Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

Mevalonate metabolism in cancer

(2015) Georg Gruenbacher et al.   CANCER LETTERS

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

(2015) Na Xu et al.   Science China-Life Sciences

Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells

(2015) Heidrun Karlic et al.   Cancer Genetics

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

(2015) Aleksandra A. Pandyra et al.   Oncotarget

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice

(2014) Peter Acs et al.   Brain Structure & Function

Primary cilium and sonic hedgehog signaling during neural tube patterning: Role of GPCRs and second messengers

(2014) Kasturi Pal et al.   Developmental Neurobiology

Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation

(2014) James P. Bridges et al.   PLoS One

Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion

(2014) Katsuhiko Warita et al.   Scientific Reports

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

SIRT6 Puts Cancer Metabolism in the Driver’s Seat

(2012) Costas A. Lyssiotis et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

(2011) Madeline A. Lancaster et al.   NATURE CELL BIOLOGY

Cancer Metabolism: Is Glutamine Sweeter than Glucose?

(2010) Weiqin Lu et al.   CANCER CELL

ATP Consumption Promotes Cancer Metabolism

(2010) William J. Israelsen et al.   CELL

Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts

(2010) Linda Schneider et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effect of statin therapy on colorectal cancer

(2010) M. Bardou et al.   GUT

Statin Use and the Risk of Prostate-Specific Antigen Recurrence After Radiation Therapy With or Without Hormone Therapy for Prostate Cancer

(2010) Anthony V. D'Amico   JOURNAL OF CLINICAL ONCOLOGY

Statin Use and Risk of Prostate Cancer Recurrence in Men Treated With Radiation Therapy

(2010) Ruchika Gutt et al.   JOURNAL OF CLINICAL ONCOLOGY

Dysregulation of the mevalonate pathway promotes transformation

(2010) J. W. Clendening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia

(2009) E. S. Seeley et al.   CANCER RESEARCH

Ciliary dysfunction and obesity

(2009) CA Mok et al.   CLINICAL GENETICS

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL