ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of eosinophilic esophagitis and hypertrophic cardiomyopathy

(2016) Benjamin P. Davis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy

(2016) Willem S. Lexmond et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

(2016) Diamant Thaçi et al.   LANCET

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

(2016) Jonathan J Lyons et al.   NATURE GENETICS

Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy

(2015) Magali Noval Rivas et al.   IMMUNITY

STAT3 selectively interacts with Smad3 to antagonize TGF-β

(2015) G Wang et al.   ONCOGENE

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

(2014) J. D. Milner et al.   BLOOD

Transforming growth factor-β (TGF-β) pathway abnormalities in tenascin-X deficiency associated with CAH-X syndrome

(2014) Rachel Morissette et al.   European Journal of Medical Genetics

GATA-3 Function in Innate and Adaptive Immunity

(2014) Irma Tindemans et al.   IMMUNITY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

(2014) Yu Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

(2014) Chider Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance

(2014) Fang Yu et al.   NATURE IMMUNOLOGY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Erbin is a negative modulator of cardiac hypertrophy

(2014) I. Rachmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders

(2013) J. Pablo Abonia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

(2013) Elissa K. Deenick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

TGF  Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease

(2013) P. A. Frischmeyer-Guerrerio et al.   Science Translational Medicine

Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner

(2013) Y Hu et al.   Oncogenesis

Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo

(2012) R B Luwor et al.   ONCOGENE

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

(2011) G. Sflomos et al.   JOURNAL OF CELL SCIENCE

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine CD4 T Cells Produce a New Form of TGF-β as Measured by a Newly Developed TGF-β Bioassay

(2011) Takatoku Oida et al.   PLoS One

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

Cutting Edge: Lack of High Affinity Competition for Peptide in Polyclonal CD4+ Responses Unmasks IL-4 Production

(2010) J. D. Milner et al.   JOURNAL OF IMMUNOLOGY

Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells

(2009) Michael P. O'Connell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion

(2009) M. S. Turner et al.   JOURNAL OF IMMUNOLOGY

Clinical Manifestations, Etiology, and Pathogenesis of the Hyper-IgE Syndromes

(2009) Alexandra F Freeman et al.   PEDIATRIC RESEARCH

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

(2008) Wei Liao et al.   NATURE IMMUNOLOGY