Article
Neurosciences
Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Summary: The study found that rats with the rs6265 SNP showed enhanced transplant efficacy and neurite outgrowth, but also experienced transplant-induced dyskinesias. This suggests that this common genetic mutation can affect transplant therapeutic efficacy and side effects development.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Aneta Bednarova, Viera Habalova, Ivan Tkac
Summary: This study investigated the association between BDNF polymorphisms and depression and schizophrenia. The results showed that BDNF rs962369 was significantly associated with an increased risk of single-episode major depression disorder (MDD) and recurrent MDD, but not with schizophrenia. The frequency of the minor allele C of BDNF rs962369 varied across different subgroups, with the highest frequency in patients with recurrent MDD and the lowest in schizophrenia patients.
Article
Genetics & Heredity
Ettore Dolcetti, Antonio Bruno, Federica Azzolini, Luana Gilio, Alessandro Moscatelli, Francesca De Vito, Luigi Pavone, Ennio Iezzi, Stefano Gambardella, Emiliano Giardina, Rosangela Ferese, Fabio Buttari, Francesca Romana Rizzo, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Georgia Mandolesi, Livia Guadalupi, Diego Centonze, Mario Stampanoni Bassi
Summary: The role of BDFN Val66Met polymorphism in multiple sclerosis (MS) is still controversial. A study on 218 relapsing-remitting MS patients found that the presence of the Met genotype is associated with elevated levels of certain pro-inflammatory cytokines and reduced cortical thickness at the time of diagnosis.
Article
Behavioral Sciences
Piyush Pathak, Aseem Mehra, Sant Ram, Arnab Pal, Sandeep Grover
Summary: This study aimed to determine the association of Val66Met polymorphism in the BDNF gene and serum BDNF level with treatment response in MDD patients. The results showed that the presence of the Met allele was associated with a better response to antidepressant medications; serum BDNF level was significantly higher in MDD patients; lower serum BDNF level was associated with better outcomes in patients treated with ECT.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Vasiliki Koute, Amalia Michalopoulou, Vasileios Siokas, Athina-Maria Aloizou, Dimitrios Rikos, Dimitrios P. Bogdanos, Eleftherios Kontopoulos, Ioanna N. Grivea, George A. Syrogiannopoulos, Alexandros Papadimitriou, Georgios M. Hadjigeorgiou, Efthimios Dardiotis
Summary: The study revealed a significant association of the BDNF rs6265 variant with decreased headache risk, particularly in the dominant and log-additive models. Additionally, Val66Met was also linked to decreased childhood migraine risk for the first time.
NEUROLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Henry Ng, Sofa Dewi Alfian, Rizky Abdulah, Melisa Barliana
Summary: The number of mental disorders has been increasing but has not received sufficient attention. The study examines the association between brain-derived neurotrophic factor val66met polymorphism and psychological distress in Indonesian Pharmacy students and finds that there is no significant effect of genotype and sociodemographic factors on psychological distress.
Article
Environmental Sciences
Juan Antonio Zarza-Rebollo, Esther Molina, Elena Lopez-Isac, Ana M. Perez-Gutierrez, Blanca Gutierrez, Jorge A. Cervilla, Margarita Rivera
Summary: This study aims to investigate the relationship between depression, the Val66Met polymorphism at the BDNF gene, and physical activity. The results show a protective effect of physical activity on depression, particularly in light intensity. Interestingly, individuals carrying the Met allele of the BDNF Val66Met polymorphism who engage in more hours of physical activity have a decreased prevalence of depression, with this effect being more pronounced in women. These findings emphasize the potential role of physical activity as a promising therapeutic strategy for preventing and treating depression, and suggest molecular and genetic differences in depression between sexes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Elisabeth Hertenstein, Marion Kuhn, Nina Landmann, Jonathan-Gabriel Maier, Carlotta Louisa Schneider, Kristoffer Daniel Feher, Lukas Frase, Dieter Riemann, Bernd Feige, Christoph Nissen
Summary: The single nucleotide polymorphism in the BDNF gene may not significantly affect creativity in university students, but non-met carriers may have an advantage in solving moderately difficult problems.
Review
Psychiatry
Adriana Farcas, Charles Hindmarch, Felicia Iftene
Summary: This article reviews recent research findings on the contribution of the BDNF gene Val66Met polymorphisms to schizophrenia. The Met/Met genotype is associated with higher positive symptom scores, while increased BDNF levels under Risperidone treatment correlate with weight gain in Val/Val genotype carriers.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Rafat Fatma, Waseem Chauhan, Mehdi Hayat Shahi, Mohammad Afzal
Summary: This study evaluated the association of BDNF gene polymorphism (rs6265) with IQ, BMI, and BP. It found a significant association between the T allele and decreased IQ, increased BMI, and decreased blood pressure. This study is important for understanding the genetic variations of this neurotrophic factor and their effects on human traits.
FRONTIERS IN NEUROLOGY
(2023)
Article
Genetics & Heredity
Buse Yuksel, Murat Dogan, Olcay Boyacioglu, Mustafa Sahin, Seda Orenay-Boyacioglu
Summary: Tinnitus is the perception of sound in the absence of external stimuli. The genes BDNF and BDNF-AS may play a role in the auditory pathway and affect hearing performance. This study suggests that certain polymorphisms in the BDNF-AS gene (rs925946, rs1488830, rs1519480, and rs10767658) may have an impact on the auditory pathway and affect hearing performance.
Article
Multidisciplinary Sciences
Louise Martens, Luisa Herrmann, Lejla Colic, Meng Li, Anni Richter, Gusalija Behnisch, Oliver Stork, Constanze Seidenbecher, Bjoern H. Schott, Martin Walter
Summary: This study found that the Met allele of the Val66Met SNP of the BDNF gene is associated with lower Glx/NAA ratio in the pregenual anterior cingulate cortex (pgACC). Met carriers did not show decreased glutamate or glutamine levels, but instead exhibited increased NAA compared to Val homozygotes. This finding may help explain conflicting evidence regarding Val66Met as a risk factor for developing psychiatric illnesses.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
N. Abanmy, J. Alsabhan, P. Gard, G. Scutt
Summary: This study found a significant association between the BDNF gene Val66Met polymorphism and cognitive performance in both elderly control group and AD patients, with carriers of GG homozygotes showing superior cognitive function. Additionally, the use of SSRIs significantly improved cognitive function in elderly participants, but not in AD patients.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Psychiatry
Lijun Chu, Xia Sun, Xiaoju Jia, Dazhi Li, Ping Gao, Yong Zhang, Jie Li
Summary: This study found that anxiety trait is associated with the BDNF polymorphism in panic disorder patients. The BDNF Met/Met genotype may decrease plasma BDNF levels and increase trait anxiety.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Surgery
Elionora Pena, Assumpta Caixas, Concepcion Arenas, Rocio Pareja, Josep Leon-Mengibar, Mercedes Rigla, Timothy R. Powell, Narcis Cardoner, Araceli Rosa
Summary: This study found that individuals carrying the BDNF Val66Met polymorphism may experience better weight loss outcomes after bariatric surgery without having type 2 diabetes (T2D). On the contrary, a T2D diagnosis at baseline was associated with a negative effect on weight loss outcomes, seemingly counteracting the positive effect of the Met variant.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)