期刊
JOURNAL OF FOOD BIOCHEMISTRY
卷 43, 期 1, 页码 -出版社
WILEY
DOI: 10.1111/jfbc.12451
关键词
bioactive peptides; dipeptidyl peptidase IV inhibition; food proteins; in silico; Type 2 diabetes
资金
- Enterprise Ireland [TC2013-0001]
Dipeptidyl peptidase IV (DPP-IV) is involved in incretin hormone processing and therefore plays a key role in glycemic regulation. This review summarizes the latest developments in food protein-derived DPP-IV inhibitory peptides. The in silico approaches currently used to develop targeted strategies for the enzymatic release of DPP-IV inhibitory peptides from food proteins are outlined. The features within the primary sequences of potent DPP-IV inhibitory di-, tri-, and larger peptides, having half maximal inhibitory activity (IC50)< 100 mu M, were evaluated and the outcomes are presented herein. It is proposed that detailed analysis of those food derived peptides identified in humans following ingestion may constitute a practical strategy for the targeted identification of novel bioavailable DPP-IV inhibitory peptides. Human intervention studies are required as the specific role of food protein-derived DPP-IV inhibitory peptides in the regulation of glycaemia in humans remains to be fully elucidated.
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