Article
Chemistry, Multidisciplinary
Jiajia Wang, Xin Hua, Baokang Jin
Summary: A facile in situ fabrication method for chitosan/polythiophene/CdTe nanocomposite was developed and connected with anti-CEA for electrochemical detection of carcinoembryonic antigen. The resulting nanocomposite showed high selectivity and excellent sensitivity, with a potential application in clinical tumor detection.
Review
Engineering, Environmental
Jyotsana Mehta, Neeraj Dilbaghi, Nitin Kumar Singhal, Giovanna Marrazza, Ajeet Kaushik, Sandeep Kumar
Summary: This review summarizes the recent advancements in electrochemiluminescent sensors based on quantum dots (QDs), highlighting their structural properties, modification methods, and roles in signal detection and specific targeting.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Chen Deng, Hui Li, Sihua Qian, Pan Fu, Hualan Zhou, Jianping Zheng, Yuhui Wang
Summary: Fluorescence lateral flow assays (FLFAs) have gained significant attention due to their low cost, rapid screening, and on-site detection. The development of high-performance label probes is crucial for improving detection limits. In this study, fluorescent carbon nanobeads (FCNBs) were introduced as a new label probe for FLFAs. The FCNBs exhibited excellent properties such as water solubility, high emissivity, and easy surface functionalization. By modifying biomolecules onto the FCNBs, lateral flow test strips were constructed for the detection of foodborne toxins and pathogenic bacteria. The proposed FCNB-based FLFAs showed lower detection limits compared to most reported methods and were successfully applied for the quantitative and rapid screening of target analytes in food samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhenqiang Ning, Erli Yang, Yongjun Zheng, Mengyuan Chen, Guoqiu Wu, Yuanjian Zhang, Yanfei Shen
Summary: This study proposed a facile synthesis strategy to prepare a self-enhanced ECL emitter DEAMTES@RuSiO2, which exhibited improved ECL properties and film-forming ability critical for ECL biosensors. By combining catalytic hairpin assembly and signal amplification, a label-free ECL biosensor was constructed for highly sensitive detection of miRNA-21 with a detection limit of 8.19 fM, showing superior reliability in detecting miRNA-21 in human serum samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Milica Jovi, Denis Prim, Edis Saini, Marc Emil Pfeifer
Summary: Globally, 70 million people are affected by traumatic brain injury (TBI) annually. Diagnosis of mild TBI (mTBI) is challenging due to the absence of apparent symptoms. Current diagnostic methods rely on patient history, clinical aspects, and neuroimaging observations, which are costly and time-consuming. As an alternative, mTBI diagnostics can be done by detecting biomarkers in patients' blood. This study proposed two strategies for detecting mTBI biomarkers using electrochemiluminescence (ECL) immunoassay. Multiplex assays on a single disposable screen-printed carbon electrode (SPCE) were also developed. The methodology presented demonstrates the feasibility of a rapid point-of-care (POC) multiplex diagnostic system for mTBI biomarkers.
Article
Chemistry, Analytical
Peng Qu, Cheng-Jie Li, Jin Hu, Ge Gao, Peng Lin, Wei-Wei Zhao
Summary: Organicphotoelectrochemical transistor (OPECT) biosensing is a promising approach for biomolecular sensing. This work demonstrates the direct enzymatic biocatalytic precipitation (BCP) modulation on a flower-like Bi(2)S(3) photosensitive gate, achieving high-efficiency OPECT operation with high transconductance (g (m)). The developed OPECT aptasensor shows good analysis performance for prostate-specific antigen (PSA).
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaojun Liu, Yuanyuan Sun, Xinyi Lin, Xiaoyan Pan, Zhangjian Wu, Hongwei Gai
Summary: This paper presents a spectral imaging-based multiplex, homogenous immunoassay that was used to detect tumor biomarkers and successfully quantify model proteins in human plasma, demonstrating the accuracy and reliability of the approach.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ying-Huan Li, Mei-Ling Zhao, Pu Zhang, Xia Yang, Ruo Yuan, Ying Zhuo
Summary: This study proposes a target-driven annular DNA walker with enhanced stability for sensitive and reliable detection of APE1. The stability of the walker is improved by purifying the microenvironment of SiQDs through dialysis. The ECL biosensor shows a wide linear range and a low limit of detection. This work provides a novel structure of a DNA walker with nuclease resistance and expands the application of SiQDs in ECL.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Nini Liang, Xuetao Hu, Wenting Li, Yueying Wang, Ziang Guo, Xiaowei Huang, Zhihua Li, Xinai Zhang, Jiukai Zhang, Jianbo Xiao, Xiaobo Zou, Jiyong Shi
Summary: A dual-signal fluorescent sensor was developed for the detection of tetracycline in milk, showing excellent reproducibility and stability. The sensor utilized two types of quantum dots, MoS2 QDs and CdTe QDs, to achieve two fluorescence emission peaks at 433 nm and 573 nm. The sensor demonstrated strong application potential with accurate detection of TET concentration in milk samples.
Review
Chemistry, Analytical
Kieu The Loan Trinh, Hoang Dang Khoa Do, Nae Yoon Lee
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a demand for accurate and cost-effective diagnostic tests for COVID-19 and other viral infections. Traditional virus screening methods have limitations in terms of equipment, personnel, and analysis time. Microfluidic-based biosensors, integrating microfluidic and biosensor technologies, offer a platform for sample preparation and simultaneous detection with high sensitivity, accuracy, portability, and real-time results. This review presents recent advances in microfluidic-based biosensors for virus detection, categorizing them into immunoassays and molecular assays, and analyzes available commercial sensing tests.
Article
Chemistry, Multidisciplinary
Guangmin Li, Xihao Zhang, Xuening Fei, Jiafeng Li, Hongfei Liu, Wei Liu, Yang Yang, Bingjing Li, Mingrui Liu, Gaoling Yang, Ti Zhang
Summary: In this study, chiral ligand-conjugated quantum dots were fabricated for inducing apoptosis in cancer cells. The circular dichroism signals of chiral quantum dots were found to effectively distinguish cancer cells from normal cells. The experimental results demonstrated the significant apoptosis-inducing ability of the chiral quantum dots and their potential as targeted anti-cancer agents.
Article
Chemistry, Analytical
Hosein Asbaghian-Namin, Pari Karami, Hamid Naghshara, Danial Gholamin, Mohammad Johari-Ahar
Summary: A novel immunoassay based on co-reactant enhancing strategy was developed for the ECL determination of CA15-3 and CA72-4 tumor markers in real samples. The signaling and capture probes were carefully prepared and constructed, leading to accurate and reproducible detection results for the tumor markers.
Article
Biochemistry & Molecular Biology
Cinthia das Dores Aguiar, Yara Luiza Coelho, Hauster Maximiler Campos de Paula, Livia Neves Santa Rosa, Luciano Sindra Virtuoso, Tiago Antonio de Oliveira Mendes, Ana Clarissa dos Santos Pires, Luis Henrique Mendes da Silva
Summary: The study investigated the dynamics and energetics of interactions between human serum albumin (HSA) and CdTe quantum dots (QDs) functionalized with different ligands, showing that the functionalization of QDs can significantly impact the kinetics and thermodynamics of interactions with HSA proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Ying He, Fangxin Hu, Jinwen Zhao, Guomin Yang, Yuanyuan Zhang, Shihong Chen, Ruo Yuan
Summary: A novel dual-signal combined nanoprobe with two different types of nanoparticles as ECL probes and hydrogen peroxide as a bifunctional moderator was designed for enzyme sensing analysis. In the presence of organophosphorus compounds, enzyme activity was inhibited, leading to changes in ECL signals. This integrated system provides a new pathway for ratiometric ECL systems involving enzyme catalytic amplification.
ANALYTICAL CHEMISTRY
(2021)
Review
Physics, Multidisciplinary
Um e Kalsoom, Rongxing Yi, Junle Qu, Liwei Liu
Summary: Recent research has shown that low-dimensional materials, such as quantum dots and core-shell quantum dots, exhibit strong nonlinear optical behavior and have potential applications in photo-electronics, photovoltaic nonlinear optics, light-emitting diode fabrication, and laser protections. Variations in core-shell shape and size, as well as the chemical composition of quantum dots, define their enhanced nonlinear optical properties. Specific nonlinear optical properties, such as nonlinear refraction, optical limiting, saturable absorption, and reverse saturable absorption of CdTe and CdSe quantum dots, along with core-shell quantum dots and their applications, were assessed in this study.
FRONTIERS IN PHYSICS
(2021)
Article
Chemistry, Analytical
Quan-Quan Zhuang, Shao-Bin He, Yan-Cheng Jiang, Kai-Yuan Huang, Ying-Ying Xu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen
Summary: This study presents a non-complex strategy for sensitive, quantitative, and rapid detection of Salmonella typhimurium with high specificity. The method utilizes fluorescent anti-Salmonella typhimurium IgG-AuNC to agglutinate Salmonella typhimurium on a glass slide, which is then observed using a fluorescence microscope. Under optimized conditions, the assay has a wide determination range, low detection limit, and fast response time.
Article
Chemistry, Analytical
Jiamei Pu, Minfang Gui, Hongbo Li, Huaping Peng, Suqin Wang, Zhanghui Lu, Ruqin Yu
Summary: In this paper, a novel CRISPR/Cas12a fluorescent biosensor for leukemia diagnosis is reported. The biosensor shows a good linear relationship and low detection limit, and maintains good detection performance in actual sample analysis. Compared to traditional CRISPR/Cas detection systems, this biosensor is more advanced and can be used in multiple fields.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Lu-Fang Chen, Meng-Ting Lin, Hamada A. A. Noreldeen, Hua-Ping Peng, Hao-Hua Deng, Shao-Bin He, Wei Chen
Summary: This study reports the fructose oxidase-like activity of CuO nanoparticles and successfully fabricates a tandem catalysis-based fructose sensor. The sensor shows a low limit of detection and a wide linear range for fructose, making it suitable for fructose detection in real samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Hamada A. A. Noreldeen, Kai-Yuan Huang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen
Summary: This study developed two deep learning models based on 3D fluorescence spectra to identify VB6Ds and transfer them for quantitative analysis in a broad concentration range. The results showed that CNN outperformed DNN in accuracy and performance, opening up new avenues for qualitative and quantitative sensing of small molecules.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Kai-Yuan Huang, Xin Huang, Xiang-Yu Fang, Sai Cheng, Wei-Ming Sun, Hamada A. A. Noreldeen, Qi Zhang, Hao-Hua Deng, Wei Chen
Summary: This study demonstrates a new and efficient way to develop high-performance sensors for bioflavonoid glycosides detection by controlling the molecule-like photoinduced charge transfer behavior of gold nanoclusters. The developed sensor showed high specificity towards baicalin and could be applied in the analysis of baicalin content in real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Zhimin Weng, Zhenglian Li, Yixuan Zhang, Mingying Zhang, Zhongnan Huang, Wei Chen, Huaping Peng
Summary: This study proposes a novel AuNC-based ECL sensing platform and explores the regulation mechanism of electron transfer on ECL. By investigating the ECL quenching effect of OM-AuNCs under the influence of Cu2+, it is found that the ECL intensity of OM-AuNCs is affected by the electron transfer process, enabling sensitive detection of Cu2+ in a low concentration range without the need for amplification techniques. This study enriches the application of ET-mediated ECL and promotes a more rational design of ECL sensors.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhang, Sai Cheng, Zhiming Xin, Haohua Deng, Ying Wang, Qiang Li, Gangwei Wu, Wei Chen
Summary: 1,2,3,4,6-O-pentagalloylglucose protects against acute lung injury (ALI) by inhibiting inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Qile Li, Ke Xu, Haipeng Zhang, Zengguang Huang, Chao Xu, Zhen Zhou, Huaping Peng, Linxing Shi
Summary: In this study, a novel Ru(bpy)(3)(2+)-Au-WS2 nanocomposite ECL probe was developed for the detection of carcinoembryonic antigen (CEA). The probe showed high sensitivity and selectivity due to the synergistic effect and biocompatibility of Au nanoparticles (Au NPs) and WS2 nanosheet. The ECL platform exhibited excellent anodic ECL performance, good reproducibility, stability, and anti-interference performance.
Article
Biophysics
Quan-Quan Zhuang, Jia-Lin Yang, Hui-Na Qiu, Kai-Yuan Huang, Yu Yang, Hua-Ping Peng, Hao-Hua Deng, Hui-Qiong Jiang, Wei Chen
Summary: This study presented a novel class of luminogen called 6-Aza-2-thiothymine-decorated gold nanoclusters (ATT-AuNCs) with aggregation-induced emission property, which demonstrated potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). By generating reactive oxygen species (ROS) and altering the expression of multiple target proteins in MRSA cells, ATT-AuNCs effectively eliminated MRSA. Additionally, ATT-AuNCs could serve as a wound-healing agent. Therefore, ATT-AuNCs are considered robust antimicrobial aggregation-induced emission luminogens (AIEgens) capable of targeting multiple pathways to eliminate drug-resistant bacteria.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Spectroscopy
Chen -Ting Zhu, Kai -Yuan Huang, Qing-Lin Zhou, Xiang -Ping Zhang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen, Hamada A. A. Noreldeen
Summary: Sulfonamides are widely used but their accumulation in the human body can cause serious diseases. Therefore, a convenient, effective, and sensitive method to detect them is needed. In this study, a sensor array using BSA-AuNCs was constructed to detect five Sulfonamides, and the changes in fluorescence intensity at different excitation wavelengths were used for identification. This method shows great potential in the fields of food and drug monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Huaping Peng, Mingchun Lai, Huijing Wang, Zhimin Weng, Yu Yang, Zhongnan Huang, Weiming Sun, Juewen Liu, Wei Chen
Summary: In this study, an energy level engineering strategy was proposed to regulate the electrochemiluminescence (ECL) performance using ligand-protected gold nanoclusters (AuNCs) as luminophores and N,N-diisopropylethylamine (DIPEA) as a coreactant. The energy level matching between the AuNCs and DIPEA effectively promoted electron transfer reactions, improving excitation efficiency and reducing trigger potential. The narrow bandgap of the AuNCs further enhanced emission efficiency. The developed theory was successfully applied to design a highly stable near-infrared ECL system with low trigger potential.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Zhongnan Huang, Zhenglian Li, Zhimin Weng, Paramasivam Balasubramanian, Mingchun Lai, Wei Chen, Juewen Liu, Huaping Peng
Summary: In this study, a model system was developed to evaluate the effect of electrocatalysis (EC) on electrochemiluminescence (ECL) through kinetic analysis of electrocatalytic reactions. The results demonstrated a dual EC-mediated ECL enhancement and identified the catalytically active sites. With a better understanding of the EC mechanism, the researchers successfully used EC to regulate ECL and developed a biosensor with a record low limit of detection.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Ruiting Chen, Hejing Chen, Huaping Peng, Yanjie Zheng, Zhen Lin, Xinhua Lin
Summary: A DNA biosensor based on a multi-walled carbon nanotube array modified electrode was developed for the detection of the MDR1 gene, which is crucial in cancer clinical therapy.
Article
Chemistry, Inorganic & Nuclear
Luyao Xu, Yu Yang, Weihua Wu, Chaoguo Wei, Guanying Luo, Zhongnan Huang, Wei Chen, Huaping Peng
Summary: A facile aqueous synthesis method was developed for ligand-free cesium lead halide perovskite nanoplatelets, showing good environmental stability and excellent photoresponse.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Yu Yang, Chaoguo Wei, Wenjun Wang, Hamada A. A. Noreldeen, Zhongnan Huang, Haohua Deng, Huaping Peng, Xinghua Xia, Wei Chen
Summary: Research has shown that using 6-aza-2-thio-thymine-AuNCs (ATT-AuNCs) as a photoactive material can achieve high performance in photoelectrochemical properties, with characteristics such as higher cathodic photocurrent density and carrier density compared to other AuNCs.
CHEMICAL COMMUNICATIONS
(2022)
