Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

(2016) S Chen et al.   LEUKEMIA

Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both

(2016) S Koschmieder et al.   LEUKEMIA

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

(2015) Koen Schepers et al.   Cell Stem Cell

Application of single-cell genomics in cancer: promise and challenges

(2015) Quin F. Wills et al.   HUMAN MOLECULAR GENETICS

Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells

(2015) Morgan Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

(2014) Petter S. Woll et al.   CANCER CELL

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells

(2013) Charlotta Böiers et al.   Cell Stem Cell

Cytokine profiles in acute myeloid leukemia patients at diagnosis: Survival is inversely correlated with IL-6 and directly correlated with IL-10 levels

(2013) Beatriz Sanchez-Correa et al.   CYTOKINE

FLT3tyrosine kinase inhibitors in acute myeloid leukemia: clinical implications and limitations

(2013) Sabine Kayser et al.   LEUKEMIA & LYMPHOMA

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

Quantitative assessment of single-cell RNA-sequencing methods

(2013) Angela R Wu et al.   NATURE METHODS

FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

(2013) Adam J. Mead et al.   Cell Reports

Regulation of Hematopoietic Stem Cell Activity by Inflammation

(2013) Laura G. Schuettpelz et al.   Frontiers in Immunology

Mapping differentiation pathways from hematopoietic stem cells using Flk2/Flt3 lineage tracing

(2012) Scott W. Boyer et al.   CELL CYCLE

FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm

(2012) S. Haihua Chu et al.   Cell Stem Cell

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

(2012) Sidinh Luc et al.   NATURE IMMUNOLOGY

Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-α

(2012) Diarmaid D Houlihan et al.   Nature Protocols

Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

(2012) M. Jan et al.   Science Translational Medicine

Multiobjective evolutionary algorithms to identify highly autocorrelated areas: the case of spatial distribution in financially compromised farms

(2011) Carlos R. García-Alonso et al.   ANNALS OF OPERATIONS RESEARCH

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

(2011) S. Kharazi et al.   BLOOD

FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells

(2011) N. Buza-Vidas et al.   BLOOD

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

All Hematopoietic Cells Develop from Hematopoietic Stem Cells through Flk2/Flt3-Positive Progenitor Cells

(2011) Scott W. Boyer et al.   Cell Stem Cell

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

(2011) Cornelis J.H. Pronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

(2010) Y. Nakamura et al.   BLOOD

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development

(2010) C. Boiers et al.   BLOOD

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells

(2009) N. Buza-Vidas et al.   BLOOD

Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia

(2009) S. Meshinchi et al.   CLINICAL CANCER RESEARCH

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes

(2008) Apostolia Maria Tsimberidou et al.   CANCER

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE