Article
Multidisciplinary Sciences
Manash Jyoti Kalita, Kalpajit Dutta, Gautam Hazarika, Ridip Dutta, Simanta Kalita, Partha Pratim Das, Manash P. Sarma, Sofia Banu, Md. Ghaznavi Idris, Anjan Jyoti Talukdar, Sangitanjan Dutta, Ajanta Sharma, Subhash Medhi
Summary: As the COVID-19 pandemic continues to impact the world, the development of a cost-effective and efficient multiplex PCR detection assay for the virus has shown promising results. The study demonstrated rapid and sensitive detection of SARS-CoV-2 using innovative PCR techniques, with results comparable to commercially available kits. The novel approach has the potential for extended commercial applicability and offers a practical solution for resource-limited settings.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Allen Herbst, Solbie Choi, Austin N. Hoang, Chiye Kim, Diana Martinez Moreno, Debbie McKenzie, Judd M. Aiken, Jonathan Wanagat
Summary: This study investigated the effects of Remdesivir on mitochondrial DNA copy number and deletion mutation frequency in aged rodents. The results showed that three months of Remdesivir treatment did not affect the quality and quantity of mitochondrial DNA in old rats.
Article
Biochemistry & Molecular Biology
Aishwarya Venkatasubramanian, Anand Thiyagaraj, Vairamuthu Subbiah, Solaipriya Solairaja, Sangaran Arumugam, Satish Ramalingam, Sivaramakrishnan Venkatabalasubramanian
Summary: This study investigated the molecular therapeutic potential of ellagic acid in treating iodoacetamide-mediated liver steatosis, demonstrating its efficacy in regulating lipid homeostasis and gene expression. Computational analysis showed promising pharmacokinetic properties of ellagic acid compared to Simvastatin, supporting its therapeutic potential against non-alcoholic fatty liver disease.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hong-Feng Liang, Lie-Jun Li, Hui Yang, Xiang-Bin Zheng, Min Lu, Yi-Yuan Ge, Fen Lin, Long-Xu Xie, Li-Ye Yang
Summary: A novel reverse dot blot assay was evaluated for the detection of common alpha-thalassaemia and beta-thalassaemia genotypes in a Chinese population. The new assay demonstrated high accuracy and efficiency, but yielded contradictory results for certain variations not included in the detection panel.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Virology
Farman Khan, Praveen Sharma, Saurabh Pandey, Deepak Sharma, V. Vijayavarman, Neeraj Kumar, Suruchi Shukla, Himanshu Dandu, Amita Jain, Ravindra K. Garg, Hardeep S. Malhotra
Summary: COVID-19 has been associated with various neurological complications, with GBS being an important post-infectious consequence. This study found SARS-CoV-2 in the CSF of an adult patient for the first time, highlighting the need to consider separate pathogenesis in cases where COVID-19 symptoms and GBS occur concurrently. The study also suggests a neuroinvasive potential of SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahtab Peyambari, Shengxi Guan, Marilyn J. Roossinck
Summary: Experimental findings show that RdRp proteins of partitiviruses have reverse transcriptase (RT) function, can be active at lower temperatures, sparking researchers to question why these viruses have RT capabilities.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Clive R. Bagshaw, Jendrik Hentschel, Michael D. Stone
Summary: Telomerases are moderately processive reverse transcriptases that extend the 3' ends of linear chromosomes using an integral RNA template. The processivity values vary at different positions, with a characteristic strong band every 6th position in gel electrophoresis due to repeat nucleotides. This analysis reveals that higher product concentrations associated with a certain type of processivity arise from a stalling of nucleotide incorporation during translocation.
Article
Cardiac & Cardiovascular Systems
Kashif Khan, Isabella Albanese, Bin Yu, Yousif Shalal, Hamood Al-Kindi, Hossney Alaws, Jean-Claude Tardif, Ophelie Gourgas, Marta Cerutti, Adel Schwertani
Summary: The expressions of UⅡ, URP, and UT were significantly upregulated in patients with AVS and correlated with calcification and fibrosis. Treating human aortic valve interstitial cells with UII or URP increased cell proliferation and decreased cholesterol efflux. These findings suggest that the urotensin system plays a role in the pathogenesis of AVS and warrant further investigation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Public, Environmental & Occupational Health
B. Dinc, F. Kirca, S. Aydogan, A. Toyran, T. Basyigit, I Omay, P. Gun, M. Caglayan, A. A. Surel
Summary: This retrospective study analysed SARS-CoV-2 Real-Time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) test results from a pandemic hospital in Turkey, finding higher positivity among females and younger patients (0-18 years old), as well as significantly higher positivity in August and September. This could contribute to the lower COVID-19 mortality rates in Turkey.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ian Leonard-Lorant, Francois Severac, Pascal Bilbault, Joris Muller, Pierre Leyendecker, Catherine Roy, Mickael Ohana
Summary: The study found that 5.2% of symptomatic confirmed COVID-19 cases had initially normal chest CT results. Patients with normal initial CT had a lower rate of death and/or mechanical ventilation compared to patients with typical COVID-19 lesions on initial CT.
EUROPEAN RADIOLOGY
(2021)
Article
Fisheries
Yifan Wang, Liwen Xu, Weixiang Ma, Heng Sun, Zengchao Huang, Shuanghu Cai, Jichang Jian, Yucong Huang
Summary: A mass mortality event among cultured Murray cod fry occurred in Foshan city, Guangdong province, China in December 2019, with a mortality rate of up to 45% within 15 days. The affected fish showed clinical signs, and testing revealed that they were infected with betanodavirus, a pathogen previously unreported in freshwater fish in China. This study provides important insights into the natural infection of betanodavirus in freshwater fish.
JOURNAL OF FISH DISEASES
(2022)
Article
Infectious Diseases
Kuan Ken Lee, Dimitrios Doudesis, Daniella A. Ross, Anda Bularga, Claire L. MacKintosh, Oliver Koch, Ingolfur Johannessen, Kate Templeton, Sara Jenks, Andrew R. Chapman, Anoop S. V. Shah, Atul Anand, Meghan R. Perry, Nicholas L. Mills
Summary: A study found that the combined nasal and throat swab with RT-PCR for SARS-CoV-2 has excellent specificity but limited sensitivity for diagnosing COVID-19 in hospitalized patients. The diagnostic performance significantly improves with repeated testing.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Karla Georges, Chuckwudozi Ezeokoli, Godwin Isitor, Alex Mutani, Olivier Sparagano, Candice Sant
Summary: This study compared two methods for detecting canine ehrlichiosis in a field setting. It found that reverse line blot hybridisation and autologous cell cultures both showed acceptable agreement in detecting E. canis, and that a definitive diagnosis of E. canis is best achieved by combining clinical signs, positive autologous cell culture, and reverse line blot hybridisation results.
Article
Cell Biology
Shipra Agarwal, Parmita Kar, Monikongkona Boruah, Soma Saha, Tabin Millo, Chitresh Kumar, Seenu Vuthaluru, Ravinder Goswami
Summary: This study examined global gene expression profiles in superior and inferior parathyroid glands and found nine genes with lower expression in the inferior glands and one gene with higher expression. These differences may be related to the preference of parathyroid tumors to occur in the inferior parathyroid glands.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Ophthalmology
Ritu Arora, Ruchi Goel, Sumit Kumar, Mohit Chhabra, Sonal Saxena, Vikas Manchanda, Palak Pumma
Summary: The study found that 24% of patients with laboratory-proven moderate to severe COVID-19 had detectable SARS-CoV-2 RNA in tears, suggesting tears could be a potential route for viral transmission.
Review
Biochemistry & Molecular Biology
Hossein Tabatabaeian, Angad Rao, Alisha Ramos, Tinghine Chu, Marius Sudol, Yoon Pin Lim
Review
Biochemistry & Molecular Biology
Alisha Ramos, Samira Sadeghi, Hossein Tabatabaeian
Summary: Cancer, with nearly 10 million deaths worldwide, remains a leading cause of mortality. Chemoresistance, whether intrinsic or acquired, causes cancer recurrence and treatment failure. Strategies to combat chemoresistance include early diagnosis and combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shaghayegh Dastjerdi, Mehdi Valizadeh, Rasoul Nemati, Mohammad Amin Honardoost, Nasrin Fattahi Dolatabadi, Atefeh Zamani, Hossein Tabatabaeian
Summary: Colorectal cancer is a major cause of human death, potentially due to lack of early diagnosis and ineffective treatment strategies. Long non-coding RNAs have emerged as important tools for improving cancer detection efficiency and targeted therapy, with potential implications for early diagnosis and treatment of colorectal cancer.
Article
Biology
Hossein Tabatabaeian, Shen Kiat Lim, Tinghine Chu, Sock Hong Seah, Yoon Pin Lim
Summary: WBP2 is a novel regulator of miRNA biogenesis that suppresses microprocessor activity and may have implications in breast cancer therapy by targeting WBP2 protein.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Ng Desi, Qing Yun Tong, Velda Teh, Jia Jia Chan, Bin Zhang, Hossein Tabatabaeian, Hui Qing Tan, Katannya Kapeli, Wenhao Jin, Chun You Lim, Zhi Hao Kwok, Hwee Tong Tan, Shi Wang, Bei-En Siew, Kuok-Chung Lee, Choon-Seng Chong, Ker-Kan Tan, Henry Yang, Dennis Kappei, Gene W. Yeo, Maxey Ching Ming Chung, Yvonne Tay
Summary: In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. This study identified LARP1 as an upregulated post-transcriptional regulator in colorectal cancer (CRC) that targets the 3' UTR of the oncogene MYC, promoting CRC tumorigenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pathology
Nasrin Jafari, Arezo Nasiran Najafabadi, Behnaz Hamzei, Nioosha Ataee, Zahra Ghasemi, Tahereh Sadeghian-Rizi, Mohammad Amin Honardoost, Atefeh Zamani, Nasrin Fattahi Dolatabadi, Hossein Tabatabaeian
Summary: Colorectal cancer is the second leading cause of cancer-related deaths in humans, and molecular tools such as lncRNAs have shown promising capabilities in early diagnosis and therapeutic management, with potential implications in clinics for improving patient survival rates.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ng Desi, Velda Teh, Qing Yun Tong, Chun You Lim, Hossein Tabatabaeian, Xiao Hong Chew, Avencia Sanchez-Mejias, Jia Jia Chan, Bin Zhang, Priyankaa Pitcheshwar, Bei-En Siew, Shi Wang, Kuok-Chung Lee, Choon-Seng Chong, Wai-Kit Cheong, Bettina Lieske, Ian Jse-Wei Tan, Ker-Kan Tan, Yvonne Tay
Summary: The study demonstrates that shortening of the MYC 3'UTR in colorectal cancer leads to activation of oncogenes, with miR-138 identified as a potent regulator of MYC expression and tumor growth inhibition.
Article
Genetics & Heredity
Mohammadreza Farrokhi, Hediyeh Rostami, Zahra Simaei, Marziye Bahrebar, Fateme Khoshbin, Niloofar Ataee, Nioosha Ataee, Maryam Ghaedi Heydari, Farzaneh Ahmadi Shapoorabadi, Atefeh Zamani, Nasrin Fattahi Dolatabadi, Hossein Tabatabaeian
Summary: The unleased proliferation of lymphoid progenitor cells could result in Acute Lymphoblastic Leukemia (ALL). Single Nucleotide Polymorphisms (SNPs) could be potential genetic factors for the diagnosis and prognosis of ALL. However, more studies are needed to improve the accuracy of predicting the risk of ALL. In this study, eight SNPs were genotyped in ALL patients and healthy controls, and the results showed that different alleles at these SNP positions could manipulate the risk of ALL incidence.
Meeting Abstract
Hematology
Joanne Lee, Hossein Tabatabaeian, Michelle Limei Poon, Nagavalli Somasundaram, Liu Xin, Yi Ching Yuen, Chia Meng Teoh, Benedict Yan, Esther Hian Li Chan, Yen Lin Chee, Sanjay De Mel, Bin Zhang, Xiao Hong Chew, Tiffany Tang, Chiea Chuen Khor, Joanne Yuen Yie Ngeow, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, E. Shyong Tai, Kee Yuan Ngiam, Soo Chin Lee, Boon Cher Goh, Anand Devaprasath D. Jeyasekharan, Yvonne Tay, Folefac Aminkeng
Article
Pathology
Faramarz Vejdandoust, Rahmaneh Moosavi, Nasrin Fattahi Dolatabadi, Atefeh Zamani, Hossein Tabatabaeian
Summary: Incomplete knowledge of the molecular basis of colorectal cancer has led to its high mortality rate. By analyzing TCGA data and using qPCR, this study identified two down-regulated long noncoding RNAs (lncRNAs), MIMT1 and LINC01550, in colorectal cancer. The results suggest that MIMT1 and LINC01550 may play important roles as tumor suppressor genes and in regulating the cancer signaling pathway(s).
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
Review
Cell Biology
Jia Jia Chan, Hossein Tabatabaeian, Yvonne Tay
Summary: The majority of human mRNAs generate alternative 3' UTRs through various processes, including RNA editing, m6A methylation, and alternative polyadenylation (APA), with 3' UTR splicing as an emerging mechanism. Regulation of these processes at the genome and transcriptome levels contribute to 3' UTR heterogeneity. Genomic variants in 3' UTR regions and aberrant 3' UTR processing are associated with cancer and their deregulation may contribute to cancer pathogenesis. In-depth characterization of these events will enhance our understanding of their significance and aid in therapeutic development.
TRENDS IN CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hamed Bashiri, Hossein Tabatabaeian
Summary: Multiple myeloma, the second most prevalent hematologic malignancy, has seen increased survival rates due to novel drugs and combination therapies. However, drug resistance remains a significant issue, with autophagic activity playing a critical role. High mobility group box protein 1 (HMGB1)-dependent autophagy and proteasome suppression-induced autophagy have been found to contribute to drug resistance in multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Mohammad Talaei, Pauline M. Emmett, Raquel Granell, Hossein Tabatabaeian, Kate Northstone, Anna Bergstrom, Seif O. Shaheen
Summary: A study found that different dietary patterns in childhood are associated with lung function and incident asthma in adolescence. A 'health-conscious' diet was positively associated with lung function, while a diet high in processed food was negatively associated with lung function. However, there was no significant association between a 'traditional' diet and lung function or incident asthma.
RESPIRATORY RESEARCH
(2023)
Article
Cell Biology
Roya Mokhtarian, Hossein Tabatabaeian, Pardis Saadatmand, Mansoureh Azadeh, Negar Balmeh, Bagher Yakhchali, Kamran Ghaedi
Article
Genetics & Heredity
Sam Tabatabaeian, Samira Sadeghi, Hossein Tabatabaeian