Article
Surgery
Michelle A. Wan, James M. Clark, Miriam Nuno, David T. Cooke, Lisa M. Brown
Summary: This study demonstrates that the currently used frailty indices are not effective predictors of 30-day morbidity and mortality in patients undergoing high-risk surgery.
Article
Surgery
Vanessa P. Ho, Wyatt P. Bensken, David F. Warner, Jeffrey A. Claridge, Heena P. Santry, Jacinta C. Robenstine, Christopher W. Towe, Siran M. Koroukian
Summary: This study examines the associations between multimorbidity domain combinations and long-term mortality in older patients with emergency general surgery (EGS) conditions. The findings suggest that functional limitations may be the most important risk factor for long-term survival in these patients.
Article
Nutrition & Dietetics
Fanny Petermann-Rocha, Stuart R. Gray, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales
Summary: The study revealed the joint association of different combinations of sarcopenia and frailty with adverse health outcomes, with the combination of sarcopenic/frail showing the strongest association with incidence and mortality of cardiovascular disease, respiratory disease, and cancer.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster, I. Aprahamian
Summary: The frailty index (FI) independently predicted mortality, with the highest impact in individuals with endocrine, lung, or heart diseases. Both multimorbidity and specific chronic disease clusters were associated with an accelerated increase in frailty over time, highlighting the importance of initiating frailty prevention in middle age.
Article
Geriatrics & Gerontology
Merve Guner Oytun, Polat Ercan, Serdar Ceylan, Arzu Okyar Bas, Meltem Halil, Mustafa Cankurtaran, Burcu Balam Dogu
Summary: The study indicates that the laboratory index was unable to predict mortality accurately and overlooked the frailty and comorbidities of patients. It is suggested that incorporating these data into the analysis can improve predictive capability.
Article
Gastroenterology & Hepatology
Michael R. Driedger, Thomas S. Yamashita, Patrick Starlinger, Kellie L. Mathis, Rory L. Smoot, Sean P. Cleary, David M. Nagorney
Summary: The concurrent resection of primary cancer and synchronous colorectal cancer liver metastases (CRCLM) may lead to increased morbidity and mortality, especially in patients undergoing major liver/major colorectal resections. Postoperative complications may result in the inability to receive adjuvant chemotherapy, which could impact survival outcomes.
Article
Oncology
Josef Horak, Ondrej Kubecek, Anna Siskova, Katerina Honkova, Irena Chvojkova, Marketa Krupova, Monika Manethova, Sona Vodenkova, Sandra Garcia-Mulero, Stanislav John, Filip Cecka, Ludmila Vodickova, Jiri Petera, Stanislav Filip, Veronika Vymetalkova
Summary: By characterizing colorectal cancer liver metastases (CRCLMs), our study revealed molecular differences between Synchronous (SmCRC) and Metachronous (MmCRC) colorectal cancer. We identified frequently mutated genes, differentially methylated and expressed genes, and deregulated miRNAs. Furthermore, we found significant differences in tumor mutational burden, duplications and deletions, and mutational signature between SmCRC and MmCRC. Our data also identified actionable targets and provided insights into molecular distinctions between these two subtypes of CRCLMs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Julia W. Wu, Amber Yaqub, Yuan Ma, Wouter Koudstaal, Albert Hofman, M. Arfan Ikram, Mohsen Ghanbari, Jaap Goudsmit
Summary: The study demonstrates that accelerated biological age is a predictor of major age-related morbidity, including dementia, among healthy elderly individuals. Additionally, microRNAs were found to be significantly associated with age, with top differentially expressed microRNAs based on biological age having a higher significance level, suggesting that biological age captures aspects of aging signals at the epigenetic level.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Jennifer C. Lai, Amy M. Shui, Andres Duarte-Rojo, Daniel R. Ganger, Robert S. Rahimi, Chiung-Yu Huang, Frederick Yao, Matthew Kappus, Brian Boyarsky, Mara McAdams-Demarco, Michael L. Volk, Michael A. Dunn, Daniela P. Ladner, Dorry L. Segev, Elizabeth C. Verna, Sandy Feng
Summary: Frail patients who undergo liver transplantation have a higher risk of post-transplantation death and increased healthcare utilization compared to nonfrail patients. Targeting pre-transplant frailty may improve post-transplant outcomes and reduce resource utilization.
Article
Oncology
Jiamin Zhou, Longhai Feng, Xinxiang Li, Miao Wang, Yiming Zhao, Ning Zhang, Longrong Wang, Ti Zhang, Anrong Mao, Ye Xu, Lu Wang
Summary: The study aimed to investigate the value of total laparoscopic simultaneous colorectal and hepatic resection in patients with synchronous colorectal cancer liver metastases. The results showed that laparoscopic surgery had longer operation time and less intraoperative blood loss compared to open surgery. There were no significant differences in postoperative morbidity and long-term survival among the different surgery groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Savio George Barreto, Jorg Kleeff
Summary: Surgery remains crucial in treating pancreatic cancer, with a focus on borderline-resectable and locally advanced tumors. The benefits of synchronous arterial and venous resections in improving overall survival are still unclear, warranting further research and analysis to determine their effectiveness.
Article
Otorhinolaryngology
Khodayar Goshtasbi, Jack L. Birkenbeuel, Brandon M. Lehrich, Arash Abiri, Yarah M. Haidar, Tjoson Tjoa, Edward C. Kuan
Summary: Preoperative frailty has a significant impact on short-term outcomes following complex head and neck surgeries, including shorter operation time, longer length of stay, and higher rates of complications.Adjusting for age, sex, race, body mass index, smoking, and other factors, the modified frailty index can independently predict surgical outcomes and help in preoperative counseling and postoperative planning for complex head and neck surgery patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Oncology
Felice Giuliante, Luca Vigano, Agostino M. De Rose, Darius F. Mirza, Real Lapointe, Gernot Kaiser, Eduardo Barroso, Alessandro Ferrero, Helena Isoniemi, Santiago Lopez-Ben, Irinel Popescu, Jean-Francois Ouellet, Catherine Hubert, Jean-Marc Regimbeau, Jen-Kou Lin, Oleg G. Skipenko, Francesco Ardito, Rene Adam
Summary: In patients with synchronous CRLM, the liver-first approach should be considered for those with multiple bilobar metastases, as it has been associated with longer survival compared to alternative approaches. The surgical strategy should be tailored based on the hepatic tumor burden.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Masaki Ueno, Koji Komeda, Hisashi Kosaka, Takuya Nakai, Takeo Nomi, Hiroya Iida, Shogo Tanaka, Hisashi Ikoma, Kenji Matsuda, Fumitoshi Hirokawa, Masataka Matsumoto, Daisuke Hokuto, Haruki Mori, Ryo Morimura, Masaki Kaibori, Hiroki Yamaue, Shoji Kubo
Summary: This retrospective study examined the efficacy of neoadjuvant chemotherapy in patients with SCRLM, and the results showed that NAC did not have a significant prognostic impact, while operative complications had a significant impact on prognosis. Reevaluation of the indications for NAC is needed.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Surgery
Kat L. Parmar, Jennifer Law, Ben Carter, Jonathan Hewitt, Jemma M. Boyle, Patrick Casey, Ishaan Maitra, Ian S. Farrell, Lyndsay Pearce, Susan J. Moug
Summary: This study on frailty in older adults undergoing emergency laparotomy found that 20% of older adults were frail, which was directly associated with increased risks of postoperative mortality and morbidity. Frailty scoring can aid decision-making and development of novel postoperative strategies.