Article
Multidisciplinary Sciences
Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudiere-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raul A. Suarez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Berube, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, Francois Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fevre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklos Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique Lopez-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Lolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguia, Mario Perezpena, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Juri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor
Summary: Medulloblastoma (MB) is a pediatric embryonal neoplasm of the hindbrain with subtypes including Sonic hedgehog MB, WNT MB and G4 MB. Somatic mutations in G4 MB converge on the core binding factor alpha (CBFA) complex, and knocking down OTX2 can relieve differentiation blockage.
Article
Cell Biology
Lishan Zhang, Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin
Summary: A novel missense mutation (NM_000523: exon2: c.G917T: p.R306L) of Hoxd13 gene was identified in a Chinese family with synpolydactyly (SPD). Mice carrying the corresponding Hoxd13 mutation exhibited synpolydactyl phenotype. Further analysis revealed that this mutation promoted osteoclast differentiation and bone loss by regulating Smad5/p65/c-Fos/Rank axis, providing new insights into the development of SPD.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Parthiv Haldipur, Silvia Bernardo, Kimberly A. Aldinger, Tarika Sivakumar, Jake Millman, Alexandria H. Sjoboen, Derek Dang, Danilo Dubocanin, Mei Deng, Andrew E. Timms, Brian D. Davis, Jasmine T. Plummer, Kshitij Mankad, Ozgur Oztekin, Lucia Manganaro, Fabien Guimiot, Homa Adle-Biassette, Rosa Russo, Joseph R. Siebert, Debora Kidron, Giulia Petrilli, Nathalie Roux, Ferechte Razavi, Ian A. Glass, Cira Di Gioia, Evelina Silvestri, Kathleen J. Millen
Summary: Dandy-Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) are common cerebellar malformations diagnosed through ultrasound and MRI. Histopathological analysis showed reduced foliation and inferior vermian hypoplasia in DWM cases. Disruption of the rhombic lip, with reduced proliferation and altered vasculature, is key in the pathogenesis of DWM.
ACTA NEUROPATHOLOGICA
(2021)
Review
Biochemistry & Molecular Biology
Ming-Li Zou, Zhong-Hua Chen, Ying-Ying Teng, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Yi Feng, Xia Li, Rui-Sheng Xu, Feng-Lai Yuan
Summary: Bone remodeling is a continuous process crucial for maintaining skeletal homeostasis, with Smad signaling pathway playing a key role in regulating osteoblast and osteoclast functions during this process. Targeting Smad signaling pathway could be a promising therapeutic strategy for treating osteoporosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Daisuke Tateiwa, Takashi Kaito, Kunihiko Hashimoto, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Hiroyuki Tsukazaki, Shinichi Nakagawa, Yuichiro Ukon, Hiromasa Hirai, Hongying Tian, Ivan Alferiev, Michael Chorny, Satoru Otsuru, Seiji Okada, Masahiro Iwamoto
Summary: BMPs have been used clinically for bone formation in musculoskeletal disorders, but high doses can lead to adverse events. A potent antagonist of RAR gamma was found to enhance BMP-induced bone formation, leading to increased bone volume and thickness, as well as promoting chondrogenic gene expression. This suggests potential for improving BMP-2 based bone regeneration procedures in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Cai-Ping Yan, Xing-Kuan Wang, Ke Jiang, Chong Yin, Chao Xiang, Yong Wang, Chaoyu Pu, Lu Chen, Yu-Ling Li
Summary: Bone defects are a global public health problem, and the available methods for inducing bone regeneration are limited. β-ecdysterone, a plant sterol similar to estrogen, has been found to promote bone regeneration by enhancing osteoblast differentiation and activating the BMP-2/Smad/Runx2/Osterix pathway. This study provides a new direction for osteogenic differentiation and offers novel therapeutic strategies for treating bone defects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Nissrine Ballout, Agnes Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trecherel, Theo Gallego, Cathy Gomila, Linda Yaker, Isabelle Gennero, Jose Kovensky, Jerome Ausseil, Sylvestre Toumieux
Summary: Bone fracture healing is a complex process involving hematoma formation, tissue formation, bony callus formation, and bone remodeling. Current therapeutic strategies for fracture repair include autografts, allografts, and tissue engineering. This study suggests that DP2, a disaccharide compound, may enhance fracture healing by promoting osteoblast differentiation and earlier mineralization in vitro. DP2 might serve as a potential therapeutic candidate for bone fracture repair.
Review
Cell Biology
Mengmeng Liu, Graham Goldman, Mary MacDougall, Shuo Chen
Summary: BMP signaling plays a crucial role in dentin development, regulating the differentiation and gene expression of odontoblasts through canonical and non-canonical Smad signaling pathways. Dysregulation of BMP signaling leads to tooth disorders, and studies in mice with BMP signaling-associated gene mutations or knockouts have provided insights into the underlying networks. This review summarizes recent advances in understanding BMP signaling in odontoblast differentiation and dentin formation, including the expression of BMPs, receptors, and downstream genes, as well as the structures of BMPs, receptors, antagonists, and their association with dentin defects.
Review
Neurosciences
Gwenvael Le Dreau
Summary: This mini-review summarizes the impact of bone morphogenetic proteins (BMPs) on various aspects of vertebrate central nervous system (CNS) formation and highlights the crucial role of canonical BMP activity in the amplification and maintenance of neural stem cells. These findings suggest the evolutionary conservation of this function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Oncology
Wangyang Meng, Han Xiao, Rong Zhao, Dong Li, Kuo Li, Yunchong Meng, Jiaping Chen, Yangwei Wang, Yongde Liao
Summary: In lung adenocarcinoma, BMP5 was identified as an independent protective prognostic factor, significantly correlated with EGFR expression and mutations, and potentially involved in targeted therapy. By co-expression with hub genes, the re-established risk model showed improved prognostic correlation and value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Jun Sik Lee, Hyung Keun Kim
Summary: BFP-4 induces stronger osteogenic differentiation of BMSCs compared to BMP-7, as well as enhancing ALP activity, calcium concentration, and osteogenic factor production. This suggests that BFP-4-stimulated cell therapy may be a more efficient and cost-effective approach to bone regeneration and formation than BMP-7-based therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Agata Wawrzyniak, Krzysztof Balawender
Summary: This article examines the development, structure, and remodeling of bone tissue. As an essential component of the skeleton, bone provides support and protection and maintains the concentration of calcium and phosphate in body fluids. Bone metabolism involves the balance of bone formation and resorption, regulated by various factors. Secretion of biologically active substances in bone tissue also influences bone function and metabolism.
Article
Ophthalmology
Fanying Jiang, Yingyan Qin, Yuanfan Yang, Zhen Li, Baoyue Cui, Rong Ju, Mingxing Wu
Summary: The study aimed to investigate the roles of BMP-4/BMP-7 in fibrotic cataract progression and underlying mechanisms. The results showed that BMP-4/BMP-7 attenuated cataract by inhibiting the proliferation, migration, and EMT of LECs via modulation of the Notch pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Junko Tachi, Takashi Onuma, Shinobu Yamaguchi, Woo Kim, Tomoyuki Hioki, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Haruhiko Tokuda, Osamu Kozawa, Hiroki Iida
Summary: The study found that duloxetine suppresses BMP-4-stimulated OPG release by inhibiting the Smad1/5/8 signaling pathway, with similar inhibitory effects observed for fluvoxamine and sertraline.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Binisha H. Mishra, Pashupati P. Mishra, Emma Raitoharju, Saara Marttila, Nina Mononen, Harri Sievanen, Jorma Viikari, Markus Juonala, Marika Laaksonen, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: This study analysed gene co-expression modules shared by early traits of osteoporosis and atherosclerosis, identifying two modules with significant joint association with both diseases. The significant member genes from these modules are involved in biological processes related to bone metabolism or atherosclerosis, potentially providing new joint biomarkers for both diseases.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Li Wang, Jiang-Yun Luo, Bochuan Li, Xiao Yu Tian, Li-Jing Chen, Yuhong Huang, Jian Liu, Dan Deng, Chi Wai Lau, Song Wan, Ding Ai, King-Lun Kingston Mak, Ka Kui Tong, Kin Ming Kwan, Nanping Wang, Jeng-Jiann Chiu, Yi Zhu, Yu Huang
Article
Multidisciplinary Sciences
Jianjian Zhu, Kin Ming Kwan, Susan Mackem
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Meeting Abstract
Developmental Biology
Tsz Ching Ma, Keng Ioi Vong, Kin Ming Kwan
MECHANISMS OF DEVELOPMENT
(2017)
Meeting Abstract
Developmental Biology
Keng Ioi Vong, Crystal Kit Ying Leung, Richard Behringer, Kin Ming Kwan
MECHANISMS OF DEVELOPMENT
(2017)
Meeting Abstract
Developmental Biology
Kin Ming Kwan, Pak Lun Baggio Liu, Ka Kui Tong
MECHANISMS OF DEVELOPMENT
(2017)
Meeting Abstract
Developmental Biology
Yue Hu, Kin Ming Kwan
MECHANISMS OF DEVELOPMENT
(2017)
Article
Multidisciplinary Sciences
Nga Chu Lui, Wing Yip Tam, Caiji Gao, Jian-Dong Huang, Chi Chiu Wang, Liwen Jiang, Wing Ho Yung, Kin Ming Kwan
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Zhefan Stephen Chen, Li Li, Shaohong Peng, Francis M. Chen, Qian Zhang, Ying An, Xiao Lin, Wen Li, Alex Chun Koon, Ting-Fung Chan, Kwok-Fai Lau, Jacky Chi Ki Ngo, Wing Tak Wong, Kin Ming Kwan, Ho Yin Edwin Chan
Article
Pharmacology & Pharmacy
Qianwen Wang, Shaohong Peng, Yue Hu, Chun-Ho Wong, Kin Ming Kwan, H. Y. Edwin Chan, Zhong Zuo
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Medicine, Research & Experimental
Mengbi Yang, Qjan Zhang, Qianwen Wang, Kasper K. Sorensen, Josephine T. Boesen, Sum Yi Ma, Knud J. Jensen, Kin Ming Kwan, Jacky Chi Ki Ngo, Ho Yin Edwin Chan, Zhong Zuo
MOLECULAR PHARMACEUTICS
(2018)
Article
Cell Biology
Tsz Ching, Keng Ioi Vong, Kin Ming Kwan
Article
Neurosciences
Xiaonan Dong, Kin Ming Kwan
Article
Multidisciplinary Sciences
Keng Ioi Vong, Tsz Ching Ma, Baiying Li, Thomas Chun Ning Leung, Wenyan Nong, Sai Ming Ngai, Jerome Ho Lam Hui, Liwen Jiang, Kin Ming Kwan
Summary: The study reveals that genetic ablation of Sox9 in the choroid plexus results in a hyperpermeable blood-CSF barrier, disrupting CSF electrolyte balance and protein composition. This disruption is mediated by the down-regulation of Col9a3 expression, leading to structural integrity loss of the epithelial basement membrane and perturbed microtubule dynamics necessary for correct tight junction assembly in the CP epithelium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jacquelyne Ka-Li Sun, Deng Wu, Genper Chi-Ngai Wong, Tsun-Ming Lau, Meigui Yang, Ronald P. Hart, Kin-Ming Kwan, Ho Yin Edwin Chan, Hei-Man Chow
Summary: Chronic binge-like drinking is a risk factor for age-related dementia, potentially due to its lasting and irreversible impact on the brain. Ethanol exposure leads to pro-ageing changes in brain cortices, particularly in neurons, by affecting the ethyl alcohol oxidation and folate metabolism. This disrupts DNA repair pathways, forces post-mitotic cells to re-enter a cell cycle-like process, and ultimately results in irreversible senescence response. Supplementation of bioactive 5-methyl tetrahydrofolate during alcohol exposure can prevent these effects, highlighting the connection between binge drinking and dementia.
