Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds

(2016) Anthi Petrou et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies

(2016) Giulio Poli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2016) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of a FLAP-Consensus Docking Mixed Strategy for the Identification of New Fatty Acid Amide Hydrolase Inhibitors

(2015) Giulio Poli et al.   Journal of Chemical Information and Modeling

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

(2015) Carlotta Granchi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

(2014) Gloria Hernández-Torres et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and characterization of a new reversible MAGL inhibitor

(2014) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extensive Consensus Docking Evaluation for Ligand Pose Prediction and Virtual Screening Studies

(2014) Tiziano Tuccinardi et al.   Journal of Chemical Information and Modeling

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

(2014) Tiziano Tuccinardi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells

(2013) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Conformer Generation with OMEGA: Learning from the Data Set and the Analysis of Failures

(2012) Paul C. D. Hawkins et al.   Journal of Chemical Information and Modeling

Synthesis and Pharmacological Evaluation of 2,4-Dinitroaryldithiocarbamate Derivatives as Novel Monoacylglycerol Lipase Inhibitors

(2012) Coco N. Kapanda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

The Glycerophospho Metabolome and Its Influence on Amino Acid Homeostasis Revealed by Brain Metabolomics of GDE1(−/−) Mice

(2010) Florian Kopp et al.   CHEMISTRY & BIOLOGY

A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling

(2010) G. Labar et al.   CURRENT MEDICINAL CHEMISTRY

pharmACOphore: Multiple Flexible Ligand Alignment Based on Ant Colony Optimization

(2010) Oliver Korb et al.   Journal of Chemical Information and Modeling

Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database

(2010) Paul C. D. Hawkins et al.   Journal of Chemical Information and Modeling

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

(2010) Mauro Mileni et al.   JOURNAL OF MOLECULAR BIOLOGY

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors

(2009) AR King et al.   BRITISH JOURNAL OF PHARMACOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Synthesis and in Vitro Evaluation of N-Substituted Maleimide Derivatives as Selective Monoglyceride Lipase Inhibitors

(2009) Nicolas Matuszak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Human Monoglyceride Lipase Inhibition

(2009) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAY10499, a Novel Monoglyceride Lipase Inhibitor Evidenced by an Expeditious MGL Assay

(2008) Giulio G. Muccioli et al.   CHEMBIOCHEM

Covalent Inhibitors of Human Monoacylglycerol Lipase: Ligand-Assisted Characterization of the Catalytic Site by Mass Spectrometry and Mutational Analysis

(2008) Nikolai Zvonok et al.   CHEMISTRY & BIOLOGY

Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

(2008) Xueqing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology