期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 37, 期 -, 页码 88-96出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jddst.2016.12.003
关键词
Polyurethane-urea; Elastomers; Thermally stable; Chain extender; Sustained release; Drug delivery
资金
- higher education commission (HEC), Pakistan
The main aim of this research was to study the effects of size and concentration of the hard segments on thermal stability, solvent resistance, hardness and drug delivery applications in polyurethane-urea (PUU) elastomers. Four diamines having different aliphatic chains, were synthesized and used as chain extenders (CE) to synthesize PUU. NCO/OH ratio was changed from 2-2.5 to study the effect of concentration of hard segments. Structure, morphology, thermal stability, hardness, solvent resistance, drug delivery and mechanical properties of polyurethane-urea elastomers were examined by means of fourier transform infrared spectroscopy (FUR), wide-angle X-ray diffraction (WAXD), thermogravimetric analysis (TGA), shore durometer, UV/Vis spectrophotometer and universal testing machine (UTM) respectively. (C) 2016 Elsevier B.V. All rights reserved.
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