Article
Health Care Sciences & Services
Oxana P. Trifonova, Dmitry L. Maslov, Elena E. Balashova, Steven Lichtenberg, Petr G. Lokhov
Summary: Diabetic nephropathy is a common complication of diabetes that requires early diagnosis. Using metabolomics analysis, researchers identified a combination of 15 compounds that showed high accuracy in diagnosing DN, particularly in the late stage, with a diagnostic performance of up to 99%.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Seungyeon Lee, Sohyen Kwon, Jiyeong Lee, Hee-Gyoo Kang
Summary: Establishing a correlation between environmental variables and chemical change is important for research in multiple fields. This study focused on temperature and humidity as related to chemical reactions and aimed to confirm metabolite changes as potential markers for bloodstain age. Blood samples were collected and metabolite concentrations were measured under eight environmental conditions. The age-of-bloodstain estimation models developed had high accuracy and highlighted the potential of blood metabolites as age markers in various environments.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Karina Khambatta, Ashley Hollings, Georgina Sauzier, Lilian M. V. P. Sanglard, Annaleise R. Klein, Mark J. Tobin, Jitraporn Vongsvivut, Mark R. Gibberd, Alan D. Payne, Fatima Naim, Mark J. Hackett
Summary: The analysis of the epicuticular wax layer on plant leaves using FTIR reflectance spectroscopic imaging provides a non-destructive in situ method to investigate the distribution of wax in plants, offering insights into how plants respond to growth, disease, and environmental stressors.
Article
Cell Biology
Mark D. Benson, Aaron S. Eisman, Usman A. Tahir, Daniel H. Katz, Shuliang Deng, Debby Ngo, Jeremy M. Robbins, Alissa Hofmann, Xu Shi, Shuning Zheng, Michelle Keyes, Zhi Yu, Yan Gao, Laurie Farrell, Dongxiao Shen, Zsu-Zsu Chen, Daniel E. Cruz, Mario Sims, Adolfo Correa, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Xiuqing Guo, Jie Yao, Yii-Der Ida Chen, Ani W. Manichaikul, Deepti Jain, Qiong Yang, Claude Bouchard, Mark A. Sarzynski, Stephen S. Rich, Jerome I. Rotter, Thomas J. Wang, James G. Wilson, Clary B. Clish, Indra Neil Sarkar, Pradeep Natarajan, Robert E. Gerszten
Summary: This study conducted protein-metabolite association studies in plasma samples from three human cohorts and identified thousands of novel protein-metabolite relationships. Furthermore, the study used Mendelian randomization analysis to identify putative causal protein-to-metabolite associations and experimentally validated these associations in murine knockout strains.
Article
Plant Sciences
Xinxin Zhang, Yuxi Li, Huiling Yan, Kewei Cai, Hanxi Li, Zhiwei Wu, Jianguo Wu, Xiangdong Yang, Haichen Jiang, Qingcheng Wang, Guanzheng Qu, Xiyang Zhao
Summary: Light is a vital energy source and regulator for plant growth and development. The mechanism of plant growth and development under low light conditions is a significant scientific question. This study measured the growth and physiological indexes of Juglans mandshurica under different shade treatments and analyzed the molecular mechanism and metabolite accumulation under light stress. The results showed that seedling height was significantly higher in the shade treatment group, especially with 50% light intensity. The transcriptome and metabolome analyses revealed differential gene expression and metabolite accumulation related to photosynthesis, plant hormone signal transduction, and chlorophyll synthesis pathways. Flavonoids were identified as the major differential metabolites under light stress. These findings enhance our understanding of the molecular mechanisms and metabolite accumulation under light stress in J. mandshurica.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Zhigao An, Xinxin Zhang, Shanshan Gao, Di Zhou, Umair Riaz, Mohamed Abdelrahman, Guohua Hua, Liguo Yang
Summary: The addition of Capsicum oleoresin to the feed can improve lactation performance and reduce rectal temperature in dairy cows. It also alters plasma metabolites.
News Item
Multidisciplinary Sciences
Dyani Lewis
Summary: Evidence from living reptiles suggests that certain dinosaurs had scales covering their teeth.
Article
Microbiology
Ruth-Sophie Taubner, Lydia M. F. Baumann, Michael Steiner, Kevin Pfeifer, Barbara Reischl, Kordian Korynt, Thorsten Bauersachs, Barbara Maehnert, Elisabeth L. Clifford, Joern Peckmann, Bernhard Schuster, Daniel Birgel, Simon K. -M. R. Rittmann
Summary: Methanogenic archaea are important anaerobic microorganisms with diverse metabolic characteristics. This study provides a comprehensive quantitative analysis of the lipidome and proteinogenic amino acid excretion patterns of three autotrophic methanogens under different temperatures and nutrient supplies. The results show that each methanogen has unique patterns and rates of amino acid excretion and lipidome modulation, which can be influenced by temperature and substrate concentration. Additionally, water production rate is higher than methane production rate for all studied methanogens. This research highlights the need for quantitative comparative physiological studies to understand microbial responses to environmental conditions.
Review
Fisheries
Malgorzata Witeska, Elzbieta Kondera, Katarzyna Lugowska, Bartosz Bojarski
Summary: Hematological analyses are commonly used in evaluating fish health and welfare, with results sensitive to various environmental factors. Both manual and automatic methods are utilized in fish hematology research.
Article
Chemistry, Analytical
Farah C. Alimagham, Dan Hutter, Nuria Marco-Garcia, Emma Gould, Victoria H. Highland, Anna Huefner, Susan Giorgi-Coll, Monica J. Killen, Agnieszka P. Zakrzewska, Stephen R. Elliott, Keri L. H. Carpenter, Peter J. Hutchinson, Tanya Hutter
Summary: Continuous monitoring of dynamic chemical changes in traumatic brain injury (TBI) patients is crucial for improved outcomes. Traditional offline hourly monitoring may miss subhourly neurochemical changes, while mid-infrared spectroscopy offers the potential for continuous, automated, reagent-free, and online monitoring of these changes.
ANALYTICAL CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Salud Caceres-Jimenez, Raquel Rodriguez-Solana, Sara Dobani, Kirsty Pourshahidi, Chris Gill, Joseï Manuel Moreno-Rojas, Tahani M. Almutairi, Alan Crozier, Gema Pereira-Caro
Summary: After consuming 300 g of mango puree, the urine and plasma samples of 10 subjects were analyzed using high-performance liquid chromatography-high-resolution mass spectrometry. The study identified or tentatively identified a total of 94 microbial-derived phenolic catabolites in the biological samples. The results demonstrate the effectiveness of the UHPLC-HRMS protocol and the use of authentic standards in studying the metabolites of mango polyphenols in human bioavailability.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemical Research Methods
Samantha Lodge, Philipp Nitschke, Ruey Leng Loo, Torben Kimhofer, Sze-How Bong, Toby Richards, Sofina Begum, Manfred Spraul, Hartmut Schaefer, John C. Lindon, Elaine Holmes, Jeremy K. Nicholson
Summary: The study demonstrates that low sample volume H-1 NMR spectroscopic experiments under in vitro diagnostic conditions can effectively recover information from blood plasma with limited availability or high value samples. Lipoprotein measurements using different volumes of NMR tubes showed similar results, with no time penalty for biomarker recovery for SARS-CoV-2.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lei Luo, Ying Wang, Lu Qiu, Xingpei Han, Yaqian Zhu, Lulu Liu, Mingwu Man, Fuguang Li, Maozhi Ren, Yadi Xing
Summary: Transcription factor MYC2 plays a critical role in the JA signaling pathway, regulating plant physiological processes and specialized metabolite synthesis. Utilizing synthetic biology approaches to design MYC2-driven chassis cells for the synthesis of valuable specialized metabolites like paclitaxel, vincristine, and artemisinin appears to be a promising strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jonelle T. R. Basso, Katarina A. Jones, Kaylee R. Jacobs, Courtney J. Christopher, Haley B. Fielland, Shawn R. Campagna, Alison Buchan
Summary: Bacterial growth substrates and viral infection both have a combined influence on the carbon and lipid metabolism of the host. Differences in growth substrates lead to variations in intracellular metabolites and lipid distribution patterns. The metabolite and lipid profiles of bacteria are mainly determined by the composition of the growth medium, and the fluctuations in carbon substrates, nutrients, and viral pressure in natural systems also affect the metabolome and lipidome of resident bacteria.
Article
Neurosciences
Brittany D. Needham, Mark D. Adame, Gloria Serena, Destanie R. Rose, Gregory M. Preston, Mary C. Conrad, A. Stewart Campbell, David H. Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K. Mazmanian
Summary: The study used mass spectrometry methods to identify metabolic differences between children with ASD and typically developing children. The findings indicated differences in amino acid, lipid, and xenobiotic metabolism, implicating oxidative stress, mitochondrial dysfunction, hormone level elevations, lipid profile changes, and altered levels of phenolic microbial metabolites. These results suggest a link between metabolism, gastrointestinal physiology, and complex behavioral traits in ASD.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Ecology
W. Alice Boyle, Elsie H. Shogren, Jeffrey D. Brawn
TRENDS IN ECOLOGY & EVOLUTION
(2020)
Article
Ecology
Mark R. Herse, Kimberly A. With, W. Alice Boyle
Article
Chemistry, Multidisciplinary
Amie S. Sommers, Andrew W. Miller, Alan D. Gift, Dana L. Richter-Egger, Joshua P. Darr, Christine E. Cutucache
Summary: This study found that students can benefit from participating in CURE courses even without a laboratory component, demonstrating the value of CURE. CURE participants focus more on discovery and hands-on experience, while students in traditional labs are more concerned with course organization and structure.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Correction
Ecology
Mark R. Herse, Kimberly A. With, W. Alice Boyle
Article
Behavioral Sciences
Elsie H. Shogren, W. Alice Boyle
Summary: The study examined display investment in male white-ruffed manakins and found that individual quality and cooperation played a significant role in shaping behavior, while competition had a lesser impact. Male individuals often reduce their effort through cooperation with neighbors to advertise lek locations, while maintaining a consistent level of investment in display sites despite competition.
Article
Zoology
Elsie H. Shogren, Megan A. Jones, W. Alice Boyle
Summary: Tropical animals exhibit population-specific responses to rainfall, with endotherms in extremely wet regions experiencing heavy rains as stressors. Studying White-ruffed manakins in Costa Rica, researchers found that rainfall directly impacts male display behavior and turnover of display sites, with differences observed between extremely wet and drier locations. The study suggests that indirect abiotic effects and direct mortality effects of rainfall likely underlie the spatial and temporal variations in the population dynamics of this species.
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2021)
Article
Ornithology
Bram H. F. Verheijen, Amy N. Erickson, W. Alice Boyle, Kiana S. Leveritte, Jennifer L. Sojka, Lauren A. Spahr, Emily J. Williams, Sarah K. Winnicki, Brett K. Sandercock
Summary: This study examined the effects of patch-burn grazing on the reproductive success of three grassland songbird species. The results showed that patch-burn grazing did not have the expected benefits on the survival and breeding of grassland birds as previously described. However, patch-burn grazing management could still benefit population dynamics of bird species that require greater amounts of vegetation cover and litter.
ORNITHOLOGICAL APPLICATIONS
(2022)
Article
Behavioral Sciences
Matthew J. Fuxjager, T. Brandt Ryder, Nicole M. Moody, Camilo Alfonso, Christopher N. Balakrishnan, Julia Barske, Mariane Bosholn, W. Alice Boyle, Edward L. Braun, Ioana Chiver, Roslyn Dakin, Lainy B. Day, Robert Driver, Leonida Fusani, Brent M. Horton, Rebecca T. Kimball, Sara Lipshutz, Claudio Mello, Eliot T. Miller, Michael S. Webster, Morgan Wirthlin, Roy Wollman, Ignacio T. Moore, Barney A. Schlinger
Summary: Organismal behavior is generated by various physiological systems, and understanding how these systems evolve to support differences in behavior is a long-standing goal in biology. However, the physiological determinants of behavioral evolution are often overlooked due to a lack of conceptual framework. This study proposes a systems approach that integrates behavior and physiology models to understand behavioral control.
HORMONES AND BEHAVIOR
(2023)
Article
Ecology
Katy M. Silber, Narmadha M. Mohankumar, Trevor J. Hefley, W. Alice Boyle
Summary: Many external factors can affect the demographic rates of bird populations, especially migratory birds that face varying weather and habitat conditions. This study examined the relationship between precipitation and vital rates of grasshopper sparrows in midcontinental grasslands. The results showed that both survival and emigration were associated with the El Nino-Southern Oscillation precipitation index, indicating the influence of weather and climate on the behavior and population dynamics of grasshopper sparrows.
JOURNAL OF WILDLIFE MANAGEMENT
(2023)
Article
Geosciences, Multidisciplinary
Narmadha M. Mohankumar, Trevor J. Hefley, Katy M. Silber, W. Alice Boyle
Summary: Species distribution models (SDMs) can be improved by fusing distance sampling (DS) and capture-recapture (CR) data, which increases spatial coverage and reduces parameter uncertainty. A model-based approach that accounts for missing data issues was developed and shown to provide unbiased parameter estimates with increased efficiency compared to existing approaches. The approach was demonstrated using data collected for Grasshopper Sparrows (Ammodramus savannarum) in north-eastern Kansas, USA.
SPATIAL STATISTICS
(2023)
Review
Ecology
Jacy S. Bernath-Plaisted, Maureen D. Correll, Scott G. Somershoe, Angela M. Dwyer, Andy Bankert, Adam Beh, Humberto Berlanga, W. Alice Boyle, J. Lizardo Cruz-Romo, T. Luke George, James Herkert, Nicola Koper, Alberto Macias-Duarte, Arvind O. Panjabi, Oscar M. Ramirez-Flores, Barry Robinson, Irene Ruvalcaba-Ortega, Julie Sibbing, Erin H. Strasser, Mieke Titulaer, William E. Van Pelt, Tammy VerCauteren
Summary: Despite decades of conservation efforts, North America's grassland birds are still facing a crisis. Their decline is driven by various threats including habitat loss, agriculture intensification, and climate change. However, there are diverse strategies and resources available for their conservation, such as land set-aside programs, incentives for producers, and policy and regulation.
RANGELAND ECOLOGY & MANAGEMENT
(2023)
Article
Biodiversity Conservation
N. E. Freeman, M. Gustafson, T. J. Hefley, W. A. Boyle
Summary: In the mid-continental grasslands of North America, climate change is leading to more intense and frequent extreme weather events, which can negatively impact an individual's condition and survival. Despite limited knowledge about the costs of these weather events, studies have shown that individuals exposed to storms have decreased fat reserves and increased lean mass, water, and hematocrit levels.
CONSERVATION PHYSIOLOGY
(2023)
Correction
Ecology
Lindsey A. Bruckerhoff, R. Kent Connell, James P. Guinnip, Elina Adhikari, Alixandra Godar, Keith B. Gido, W. Alice Boyle, Andrew G. Hope, Anthony Joern, Ellen Welti
Meeting Abstract
Zoology
E. H. Shogren, W. A. Boyle
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2021)
Meeting Abstract
Zoology
W. A. Boyle, D. J. Bodony, E. H. Shogren, L. Nguyen, E. B. Day
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2021)