Review
Gastroenterology & Hepatology
Nick Dai, Omar Haidar, Alan Askari, Jonathan P. Segal
Summary: This study aimed to understand the changing prevalence of colectomy in Ulcerative Colitis (UC) over time. The results showed that the overall colectomy rate has decreased over the past three decades. Biologics may have played a role in reducing the risk of colectomy, but the relative risk reduction is likely to be modest.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Guillaume Le Cosquer, Lena Capirchio, Pauline Riviere, Marie Armelle Denis, Florian Poullenot, Christophe Remue, Frank Zerbib, Daniel Leonard, Bertrand Celerier, Alex Kartheuser, David Laharie, Olivier Dewit
Summary: This study aimed to determine the trend of colectomy in ulcerative colitis (UC) by comparing colectomy indications and outcomes between 2000 and 2010 and 2011-2020. The results showed that the proportion of surgery for refractory UC significantly decreased compared to other surgical indications while surgical outcomes improved despite larger exposure to biologics.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Pediatrics
Rebecca A. Saberi, Gareth P. Gilna, Cindy Rodriguez, Walter A. Ramsey, Carlos T. Huerta, Christopher F. O'Neil, Joshua P. Parreco, Amber H. Langshaw, Chad M. Thorson, Juan E. Sola, Eduardo A. Perez
Summary: This study compared the morbidity of open versus laparoscopic colectomy or proctocolectomy for pediatric patients with ulcerative colitis using national readmission outcomes. The results showed that laparoscopic surgery was associated with shorter hospital stay, fewer post-operative complications, and improved readmission outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Eun Mi Song, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
Summary: Through retrospective review of 121 Korean patients with SR-ASUC, it was found that there were no significant differences in the rates of treatment failure and colectomy at 3 months between the CsA and IFX treatment groups. Additionally, prior use of azathioprine and Mayo score at the time of rescue therapy were both associated with treatment failure or colectomy within 3 months.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gaurav Syal, Lori Robbins, Amir Kashani, Nirupama Bonthala, Edward Feldman, Phillip Fleshner, Eric Vasiliauskas, Dermot McGovern, Christina Ha, Stephan Targan, Gil Y. Melmed
Summary: Serum albumin and band neutrophil percentage are independent predictors of failure of infliximab rescue therapy in patients with acute severe ulcerative colitis. The combination of serum albumin <= 2.5 g/dl and band neutrophil count >= 13% has a 100% positive predictive value for 90-day colectomy.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Abhishek Bhurwal, Carlos D. Minacapelli, Anish Patel, Hemant Mutneja, Akshay Goel, Ishani Shah, Vikas Bansal, Bhaumik Brahmbhatt, Kiron M. Das
Summary: This study revealed racial and geographical disparities in colectomy rates among hospitalized patients with UC after the introduction of anti-TNF therapy. African American and Hispanic patients had significantly lower colectomy rates compared to White patients, while the western regions of the United States had the highest colectomy rates. Further research is needed to understand the underlying social and biological factors contributing to these disparities.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Neasa Mc Gettigan, Aman Shah Afridi, Grace Harkin, Caroline Lardner, Stephen Patchett, Danny Cheriyan, Gavin Harewood, Karen Boland, Aoibhlinn O'Toole
Summary: The study aimed to identify optimal management strategies for anti-drug antibodies (ADAs) in patients receiving infliximab (IFX) to prevent therapy discontinuation. Results showed that increasing IFX dosage and adjusting combination therapy can lower rates of discontinuation of IFX, with significant cut-off values for ADA trough levels and important clinical outcomes identified through ROC curve analysis.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Surgery
Mohamed A. Abd El Aziz, William R. G. Perry, Fabian Grass, Amit Merchea, Laura E. Raffals, Kellie L. Mathis, Kevin T. Behm
Summary: Limited literature on the impact of the extent of resection on short-term outcomes in elective surgery for UC. The operative approach has a greater impact on short-term outcomes and length of stay than the extent of resection. Laparoscopic TPC has a higher rate of prolonged length of stay compared to laparoscopic STC.
UPDATES IN SURGERY
(2021)
Article
Gastroenterology & Hepatology
D. Boldovjakova, D. S. G. Scrimgeour, C. N. Parnaby, G. Ramsay
Summary: Implementing a multidisciplinary care bundle can reduce complication rates in patients undergoing subtotal colectomy for IBD, especially post initiation of a MDT bundle. Increasing age and procedures performed before the initiation of the MDT bundle were independent predictors for post-operative complications.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Jeffrey A. Berinstein, Jessica L. Sheehan, Michael Dias, Elliot M. Berinstein, Calen A. Steiner, Laura A. Johnson, Randolph E. Regal, John I. Allen, Kelly C. Cushing, Ryan W. Stidham, Shrinivas Bishu, Jami A. R. Kinnucan, Shirley A. Cohen-Mekelburg, Akbar K. Waljee, Peter D. R. Higgins
Summary: The study suggests that tofacitinib with concomitant intravenous corticosteroids may reduce the risk of colectomy in ASUC patients, especially with a dosage of 10 mg three times daily. Rates of complications and steroid dependence were similar between the tofacitinib group and controls. Prospective trials are needed to further investigate the safety and optimal dosing of tofacitinib in ASUC patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Panu Wetwittayakhlang, Lorant Gonczi, Laszlo Lakatos, Zsuzsanna Kurti, Petra Golovics, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Peter L. Lakatos
Summary: This study aimed to assess the colectomy rates of ulcerative colitis (UC) patients in Veszprem Province, Hungary over 40 years. The results showed no significant differences in colectomy rates among different therapeutic eras, despite increasing use of immunomodulators and biologic therapies.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Aderson Omar Mourao Cintra Damiao, Natalia Sousa Freitas Queiroz
Summary: Despite improvements in the management of ulcerative colitis, there is still a subset of medically refractory patients who require surgery. Recent studies show a decrease in surgery rates for ulcerative colitis patients in the biological era, but the potential for disease modification with these treatments is still debated. Medically refractory patients may receive multiple treatments, resulting in missed opportunities for surgery and the development of complications.
CLINICS IN COLON AND RECTAL SURGERY
(2022)
Article
Surgery
Hugh L. Giddings, Kheng-Seong Ng, Michael J. Solomon, Daniel Steffens, Joe Van Buskirk, Jane Young
Summary: This study aims to investigate the trends in total abdominal colectomy (TAC) rates for ulcerative colitis (UC) in New South Wales (NSW). The study found that the rate of TACs has decreased over the past two decades, which may have been influenced by the introduction of biologics. However, in the biologic era, there were higher rates of complications and ICU admissions, suggesting poorer patient physiological status at the time of surgery.
ANZ JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Alix Demaris, Ella S. K. Widigson, Johan F. K. F. Ilvemark, Casper Steenholdt, Jakob B. Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte Kloft
Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.
Article
Gastroenterology & Hepatology
Brandon K. Chu, Frank I. Scott, Meenakshi Bewtra
Summary: This simulation study suggests that early incorporation of colectomy for patients medically refractory to infliximab and azathioprine combination therapy may lead to better quality of life for patients with steroid-dependent UC. This finding highlights the importance of a combined medical-surgical approach in the treatment of UC.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Ophthalmology
Suzann Pershing, Victor W. Henderson, Mary K. Goldstein, Ying Lu, M. Kate Bundorf, Moshiur Rahman, Joshua D. Stein
Summary: Among US Medicare beneficiaries undergoing cataract surgery, those with dementia are more likely to have "complex" surgery lasting more than 30 minutes. However, they do not have greater likelihood of surgical complications, higher-acuity setting, advanced anesthesia care, or postoperative hospitalization. This may be influenced by case selection and may suggest missed opportunities to improve vision. Future research is needed to identify dementia patients likely to benefit from cataract surgery.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vinita Shivakumar, M. Kate Bundorf, Alexander M. Vezeridis, Nishita Kothary
Summary: This study analyzed the impact of physician-specific equipment preference on cost variation for interventional radiology procedures. The research found significant differences in item selection and cost variation among physicians, suggesting that standardization could potentially lead to cost savings. Additionally, the study also revealed that there was no significant correlation between average spending by physicians and case volume.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Medicine, General & Internal
Cindy Kin, Loretta Chou, Debra L. Safer, Arden Morris, Qian Ding, Amber Trickey, Sabine Girod
Summary: Long-term opioid therapy among patients with foot/ankle, anorectal, and temporomandibular joint pain is significantly associated with older age, recent psychiatric diagnoses, surgical history, male sex, and geographic region. Surgeons should be aware of these risk factors to make high quality clinical decisions when consulting with these patients.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Public, Environmental & Occupational Health
P. R. Cyr, K. Pedersen, A. L. Iyer, M. K. Bundorf, J. D. Goldhaber-Fiebert, D. Gyrd-Hansen, I. S. Kristiansen, E. A. Burger
Summary: The study found that additional information did not significantly impact women's intention to participate in cervical cancer screening, but it may increase uncertainty about seeking treatment. Norwegian women preferred information from national public health agencies, while American women preferred information from specialist care providers.
PREVENTIVE MEDICINE REPORTS
(2021)
Article
Surgery
Kirbi Yelorda, Liam Rose, M. Kate Bundorf, Huda A. Muhammad, Arden M. Morris
Summary: This retrospective cohort analysis investigates the association between enrollment in high-deductible health plans (HDHPs) and the presentation of incarcerated or strangulated hernia. The study finds that patients enrolled in HDHPs are more likely to present with hernia that requires emergency surgery and may experience delays in surgical care.
Article
Surgery
Angela Lee, Elizabeth Shelton, Serena Bidwell, Kreeti Shankar, Kazuo Ando, Brice Gaudilliere, Andrew Shelton, Cindy Kin
Summary: A preoperative diet and exercise intervention may reduce inpatient opioid use after major elective colorectal surgery.
JOURNAL OF SURGICAL RESEARCH
(2022)
Editorial Material
Gastroenterology & Hepatology
Cintia Kimura, Serena Bidwell, Kreeti Shankar, Elizabeth Shelton, Andrew Shelton, Cindy Kin
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Health Care Sciences & Services
Kate Bundorf, Jessica S. Banthin, Christine Young Kim, Sumedha Gupta
Summary: The passage of temporary measures in response to the health risks of COVID-19 and economic instability in the US led to increased access to health insurance. Analysis of data from the Household Pulse Survey revealed that approximately eight million individuals gained coverage between 2021 and early 2022, primarily through Medicaid and other public programs. Despite a rise in employment, employer-sponsored coverage rates remained unchanged. In states that expanded Medicaid, there was a significant increase in employment rates among Medicaid beneficiaries. Findings suggest that individuals currently enrolled in Medicaid in expansion states may lose eligibility once the public health emergency ends, necessitating support from policymakers and employers to navigate alternative health insurance options.
Article
Oncology
Deborah R. Kaye, Hui-Jie Lee, Alexander Gordee, Daniel J. George, Peter A. Ubel, Charles D. Scales, M. Kate Bundorf
Summary: This study examined the gross and out-of-pocket payments for first-line drugs for metastatic castrate-resistant prostate cancer (mCRPC). The results showed significant variation in gross payments across different drugs, while out-of-pocket payments were relatively low and varied widely.
JCO ONCOLOGY PRACTICE
(2023)
Article
Emergency Medicine
Emily Shearer, M. Kate Bundorf
Summary: According to this study, the expansion of Medicaid appears to have little impact on emergency department use, whether it is through traditional or waiver expansions.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2023)
Article
Health Care Sciences & Services
Brystana G. Kaufman, Kelley A. Jones, Melissa A. Greiner, Abhigya Giri, Lucas Stewart, Amanda He, Amy G. Clark, Donald H. Taylor, M. Kate Bundorf, Rebecca G. Whitaker, Courtney H. Van Houtven, Aparna Higgins
Summary: This study aims to describe the healthcare utilization and spending for need-based subgroups in North Carolina's full benefit, dual-eligible population, to inform the design of integrated programs. The study found substantial use of both Medicare and Medicaid-funded services across all need-based subgroups, with different proportions of total spending. This suggests the need for a tailored approach to integration strategies.
Article
Health Care Sciences & Services
Rebecca A. Bromley-Dulfano, Maya Rossin-Slater, M. Kate Bundorf
Summary: This cross-sectional study found an association between additional recommended cervical cancer screenings and increased risk of preterm delivery among females aged 18 to 24 years.
Article
Health Care Sciences & Services
M. Kate Bundorf, Sumedha Gupta, Christine Kim
Summary: During the COVID-19 pandemic in the US, employer-sponsored coverage declined while other types of coverage increased, leading to an overall decline in health insurance coverage. Public programs helped protect adults from declines in employer-sponsored coverage, but many people became uninsured during the pandemic.
Letter
Health Care Sciences & Services
Maria Polyakova, Vinayak Bhatia, M. Kate Bundorf
Article
Economics
Laurence C. Baker, M. Kate Bundorf, Daniel P. Kessler
AMERICAN JOURNAL OF HEALTH ECONOMICS
(2020)