Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

(2016) Jianhua Li et al.   NATURE

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens

(2015) Michael Y. Gerner et al.   IMMUNITY

Immune homeostasis enforced by co-localized effector and regulatory T cells

(2015) Zhiduo Liu et al.   NATURE

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

Lymph-Node Resident CD8α+ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8+ T Cell Responses

(2015) Andrea J. Radtke et al.   PLoS Pathogens

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

(2014) Michelle A Linterman et al.   eLife

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

The nature of activatory and tolerogenic dendritic cell-derived signal II

(2013) Ghaith Bakdash et al.   Frontiers in Immunology

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

(2012) Michael Y. Gerner et al.   IMMUNITY

Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells

(2012) Beatriz León et al.   NATURE IMMUNOLOGY

Determining germinal centre B cell fate

(2012) Dimitra Zotos et al.   TRENDS IN IMMUNOLOGY

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

B Cell-Specific Expression of B7-2 Is Required for Follicular Th Cell Function in Response to Vaccinia Virus

(2011) S. Salek-Ardakani et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

(2011) Stephen L Nutt et al.   NATURE IMMUNOLOGY

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

(2010) Jennifer L. Cannons et al.   IMMUNITY

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE