Review
Polymer Science
Karen Guillen-Carvajal, Benjamin Valdez-Salas, Ernesto Beltran-Partida, Jorge Salomon-Carlos, Nelson Cheng
Summary: Hydrogels are versatile biomaterials with three-dimensional, cross-linked, highly hydrated polymeric networks. They have a variety of biochemical and biophysical properties, allowing for diffusion of diverse molecules and control of cellular interactions. Hydrogels can be molded into different structures resembling surrounding tissues and bone defects. Their application in bone tissue engineering has garnered significant attention due to the beneficial bone improvement results achieved. Synthetic polymers have played a key role, but there is a trend towards using biological precursors like chitosan, collagen, and gelatin for their high biocompatibility, degradability, and mechanical control.
Article
Nanoscience & Nanotechnology
He Wang, Bo Hu, Hong Li, Ge Feng, Shengyuan Pan, Ziqi Chen, Bo Li, Jinlin Song
Summary: In this study, hydroxyapatite nanofibers (HANFs) were incorporated into GelMA hydrogel to improve its mechanical properties and bone regenerative ability. The results showed that a certain amount of mineralized nanofibers significantly improved the biocompatibility and bone repair effect of the composite hydrogel, but increasing the amount of nanofibers did not lead to further improvement in performance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xiaojing Mo, Dianjian Zhang, Keda Liu, Xiaoxi Zhao, Xiaoming Li, Wei Wang
Summary: This review summarizes the classification of n-HAp composites, the application of n-HAp composite scaffolds loaded with bioactive factors and drugs in bone tissue engineering, the drug loading methods of n-HAp composite scaffolds, and prospects the research direction of n-HAp composite scaffolds in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sourav Mohanto, Soumya Narayana, Khushboo Paresh Merai, Jahanvee Ashok Kumar, Adrija Bhunia, Umme Hani, Adel Al Fatease, B. H. Jaswanth Gowda, Sagnik Nag, Mohammed Gulzar Ahmed, Karthika Paul, Lalitkumar K. Vora
Summary: A gelatin-based hydrogel system is a biocompatible and biodegradable polymer system that responds to stimuli and has solid-like rheology. It can entangle moisture and gradually assemble a hierarchical crosslinked structure, allowing for controlled release of encapsulated payloads and providing mechanical signals to adjacent cells. The use of functional tunable biopolymers in hydrogels has increased their porosity and mechanical ability, enabling higher loading of therapeutic molecules. This review presents gelatin-based hydrogel as a potential biomaterial for various biomedical applications, highlighting its sources, structural characteristics, challenges, and designs for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Shouye Sun, Yutao Cui, Baoming Yuan, Minghan Dou, Gan Wang, Hang Xu, Jingwei Wang, Wen Yin, Dankai Wu, Chuangang Peng
Summary: This paper reviews the application of polyethylene glycol (PEG)-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shanyong Zhang, Lei Ding, Gaoyang Chen, Jiayin Zhang, Wanbao Ge, Yuan Qu
Summary: This study aimed to develop a Sr-HA/PTH1-34-loaded composite hydrogel system with high biocompatibility to improve bone induction property in bone tissue engineering and regenerative medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Massimiliano Dapporto, Marta Tavoni, Elisa Restivo, Francesca Carella, Giovanna Bruni, Laura Mercatali, Livia Visai, Anna Tampieri, Michele Iafisco, Simone Sprio
Summary: Injectable calcium phosphate cements (CPCs) are promising candidates for bone defect regeneration. By enriching strontium-doped CPCs with hydroxyapatite nanoparticles (HA-NPs) functionalized with tetracycline (TC), a sustained and tunable drug release control can be achieved, along with effective antibacterial activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
He Wang, Xiaowei Chang, Qian Ma, Boyang Sun, Han Li, Jinmin Zhou, Yiyao Hu, Xiaoyu Yang, Jie Li, Xin Chen, Jinlin Song
Summary: Researchers have designed a bioinspired drug-delivery system for diabetic periodontal bone regeneration. The system emulates the natural bone healing cascade by releasing drugs and recruiting stem cells to promote bone regeneration. In vitro and in vivo experiments have shown that the system is effective in restoring bone healing in diabetic patients.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jun Liu, Siyu Wu, Jiayi Ma, Chun Liu, Ting Dai, Xiaoyu Wu, Hongbin Zhao, Dong Zhou
Summary: This study manufactured nanofibrous scaffolds incorporating different ratios of attapulgite (ATP) and Hydroxyapatite (HA) to enhance the osteoinductive effect in bone tissue engineering. The synergistic effect of ATP and HA on bone formation was explored both in vivo and in vitro. The study found that the ATP/HA ratio of 2:1 had the most significant synergistic effect.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Feng Li, Jian Li, Xujun Song, Tong Sun, Lian Mi, Jian Liu, Xiaomin Xia, Na Bai, Xue Li
Summary: This study developed and evaluated an appropriate GA-nCeO2 hydrogel scaffold for bone tissue engineering. The results showed that the scaffold had a favorable structure, biocompatibility, and strong osteogenic potential. This research provides a potential new material for the treatment of bone defects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Shuai Chang, Chao Li, Nanfang Xu, Jiedong Wang, Zehao Jing, Hong Cai, Yun Tian, Shaobo Wang, Zhongjun Liu, Xing Wang
Summary: The construction of a tetra-PEG hydrogel with sustained drug release capability has shown promising potential in treating bone defects by promoting stem cell growth and bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Shangsi Chen, Yue Wang, Xin Zhang, Jun Ma, Min Wang
Summary: In this study, multifunctional double-crosslinked alginate/allylated gelatin hydrogels incorporated with polydopamine particles were designed and made. The hydrogels showed the potential for combined chemotherapy and phototherapy to ablate bone tumor cells, as well as promoting bone tissue regeneration. In vitro experiments demonstrated their effectiveness in killing tumor cells and their ability to promote the proliferation of bone mesenchymal stem cells and osteogenic activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Wenfeng Zhu, Rui Chen, Weiheng Wang, Yi Liu, Changgui Shi, Songjun Tang, Guoke Tang
Summary: In this study, we developed an acetylsalicylic acid (ASA)-based double-network (DN) hydrogel with suitable porous structure and favorable mechanical properties. The in situ encapsulated ASA in the DN hydrogel showed sustained release, anti-inflammation, and osteoinductive properties, demonstrating a new strategy for bone tissue regeneration.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Hajime Matsumine, Yosuke Niimi
Summary: The study compared the take rate of skin grafts in patients who underwent autologous skin grafting within different waiting periods after the first stage of full-thickness skin reconstruction using bFGF-CGS. The results showed no significant difference in skin graft take rate between the groups, but there was a significant difference in healing time.
REGENERATIVE THERAPY
(2022)
Article
Materials Science, Biomaterials
Xuanwen Xu, Xinyu Li, Shuang Qiu, Yi Zhou, Lu Li, Xu Chen, Kai Zheng, Yan Xu
Summary: This study aimed to explore the appropriate concentration ratio of biofriendly transglutaminase-modified gelatin hydrogels for promoting periodontal alveolar bone regeneration. Through a series of characterization and cell experiments, it was found that all the hydrogels possessed multi-space network structures and demonstrated their biocompatibility. In vivo and in vitro osteogenic differentiation experiments also confirmed that the group 40-5 (transglutaminase-gelatin concentration ratio) possessed a favorable osteogenic potential.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
