NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury

(2017) Guangbi Li et al.   JOURNAL OF LIPID RESEARCH

Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps

(2017) Marcel P.B. Jansen et al.   KIDNEY INTERNATIONAL

NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells

(2015) Kritarth Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Suppression of NLRX1 in chronic obstructive pulmonary disease

(2015) Min-Jong Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria: a therapeutic target in acute kidney injury

(2015) Yu Ishimoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Modeling-Enabled Characterization of Novel NLRX1 Ligands

(2015) Pinyi Lu et al.   PLoS One

The effect of ischemia/reperfusion on the kidney graft

(2014) Julia Menke et al.   Current Opinion in Organ Transplantation

The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

(2014) Fraser Soares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium

(2014) G. Stokman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Pattern recognition receptors and the inflammasome in kidney disease

(2014) Jaklien C. Leemans et al.   Nature Reviews Nephrology

Nlrx1 regulates neuronal cell death

(2014) Emilie Imbeault et al.   Molecular Brain

Non-Inflammasome Forming NLRs in Inflammation and Tumorigenesis

(2014) Irving Coy Allen   Frontiers in Immunology

World Incidence of AKI: A Meta-Analysis

(2013) P. Susantitaphong et al.   Clinical Journal of the American Society of Nephrology

Mitochondrial Complex III Deficiency Caused by a HomozygousUQCRC2Mutation Presenting with Neonatal-Onset Recurrent Metabolic Decompensation

(2012) Noriko Miyake et al.   HUMAN MUTATION

NLRX1 does not inhibit MAVS-dependent antiviral signalling

(2012) Fraser Soares et al.   Innate Immunity

NLRX1/NOD5 deficiency does not affect MAVS signalling

(2011) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Epac-Rap Signaling Reduces Cellular Stress and Ischemia-induced Kidney Failure

(2011) G. Stokman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR4 Promotes Fibrosis but Attenuates Tubular Damage in Progressive Renal Injury

(2010) W. P. Pulskens et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Stem Cell Factor Expression after Renal Ischemia Promotes Tubular Epithelial Survival

(2010) Geurt Stokman et al.   PLoS One

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

(2009) Jaklien C. Leemans et al.   PLoS One

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

(2008) Wilco P. Pulskens et al.   PLoS One