Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

Microwave-assisted synthesis and bioevaluation of new sulfonamides

(2017) Halise Inci Gul et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors

(2017) İlhami Gulçin et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus

(2017) Lucas Canto de Souza et al.   NEUROPHARMACOLOGY

Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles

(2017) Umit Muhammet Kocyigit et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Structure and function of carbonic anhydrases

(2016) C. T. Supuran   BIOCHEMICAL JOURNAL

Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII

(2016) Mustafa Durgun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

A class of carbonic anhydrase I – selective activators

(2016) Erol Licsandru et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas

(2016) Suleyman Akocak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties

(2015) Mariangela Ceruso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

(2015) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII

(2015) Mustafa Durgun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

(2015) Özlen Güzel-Akdemir et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: Identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones

(2014) Busra Sarikaya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

(2014) Bogdan Draghici et al.   CHEMICAL COMMUNICATIONS

An overview of the alpha-, beta- and gamma-carbonic anhydrases fromBacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?

(2014) Clemente Capasso et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Antiglaucoma carbonic anhydrase inhibitors: a patent review

(2013) Emanuela Masini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture

(2013) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase binding site parameterization in OPLS-AA force field

(2012) Guillaume Bernadat et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Sulfonamides: a patent review (2008 – 2012)

(2012) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII

(2011) Khyati Dave et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

(2011) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II

(2010) Khyati Dave et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

(2010) Fabio Pacchiano et al.   CHEMICAL COMMUNICATIONS

High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design

(2009) Katherine H. Sippel et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Carbonic Anhydrase Activation and the Drug Design

(2008) Claudia Temperini et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY