Article
Medicine, Research & Experimental
Liang Wang, Ting Liu, Yaofu Zheng, Jiamin Zhou, Hexiang Hua, Liming Kong, Weilin Huang, Xiaoping Peng, Tong Wen
Summary: This study investigated the molecular mechanisms of YAP1/TEAD signaling during neointima formation, and found that P4HA2 plays a crucial role in VSMC differentiation and neointima formation through its regulation of YAP1. These findings suggest that targeting P4HA2-mediated prolyl hydroxylation of YAP1 may be a promising therapeutic approach for preventing injury-induced neointima formation in cardiovascular disease.
Article
Oncology
Jian Huang, Fanglin Tian, Ying Song, Mengru Cao, Shi Yan, Xiuwen Lan, Yimeng Cui, Yaowen Cui, Yue Cui, Dexin Jia, Li Cai, Ying Xing, Xin Wang
Summary: The study demonstrated that EHD1 plays a crucial role in non-small cell lung cancer, regulating the glycolysis pathway through the Wnt/beta-catenin signaling, promoting aerobic glycolysis and proliferation. These findings suggest a potential therapeutic target for NSCLC.
Article
Biochemistry & Molecular Biology
Xiaomai Liu, Yujia Sun, Shaocong Wang, Shoutao Zhang, Qingnan Tian
Summary: A homolog of actin in planarian Dugesia japonica was identified, and it was found that RNAi targeting actin can affect planarian regeneration, resulting in the formation of protrusions on the dorsal side, increased division of phospho-H3 mitotic cells, and decreased differentiation in regenerating tissues, indicating that actin plays an important role in proliferation and differentiation control in planarian regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Chien -Der Lee, Naomi Ziv, Alexander D. Johnson
Summary: The paper explores the stability of different cell types in the fungal species Candida albicans. By using an auxin-mediated degradation system, the researchers quickly removed the primary transcription activator Wor1, and observed that within approximately 1 hour, cells irreversibly lost their memory and switched to a different cell state. This study provides insights into the mechanisms underlying cell memory in eukaryotic cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Plant Sciences
Meijie Li, Shunsuke Watanabe, Fei Gao, Christian Dubos
Summary: Iron is an essential micronutrient for plant growth and development. Plants have evolved two different strategies, Strategy I and Strategy II, to acquire iron from soils. Recent findings show that the choice of strategy is influenced by soil characteristics, such as pH and oxygen concentration. This review summarizes recent research on plant iron uptake and discusses its impact on our understanding of plant iron nutrition.
Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Cell Biology
Xin Xu, Dan -Dan Zhang, Peng Kong, Ya-Kun Gao, Xiao-Fu Huang, Yu Song, Wen-Di Zhang, Rui-Juan Guo, Chang-Lin Li, Bo-Wen Chen, Yue Sun, Yong-Bo Zhao, Fang-Yue Jia, Xu Wang, Fan Zhang, Mei Han
Summary: Vascular smooth muscle cells (VSMCs) can transform into macrophage-like cells, contributing to vascular hyperplasia. This study identifies Sox10 as a key regulator of VSMC transdifferentiation and inflammation, and suggests its potential as a therapeutic target for inflammation-related vascular diseases. RGS5 interacts with AKT and inhibits PI3K/AKT signaling, thereby suppressing VSMC transdifferentiation and inflammation.
Article
Oncology
Qiang Li, Xiao Wang, Liheng Zhou, Mingyun Jiang, Guansheng Zhong, Shuguang Xu, Minjun Zhang, Yigan Zhang, Xiaodong Liang, Lei Zhang, Jianming Tang, Haibo Zhang
Summary: The study revealed that LINC00152 is significantly upregulated in breast cancer, serving as an indicator of poor prognosis. Knockdown of LINC00152 suppresses cell proliferation and tumorigenicity, and its interaction with KLF5 promotes tumor progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Jean-Claude Farre, Krypton Carolino, Lou Devanneaux, Suresh Subramani
Summary: This study investigates the relationship between peroxisomes and mitochondria, and reveals that mitochondrial oxidative phosphorylation deficiency inhibits peroxisome proliferation and affects the expression of proteins related to fatty acid and methanol metabolism. This process is regulated by the SNF1 signaling pathway.
Article
Plant Sciences
Kumud Saini, Aditi Dwivedi, Aashish Ranjan
Summary: High ambient temperature suppresses Arabidopsis leaf growth by reducing cell proliferation. PIF4 and TCP4 transcription factors play key roles in regulating leaf size under high temperature, with PIF4 depending on TCP4 and KRP1 to control cell proliferation.
Article
Biochemistry & Molecular Biology
So Young Kim, Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, Da Hye Kim, Hyesook Lee, Gi-Young Kim, Sung-Kwon Moon, Sun-Hee Leem, Seok Joong Yun, Wun-Jae Kim, JaeHun Cheong, Cheol Park, Yung Hyun Choi
Summary: The study demonstrates that betulinic acid induces apoptosis, necrosis, and cell cycle arrest in bladder cancer cells through modulation of cell cycle regulators and mitochondrial function, leading to decreased proliferation and migration.
Article
Chemistry, Multidisciplinary
Mengting Du, Tingting Geng, Rongrong Yu, Gang Song, Hui Cheng, Yu Cao, Weidong He, Abdul Haleem, Qinglin Li, Rongfeng Hu, Shengqi Chen
Summary: This study presents a charge-reversible nanoparticle CRNP-GNA that can induce a positive feedback loop to enhance tumor vascular permeability and drug accumulation in tumors with low vascular density, thereby improving the efficacy of anti-vascular therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Zhongwen Li, Guojun Yue, Tingyou Zhang, Jinzhi Wu, Xin Tian
Summary: A recent study identified ADAMTS9-AS1 as a potential prognostic marker in NSCLC, with high expression associated with poor prognosis and disease progression. Knockdown of ADAMTS9-AS1 in NSCLC cells led to inhibition of cell proliferation, migration, and invasion, as well as cell cycle arrest and apoptosis. The results suggest that ADAMTS9-AS1 could be a promising therapeutic target for NSCLC patients.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Biology
Paul Pfeiffer, Federico Jose Barreda Tomas, Jiameng Wu, Jan-Hendrik Schleimer, Imre Vida, Susanne Schreiber
Summary: This study introduces a new technique called capacitance clamp, which allows for simulation of altered capacitance in biological neurons. Through mathematical modeling and experimental validation, the feasibility of this technique is demonstrated, providing a new avenue for probing the mechanisms of neuronal signaling.
Article
Cell Biology
Jessica Perochon, Yachuan Yu, Gabriel N. Aughey, Andre B. Medina, Tony D. Southall, Julia B. Cordero
Summary: In Drosophila, a previously unrecognized crosstalk between adult intestinal stem cells and the vasculature-like tracheal system has been uncovered, which is essential for intestinal regeneration. Gut-derived reactive oxygen species activate tracheal signaling pathways, leading to reversible remodeling of gut-associated terminal tracheal cells and intestinal stem cell proliferation. This inter-organ communication program is crucial for adapting the stem cell response to the proliferative demands of the intestinal epithelium.
NATURE CELL BIOLOGY
(2021)
Article
Plant Sciences
Ana P. Santos, Carolina Belfiore, Cristina Urbez, Alejandro Ferrando, Miguel A. Blazquez, Maria E. Farias
Summary: This study found that bacteria from extreme environments can promote plant growth and enhance the tolerance of soybean plants to salt stress. These bacteria not only increased the germination rate of soybeans but also doubled the length and dry biomass of soybean roots under salt stress. Additionally, the presence of these bacteria resulted in changes in plant gene expression, particularly in genes related to growth and stress responses. This research suggests that these extremophilic bacteria could serve as potential bio-inoculants to alleviate salt stress and promote plant growth.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Plant Sciences
Alexandros Phokas, Rabea Meyberg, Asier Briones-Moreno, Jorge Hernandez-Garcia, Panida T. Wadsworth, Eleanor F. Vesty, Miguel A. Blazquez, Stefan A. Rensing, Juliet C. Coates
Summary: DELLA proteins play a role in integrating environmental signals to regulate growth and development in plants, but their function and regulation differ in different plant lineages.
Article
Plant Sciences
Maite Saura-Sanchez, Tai Sabrina Chiriotto, Jimena Cascales, Gabriel Gomez-Ocampo, Jorge Hernandez-Garcia, Zheng Li, Jose Luis Pruneda-Paz, Miguel Angel Blazquez, Javier Francisco Botto
Summary: Shade avoidance syndrome (SAS) is an adaptive strategy that involves elongation of the stem and petiole, leaf hyponasty, and altered phototropic orientation in response to reduced blue light and low red:far-red ratio. BBX24 and JAZ3 are key regulators in the SAS pathway, jointly controlling DELLA activity and plant growth.
PLANT AND CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vanessa Polet Carrillo-Carrasco, Jorge Hernandez-Garcia, Sumanth K. Mutte, Dolf Weijers
Summary: The signaling molecule auxin is found in various life kingdoms. It has primarily been studied as a phytohormone regulating growth and development in land plants. Recent advancements in genomic and transcriptomic data, along with phylogenetic inference, have allowed us to trace the evolutionary history of auxin biology in bryophytes and streptophyte algae. This review examines auxin biosynthesis, transport, physiological and molecular responses, as well as its role as a chemical messenger in ecological communication. Validating predicted orthologs will further our understanding of the conserved properties of auxin biology among streptophytes.
Article
Biochemistry & Molecular Biology
Chen Liu, Andriani Mentzelopoulou, Amna Muhammad, Andriy Volkov, Dolf Weijers, Emilio Gutierrez-Beltran, Panagiotis N. Moschou
Summary: Cellular condensates known as processing bodies (PBs) in Arabidopsis thaliana were investigated using a proximity-biotinylation proteomics approach. The study revealed that PBs comprise networks that interface with membranes, and the conserved component DCP1 can localize to unique plasma membrane subdomains. A developmental module controlled by DCP1 and the actin-nucleating SCAR-WAVE complex was discovered at these membrane interfaces, which regulate cell shape. This study uncovers an unexpected function for a conserved condensate at unique membrane interfaces.
Article
Plant Sciences
Eugenia Pitsili, Ricardo Rodriguez-Trevino, Nerea Ruiz-Solani, Fatih Demir, Elizabeth Kastanaki, Charlene Dambire, Roger de Pedro-Jove, Dominique Vercammen, Jose Salguero-Linares, Hardy Hall, Melissa Mantz, Martin Schuler, Hannele Tuominen, Frank Van Breusegem, Marc Valls, Sergi Munne-Bosch, Michael J. Holdsworth, Pitter F. Huesgen, Antia Rodriguez-Villalon, Nuria S. Coll
Summary: Increasing drought poses a serious threat to agriculture, and understanding plant response mechanisms is crucial. By using genetic, proteomic, and physiological approaches, the role of AtMC3, a phloem-specific protein, in osmotic stress responses was investigated. The results showed that overexpression of AtMC3 enhances vascular tissue differentiation and maintains higher levels of vascular-mediated transportation, leading to improved drought tolerance.
Article
Multidisciplinary Sciences
Mattia Fontana, Mark Roosjen, Isidro Crespo Garcia, Willy van den Berg, Marc Malfois, Roeland Boer, Dolf Weijers, Johannes Hohlbein
Summary: The signaling molecule auxin coordinates various growth and development processes in plants by modulating gene expression. Transcriptional response is mediated by the family of auxin response factors (ARF), which recognize a DNA motif and can form homodimers. In this study, the affinity and kinetics of ARFs' interaction with an auxin-responsive element were investigated using a single-molecule Forster resonance energy transfer (smFRET) DNA binding assay. The results showed that both the DNA-binding domain (DBD) and the PB1 domain of ARF contribute to DNA binding, and ARF dimer stability plays a key role in defining binding affinity and kinetics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Developmental Biology
Yosapol Harnvanichvech, Cecilia Borassi, Diaa Eldin S. Daghma, Hanne M. van der Kooij, Joris Sprakel, Dolf Weijers
Summary: Plant external surfaces are often covered by barriers that control the exchange of molecules, protect from pathogens, and offer mechanical integrity. A new study shows that during the earliest stages of embryogenesis, there is a structure called the embryonic envelope that wraps around the embryonic surface. This structure is composed of extensin, arabinogalactan O-glycoproteins, and lipids, and it acts as both a diffusion barrier and a means to mechanically confine the embryo.
Editorial Material
Biochemistry & Molecular Biology
Shruti Choudhary, Hannele Tuominen
Article
Plant Sciences
Gabriel Gomez-Ocampo, Carlos D. Crocco, Jimena Cascales, Jana Oklestkova, Danuse Tarkowska, Miroslav Strnad, Santiago Mora-Garcia, Jose L. Pruneda-Paz, Miguel A. Blazquez, Javier F. Botto
Summary: B-Box-containing zinc finger transcription factor BBX21 inhibits hypocotyl elongation in Arabidopsis through the brassinosteroid pathway. It reduces sensitivity to synthetic active brassinosteroid 24-epiBL at low concentrations in simulated shade and represses the biosynthesis and signaling genes of brassinosteroids. BBX21 integrates brassinosteroid homeostasis and shade-light signaling to fine-tune hypocotyl elongation in Arabidopsis.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Carlos de Ollas, Clara Segarra, Miguel A. A. Blazquez, Javier Agusti, Aurelio Gomez-Cadenas
Summary: Plant transpiration is a fundamental process that affects plant water use efficiency, thermoregulation, nutrition, and growth. This study investigated the genetic and environmental factors that influence natural variation in plant transpiration and water use efficiency in Arabidopsis thaliana. The results showed that there was significant variation in transpiration capacity, transpiration per surface unit, and water use efficiency among different accessions of A. thaliana. Interestingly, water use efficiency was found to be directly correlated with projected leaf area, suggesting that plant size is an important adaptive trait for water use in A. thaliana.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biotechnology & Applied Microbiology
Sacha Escamez, Kathryn M. M. Robinson, Mikko Luomaranta, Madhavi Latha Gandla, Niklas Mahler, Zakiya Yassin, Thomas Grahn, Gerhard Scheepers, Lars-Goran Stener, Stefan Jansson, Leif J. J. Jonsson, Nathaniel R. R. Street, Hannele Tuominen
Summary: This study explored the properties and genetics of wood that affect bioconversion, aiming to identify superior tree feedstocks for biorefining. The results revealed that certain traits, such as stem height and diameter, can predict the potential for wood saccharification yield in aspen trees. Additionally, a genome-wide association study identified genetic markers for bioconversion of bioenergy tree feedstocks.
BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
(2023)
Article
Plant Sciences
Asier Briones-Moreno, Jorge Hernandez-Garcia, Carlos Vargas-Chavez, Noel Blanco-Tourinan, Alexandros Phokas, Cristina Urbez, Pablo D. Cerdan, Juliet C. Coates, David Alabadi, Miguel A. Blazquez
Summary: DELLA proteins are specific transcriptional regulators in land plants that transmit environmental information to various plant processes. The regulation of DELLA stability by gibberellins and their interaction with hundreds of transcription factors are the molecular basis for their critical function in angiosperms. It is unclear whether the ability to establish interaction networks is an ancestral property of DELLA proteins or is linked to their role in gibberellin signaling.
