Article
Cell Biology
Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. Macisaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Summary: Insulin resistance in muscle in older individuals is associated with differential DNA methylation, with muscle mass and body composition playing a significant role in these methylation changes.
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Endocrinology & Metabolism
Yi-Lin Ma, Jiang-Feng Ke, Jun-Wei Wang, Yu-Jie Wang, Man-Rong Xu, Lian-Xi Li
Summary: This study aimed to investigate the association between blood lactate levels and metabolic dysfunction-associated fatty liver disease (MAFLD) in type 2 diabetes mellitus (T2DM) patients. The results showed a significant increase in MAFLD prevalence and HOMA2-IR value across quartiles of blood lactate levels. Blood lactate levels were independently associated with an increased risk of MAFLD in T2DM patients, regardless of metformin use. Therefore, blood lactate levels may serve as a practical indicator for assessing the risk of MAFLD in T2DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Joan Ericka Flores, Alexander J. Thompson, Marno Ryan, Jessica Howell
Summary: Hepatitis B vaccination remains crucial for preventing liver cancer and achieving global hepatitis B elimination targets, but there is variability in vaccination coverage and challenges in meeting the targets.
Review
Medicine, General & Internal
Satinder P. Kaur, Arslan Talat, Hamidreza Karimi-Sari, Andrew Grees, Hao Wei Chen, Daryl T. Y. Lau, Andreea M. Catana
Summary: Hepatitis B virus (HBV) infection is one of the main risk factors for hepatocellular carcinoma (HCC), and the risk of HCC is not completely eliminated even after viral suppression. Cirrhosis, HBV viral DNA levels, age, male gender, the immune response, and a combination of obesity and diabetes are among the main risk factors for HCC. Active viral replication and long-standing inflammation are associated with a higher risk of HCC. Treatment of HBV with nucleos(t)ide analogues can decrease the risk of HCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Seong Gyu Hwang, Sang Hoon Ahn
Summary: This study found that patients with chronic viral hepatitis and concurrent fatty liver have a higher risk of developing hepatocellular carcinoma and mortality, highlighting the importance of managing fatty liver in reducing these risks for patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Baoqi Fan, Hongjiang Wu, Mai Shi, Aimin Yang, Eric S. H. Lau, Claudia H. T. Tam, Dandan Mao, Cadmon K. P. Lim, Alice P. S. Kong, Ronald C. W. Ma, Elaine Chow, Andrea O. Y. Luk, Juliana C. N. Chan
Summary: In young Chinese adults, insulin deficiency and resistance contribute to the progression to type 2 diabetes and glycaemic deterioration.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Hyun Yang, Si Hyun Bae, Heechul Nam, Hae Lim Lee, Sung Won Lee, Sun Hong Yoo, Myeong Jun Song, Jung Hyun Kwon, Soon Woo Nam, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang
Summary: After HBsAg seroclearance, there is still a risk of developing hepatocellular carcinoma (HCC). Age, cirrhosis, family history, and more-than-moderate alcohol consumption are independent factors predictive of HCC. The novel prediction model based on these four variables allows reliable risk estimation of HCC after HBsAg seroclearance.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Xian Yu, Jennifer Kramer, Aaron P. Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study evaluated the performance of 10 HCC risk prediction models in patients with HBV, showing that most models performed well in predicting HCC risk and identified low-risk subsets for exclusion from HCC surveillance. Further research is needed to validate these findings.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Ruonan Sun, Jiawei Li, Xianyi Lin, Yidong Yang, Bing Liu, Tianbi Lan, Shuang Xiao, Anyi Deng, Zhinan Yin, Yan Xu, Zheng Xiang, Bin Wu
Summary: This study aimed to explore the changes in peripheral immunity in patients with HBV-related hepatocellular carcinoma (HBV-HCC). The results showed that circulating lymphocytes in HBV-HCC patients exhibited features of immune exhaustion, especially in patients with persistent viral replication and in those with intermediate and advanced HBV-HCC. The combination of CD3(+) T cells and CD8(+)HLADR(+)CD38(+) T cells may serve as a potential diagnostic indicator for HBV-HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
James Lok, Kosh Agarwal
Summary: Multiple models have been developed to predict the risk of HCC development in individuals with chronic hepatitis B infection, with most models derived from Asian populations. Further research is needed to validate and refine these models for more tailored HCC surveillance programs in the future.
Article
Gastroenterology & Hepatology
Yewan Park, Dong Hyun Sinn, Kyunga Kim, Geum-Youn Gwak
Summary: This study revealed that adolescent children with a parent with NAFLD have an increased risk of developing NAFLD, with an even higher risk when both parents have NAFLD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Yewan Park, Dong H. Sinn, Geum-Youn Gwak
Summary: This article is linked to the papers by Park et al. To view these articles, visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Kyong Joo Lee, Se Woo Park, Da Hae Park, Jung Hee Kim, Jang Han Jung, Dong Hee Koh, Jin Lee, Mi Gang Kim
Summary: This study evaluated the efficacy of routinely placing long plastic stents after direct endoscopic necrosectomy (DEN) to treat laterally extended walled-off necrosis (WON). In 6 patients with symptomatic laterally extended WON, the clinical success rate of DEN with long plastic stent placement was 100%, without major adverse events. The size of WON ranged from 18.6 to 35.8 cm in length, and 2-3 long plastic stents were placed after each DEN session.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Mo-Jong Kim, Jung-Hee Kim, Jang-Han Jung, Sung-Eun Kim, Hyoung-Su Kim, Myoung-Kuk Jang, Sang-Hoon Park, Myung-Seok Lee, Ki Tae Suk, Dong Joon Kim, Eun-Kyoung Choi, Ji-Won Park
Summary: This study aimed to investigate the diagnostic ability of serum S100B in discriminating the grade of hepatic encephalopathy (HE) and its correlation with other parameters. The results showed that serum S100B level was not useful for differentiating the severity of HE, but it could be affected by age, serum bilirubin, and creatinine levels and was associated with MELD scores. Additionally, serum S100B levels showed the possibility of predicting 1-year mortality in cirrhotic patients.
Letter
Gastroenterology & Hepatology
Yewan Park, Dong Hyun Sinn, Geum-Youn Gwak
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jong-In Chang, Jung Hee Kim, Dong Hyun Sinn, Ju-Yeon Cho, Kwang Min Kim, Joo Hyun Oh, Yewan Park, Won Sohn, Myung Ji Goh, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung-Woon Paik
Summary: The study validated the effectiveness of the UDCA response score (URS) in predicting the response to UDCA treatment in Asian patients with primary biliary cholangitis (PBC). URS can be used to predict the treatment response and clinical outcome in patients with PBC.
Article
Gastroenterology & Hepatology
Byeong Geun Song, Myung Ji Goh, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Seung Woon Paik, Dong Hyun Sinn
Summary: This study evaluated the usefulness of the Baveno VII consensus in predicting the risk of decompensation in patients with compensated advanced chronic liver disease (cACLD). The study found that patients with clinically significant portal hypertension (CSPH) had the highest risk of decompensation, followed by the grey zone high-risk group, grey zone low-risk group, and those without CSPH. Compared to the CSPH excluded group, the CSPH included group, grey zone high-risk group, and grey zone low-risk group had significantly higher risk of decompensation.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Jeong-Ju Yoo, Jong-In Chang, Ji Eun Moon, Dong Hyun Sinn, Sang Gyune Kim, Young Seok Kim
Summary: A new predictive model, which considers both the MELD 3.0 and albumin, has been proposed for predicting the 3-month survival of East Asian patients with cirrhosis. The study found that the MELD 3.0 score with albumin showed slightly better discrimination compared to other MELD-based scores, but not significantly different. However, it was significantly better than the original MELD in predicting the short-term prognosis of East Asian patients on the liver transplantation waitlist.
LIVER TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Yewan Park, Dong Hyun Sinn, Kyunga Kim, Geum-Youn Gwak
Summary: This study investigated the associations between different types and domains of exercise and non-alcoholic fatty liver disease (NAFLD). It found that increasing overall physical activity and muscle strength exercise can reduce the risk of NAFLD, but the effects vary depending on the domain of physical activity. Therefore, the management of NAFLD should consider differentiating physical activity by its domains.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Kyong Joo Lee, Se Woo Park, Hyun Joo Jang, Da Hae Park, Jung Hee Kim, Jang Han Jung, Dong Hee Koh, Jin Lee
Summary: The feasibility of using a cap-assisted colonoscope as the primary approach for ERCP in patients undergoing REY reconstruction was evaluated. The intubation success rate using a cap-assisted colonoscope was higher in the SS-JJ group compared to the SE-JJ group. SS-JJ was a predictive factor for successful intubation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Gastroenterology & Hepatology
Byeong Geun Song, Dong Hyun Sinn
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Joo Hyun Oh, Dong Hyun Sinn
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Correction
Gastroenterology & Hepatology
Joo Hyun Oh, Dong Hyun Sinn
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Joo Hyun Oh, Dong Hyun Sinn
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Seo Yeon Yoo, Jong-In Chang, Seungbong Han, Young Seok Kim, Dong Hyun Sinn, Sang Hyun Choi, Dong Il Gwon, Young-Suk Lim
Summary: This study aimed to develop and validate a prognostic model for identifying patients with a risk of poor short-term survival after PSSE. Results showed that baseline levels of serum albumin, total bilirubin, and international normalized ratio were significantly associated with 1-year overall survival after PSSE. The ABI score, developed based on these factors, showed good discrimination performance in predicting 3-month and 6-month survival.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)