Article
Environmental Sciences
Hsin-Ling Yang, Yao-Hsien Chang, Sudhir Pandey, Asif Ali Bhat, Chithravel Vadivalagan, Kai-Yuan Lin, You-Cheng Hseu
Summary: This study found that Antrodia camphorata (AC) and Coenzyme Q(0) (CoQ(0)) have anti-tumor and anti-metastasis effects in human glioblastoma (GBM8401) cells. AC treatment inhibited tumor cell growth and migration/invasion and induced autophagy. CoQ(0) treatment also inhibited migration/invasion and downregulated metastasis-related proteins. Autophagy inhibitors reversed the effects of CoQ(0) on migration/invasion and metastasis-related proteins. CoQ(0) inhibited HIF-1 alpha and metastasis in GBM8401 cells and prolonged the survival rate in GBM8401-xenografted mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Plant Sciences
Ruqian Ding, Xianling Ning, Min Ye, Yuxin Yin
Summary: The study demonstrates the potential of Antrodia camphorata extract (ACE) as an anticancer agent that induces apoptosis in human colon cancer cells through BMP4 and p53-dependent response to ROS.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ping-Chen Tu, Wen-Ping Jiang, Ming-Kuem Lin, Guan-Jhong Huang, Yi-Jen Li, Yueh-Hsiung Kuo
Summary: This study screened anti-inflammatory compounds from the methanolic extract of the mycelium of Antrodia camphorata and identified 4-acetylantroquinonol B (1) as the most potent compound against poly I:C-induced NO production.
Review
Biochemistry & Molecular Biology
Yi Kuang, Bin Li, Zilong Wang, Xue Qiao, Min Ye
Summary: Antrodia camphorata is a medicinal mushroom endemic to Taiwan used for the treatment of intoxication, liver injury, cancer, and inflammation. Its terpenoids show various pharmacological activities such as anti-cancer and hepatoprotective effects, making them potentially valuable for medicinal use.
NATURAL PRODUCT REPORTS
(2021)
Article
Nutrition & Dietetics
Chih-Jung Yao, Chia-Lun Chang, Ming-Hung Hu, Chien-Huang Liao, Gi-Ming Lai, Tzeon-Jye Chiou, Hsien-Ling Ho, Hui-Ching Kuo, Ya-Yu Yang, Jacqueline Whang-Peng, Shuang-En Chuang
Summary: Combinatorial treatment with Antrodia camphorata and lovastatin has a synergistic effect in androgen-refractory prostate cancer cells, inhibiting cell cycle and inducing apoptosis. The treatment also reduces the expression of molecules related to cellular proliferation, aggressiveness, and stemness. This study provides new insights for the development of dietary natural products as therapeutic strategies against androgen-refractory prostate cancer.
Article
Cell Biology
Chenxi Cao, Hai Zhong, Zhenwei Chen, Zhengwei Song, Biwen Hu, Xiaoguang Wang
Summary: This study aimed to investigate the role and mechanism of Antcin A in resisting liver injury. It was found through network pharmacology analysis that MAPK3 was the major action target of Antcin A. Experimental research indicated that Antcin A suppressed mouse liver injury, reduced inflammatory factor levels, and enhanced anti-oxidative capacity. It also suppressed the expression of MAPK3 and the downstream NF-KB signal.
Article
Multidisciplinary Sciences
Ya-Dong Zhang, Liang-Yan Liu, Dong Wang, Xiao-Long Yuan, Yuan Zheng, Yi Wang
Summary: Antimicrobial resistance poses a major threat to human health worldwide. This study discovered that 5-methyl-benzo [1,3]-dioxole-4,7-diol (MBBD) isolated from Antrodia camphorata exhibits broad-spectrum antibacterial activity, particularly against Acinetobacter baumannii. MBBD shows potential as a candidate for new antimicrobial drugs.
Article
Food Science & Technology
Dandan Liu, Liping Zhu, Yiting Guo, Yiming Zhao, Garba Betchem, Yolandani Yolandani, Haile Ma
Summary: This study aimed to investigate the effect of low-frequency alternating magnetic field (LF-AMF) on the fermentation of Antrodia camphorata. The results showed that under optimal magnetic treatment conditions, the mycelial biomass and the yields of polysaccharides and triterpenoids increased significantly compared to the control. The microstructures of the magnetically treated mycelium displayed characteristic changes, and the cytomembrane fluidity increased over time. Transcriptomic analysis revealed the molecular mechanism behind the enhanced fermentation.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Jin Li, Sai Wen, Baoyuan Zhang, Fenghuan Wang
Summary: Selenium (Se) is a crucial nutrient in human physiology and immune function, and supplementing bioavailable Se can be beneficial for human health. The Antrodia camphorata mushroom, native to Taiwan, can assimilate and transform sodium selenite into organic selenium. The study found that the organic selenium content accounted for 88.1% of the total selenium content in selenium-enriched A. camphorata mycelia, and selenium-enriched polysaccharide was the main form of Se present in the mushroom. The selenium-enriched polysaccharides also showed a significant improvement in antioxidant capacity.
Article
Agriculture, Multidisciplinary
Zhi-Shan Luo, Zhen-Ming Lu, Miao-Miao Hu, Xin-Yang Li, Guo-Qiang Xu, Jin-Song Gong, Jin-Song Shi, Zheng-Hong Xu
Summary: This study found that the methanol extract of Cinnamomum kanehirae trunk (MECK) can stimulate the production of triterpenoids and increase the abundance of secondary metabolites in Antrodia camphorata. It also identified 93 terpenoids in the MECK-treated mycelia, with 21 of them being the same as those found in the fruiting bodies. Furthermore, two terpenoids, linalool and alpha-pinene, were found to significantly increase the terpenoid production of A. camphorata and regulate the mRNA expression levels of nine key genes in the mevalonate pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Medicinal
C. Y. Chen, J. J. Wang, C. L. Kao, H. T. Li, M. D. Wu, M. J. Cheng
Summary: A new benzoquinone, along with 11 known compounds, was isolated from the fruiting body of Antrodia camphorata. These compounds were characterized and identified by physical and spectral evidences.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Chemistry, Organic
Hui-Fei Su, Bin Li, Yang Yi, Meng Zhang, Rong Yu, Yang-Oujie Bao, Kuan Chen, Min Ye
Summary: In this study, the bacterial glycosyltransferase YjiC1 was used for glycosylation of triterpenoids from Antrodia camphorata. Eleven new compounds were obtained through enzymatic reactions. Glucosylation enhanced the inhibitory activities against COX-2 and improved the anti-inflammatory activities of Antrodia ergostanes on acute lung injury mice, especially (25R)-antcin C 7-O-beta-d-glucoside.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Microbiology
Chia-Ling Chen, Wan-Chen Li, Yu-Chien Chuang, Hou-Cheng Liu, Chien-Hao Huang, Ko-Yun Lo, Chung-Yu Chen, Fang-Mo Chang, Guo-An Chang, Yu-Ling Lin, Wen-Der Yang, Ching-Hua Su, Tsung-Ming Yeh, Ting-Fang Wang
Summary: Taiwanofungus camphoratus mushrooms are used as a medicinal alternative for various health issues, and this study provides valuable genomic resources for understanding its biology and evolution. The research also highlights the importance of genetic manipulation and synthetic biology applications for producing natural medicinal products.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Organic
Hui-Fei Su, Bin Li, Yang Yi, Meng Zhang, Rong Yu, Yang-Oujie Bao, Kuan Chen, Min Ye
Summary: Eleven new compounds were obtained from enzymatic reactions using the bacterial glycosyltransferase YjiC1 to glycosylate triterpenoids from the medicinal fungus Antrodia camphorata. Glucosylation could increase the inhibitory activities against COX-2, and improve the anti-inflammatory activities of Antrodia ergostanes on acute lung injury mice, particularly (25R)-antcin C 7-O-beta-d-glucoside.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Plant Sciences
Xiaofeng Liu, Shuzhen Yu, Yao Zhang, Wei Zhang, Hao Zhong, Xiaoqin Lu, Rongfa Guan
Summary: This paper summarizes the occurrence and development of alcoholic liver disease (ALD) and its effect on the gut-liver axis. Antrodia camphorata, a valuable medicinal fungus in Taiwan, has a great protective effect on the liver and potential therapeutic value for ALI. It contains rich active components with antioxidant, anti-inflammatory, and intestinal protection activities, making it widely applied in the prevention and treatment of ALI.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)