Review
Cell Biology
Siyu Fan, Xin Sun, Chuanchao Su, Yiwen Xue, Xiao Song, Runzhi Deng
Summary: Bone healing is crucial for various orthopedic conditions, and the involvement of macrophages and bone marrow mesenchymal stem cells (BMSCs) in this process has been highlighted. The interaction between these two cell types plays a vital role in regulating the balance between inflammation and regeneration, and any disruption in this balance can lead to impaired bone healing. Understanding the function and relationship of macrophages and BMSCs in bone regeneration can provide new insights to enhance bone healing. This review paper discusses the role of macrophages and BMSCs in bone healing, as well as the mechanism and significance of their interaction. It also explores several new therapeutic approaches targeting the crosstalk between these cell types to regulate the inflammatory response in bone healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell & Tissue Engineering
Yu-Hao Wang, Cheng-Zhi Zhao, Ren-Yi Wang, Qian-Xin Du, Ji-Yuan Liu, Jian Pan
Summary: Bone injury is a global problem that affects millions of patients and puts a heavy burden on the public medical insurance system. Autologous bone transplantation is considered to be the gold standard for treating large-scale bone defects, but it has limitations. Therefore, there is an urgent need for basic research on new therapeutic methods. In-depth research on the crosstalk between macrophages and bone marrow mesenchymal stem cells reveals a close relationship between inflammation and regeneration. The interaction between macrophages, bone marrow mesenchymal stem cells, and biomaterials is expected to be the mainstream for exploring new methods for bone injury in the future.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Immunology
Byunghyuk Lee, Seung-Hyo Lee, Kihyuk Shin
Summary: Fibroblasts play a crucial role in supporting organ structures and regulating immune responses. They have diverse origins and functions, leading to distinct phenotypes and functions in different organs. Fibroblasts can interact with T cells to modulate immune responses, influencing the development and progression of inflammatory diseases. Understanding the mechanisms of fibroblast-T cell interactions could provide new insights into therapeutic targets for various diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Daphne N. Pariser, Zachary T. Hilt, Sara K. Ture, Sara K. Blick-Nitko, Mark R. Looney, Simon J. Cleary, Estheany Roman-Pagan, Jerry Saunders, Steve N. Georas, Janelle Veazey, Ferralita Madere, Laura Tesoro Santos, Allison Arne, Nguyen P. T. Huynh, Alison C. Livada, Selena M. Guerrero-Martin, Claire Lyons, Kelly A. Metcalf-Pate, Kathleen E. McGrath, James Palis, Craig N. Morrell
Summary: Platelets, previously known as cellular mediators of thrombosis, are also immune cells that interact with immune cells, impacting their activation and differentiation. Lung megakaryocytes (Mk(L)) have gene expression patterns similar to antigen-presenting cells, and have key immune regulatory roles influenced by the tissue environment. This indicates the plasticity of the immune phenotype of Mk(L) and their ability to induce T cell activation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Matteo Calafatti, Germana Cocozza, Cristina Limatola, Stefano Garofalo
Summary: In recent years, biomedical research has focused on understanding the mechanisms of motor neuron death in amyotrophic lateral sclerosis (ALS). While initially focused on motor neurons, recent studies highlight the important role of microglia, astrocytes, and infiltrating immune cells in the pathological processes of the central nervous system microenvironment. This review examines the current knowledge of microglial interactions with other cell populations in ALS progression, including astrocytes and immune cells, using in vitro and in vivo studies. Additionally, it highlights experimental therapeutic approaches that aim to modulate microglial phenotype and counteract ALS progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Mousumi Mahapatro, Lena Erkert, Christoph Becker
Summary: Cytokines play a crucial role in the gut by regulating immune responses and disease susceptibility loci, influencing gut health. Intestinal epithelial cells act as translators between the microbiota and the immune system, maintaining gut homeostasis.
Review
Cell Biology
Jianwen Fang, Yue Lu, Jingyan Zheng, Xiaocong Jiang, Haixing Shen, Xi Shang, Yuexin Lu, Peifen Fu
Summary: The tumor microenvironment, consisting of various components, plays a significant role in tumor initiation and progression. Endothelial cells orchestrate angiogenesis in the microenvironment, impacting the proliferation and metastasis of malignant cells. Understanding the intricate crosstalk between endothelial cells and immune cells is crucial for advancing immunotherapeutic interventions.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Sonia Kiran, Vijay Kumar, Santosh Kumar, Robert L. Price, Udai P. Singh
Summary: Obesity is a complex disease affecting global populations, characterized by excess adipose tissue accumulation and immune response alterations. miRs, novel adipokines expressed in various tissues, play a crucial role in immune response, insulin resistance, and obesity-related inflammation. The dysregulated expression of miRs in adipocytes, T-cells, and macrophages suggests their importance as potential biomarkers and therapeutic targets for metabolic diseases associated with obesity.
Review
Immunology
Jianrui Zheng, Zhi Yao, Lixiang Xue, Deli Wang, Zhen Tan
Summary: Osteonecrosis is caused by the death of bone marrow cells, leading to abnormal immune function and chronic inflammation that interferes with bone regeneration and repair. Osteoimmunology explores the interactions between immune cells and bone cells, and understanding the chronic inflammatory environment regulated by abnormal osteoimmune function can help develop new treatments for osteonecrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Wenzhi Shu, Mengfan Yang, Jiayin Yang, Shengda Lin, Xuyong Wei, Xiao Xu
Summary: The liver has a unique ability to regenerate and recover from injuries and diseases through hepatocyte proliferation and coordinated actions of nonparenchymal cells. The interactions between hepatocytes and surrounding cells, as well as among nonparenchymal cells, play a crucial role in liver regeneration. There are two modes of liver regeneration, self-replication of liver epithelial cells and transdifferentiation between liver epithelial cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Zhiqin Deng, Qian Zhang, Zhe Zhao, Yongshen Li, Xiaoqiang Chen, Zicong Lin, Zhenhan Deng, Jianquan Liu, Li Duan, Daping Wang, Wencui Li
Summary: Osteoimmunology studies the interactions between the immune system and the skeletal system, with different immune cells playing various roles in regulating osteoclasts and chondrocytes. These cells maintain a dynamic balance through multiple signaling mechanisms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Masahiro Kamata, Yayoi Tada
Summary: Psoriasis is an immune-mediated disease in which immune cells and skin cells interact, leading to aberrant differentiation and proliferation of keratinocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Fenyao Li, Xinxin Wang, Jin Shi, Shuting Wu, Wenbo Xing, Yan He
Summary: Dental pulp stem cells have strong immunomodulatory capabilities and can be used to treat inflammation-related diseases and autoimmune disorders. The mechanism of action is complex and may involve the regulation of immune cells through inflammatory immune-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mizuki Doi, Hiroki Tanaka, Takara Ohoto, Naoya Miura, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita
Summary: The reactivation of anticancer immunity using immune checkpoint inhibitors (ICIs) is a crucial aspect in cancer immunotherapy. However, the low objective response rate (<40%) of ICIs remains a major challenge. This study demonstrates that myeloid-derived suppressor cells (MDSCs) can be depleted by delivering synthetic glucocorticoid dexamethasone to phagocytic cells in the spleen using lipid nanoparticles. Additionally, the nanoparticulated dexamethasone exhibits a synergistic anticancer effect with ICIs.
Review
Oncology
Josefine de Stricker Borch, Jeppe Haslund-Vinding, Frederik Vilhardt, Andrea Daniela Maier, Tiit Mathiesen
Summary: Meningioma is the most common primary intracranial tumor, with surgery being the primary treatment and radiation therapy as secondary treatment. Traditional chemotherapy has been ineffective due to tumor resistance, and the understanding of meningioma biology is lacking compared to other tumor types. Further research is needed to explore the relationship between tumor cells and the tumoral microenvironment (TME) to improve treatment outcomes.
