Article
Chemistry, Physical
Aysel Aydin Kocaeren, Dilek Senol Bahceci, Neslihan Demir, Busra Dalgic, Elifnur Karatag
Summary: New Schiff bases, ligand (L), poly-ligand (PL) and metal complexes [M(PL)2], were synthesized and characterized. The metal complexes showed better biological properties than PL, including DNA binding-cleavage, antioxidant and antibacterial activities. The [Cu(PL)2] complex exhibited excellent oxidative cleavage activity and denaturing ability, while [Hg(PL)2] complex showed high antioxidant and antibacterial activities. The UV-Vis spectra confirmed the electrostatic mode of DNA binding for the poly-ligand and its metal complexes. Rating: 8 points
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Ameneh Malekhoseini, Morteza Montazerozohori, Reza Naghiha, Esmaeel Panahi Kokhdan, Payam Hayati, Jonathan M. White
Summary: A new N2O2-tetradentate Schiff base ligand was synthesized and characterized. Novel cadmium coordination compounds were prepared and confirmed. The compounds showed antimicrobial, anti-cancer, and antioxidant activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad
Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
S. Sukkur Saleem, M. Sankarganesh, P. Adwin Jose, J. Dhaveethu Raja
Summary: This study synthesized and characterized a morpholine-based Schiff base ligand and its metal(II) complexes. They exhibited good free radical scavenging and antimicrobial activities, with the metal complexes showing stronger antimicrobial effects. In addition, L and its complexes may interact with DNA through an intercalative mode.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Engineering, Chemical
Serpil Gonca, Sadin ozdemir, Atakan Tekgul, Cumhur Gokhan Unlu, Kasim Ocakoglu, Nadir Dizge
Summary: The enhanced biological activity of perovskite type La1-xBaxMnO3 (x = 0.2, 0.3, 0.4) nanoparticles was investigated in terms of antioxidant, antimicrobial, anti-biofilm, bacterial viability inhibition, and DNA cleavage studies. The nanoparticles showed favorable biological activities, making them promising for various applications.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed R. Shehata, Ehab M. Abdalla
Summary: In this study, five novel metal ion complexes were synthesized and characterized, showing anticancer potential with antiproliferative effects on cancer cell lines, as well as antioxidant and antibacterial activities. The binding nature of the complexes with CT-DNA was investigated to determine intercalation or replacement mode.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Naghmana Kausar, Shahzad Murtaza, Muhammad Nadeem Arshad, Rubina Munir, Rahman Shah Zaib Saleem, Hummera Rafique, Abdul Tawab
Summary: A series of novel hydrazone derivatives of thiophene-2-carboxamide based benzohydrazide were synthesized and evaluated for their dual inhibitory activities against cholinesterases and antioxidant potential. Compound 13 was identified as the most active inhibitor, showing promising inhibitory effects against both cholinesterases.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Aveli Rambabu, Sreenu Daravath, Dasari Shiva Shankar, Shivaraj
Summary: The two mononuclear metal complexes bind to DNA through an intercalation mode and exhibit good cleavage ability under oxidative and photolytic conditions. Both complexes show marked biocidal potential in vitro.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Applied
Ashu Mamta, Pinki, Subhash, Ashu Chaudhary
Summary: The threat of antibiotic resistance is causing significant mortality worldwide, leading researchers to develop novel antibiotics. In this study, a new series of Schiff base macrocyclic ligands and their manganese complexes were synthesized and analyzed for their biological activities. The synthesized compounds exhibited high antimicrobial activity against bacterial and fungal strains, and the macrocyclic metal complex showed excellent antioxidant activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Wardha Zafar, Sajjad H. Sumrra, Zahid H. Chohan
Summary: Clinical reports have emphasized the increasing threat of multidrug resistance due to antibiotic resistance. Research has shown that organic compounds now require metal ions for bio-transformation in order to enhance their potentiality against resistance. Metal based drugs have played an imperative role in developing new strategies with significant biological activity, safety, and efficacy. In recent years, metal based compounds have been of great interest for treating various diseases, filling the gap left by conventional methodologies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandar Mijatovic, Nevenka Gligorijevic, Dusan Cocic, Snezana Spasic, Aleksandar Lolic, Sandra Arandelovic, Milan Nikolic, Rada Baosic
Summary: The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes was investigated. One of the complexes, CuAA, showed superior antioxidant activity than Trolox, as well as antimicrobial, antifungal, and antiproliferative properties. The complexes also interacted with human serum albumin and DNA fragments.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ahmet Kilic, Rahime Soylemez, Veysi Okumu
Summary: Novel catechol spiroborates were synthesized and characterized. They exhibited interesting optical properties, antioxidant activities, antibacterial activities, and DNA binding and cleavage activities.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Spectroscopy
Anshita Varshney, A. P. Mishra
Summary: Cobalt, Copper, Nickel, and Zinc coordinated metal complexes were synthesized using a new thiazole Schiff base ligand. The synthesized compounds were characterized using various spectroscopic techniques and thermal analysis. Theoretical computational studies were performed to investigate the properties of the compounds, including their antimicrobial activity. The synthesized ligand and metal complexes showed good antifungal activity, as well as DNA binding, DNA cleaving, and antioxidant activity. They also exhibited potential fluorescence properties.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Savitha D. Pradeep, Anjali K. Gopalakrishnan, Divya K. Manoharan, Rema S. Soumya, Raghu K. Gopalan, Puzhavoorparambil Mohanan
Summary: Novel Schiff bases were synthesized and characterized. They were evaluated for various pharmacological activities and their drug-likeness properties were assessed. In addition, their cytotoxicity and blood-brain barrier permeability were investigated.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Priyanka Ghanghas, Anita Choudhary, Dinesh Kumar, Kavita Poonia
Summary: Antibiotic-resistant infections have burdened the healthcare system and population, prompting the development of new synthetic molecules. Schiff base metal complexes show various biological activities, making them versatile pharmacophores for designing bioactive compounds.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Ayman A. Abdel Aziz, Ahmed Shawky, Mostafa M. H. Khalil
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Rania G. Mohamed, Abdelmoneim A. Makhlouf, Sherin A. Mosad, Ayman A. Abdel Aziz, Samir M. El-Medani, Ramadan M. Ramadan
JOURNAL OF COORDINATION CHEMISTRY
(2018)
Article
Chemistry, Physical
Rania G. Mohamed, Fatma M. Elantabli, Ayman A. Abdel Aziz, H. Moustafa, Samir M. El-Medani
JOURNAL OF MOLECULAR STRUCTURE
(2019)
Article
Biochemical Research Methods
Ayman A. Abdel Aziz, Mostafa A. Sayed
ANALYTICAL BIOCHEMISTRY
(2020)
Article
Chemistry, Applied
Abdulnasir A. Majeed, Mostafa M. H. Khalil, Ahmed Fetoh, Ayman A. Abdel Aziz, G. M. Abu El-Reash
Summary: A novel carbonyl thiourea ligand and its metal complexes were synthesized and characterized in this study, with discussions on their thermal decomposition behavior and evaluation of their antimicrobial, antioxidant, and cytotoxic activities. The results indicated promising activity of the Cd(II) complex in antimicrobial and antioxidant studies, while the Mn(II) complex showed potent cytotoxic activity against liver and breast cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Mosad A. El-ghamry, Khadija M. Nassir, Fatma M. Elzawawi, Ayman A. Abdel Aziz, Samy M. Abu-El-Wafa
Summary: Novel nano-sized metal complexes derived from ACV were synthesized and characterized, showing good thermal stability and nano-scale size. Enhanced antimicrobial and antitumor activities were observed upon complex formation, with the Cu(II) complex potentially inducing cancer cell death through apoptosis/necrosis pathways. The Cu(II) complex also exhibited stronger binding affinity to DNA compared to the free ligand. The electrical conductivity measurements indicated that the complexes behave as semiconductors.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Applied
Ramadan M. Ramadan, Samir M. El-Medani, Abdelmoneim Makhlouf, Hussein Moustafa, Manal A. Afifi, Matti Haukka, Ayman Abdel Aziz
Summary: Three molecularly designed phenylacetohydrazide Schiff base derivatives were synthesized and complexed with bivalent metal ions, and their properties were investigated using various spectroscopic and analytical techniques. The complexes showed biological activities, DNA binding abilities, and nonlinear optical properties.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Mostafa A. Sayed, M. M. Abo-Aly, Ayman A. Abdel Aziz, Amr Hassan, Abdel Naby M. Salem
Summary: The photocatalytic activity of CeO2 nanoparticles can be significantly enhanced by incorporating narrow band gap semiconductors like CdSe and CdTe, forming nanocomposites with a heterojunction structure to improve visible-light absorption efficiency. The synthesis of CeO2/CdSe and CeO2/CdTe nanocomposites through a simple hydrothermal route at a 1:1:1 molar ratio was successful without the need for expensive surfactants or capping agents. Characterization using XRD, Raman spectroscopy, and TEM confirmed the structure of the materials, while BET surface area measurements showed the high surface areas of the nanocomposites. The photocatalytic performance of the nanocomposites was excellent, with CeO2/CdSe exhibiting a degradation efficiency of 97.3% under visible-light irradiation in the degradation of Congo red dye.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Environmental Sciences
Mai M. Yousef, Hamdy A. El-Sayed, Ayman M. Kandeel, Mahmoud Gharieb, Ayman A. Abdel Aziz
Summary: The national strategic plan in Egypt supports the establishment of new towns and urban settlements along the coast to relieve pressure in the Nile Valley and Delta, while also encouraging internal migration to these areas. A research program has been designed to address the effects of sulfate and chloride attack, utilizing sulfate-resisting cement and chloride-binders for concrete preparation and steel protection. Initial findings show that these compounds can delay setting time, but improve workability, alkalinity, and compressive strength in hardened pastes exposed to seawater.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sara E. Mohamed, Ramadan M. Ramadan, Amir E. Aboelhasan, Ayman A. Abdel Aziz
Summary: A series of bioactive water-soluble mononuclear Ru(II)-mixed ligand complexes, containing 2,2'-bipyridyl and V-shaped Schiff base ligands, were synthesized and characterized. Their biomedical activities, including antioxidant activities, interaction with CT-DNA, and anticancer performance, were investigated. The optimized structure of these complexes was supported by DFT calculations, and molecular docking studies with DNA using MOE software further validated the interaction of some complexes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Mina E. Sidqi, Ayman A. Abdel Aziz, Amir E. Abolehasan, Mostafa A. Sayed
Summary: A novel efficient fluorescent probe PAMN was synthesized for the recognition of Al3+ ions, showing strong fluorescence through chelation-controlled C=N isomerization and inhibition of ESIPT mechanism. The complex of PAMN-Al3+ exhibited high association constant and low detection limit, making it suitable for intracellular Al3+ ion tracing.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Mosad A. El-ghamry, Fatma M. Elzawawi, Ayman A. Abdel Aziz, Khadija M. Nassir, Samy M. Abu-El-Wafa
Summary: A new Schiff base ligand derived from antiviral valacyclovir and its metal complexes (Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II)) were synthesized. The type of bonding between the ligand and metal ions was clarified and the complexes showed high thermal stability and antimicrobial and antitumor activity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Ayman A. Abdel A. Aziz, Ramadan M. M. Ramadan, Mina E. E. Sidqi, Mostafa A. A. Sayed
Summary: New mononuclear metal complexes derived from a tetradentate Schiff base ligand were successfully synthesized and characterized. The complexes exhibited strong binding affinity and antioxidant activity, particularly for Mn(II) and Cu(II) complexes. In vitro cell experiments demonstrated that the complexes had good anti-proliferative activity against tumor cells. The molecular geometry and DNA-interaction of the complexes were investigated using computational simulations and molecular docking experiments.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ayman A. A. Aziz, Amir E. Aboelhasan, Mostafa A. Sayed
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Applied
Ramadan M. Ramadan, Walid M. Elsheemy, Nahla S. Hassan, Ayman A. Abdel Aziz
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)