Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors

(2016) Pingping Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking

(2016) Xuefei Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel diazaphosphinanes coumarin derivatives with promoted cytotoxic and anti-tyrosinase activities

(2016) Marwa Gardelly et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ensemble-Based Virtual Screening Led to the Discovery of New Classes of Potent Tyrosinase Inhibitors

(2016) Joonhyeok Choi et al.   Journal of Chemical Information and Modeling

The Structure of a Plant Tyrosinase from Walnut Leaves Reveals the Importance of “Substrate-Guiding Residues” for Enzymatic Specificity

(2015) Aleksandar Bijelic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluation of Novel Chalcone Oximes as Inhibitors of Tyrosinase and Melanin Formation in B16 Cells

(2015) Sini K. Radhakrishnan et al.   ARCHIV DER PHARMAZIE

Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng

(2015) Dae-Young Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

(E)-2-Cyano-3-(substituted phenyl)acrylamide analogs as potent inhibitors of tyrosinase: A linear β-phenyl-α,β-unsaturated carbonyl scaffold

(2015) Sujin Son et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational design, synthesis and structure–activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors

(2015) Ao You et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase

(2015) Zaman Ashraf et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitory kinetics of novel 2,3-dihydro-1 H -inden-1-one chalcone-like derivatives on mushroom tyrosinase

(2015) Sini Radhakrishnan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Azachalcones: A new class of potent polyphenol oxidase inhibitors

(2015) Sini Karanayil Radhakrishnan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors

(2015) Ao You et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kinetic and in silico studies of novel hydroxy-based thymol analogues as inhibitors of mushroom tyrosinase

(2015) Zaman Ashraf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of melanogenesis: a patent review (2009 – 2014)

(2015) Thanigaimalai Pillaiyar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors

(2015) Joonhyeok Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

(2015) Tien-Sheng Tseng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure–Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase

(2015) Shailendra Asthana et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alpha-Substituted Derivatives of Cinnamaldehyde as Tyrosinase Inhibitors: Inhibitory Mechanism and Molecular Analysis

(2015) Yi Cui et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Design, synthesis and bioevaluation of novel umbelliferone analogues as potential mushroom tyrosinase inhibitors

(2015) Zaman Ashraf et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of Triazole Schiff’s Base Derivatives and Their Inhibitory Kinetics on Tyrosinase Activity

(2015) Feng Yu et al.   PLoS One

Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling

(2015) Wang-Chuan Chen et al.   Scientific Reports

Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation

(2014) Yen-Kim Won et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

(2014) Taek Hwan Lee et al.   Biomolecules & Therapeutics

Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis

(2014) Chin-Feng Chan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors

(2014) Zhiyong Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationships of the thujaplicins for inhibition of human tyrosinase

(2014) Atsushi Yoshimori et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots

(2014) Yan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploring the Interaction of N/S Compounds with a Dicopper Center: Tyrosinase Inhibition and Model Studies

(2014) Elina Buitrago et al.   INORGANIC CHEMISTRY

S-(−)-10,11-Dihydroxyfarnesoic Acid Methyl Ester Inhibits Melanin Synthesis in Murine Melanocyte Cells

(2014) Seung-Hwa Baek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serendipitous Discovery of Short Peptides from Natural Products as Tyrosinase Inhibitors

(2014) Nai-Wan Hsiao et al.   Journal of Chemical Information and Modeling

Novel Virtual Screening Approach for the Discovery of Human Tyrosinase Inhibitors

(2014) Ni Ai et al.   PLoS One

Benzylidene-linked thiohydantoin derivatives as inhibitors of tyrosinase and melanogenesis: importance of the β-phenyl-α,β-unsaturated carbonyl functionality

(2014) Hye Rim Kim et al.   MedChemComm

Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

(2014) Ryuji Uchida et al.   Acta Pharmaceutica Sinica B

Anti-melanogenic effect of (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione, a novel tyrosinase inhibitor

(2013) So Hee Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Inhibitory effect of ectoine on melanogenesis in B16-F0 and A2058 melanoma cell lines

(2013) Chao-Ling Yao et al.   BIOCHEMICAL ENGINEERING JOURNAL

In vitroandin vivostudies disclosed the depigmenting effects of gallic acid: A novel skin lightening agent for hyperpigmentary skin diseases

(2013) K. J. Senthil Kumar et al.   BIOFACTORS

A Novel Synthesized Tyrosinase Inhibitor: (E)-2-((2,4-Dihydroxyphenyl)diazenyl)phenyl 4-Methylbenzenesulfonate as an Azo-Resveratrol Analog

(2013) Sung Jin BAE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB)

(2013) V. Arulmozhi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Co-Drug Strategy for Promoting Skin Targeting and Minimizing the Transdermal Diffusion of Hydroquinone and Tranexamic Acid

(2013) Pei-Wen Hsieh et al.   CURRENT MEDICINAL CHEMISTRY

Design and Synthesis of Hydroxypyridinone-l-phenylalanine Conjugates as Potential Tyrosinase Inhibitors

(2013) Dong-Fang Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tranexamic acid: an important adjuvant in the treatment of melasma

(2013) Tsz Wah Tse et al.   Journal of Cosmetic Dermatology

Skin Delivery of Kojic Acid-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging

(2013) M. L. Gonçalez et al.   Biomed Research International

Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2,4 dihydroxybenzylidene)pyrrolidine-2,5-dione (3-DBP)

(2012) Ki Wung Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibitory Effect of Gnetin C, a Resveratrol Dimer from Melinjo (Gnetum gnemon), on Tyrosinase Activity and Melanin Biosynthesis

(2012) Miyako Yanagihara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

New saccharin derivatives as tyrosinase inhibitors

(2012) Nahit Gençer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors

(2012) Yu Min Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors

(2012) Argyro Vontzalidou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preformulation and formulation of newly synthesized QNT3-18 for development of a skin whitening agent

(2012) Do-Hyung Ki et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Design, synthesis, and evaluation of (E)-N-substituted benzylidene–aniline derivatives as tyrosinase inhibitors

(2012) Sung Jin Bae et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive oligopeptides in dermatology: Part I

(2012) Bobby Reddy et al.   EXPERIMENTAL DERMATOLOGY

Synthesis of 4′-Thiosemicarbazonegriseofulvin and Its Effects on the Control of Enzymatic Browning and Postharvest Disease of Fruits

(2012) Zhi-Zhen Pan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kinetic study on the tyrosinase and melanin formation inhibitory activities of carthamus yellow isolated from Carthamus tinctorius L.

(2012) Yi-Shyan Chen et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells

(2012) Makoto Takahashi et al.   Journal of Oleo Science

A focused review on acne-induced and aesthetic procedure-related postinflammatory hyperpigmentation in Asians

(2012) S. Eimpunth et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation

(2012) L. Kolbe et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Transdermal delivery of three vitamin C derivatives by Er:YAG and carbon dioxide laser pretreatment

(2012) Chun-Hsun Huang et al.   LASERS IN MEDICAL SCIENCE

Effect of time and temperature on vitamin C stability in horticultural extracts. UHPLC-PDA vs iodometric titration as analytical methods

(2012) Vítor Spínola et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

(2012) Danielle Cristina Zimmermann Franco et al.   MOLECULES

The evaluation of depigmenting efficacy in the skin for the development of new whitening agents in Korea

(2012) K. H. Son et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation

(2011) Young Mi Ha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Resveratrol as a kcat type inhibitor for tyrosinase: Potentiated melanogenesis inhibitor

(2011) Hiroki Satooka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

(2011) Fatih Sonmez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase

(2011) Pillaiyar Thanigaimalai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New halogenated phenylcoumarins as tyrosinase inhibitors

(2011) Maria João Matos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ketonethiosemicarbazones: Structure–activity relationships for their melanogenesis inhibition

(2011) Pillaiyar Thanigaimalai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activity of hydroxybenzylidenyl pyrrolidine-2,5-dione derivatives as new potent inhibitors of tyrosinase

(2011) Young Mi Ha et al.   MedChemComm

The Efficacy and Safety of 4-n-butylresorcinol 0.1% Cream for the Treatment of Melasma: A Randomized Controlled Split-face Trial

(2010) Sun Young Huh et al.   Annals of Dermatology

Structural requirement(s) of N-phenylthioureas and benzaldehyde thiosemicarbazones as inhibitors of melanogenesis in melanoma B 16 cells

(2010) P. Thanigaimalai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

(2010) Bin Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare

(2010) Tzung-Han Chou et al.   EXPERIMENTAL DERMATOLOGY

Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase

(2010) Hui-Min Wang et al.   EXPERIMENTAL DERMATOLOGY

Signaling pathways in melanosome biogenesis and pathology

(2010) Maria Vittoria Schiaffino   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tyrosinase-Expressing Neuronal Cell Line as in Vitro Model of Parkinson’s Disease

(2010) Takafumi Hasegawa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy and safety of liposome-encapsulated 4-n-butylresorcinol 0.1% cream for the treatment of melasma: A randomized controlled split-face trial

(2010) Sun Young HUH et al.   JOURNAL OF DERMATOLOGY

The Melanin Synthesis inhibition and Radical Scavenging Activities of Compounds Isolated from the Aerial Part of Lespedeza cyrtobotrya

(2010) ChoongHwan Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Melanogenesis Inhibition by Gallotannins from Chinese Galls in B16 Mouse Melanoma Cells

(2009) Lih-Geeng Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibitory Effects of Calycosin Isolated from the Root of Astragalus membranaceus on Melanin Biosynthesis

(2009) Jin Hee Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors

(2009) Qin Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities

(2009) Qin Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors

(2009) Wei Yi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Short-Sequence Oligopeptides with Inhibitory Activity against Mushroom and Human Tyrosinase

(2009) Anan Abu Ubeid et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Benzene Metabolite Hydroquinone Up-Regulates Chondromodulin-I and Inhibits Tube Formation in Human Bone Marrow Endothelial Cells

(2009) H. Zhou et al.   MOLECULAR PHARMACOLOGY

Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids

(2009) Antonella Fais et al.   MOLECULES

Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis

(2008) Yumi Cho et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibitory Effects of Cinnamic Acid on Melanin Biosynthesis in Skin

(2008) Yeon Hee Kong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Analogues of N-hydroxy-N′-phenylthiourea and N-hydroxy-N′-phenylurea as inhibitors of tyrosinase and melanin formation

(2008) Marc Criton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Reaction of α-Synuclein with Tyrosinase

(2008) Isabella Tessari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY