Article
Microbiology
Manuel Madrazo, Ian Lopez-Cruz, Laura Piles, Sofia Vinola, Juan Alberola, Jose Maria Eiros, Arturo Artero
Summary: This study analyzed the risk factors for multidrug-resistant bacteria (MDRB) in community-acquired urinary sepsis (US) and their influence on outcomes. The results showed that healthcare-associated US was an independent risk factor for MDR bacteria. Although the impact of MDR bacteria on the outcomes of community-acquired US was mild, this study still has important implications for understanding the risk factors and outcomes of MDR bacteria.
Article
Infectious Diseases
Kanit Assawatheptawee, Pornpit Treebupachatsakul, Taradon Luangtongkum, Pannika R. Niumsup
Summary: This study found that being a farmer is an independent risk factor for MDRE-associated CA-UTIs, and the first report of mcr-9-positive Enterobacter cloacae from a Thai patient in the community.
Article
Infectious Diseases
Benoit Bailly, Maxime Lecheneaut, Houssein Gbaguidi-Haore, Catherine Chirouze, Francois Kleinclauss, Kevin Bouiller
Summary: The aim of this study was to determine the incidence and risk factors of febrile ureteral stent-associated urinary tract infections (FUSAUTI). The results showed that 7.24% of patients developed at least one FUSAUTI after ureteral stent placement, and in a quarter of cases, it led to a serious infection. Urethral stent placement was identified as the only modifiable risk factor.
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Yosef Gebretensaie, Abay Atnafu, Selfu Girma, Yonas Alemu, Kassu Desta
Summary: The study aimed to determine the prevalence, associated factors, and antibiotic resistance pattern of urinary tract infections (UTIs) in UTI-suspected patients. Different bacterial uropathogens were identified and antibiotic resistance was observed, especially among commonly used antibiotics. Female gender and previous UTIs were found to be possible risk factors associated with UTIs.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Manuel Madrazo, Ian Lopez-Cruz, Laura Piles, Silvia Artero, Juan Alberola, Juan Alberto Aguilera, Jose Maria Eiros, Arturo Artero, Fernando Cobo
Summary: This study aimed to determine the risk factors for bacteremia and its clinical impact on hospitalized patients with complicated community-acquired urinary tract infections. Febrile community-acquired urinary tract infections and elevated procalcitonin were found to be risk factors for bacteremia. The outcomes in patients with bacteremia were slightly worse, but without significant differences in mortality.
Article
Public, Environmental & Occupational Health
Xiaoyu Ma, Fan Zhang, Bing Bai, Zhiwei Lin, Guangjian Xu, Zhong Chen, Xiang Sun, Jinxin Zheng, Qiwen Deng, Zhijian Yu
Summary: This study investigated the resistance mechanisms, molecular characteristics, and risk factors of E. faecalis clinical isolates from UTI patients in China. The findings revealed a high frequency of linezolid and tedizolid resistance in E. faecalis isolates, with erm(A) being the predominant resistance gene. Indwelling catheters and tracheal cannulas were identified as independent predictors of linezolid resistance. Further research is needed to understand the transmission mechanisms of linezolid-resistant E. faecalis in this hospital setting.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Hala Alghoraibi, Aisha Asidan, Raneem Aljawaied, Raghad Almukhayzim, Aljoharah Alsaydan, Elaf Alamer, Waleed Baharoon, Emad Masuadi, Abeer Al Shukairi, Laila Layqah, Salim Baharoon
Summary: This study retrospectively analyzed the prescription pattern of continuous antibiotic prophylaxis for recurrent urinary tract infections (UTIs) in adult patients from January 2016 to December 2018. The results showed that although continuous prophylactic antibiotics were effective in reducing the recurrence rate, emergency room visits, and hospital admissions due to UTIs, they were only used in 55% of patients with recurrent infections. Trimethoprim/sulfamethoxazole was the most frequently prescribed prophylactic antibiotic.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2023)
Article
Pediatrics
Luke Harper, Nathalie Botto, Matthieu Peycelon, Jean-Luc Michel, Marc-David Leclair, Sarah Garnier, Pauline Clermidi, Alexis P. Arnaud, Anne-Laure Dariel, Eric Dobremez, Alice Faure, Laurent Fourcade, Nadia Boudaoud, Yann Chaussy, Fideline Collin, Laetitia Huiart, Cyril Ferdynus, Valery Bocquet, Frederique Sauvat
Summary: In boys with PUV, the presence of high-grade VUR is associated with a higher risk of fUTI. The rate of febrile UTIs seems to decrease after 9 months.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nursing
Yielin Kim, Mi Hwa Cho, Kyungmin Do, Hye Jin Kang, Jin Ju Mok, Mi Kyoung Kim, Gwang Suk Kim
Summary: This study investigated the incidence of urinary tract infection and its risk factors among hospitalised patients with spinal cord injury. The results showed that sex, completeness of injury, type of bladder emptying, detrusor function and urethral pressure were significant factors affecting urinary tract infection. Patients who were male and those with injury classifications A, B and C had higher risk of urinary tract infection.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Immunology
Jennifer A. Frontera, Erwin Wang, Michael Phillips, Martha Radford, Stephanie Sterling, Karen Delorenzo, Archana Saxena, Shadi Yaghi, Ting Zhou, D. Ethan Kahn, Aaron S. Lord, Joseph Weisstuch
Summary: The novel protocol for urine sampling and testing significantly reduced rates of CAUTI infection and urinary catheter days.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Javier Martinez-Casanova, Silvia Gomez-Zorrilla, Nuria Prim, Agustina Dal Molin, Daniel Echeverria-Esnal, Maria Pilar Gracia-Arnillas, Elena Sendra, Robert Guerri-Fernandez, Xavier Duran-Jorda, Eduardo Padilla, Juan Pablo Horcajada, Santiago Grau
Summary: This study identified previous exposure to amoxicillin-clavulanate or fluoroquinolones as the only independent risk factors associated with the development of amoxicillin-clavulanate resistance in urinary isolates of E. coli and K. pneumoniae from patients attending the emergency department.
Article
Critical Care Medicine
Karen Perrin, Anu Vats, Aater Qureshi, Jeannette Hester, Angela Larson, Alfeil Felipe, Andressa Sleiman, Jacqueline Baron-Lee, Katharina Busl
Summary: This study aimed to identify characteristics and risk factors associated with CAUTI development in neuro-critically ill patients. Older age, female gender, longer neuroICU length of stay, and presence of comorbidities such as HTN and diabetes were found to be associated with CAUTI development. Average Time-to-CAUTI after catheter placement was 6 days with earlier occurrence if more frequent catheterizations.
NEUROCRITICAL CARE
(2021)
Article
Infectious Diseases
Adi Turjeman, Tanya Babich, Miquel Pujol, Jordi Carratala, Evelyn Shaw, Aina Gomila-Grange, Cuong Vuong, Ibironke Addy, Irith Wiegand, Sally Grier, Alasdair MacGowan, Christiane Vank, Nienke Cuperus, Leo van den Heuvel, Leonard Leibovici, Noa Eliakim-Raz
Summary: The study aimed to identify risk factors for enterococcal urinary tract infection in patients with complicated UTI, finding that male gender, age range of 55-75 years, catheter-associated UTI, and urinary retention were associated risk factors for enterococcal UTI.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Ghulam H. Saadat, Daniel Alsoof, Bilal Ahmad, Bennet A. Butler, Thomas A. Messer, Faran Bokhari
Summary: This study investigated the risk factors and clinical impact of postoperative urinary tract infection (UTI) in geriatric patients with hip fractures. The results showed that postoperative UTI was associated with pneumonia, deep vein thrombosis, sepsis, prolonged hospital stay, and hospital readmission.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Obstetrics & Gynecology
Innocentia Nji Ngong, Jerome Fru-Cho, Melduine Akom Yung, Jane-Francis Kihla Tatah Akoachere
Summary: Urinary tract infections (UTIs) are common during pregnancy, especially in women. Dipstick analysis of urine has a certain level of accuracy in diagnosis, but pregnant women show varying sensitivity and resistance to antibiotics. Risk factors do not show a significant association with UTIs.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Immunology
Nina J. Zhu, Timothy M. Rawson, Siddharth Mookerjee, James R. Price, Frances Davies, Jonathan Otter, Paul Aylin, Russell Hope, Mark Gilchrist, Yeeshika Shersing, Alison Holmes
Summary: The COVID-19 pandemic has affected the patterns of community- and hospital-acquired bloodstream infections in COVID-19 and non-COVID-19 patients. There was a high incidence of hospital-acquired bacteremia during the COVID-19 waves, especially in SARS-CoV-2-negative elective patients.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Stephanie Evans, James Stimson, Diane Pople, Alex Bhattacharya, Russell Hope, Peter J. White, Julie Robotham
Summary: Despite evidence of nosocomial transmission of SARS-CoV-2 in hospitals, the contributions of different transmission pathways are poorly quantified. This study analyzed national hospital records and found that indirect transmission between patients, such as through healthcare workers or contaminated objects, was the most likely route of nosocomial transmission. The risk of transmission to patients from healthcare workers is low but significant when the number of infected patients is low. The risk of healthcare workers acquiring SARS-CoV-2 in the hospital is equal to that in the community.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Nick Andrews, Elise Tessier, Julia Stowe, Charlotte Gower, Freja Kirsebom, Ruth Simmons, Eileen Gallagher, Simon Thelwall, Natalie Groves, Gavin Dabrera, Richard Myers, Colin N. J. Campbell, Gayatri Amirthalingam, Matt Edmunds, Maria Zambon, Kevin Brown, Susan Hopkins, Meera Chand, Shamez N. Ladhani, Mary Ramsay, Jamie Lopez Bernal
Summary: A study conducted in England showed that vaccines against SARS-CoV-2 provide high protection against hospitalization and death from Covid-19 at 20 weeks or more after vaccination. However, the effectiveness of the vaccines decreases over time, especially in individuals aged 65 and older and those with underlying risk factors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Infectious Diseases
Adrienn Angyal, Stephanie Longet, Shona C. Moore, Rebecca P. Payne, Adam Harding, Tom Tipton, Patpong Rongkard, Mohammad Ali, Luisa M. Hering, Naomi Meardon, James Austin, Rebecca Brown, Donal Skelly, Natalie Gillson, Sue L. Dobson, Andrew Cross, Gurjinder Sandhar, Jonathan A. Kilby, Jessica K. Tyerman, Alexander R. Nicols, Jarmila S. Spegarova, Hema Mehta, Hailey Hornsby, Rachel Whitham, Christopher P. Conlon, Katie Jeffery, Philip Goulder, John Frater, Christina Dold, Matthew Pace, Ane Ogbe, Helen Brown, M. Azim Ansari, Emily Adland, Anthony Brown, Meera Chand, Adrian Shields, Philippa C. Matthews, Susan Hopkins, Victoria Hall, William James, Sarah L. Rowland-Jones, Paul Klenerman, Susanna Dunachie, Alex Richter, Christopher J. A. Duncan, Eleanor Barnes, Miles Carroll, Lance Turtle, Thushan de Silva
Summary: This study compares immune responses to the BNT162b2 mRNA vaccine in healthcare workers with and without previous SARS-CoV-2 infection. The results show that previously infected individuals have stronger spike-specific T-cell and antibody responses after receiving a single dose of the vaccine compared to SARS-CoV-2-naive individuals. This suggests that a single dose of the BNT162b2 vaccine is likely to provide better protection against SARS-CoV-2 infection in individuals with previous infection.
Article
Dermatology
Ketaki Bhate, Kathryn E. Mansfield, Sarah-Jo Sinnott, David J. Margolis, Elizabeth Adesanya, Nick Francis, Clemence Leyrat, Susan Hopkins, Richard Stabler, Laura Shallcross, Sinead M. Langan, Rohini Mathur
Summary: This study investigated the use of oral antibiotics for moderate-to-severe acne vulgaris using primary care data. It was found that 44.5% of individuals received long-term oral antibiotic treatment, with a median of four continuous courses per person. Further research is needed to understand the consequences of using antibiotics for shorter periods.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Infectious Diseases
Rebecca Guy, Katherine L. Henderson, Juliana Coelho, Helen Hughes, Emily L. Mason, Sarah M. Gerver, Alicia Demirjian, Conall Watson, Ashley Sharp, Colin S. Brown, Theresa Lamagni
Summary: There has been an increase in invasive group A streptococcal (iGAS) infection and associated deaths, especially in children, exceeding seasonally expected levels in England (772 notifications reported in weeks 37 to 48 in 2022). Diagnoses of iGAS infection from lower respiratory tract specimens in children under 15 years increased to 28% in November 2022. Medical practitioners have been alerted to the exceptional rise in incidence, including unusual numbers of children presenting with pulmonary empyema.
Letter
Pediatrics
Shamez N. Ladhani, Rebecca Guy, Sunil S. Bhopal, Colin S. Brown, Theresa Lamagni, Ashley Sharp
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Infectious Diseases
Katie Harman, Sophie Grace Nash, Harriet H. Webster, Natalie Groves, Jo Hardstaff, Jessica Bridgen, Paula B. Blomquist, Russell Hope, Efejiro Ashano, Richard Myers, Sakib Rokadiya, Susan Hopkins, Colin S. Brown, Meera Chand, Gavin Dabrera, Simon Thelwall
Summary: There are concerns about the reduced efficacy of sotrovimab in reducing hospitalisation risk for the BA.2 sub-lineage of the Omicron variant. A retrospective study was conducted to compare the risk of hospitalisation between BA.2 and BA.1 cases treated with sotrovimab. The results suggest that the risk of hospital admission was similar for both sub-lineages.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Microbiology
Emma McGuire, Claire Neill, Simon M. Collin, Hannah Higgins, Rebecca Guy, Mark Ganner, Juliana Coelho, Bruno Pichon, Russell Hope, Colin S. Brown
Summary: PVL toxin detection was not associated with worse outcomes in patients with community-acquired S. aureus bacteremia.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Editorial Material
Pediatrics
Shamez N. Ladhani, Rebecca Guy, Helen E. Hughes, Alex J. Elliot, Sunil S. Bhopal, Colin Brown, Theresa Lamagni
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Kirsty F. Bennet, Rebecca L. Guy, Sarah M. Gerver, Katie L. Hopkins, Richard Puleston, Colin S. Brown, Katherine L. Henderson
Summary: Hospitals in England have screening policies for carbapenemase-producing Enterobacterales (CPE), but the RCPath recommendations had minimal impact on reducing CPE screening. The reduction in screening was primarily due to a decrease in patient admissions related to the COVID-19 pandemic.
INFECTION PREVENTION IN PRACTICE
(2023)
Letter
Infectious Diseases
Nurin Abdul Aziz, Sophie Grace Nash, Asad Zaidi, Tommy Nyberg, Natalie Groves, Russell Hope, Jamie Lopez Bernal, Gavin Dabrera, Simon Thelwall
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Rebecca L. Guy, Jamie Rudman, Hannah Higgins, Emma Carter, Katherine L. Henderson, Alicia Demirjian, Sarah M. Gerver
Summary: This study in England reveals that MDR and XDR phenotypes occur more frequently in nitrofurantoin-resistant Escherichia coli urinary isolates compared to nitrofurantoin-susceptible isolates.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Emma Sherwood, Stefania Vergnano, Isona Kakuchi, Michael G. Bruce, Suman Chaurasia, Samara David, Angela Dramowski, Scarlett Georges, Rebecca Guy, Theresa Lamagni, Daniel Levy-Bruhl, Outi Lyytikainen, Monika Naus, Jennifer Onukwube Okaro, Oddvar Oppegaard, Didrik F. Vestrheim, Tammy Zulz, Andrew C. Steer, Chris A. Van Beneden, Anna C. Seale
Summary: The study revealed a significant burden of invasive GAS in young children, with insufficient data on neonates and children in low- and middle-income countries, as well as a complete lack of data on pregnant women. Incidence of invasive GAS is likely underestimated, especially in low- and middle-income countries, due to limited GAS surveillance. Improving available data is crucial for the development of prevention and management strategies for invasive GAS.
LANCET INFECTIOUS DISEASES
(2022)