Review
Medicine, Research & Experimental
Yenan Fang, Bingyan Shen, Qin Dai, Qiqi Xie, Wencan Wu, Min Wang
Summary: Orbital inflammatory pseudotumor (OIP) is a benign inflammatory disorder that commonly occurs in middle-aged adults. Its clinical manifestations vary greatly and diagnostic evaluations are necessary. The pathogenesis of OIP is not fully understood, but it may be related to immunity or infection. Glucocorticoids are the first-line treatment, and other options can be considered for treatment-resistant cases. This review focuses on new diagnostic criteria, pathogenesis, and discoveries in new drugs and treatment strategies, with emphasis on the role of T cell-mediated immune responses.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Oncology
Zhongyi Xu, Yuecen Ding, Leihong Flora Xiang, Chengfeng Zhang
Summary: Riehl's melanosis is a hyperpigmentation disorder that has a significant psychological and social impact on individuals. The mechanism of this disease remains unclear, but it is believed to be caused by allergic sensitization, genetic factors, ultraviolet radiation, and autoimmune factors. Various diagnostic methods and treatments have been used, including dermoscopy, patch/photopatch testing, and topical skin-lightening agents. The latest findings on possible biomarkers and their relationship to other autoimmune diseases were also summarized.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Review
Pediatrics
Ying-Hu Chen, Jin-Gan Lou, Zi-Hao Yang, Qing-Jiang Chen, Chun-Zhen Hua, Sheng Ye, Chen-Mei Zhang, Jie Chen, Zong-Wei Huang, Jin-Dan Yu, Zhi-Gang Gao, Qiang Shu
Summary: Severe acute hepatitis of unknown etiology in children is exhibiting a global trend of concentrated occurrence. Most cases tested positive for adenovirus, and immunoreactivity was detected in liver samples. Treatment includes symptomatic and supportive therapy, management of coagulation disorders and hepatic encephalopathy, and liver transplantation.
WORLD JOURNAL OF PEDIATRICS
(2022)
Review
Infectious Diseases
Mikaela M. Walker, Jason A. Roberts, Benjamin A. Rogers, Patrick N. A. Harris, Fekade B. Sime
Summary: Escherichia coli is a common commensal and pathogenic bacterium in the human microbiota, but multi drug resistance poses challenges in its treatment. This paper reviewed the literature on the development of multi drug resistance in uropathogenic E. coli (UPEC) and explored current and emerging treatment strategies. Overreliance on carbapenems has led to the dissemination of carbapenem resistance, calling for alternative treatment options. The emergence of new antimicrobials brings hope to the treatment of multi drug resistant E. coli urosepsis.
Review
Gastroenterology & Hepatology
Michael W. Dougherty, Christian Jobin
Summary: The development of colorectal cancer is influenced by the presence of bacterial communities in the gastrointestinal tract. These microorganisms obtain essential nutrients from indigestible compounds and play a role in molecular signaling pathways that are necessary for normal tissue and immune function. Several bacterial species, such as Fusobacterium nucleatum, Enterotoxigenic Bacteroides fragilis, and pks(+) E. coli, have been identified to potentially increase the risk of colorectal cancer. Recent research has expanded on this topic to include host mutational status, microbial heterogeneity within tumors, transient infections, and the cumulative effects of multiple carcinogenic bacteria. This review provides an updated overview of how host-bacteria interactions influence colorectal cancer development, potential applications in diagnosis or prevention, and the impact of the gut microbiome on colorectal cancer treatment efficacy.
Review
Oncology
Prodromos Hytiroglou, Paulette Bioulac-Sage, Neil D. Theise, Christine Sempoux
Summary: This article summarizes the mechanisms and diagnostic methods for hepatocellular adenoma and hepatocellular carcinoma, emphasizing the importance of histological examination and discussing the practical implications of hepatocellular neoplasms.
Review
Immunology
Miao He, Djandan Tadum Arthur Vithran, Linyuan Pan, Haijin Zeng, Guang Yang, Bangbao Lu, Fangjie Zhang
Summary: Acute septic arthritis is increasing among all patients and requires extensive assessment, identification, and treatment. Intravenous antimicrobial therapy has long been the standard treatment, but recent research suggests that parenteral antibiotics followed by oral antibiotics can be safe and effective. This article aims to update physicians on the latest findings and discussions about the epidemiology, etiology, diagnosis, and treatment of acute septic arthritis, and highlights the need for research to enhance treatment approaches and develop innovative diagnosis methods and drugs. It seeks to provide contemporary insights and foster collaboration among medical practitioners to improve patient outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Lina Wang, Zhenfeng Guo, Yuezhong Zheng, Qingyu Li, Xiaoyong Yuan, Xia Hua
Summary: Uveitis, a common and potentially sight-threatening intraocular inflammatory disorder, has a significant impact on visual acuity. Early diagnosis and effective treatment are essential to reduce complications and protect vision. Detailed clinical examination, laboratory tests, and appropriate treatment are crucial in managing uveitis and preventing ocular complications.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Review
Urology & Nephrology
Robert H. Drury, Brendan King, Bryan Herzog, Wayne J. G. Hellstrom
Summary: Hematospermia refers to the presence of blood in ejaculatory fluid. It is a rare condition that is often idiopathic or associated with sexual behavior. Iatrogenic interventions, such as transrectal ultrasound-guided prostate biopsies, are the most common cause of HS. Infection and/or nonspecific inflammation are the most common non-iatrogenic etiology. HS can have various sexual ramifications, including anxiety affecting libido, social repercussions, increased risk of erectile dysfunction or transmission of sexual infections, and compromised fertility, especially with cryopreservation.
SEXUAL MEDICINE REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Hitomi Sugino, Yu Sawada, Motonobu Nakamura
Summary: IgA, previously known as Henoch-Schonlein vasculitis, is an important immune component that can respond flexibly to various microorganisms, but may also cause autoreactive responses in the host human body, leading to IgA vasculitis and other autoimmune diseases. Bacterial and viral infections are often triggers of IgA vasculitis, while recent research has found that drugs and COVID-19 can also trigger this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Sylwia Bulanda, Danuta Ilczuk-Rypula, Aleksandra Nitecka-Buchta, Zuzanna Nowak, Stefan Baron, Lidia Postek-Stefanska
Summary: Bruxism in children is a complex condition with varying prevalence rates, diagnosed subjectively through observation and clinical examination. Treatment typically involves physiotherapy and psychotherapy for sleep bruxism, highlighting the importance of accurate diagnosis and development of clinical guidelines.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Michaela Mihal'ova, Nadja Supcikova, Alexandra Gaal Kovalcikova, Jan Breza Jr, L'ubomira Tothova, Peter Celec, Jan Breza Sr
Summary: Extracellular DNA (ecDNA) in the plasma and urine of urinary tract infection (UTI) patients was studied to understand its dynamics. The study found that urinary ecDNA levels decreased significantly during hospitalization and remained low during follow-up. Plasma ecDNA levels did not change, but plasma DNase activity increased during follow-up. C-reactive protein (CRP) and procalcitonin levels in plasma and urine were positively correlated with ecDNA, and urinary ecDNA levels were also correlated with urinary bacterial burden in a mouse UTI model.
Review
Clinical Neurology
Jeffrey Mullen, Khalid Alrasheed, Tahseen Mozaffar
Summary: GNE myopathy is a rare muscle disease characterized by slowly progressive muscle weakness. It is caused by mutations in the GNE gene, affecting the synthesis pathway of sialic acid. The clinical features of this disease include muscle weakness and atrophy that start in early adulthood, primarily affecting the tibialis anterior muscles while sparing the quadriceps muscles.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Nir Shimony, Meleine Martinez-Sosa, Brooks Osburn, George I. Jallo
Summary: Intracranial hypertension can be a life-threatening condition caused by various etiologies, requiring timely diagnosis and appropriate treatment to prevent neurological function loss. Tailoring management strategies based on the underlying cause is crucial for effective outcomes.
ACTA NEUROLOGICA BELGICA
(2021)
Review
Surgery
Yulong Yin, Xianghua Liu, Qingjie Meng, Xiaogang Han, Haomeng Zhang, Yonggang Lv
Summary: Idiopathic granulomatous mastitis is a rare form of chronic inflammatory breast disease with unknown cause. It can be difficult to distinguish from breast cancer and is associated with autoimmunity, abnormal hormone levels, and infection. Treatment options vary from observation to medical treatments and surgical intervention.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Critical Care Medicine
Daniel O. Thomas-Rueddel, Bernhard Poidinger, Manfred Weiss, Friedhelm Bach, Karin Dey, Helene Haeberle, Udo Kaisers, Hendrik Rueddel, Dirk Schaedler, Christian Scheer, Torsten Schreiber, Tobias Schuerholz, Philipp Simon, Armin Sommerer, Daniel Schwarzkopf, Andreas Weyland, Gabriele Woebker, Konrad Reinhart
JOURNAL OF CRITICAL CARE
(2015)
Article
Critical Care Medicine
Frank Bloos, Hendrik Rueddel, Daniel Thomas-Rueddel, Daniel Schwarzkopf, Christine Pausch, Stephan Harbarth, Torsten Schreiber, Matthias Guerndling, John Marshall, Philipp Simon, Mitchell M. Levy, Manfred Weiss, Andreas Weyland, Herwig Gerlach, Tobias Schuerholz, Christoph Engel, Claudia Matthaeus-Kraemer, Christian Scheer, Friedhelm Bach, Reimer Riessen, Bernhard Poidinger, Karin Dey, Norbert Weiler, Andreas Meier-Hellmann, Helene H. Haeberle, Gabriele Woebker, Udo X. Kaisers, Konrad Reinhart
INTENSIVE CARE MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
Bassam Redwan, Christian Biancosino, Felix Giebel, Gabriele Woebker, Michael Eberlein, Servet Bolukbas
Article
Critical Care Medicine
Tobias Welte, R. Phillip Dellinger, Henning Ebelt, Miguel Ferrer, Steven M. Opal, Mervyn Singer, Jean-Louis Vincent, Karl Werdan, Ignacio Martin-Loeches, Jordi Almirall, Antonio Artigas, Jose Ignacio Ayestaran, Sebastian Nuding, Ricard Ferrer, Gonzalo Sirgo Rodriguez, Manu Shankar-Hari, Francisco Alvarez-Lerma, Reimer Riessen, Josep-Maria Sirvent, Stefan Kluge, Kai Zacharowski, Juan Bonastre Mora, Harald Lapp, Gabriele Woebker, Ute Achtzehn, David Brealey, Axel Kempa, Miguel Sanchez Garcia, Joerg Brederlau, Matthias Kochanek, Henrik Peer Reschreiter, Matthew P. Wise, Bernd H. Belohradsky, Iris Bobenhausen, Benjamin Dalken, Patrick Dubovy, Patrick Langohr, Monika Mayer, Joerg Schuettrumpf, Andrea Wartenberg-Demand, Ulrike Wippermann, Daniele Wolf, Antoni Torres
INTENSIVE CARE MEDICINE
(2018)
Article
Critical Care Medicine
Marius M. Mader, Anna Leidorf, Andreas Hecker, Axel Heimann, Petra S. M. Mayr, Oliver Kempski, Beat Alessandri, Gabriele Woebker
NEUROCRITICAL CARE
(2018)
Article
Infectious Diseases
Jan De Waele, Jeffrey Lipman, Yasser Sakr, John C. Marshall, Philippe Vanhems, Casiano Barrera Groba, Marc Leone, Jean-Louis Vincent
BMC INFECTIOUS DISEASES
(2014)
Article
Gastroenterology & Hepatology
Thierry Gustot, Peter Felleiter, Peter Pickkers, Yasser Sakr, Jordi Rello, Dimitrios Velissaris, Charalampos Pierrakos, Fabio S. Taccone, Pavel Sevcik, Christophe Moreno, Jean-Louis Vincent
LIVER INTERNATIONAL
(2014)
Article
Clinical Neurology
Marius Marc-Daniel Mader, Axel Heimann, Oliver Kempski, Gabriele Woebker, Beat Alessandri
Summary: This study investigates the early changes in brain tissue oxygen pressure (ptiO(2)) and cerebral blood flow (CBF) in a pig model of ischemic stroke. The results show that bilateral common carotid artery occlusion (CCAO) leads to a consistent decrease in ptiO(2), which correlates with early degenerative histologic changes, but CBF remains unchanged. This suggests that real-time monitoring of ptiO(2) could be useful in large animal models of ischemia.
WORLD NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Jannik Schumann, Ulrike Johanns, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Gabriele Woebker
Summary: Empirical therapy and time to first effective treatment are critical in patients with bloodstream infections. The study evaluated the impact of additional FA BCID analysis on optimizing antimicrobial regimen in ICU patients with BSI. Results showed that optimal antimicrobial therapy occurred earlier in the intervention group by 17 hours compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Stefanie Voelk, Markus Pfirrmann, Uwe Koedel, Hans-Walter Pfister, Thomas Lang, Franziska Scheibe, Farid Salih, Julia Herzig-Nichtweiss, Julian Zimmermann, Angelika Alonso, Matthias Wittstock, Andreas Totzeck, Patrick Schramm, Ingo Schirotzek, Oezguer A. Onur, Johann Otto Pelz, Caroline Ottomeyer, Sebastian Luger, Kristian Barlinn, Tobias Binder, Gabriele Woebker, Gernot Reimann, Christian Urbanek, Jan Heckelmann, Piergiorgio Lochner, Martin Berghoff, Silvia Schoenenberger, Bernhard Neumann, Wolf-Dirk Niesen, Christian Dohmen, Hagen B. Huttner, Albrecht Guenther, Matthias Klein
Summary: This study demonstrates a decrease in the number of patients with bacterial and viral meningitis as well as otolaryngological infections during the COVID-19 pandemic, suggesting a possible correlation with hygiene measures.
JOURNAL OF NEUROLOGY
(2022)
Article
Critical Care Medicine
Hendrik Ruddel, Daniel O. Thomas-Ruddel, Konrad Reinhart, Friedhelm Bach, Herwig Gerlach, Matthias Lindner, John C. Marshall, Philipp Simon, Manfred Weiss, Frank Bloos, Daniel Schwarzkopf
Summary: The timing of antimicrobial therapy and surgical source control in patients with sepsis has a significant impact on clinical outcomes. Early anti-infective treatment can reduce mortality, while delays in source control may lead to disease progression.
Article
Critical Care Medicine
Daniel O. Thomas-Rueddel, Peter Hoffmann, Daniel Schwarzkopf, Christian Scheer, Friedhelm Bach, Marcus Komann, Herwig Gerlach, Manfred Weiss, Matthias Lindner, Hendrik Rueddel, Philipp Simon, Sven-Olaf Kuhn, Reinhard Wetzker, Michael Bauer, Konrad Reinhart, Frank Bloos
Summary: Septic patients may present with hypothermia or fever response, with rare normothermia cases. Hypothermia is associated with higher mortality, while high fever is correlated with bacteremia and elevated procalcitonin values. The study did not definitively determine whether hypothermia is a maladaptive or adaptive response.
Article
Clinical Neurology
Anna Leidorf, Marius M. Mader, Andreas Hecker, Axel Heimann, Beat Alessandri, Petra S. M. Mayr, Oliver Kempski, Gabriele Woebker
TURKISH NEUROSURGERY
(2014)
Article
Critical Care Medicine
Frank Bloos, Daniel Thomas-Ruddel, Hendrik Rueddel, Christoph Engel, Daniel Schwarzkopf, John C. Marshall, Stephan Harbarth, Philipp Simon, Reimer Riessen, Didier Keh, Karin Dey, Manfred Weiss, Susanne Toussaint, Dirk Schaedler, Andreas Weyland, Maximillian Ragaller, Konrad Schwarzkopf, Juergen Eiche, Gerhard Kuhnle, Heike Hoyer, Christiane Hartog, Udo Kaisers, Konrad Reinhart