone showed significantly higher proportions of VAP, and dexamethasone treatment was identified as a risk factor for ICU-RTI.
JOURNAL OF CRITICAL CARE
(2022)
Article
Respiratory System
Sergi Pascual-Guardia, Francesco Amati, Judith Marin-Corral, Stefano Aliberti, Joaquim Gea, Nilam J. Soni, Alejandro Rodriguez, Oriol Sibila, Francisco Sanz, Giovanni Sotgiu, Pedro J. Marcos, Ane Uranga, Branislava Milenkovic, Christian N. Meyer, Martin Kolditz, Antonio R. Anzueto, Marcos I. Restrepo
Summary: This study aimed to assess the microbiological patterns associated with risk factors for empiric anti-pseudomonal antibiotic therapy in hospitalized COPD patients with CAP. By analyzing observational data from 689 hospitalized COPD patients, it was found that different microbiological profiles were present in COPD patients with CAP, and a new scoring system was proposed to guide decision-making about empiric anti-pseudomonal antibiotic therapy.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Respiratory System
Jessica Gonzalez, Jordi de Batlle, Ivan D. Benitez, Gerard Torres, Sally Santisteve, Adriano D. S. Targa, Clara Gort-Paniello, Anna Moncusi-Moix, Maria Aguila, Fatty Seck, Adrian Ceccato, Ricard Ferrer, Anna Motos, Jordi Riera, Laia Fernandez, Rosario Menendez, Jose Angel Lorente, Oscar Penuelas, Dario Garcia-Gasulla, Yhivian Penasco, Pilar Ricart, Elena Abril Palomares, Luciano Aguilera, Alejandro Rodriguez, Maria Victoria Boado Varela, Belen Betere, Juan Carlos Pozo-Laderas, Jordi Sole-Violan, Inmaculada Salvador-Adell, Mariana Andrea Novo, Jose Barberan, Rosario Amaya Villar, Jose Garnacho-Montero, Jose M. Gomez, Aaron Blandino Ortiz, Luis Tamayo Lomas, Alejandro Ubeda, Mercedes Catalan-Gonzalez, Angel Sanchez-Miralles, Ignacio Martinez Varela, Ruth Noemi Jorge Garcia, Nieves Franco, Victor D. Gumucio-Sanguino, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesus Caballero, Elena Gallego, Covadonga Rodriguez, Alvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M. Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vazquez, Pablo Vidal, Jose M. Anon, Cristina Carbajales Perez, Victor Sagredo, Nieves Carbonell, Lorenzo Socias, Carme Barbera, Angel Estella, Emili Diaz, David de Gonzalo-Calvo, Antoni Torres, Ferran Barbe
Summary: A study found that critical COVID-19 survivors are at high risk of impaired lung function and CT scan abnormalities during follow-up. Key factors associated with DLCO < 60% include chronic lung disease, duration of invasive mechanical ventilation, age, urea, and estimated glomerular filtration rate. Factors associated with fibrotic lesions include bacterial pneumonia and duration of ventilation. Age and chronic lung disease are important factors associated with impaired lung function and CT abnormalities in critical COVID-19 patients.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Critical Care Medicine
Jessica Gonzalez, Ivan D. Benitez, Anna Motos, Antoni Torres, Ferran Barbe
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Alisa M. Higgins, Lindsay R. Berry, Elizabeth Lorenzi, Srinivas Murthy, Zoe McQuilten, Paul R. Mouncey, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma Van Bentum-Puijk, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Aiden Burrell, Adrian Buzgau, Meredith Buxton, Walton N. Charles, Matthew Cove, Michelle A. Detry, Lise J. Estcourt, Elizabeth O. Fagbodun, Mark Fitzgerald, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, Christopher M. Horvat, David T. Huang, Nao Ichihara, Francois Lamontagne, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Matthew D. Neal, Alistair D. Nichol, Rachael L. Parke, Jane C. Parker, Karen Parry-Billings, Sam E. C. Peters, Luis F. Reyes, Kathryn M. Rowan, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Ary Serpa-Neto, Christopher W. Seymour, Manu Shankar-Hari, Lucy M. Stronach, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Lennie P. G. Derde, Anthony C. Gordon, Steve A. Webb, Patrick R. Lawler
Summary: The longer-term effects of therapies for critically ill COVID-19 patients are unknown. In this study, 4869 patients were randomized to receive different interventions, and it was found that treatment with IL-6 receptor antagonists and antiplatelet agents significantly improved survival rates after 180 days. These findings suggest that most therapies have consistent effects over a 6-month period.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Letter
Infectious Diseases
Catia Cilloniz, Anna Motos, Tatiana Castaneda, Albert Gabarrus, Ferran Barbe, Antoni Torres
JOURNAL OF INFECTION
(2023)
Review
Critical Care Medicine
Marcos I. Restrepo, Judith Marin-Corral, Juan J. Rodriguez, Valeria Restrepo, Rodrigo Cavallazzi
Summary: The COVID-19 pandemic has had devastating effects on global morbidity and mortality. The virus has a specific tropism for the cardiovascular system, causing endothelial injury and leading to inflammation, microthrombosis, and angiogenesis. The disease is associated with various cardiovascular complications such as myocarditis, arrhythmias, heart failure, ischemic heart disease, stroke, and thromboembolic disease. This review summarizes the literature on the epidemiology, diagnosis, treatment, and preventive measures related to cardiovascular complications in COVID-19.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tomas Segura, Ignacio Medrano, Sergio Collazo, Claudia Mate, Carlo Sguera, Carlos Del Rio-Bermudez, Hugo Casero, Ignacio Salcedo, Jorge Garcia-Garcia, Cristian Alcahut-Rodriguez, Miren Taberna
Summary: This study used real-world data to describe the clinical profile and timing of diagnosis in ALS patients. The results showed a significant diagnostic delay in ALS, with only 38.8% of patients visiting a neurologist prior to diagnosis. The study highlights the importance of early diagnosis and reveals differences in clinical characteristics across ALS subtypes.
SCIENTIFIC REPORTS
(2023)