期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13045-017-0534-8
关键词
Autophagy; Endosome; Exosomes; Immune; MHC presentation; Cancer; Immunotherapeutic
资金
- National Natural Science Foundation of China [81500110, 81370645, 81670178]
- National Key Research and Development Program of China [2016YFC090150X]
- Research Project for Practice Development of National TCM Clinical Research Bases [JDZX2015113]
T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cytoplasmic constituents for lysosomal degradation, has been observed to provide a substantial source of intra-and extracellular antigens for MHC presentation to T cells, which will impact the tumor-specific immune response. Meanwhile, extracellular components are transported to cytoplasm for the degradation/secretion process by the endo-/exosomal pathway and are thus involved in multiple physiological and pathological processes, including immune responses. Autophagy and endo-/exosomal pathways are intertwined in a highly intricate manner and both are closely involved in antigen processing for MHC presentation; thus, we propose that they may coordinate in antigen processing and presentation in anticancer T cell immune responses. In this article, we discuss the molecular and functional crosstalk between autophagy and endo-/exosomal pathways and their contributions to antigen processing for MHC presentation in anticancer T cell immune responses.
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