Article
Chemistry, Analytical
Dandan Song, Jing Zheng, Nosang Myung, Jingli Xu, Min Zhang
Summary: A sandwich-type electrochemical immunosensor was developed for the detection of CEA, with excellent sensing performance and low detection limit. The magnetic assembly of nanocomposites simplifies further modification process, improving the reliability and reproducibility of the sensor.
Article
Chemistry, Analytical
Angelica Dominguez-Aragon, Erasto Armando Zaragoza-Contreras, Gabriela Figueroa-Miranda, Andreas Offenhausser, Dirk Mayer
Summary: A novel sandwich-type electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen, a significant tumor marker. The immobilization of antibodies was achieved through Au-S bonds using a novel photochemical technique, allowing control over antibody orientation. The SWCNH/Thi/AuNPs nanocomposite acted as a signal tag for detection and signal amplification. The immunoassay demonstrated a linear detection range from 0.001-200 ng/mL with a low detection limit of 0.1385 pg/mL. Carbon nanohorns hold promise as a conductive and binding matrix for signal amplification in clinical diagnostics.
Article
Chemistry, Analytical
Hayati Filik, Asiye Aslihan Avan, Nilay Altas Puntar, Mustafa Ozyurek, Zeynep Banu Gungor, Mine Kucur, Handan Kamis, Diclehan Ali Dicle
Summary: A sensitive sandwich-model immunoassay was designed for simultaneous electrochemical measurement of alphafetoprotein and carcinoembryonic antigen using multiple-label strategy. The immunoassay showed good linear relationship and low detection limits for both analytes. The sandwich-type immunosensor was successfully applied to real serum sample analysis.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Mengyue Wang, Feng Gao, Shoujie Ni, Yanan Song, Cai Wang, Qian Li, Peng Zhao
Summary: In clinical work, early diagnosis of subarachnoid hemorrhage (SAH) is primarily based on conventional imaging techniques and neurological assessments. However, the association between imaging manifestations and clinical findings is imperfect, especially in SAH patients with a lower amount of blood. The development of a direct, rapid, and ultra-sensitive detection method based on electrochemical biosensors has emerged as a new competitive challenge in SAH biomarkers research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biophysics
Jin Wang, Jiali Bei, Xu Guo, Yue Ding, Tingting Chen, Bing Lu, Yang Wang, Yukou Du, Yong Yao
Summary: In this study, an ultrasensitive and specific photoelectrochemical (PEC) immunosensor was developed for the detection of carcinoembryonic antigen (CEA). The developed PEC immunosensor demonstrated high specificity, good stability, and excellent reproducibility, making it a promising tool for biomarker immunosensing.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Jin Wang, Jiali Bei, Xu Guo, Yue Ding, Tingting Chen, Bing Lu, Yang Wang, Yukou Du, Yong Yao
Summary: An ultrasensitive and specific photoelectrochemical immunosensor has been developed for the detection of carcinoembryonic antigen (CEA). The immunosensor exhibits high specificity, good stability, and a sensitive linear response within the detection range.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Zhe Zhao, Ping Wang, Feng Tang, Yao Wang, Shujun Wang, Qing Liu, Yueyun Li
Summary: Here, an innovative sandwich-type electrochemical immunosensor based on multi-order Rubik's cube-type platinum nickel nanocubes and Au NPs/cPDA NTs was developed for ultrasensitive detection of CEA. The immunosensor exhibited a broad linear range, low detection limit, and excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2023)
Article
Environmental Sciences
Peng Huang, Lingzhang Meng, Jun Pang, Haiting Huang, Jing Ma, Linlin He, Parnian Amani
Summary: This study successfully developed a label-free electrochemical immunosensor based on a metal-organic framework (MOF)-graphene oxide nanocomposite for the detection of carcinoembryonic antigen (CEA), a tumor marker in lung cancer for early cancer diagnosis. The immunosensor showed improved sensitivity, stability, and selectivity, and demonstrated satisfactory accuracy in detecting CEA in human serum samples. These findings suggest that the prepared CEA immunosensor has potential for clinical applications and analysis of human fluids.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Priyanka Singh, Pranav K. Katkar, Umakant M. Patil, Raghvendra A. Bohara
Summary: This study successfully developed an immunosensor for detecting carcinoembryonic antigen by coating silver nanoparticles with silica, improving sensitivity and stability of the reaction with a detection limit of 0.01 ng/mL.
Article
Biochemical Research Methods
Maryam Jozghorbani, Mojtaba Fathi, Sayed Habib Kazemi, Navid Alinejadian
Summary: A label-free electrochemical immunosensor for detecting CEA was developed, which showed promising results for clinical screening through studying the electrochemical behavior of antibody-antigen immune complexes.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Hongli Yang, Zaihua Zhang, Xiaohong Zhou, Norhefozge Binbr Abe Menen, Omid Rouhi
Summary: In this study, electrochemical immunosensing for monitoring carcinoembryonic antigen (CEA) was successfully achieved by immobilizing the antibody on a thionine, chitosan, or graphene oxide nanocomposite modified electrode. The resulting immunosensor showed exceptional sensitivity and selectivity towards CEA compounds, with a low detection limit of 0.8 pg/mL. The application of the immunosensor in detecting CEA in human serum samples demonstrated high accuracy and consistency with ELISA results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Linlin Cao, Wen Zhang, Sumei Lu, Chengjie Guo, Peijun Wang, Dantong Zhang, Wanshan Ma
Summary: In this study, a snowflake Cu2S/Pd/CuO nanocomposite was developed to construct an original label-free electrochemical immunosensor for ultrasensitive detection of CEA levels. The immunosensor showed excellent detection performance and potential value for clinical application in detecting human serum samples.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jingxian Li, Hongfen Yang, Ren Cai, Weihong Tan
Summary: A novel sandwich-type immunosensor was developed using Pt@ SnS2 as a matrix and N,B-Eu MOFs as a signal amplifier. The immunosensor showed high sensitivity and selectivity for the detection of CEA. It exhibited excellent ECL performance and stability, making it suitable for real human serum.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Mengmeng Zhang, Lisha Mei, Li Zhang, Xiao Wang, Xiaochen Liao, Xiuwen Qiao, Chenglin Hong
Summary: In this study, Ti3C2 MXene anchored CuAu-LDH two-dimensional hydroxide heterojunctions were fabricated for dual-mode electrochemical immunosensors, improving sensitivity for biomarker detection and demonstrating excellent electrocatalytic activity.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jing Zhang, Luoxing Yang, Jie Pei, Yanzhang Tian, Jiyang Liu
Summary: A convenient and sensitive reagentless electrochemical immunosensor for the detection of tumor marker CEA has been successfully fabricated. The immunosensor showed high sensitivity and excellent regenerability, making it suitable for early diagnosis of cancer.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Huy L. Nguyen, Van-Anh Nguyen, Duy T. Bui, Nam Thi Pham, Quan P. Do, Dzung T. Nguyen, Ha Hong Cao, Tran Dai Lam
Summary: This work presents a design of a sensing interface using a graphene/poly(1,5-diaminonaphthalene) nanocomposite and graphene decorated with silver nanoparticles for the electrochemical detection of bisphenol A (BPA). The results showed a linear relationship between the response to BPA concentration and a detection limit of 0.6 nM within a concentration range of 1.0-8.0 nM. It is a promising approach for BPA analysis with a low-cost and easy-to-fabricate sensor.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Environmental Sciences
Kim Nguyen Van, Ha Tran Huu, Viet Nga Nguyen Thi, Thanh Lieu Le Thi, Duy Huong Truong, Thanh Tam Truong, Ngoc Nhiem Dao, Vien Vo, Dai Lam Tran, Yasser Vasseghian
Summary: The study successfully fabricated SnO2/g-C3N4 composites and investigated the mechanism behind the improved photocatalytic performance in degrading Rhodamine B. The effective charge transfer in the S-scheme pathway was shown to suppress recombination of electron-hole pairs, leading to enhanced photocatalytic activity.
Article
Chemistry, Multidisciplinary
Vy Do Truc, Thien Vuong Nguyen, Tien Viet Vu, Tuan Anh Nguyen, Thanh Dung Ngo, The Tam Le, Trong Lu Le, Lan Thi Pham, Lam Dai Tran
Summary: This study explores the use of hybrid nanoparticles to enhance the antibacterial properties of single nanoparticles and their polymeric nanocomposite coatings. By combining different nanoparticles, such as nano-ZnO and silver nanoparticles, the advantages of each individual particle can be utilized. The results show that the hybrid nanoparticles and their nanocomposite coatings exhibit high antibacterial activity against E. coli, especially under visible light exposure. This research demonstrates the potential of hybrid nanoparticles in improving the antibacterial performance of materials and the benefit of visible light irradiation in enhancing bactericidal efficiency.
Article
Chemistry, Inorganic & Nuclear
Thien Vuong Nguyen, Vy Do Truc, Tuan Anh Nguyen, Thi Lan Pham, Dai Lam Tran
Summary: This study aims to explore how ZnO-Ag hybrid nanoparticles can provide self-cleaning behavior to UV-curable acrylate urethane coating. It is the first work reporting the self-cleaning organic nanocoating for indoor and outdoor applications under visible light irradiation. Self-cleaning tests of dirty UVACU coatings were conducted with artificial dirty mixture or methylene blue under visible light and UV irradiation. The results showed that the cross-linked UVACU/ZnO-Ag nanocomposite coatings significantly removed methylene blue from the coating surface, indicating the self-cleaning property provided by ZnO-Ag nanoparticles.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Minh Thu Vu, Thi Thanh Ngan Nguyen, Tran Quang Hung, Thuan-Nguyen Pham-Truong, Magdalena Osial, Philippe Decorse, Thi Thom Nguyen, Benoit Piro, Vu Thi Thu
Summary: This study investigates the effect of chemical functional groups (thiol and amine) on the morphology and catalytic activity of platinum nanoparticles for methanol oxidation. It is found that functionalized graphene oxide supports can achieve good dispersion of nanoparticles and enhance the durability of the catalysts.
Article
Chemistry, Multidisciplinary
Thi Lan Pham, Van Dat Doan, Quang Le Dang, Tuan Anh Nguyen, Thi Lan Huong Nguyen, Thi Dieu Thuy Tran, Thi Phuong Lan Nguyen, Thi Kieu Anh Vo, Trung Huy Nguyen, Dai Lam Tran
Summary: In this study, stable silver nanoparticles (BioAgNPs) were successfully biosynthesized using an aqueous extract from Syzygium nervosum buds as a reducing and stabilizing agent. The BioAgNPs were predominantly spherical with an average size of 10-30 nm. The outstanding stability of the BioAgNPs solution was attributed to the protective organic layer and the highly negatively charged surface of the nanoparticles. The BioAgNPs exhibited good antibacterial activity against various bacterial strains and also demonstrated catalytic activity in converting 2-NP, 3-NP, and 4-NP into aminophenols. The BioAgNPs formulations effectively suppressed anthracnose disease in tea plants without affecting plant growth.
Article
Chemistry, Multidisciplinary
Wanwipa Rasri, Vu Thi Thu, Angelica Corpuz, Loc Thai Nguyen
Summary: Cellulose nanocrystals were prepared via hydrolysis of corncob biomass using an acid ionic liquid catalyst. The effects of process conditions on the size of the nanocrystals were investigated and optimized. The obtained nanocrystals had desirable physicochemical characteristics and could be produced at a high yield.
Article
Chemistry, Multidisciplinary
Thanh Chung Pham, Dong Joon Lee, Do Hun Kim, Juyoung Yoon, Tran Dai Lam, Hwan Myung Kim, Songyi Lee
Summary: A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Nguyen Dieu Linh, Nguyen Thi Trang Huyen, Nguyen Hai Dang, Benoit Piro, Vu Thi Thu
Summary: The study aims to develop an electrochemical interface based on polydopamine, gold nanoparticles, and reduced graphene oxide for impedimetric detection of late-stage lung cancer cells. Gold nanoparticles were dispersed onto reduced graphene oxide material pre-electrodeposited onto fluorine doped tin oxide electrodes. Polydopamine was introduced onto modified electrodes via self-polymerization of dopamine in an alkaline solution. The result demonstrated good adhesion and biocompatibility of polydopamine towards lung cancer cells, leading to a significant decrease in charge transfer resistance.
Article
Chemistry, Multidisciplinary
X. T. Nguyen, A. O. Bulanov, V. V. Lukov, G. Borodkin, T. T. T. Nguyen, L. D. Tran, H. D. Vu, B. N. Duong, V. A. Lazarenko, I. N. Shcherbakov
Summary: This study focuses on the properties of the formyl derivative of 2-oxaindane series spiropyran under its condensation reaction. The results show that the products are thermodynamically stable enamine-ketone tautomeric forms in both DMSO solution and solid state. The compounds were evaluated for their cytotoxic activity and showed moderate activity against various human cell lines, while exhibiting weak or no antioxidant activity.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Nguyen Tien Dat, Nguyen Ngoc Tien, Nguyen Thi Thanh Ngan, Vu Thi Thu
Summary: The use of metal-organic framework materials in electrochemical sensors has gained attention due to their porous structure and electrocatalytic activity. In this study, a novel electrochemical sensor for paracetamol detection was introduced, based on a Cu-BTC microporous film grown onto a glassy carbon electrode. The deposition of the film was achieved via an electrochemical approach, resulting in a microporous structure with improved molecular adsorption. The electrocatalytic activity of the Cu-BTC film was found to enhance the sensing parameters of the paracetamol sensor. Further research is needed to optimize the ligand structure and improve the electrical conductivity of metal-organic frameworks for sensing purposes.
Article
Chemistry, Multidisciplinary
Manh B. Nguyen, Pham Thi Lan, Nguyen Tuan Anh, Nguyen Ngoc Tung, Shaoliang Guan, Valeska P. Ting, T. -Thanh-Bao Nguyen, Huan V. Doan, Mai Thanh Tung, Tran Dai Lam
Summary: This study investigates the advanced integration of a ternary heterogeneous Z-scheme photocatalyst, TiO2/CuInS2/OCN (OCN: O-g-C3N4), with carbon quantum dot (CQD) to enhance the degradation efficiency of reactive yellow 145 (RY145) dye in water. The findings demonstrate that the novel catalyst integration significantly improves RY145 degradation efficiency and possesses superior stability.
Article
Materials Science, Multidisciplinary
Nguyen Ngoc Tien, Nguyen Tien Dat, Nguyen Ba Manh, Nguyen Dinh Hieu, Vu Cam Tu, Nguyen Thi Thanh Ngan, Vu Thi Thu Ha, Philippe Decorse, Benoit Piro, Vu Thi Thu
Summary: In this study, an electrochemical sensor based on a metal organic framework (Cu, Zr-BTC) combined with carbon nanotubes (CNT) was developed for rapid on-site detection of bisphenol A. The sensor showed a linear response for bisphenol A concentrations, with a low detection limit and good stability. The results demonstrate the potential use of MOF materials in sensor applications.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Manh B. Nguyen, Nguyen Hai Anh, Vu Thi Thu, Pham Thi Hai Yen, Pham Hong Phong, Le Quoc Hung, Nguyen Thi Thanh Ngan, Tran Quang Hai, Vu Thi Thu Ha
Summary: In this paper, a novel bimetallic Fe-Cu metal-organic framework (Fe-Cu-BTC) was synthesized and composite with gold nanoparticles to improve conductivity and synergistic effect. A new BPA sensor was prepared by dropcasting Fe-Cu-BTC on GCE followed by AuNPs electrodeposition. The sensor exhibited a linear range of BPA concentration and was used to measure BPA concentration in rain coat samples with good recovery rate.
Article
Chemistry, Multidisciplinary
Thien Vuong Nguyen, Truc Vy Do, Thanh Dung Ngo, Tuan Anh Nguyen, Le Trong Lu, Quoc Trung Vu, Lan Pham Thi, Dai Lam Tran
Summary: In this study, a UV-curable acrylate epoxy nanocomposite coating was prepared by incorporating ZnO-Ag hybrid nanoparticles, which significantly improved the abrasion resistance and antibacterial properties of the coating.
