期刊
DEVELOPMENT
卷 142, 期 3, 页码 409-419出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.107441
关键词
Periodic patterning; Reaction-diffusion; Turing; Mathematical biology; Pattern formation; Pigment pattern
资金
- National Institutes of Health [DC010791]
- Herchel Smith Graduate Fellowship
How periodic patterns are generated is an open question. A number of mechanisms have been proposed - most famously, Turing's reaction-diffusion model. However, many theoretical and experimental studies focus on the Turing mechanism while ignoring other possible mechanisms. Here, we use a general model of periodic patterning to show that different types of mechanism (molecular, cellular, mechanical) can generate qualitatively similar final patterns. Observation of final patterns is therefore not sufficient to favour one mechanism over others. However, we propose that a mathematical approach can help to guide the design of experiments that can distinguish between different mechanisms, and illustrate the potential value of this approach with specific biological examples.
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