Review
Immunology
Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji, Tao Wu
Summary: "Application of Metabolomics in Irritable Bowel Syndrome: A Review" provides an updated overview of metabolomics studies related to irritable bowel syndrome (IBS) in the past 5 years, including clinical studies, animal studies, and traditional Chinese medicine interventions. The review highlights the potential of metabolomics in the diagnosis and treatment of IBS, as well as the role of traditional Chinese medicine in improving IBS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Liping Yuan, Hongyun Xiao, Huan Li, Bo Yan
Summary: The study found that APETx2 can improve intestinal motility and visceral sensitivity in PI-IBS mice through the 5-HT signaling pathway. The results showed that APETx2 significantly improved gastrointestinal function and visceral sensitivity in mice, and reduced the expression level of ASIC3 protein in the DRG of PI-IBS mice. In addition, APETx2 also increased the expression levels of 5-HT in serum and colon, CRF and 5-HT4R in the colon, and 5-HT4R in brain tissue in PI-IBS mice.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Review
Neurosciences
Enfu Tao, Zhenya Zhu, Chenmin Hu, Gao Long, Bo Chen, Rui Guo, Marong Fang, Mizu Jiang
Summary: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, and the pathophysiology is still not clear. Early life stress (ELS) is a common risk factor for the development of IBS. Enterochromaffin cells (ECs) play a crucial role in intestinal function and can sense various stimuli and microbiota metabolites. Evidence suggests that an imbalance in ECs-5-HT signaling is involved in ELS-induced IBS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Parasitology
Junnan Zheng, Jingwei Xu, Ruiming Zhang, Jiajia Du, Huan Wang, Jinze Li, Dan Zhou, Yan Sun, Bo Shen
Summary: This study demonstrated that miR-989 is crucial for reproduction in female mosquitoes by targeting 5-HTR1. The deletion of miR-989 led to smaller ovaries and reduced egg production, which could be rescued by knocking down 5-HTR1. These findings expand our understanding of reproduction-related miRNAs and could lead to new strategies for mosquito control.
PARASITES & VECTORS
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Food Science & Technology
Lei Wu, Liming Gao, Xiang Jin, Zhikang Chen, Xutong Qiao, Xiting Cui, Jianhua Gao, Liwei Zhang
Summary: In this study, the therapeutic effect of MJGT_EE on IBS-C was investigated in a rat model. The results showed that MJGT_EE increased FWC and CRD volume, promoted gastric emptying and small intestinal propulsion. It also regulated the expression of proteins related to the 5-HT pathway, enhanced the diversity of gut microbiota, and increased the proportion of beneficial bacteria.
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Rui Fu, Saiyue Liu, Mingjin Zhu, Jiajie Zhu, Mingxian Chen
Summary: Exosomes derived from IBS patients (IBS-exos) have regulatory effects on human colon epithelial cells. Apigenin counteracted the inhibitory effect of IBS-exo on autophagy of CACO-2 cells by regulating the miR-148b-3p/ATG14 signaling pathway.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Tu, Shengping Yao, Qiong Chen, Wenqin Li, Yinghui Song, Pei Zhang
Summary: 5-HT signaling plays a crucial role in the development of non-small cell lung cancer (NSCLC), and inhibitors of 5-HT uptake have potential therapeutic value in the treatment of NSCLC patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Article
Multidisciplinary Sciences
A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: Alterations in the gut mycobiome were found to be significantly different between patients with Irritable Bowel Syndrome (IBS) and control subjects, but not among clinical subtypes of IBS. The mycobiome changes were significantly associated with alterations in the bacteriome and metabolome, but did not show a link with dietary habits. Despite co-variation with bacterial components, the mycobiome presents limited therapeutic and diagnostic potential for IBS.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Qi Su, Hein M. Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis K. L. Chan, Siew C. Ng
Summary: This study examined the association between gut microbiota and Irritable bowel syndrome (IBS) subtypes, and found that there are distinct differences in microbiota composition among different IBS subtypes. The microbial diversity is significantly reduced in IBS-D and IBS-U, but not in IBS-C. The study also identified microbial signatures associated with depression in IBS patients. Factors such as gender, age, and dietary patterns have significant effects on gut microbiota in different IBS subtypes. These findings emphasize the importance of personalized gut microbiome modulation approaches for optimal therapeutic effects in different subtypes of IBS.
Review
Nutrition & Dietetics
Robin Spiller
Summary: IBS is strongly influenced by diet, but identifying specific food intolerances is difficult due to the complexities of diet. Rapidly fermented carbohydrates and gut-specific mast cell activation may cause symptoms in IBS patients. More research is needed to fully understand the mechanisms of food intolerances and improve personalized medicine approaches to diet in IBS.
Article
Plant Sciences
Yueqin Cai, Jue Tu, Shuizhen Pan, Jianping Jiang, Qiyang Shou, Yun Ling, Yunxiang Chen, Dejun Wang, Weiji Yang, Letian Shan, Minli Chen
JOURNAL OF ETHNOPHARMACOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Zhaowei Cai, Haitao Xi, Yongming Pan, Xiaoling Jiang, Liang Chen, Yueqin Cai, Keyan Zhu, Cheng Chen, Xiaoping Xu, Minli Chen
LIPIDS IN HEALTH AND DISEASE
(2015)
Article
Pharmacology & Pharmacy
Qiyang Shou, Yongming Pan, Xiaoping Xu, Jianqin Xu, Dejun Wang, Yun Ling, Minli Chen
EUROPEAN JOURNAL OF PHARMACOLOGY
(2012)
Article
Plant Sciences
Yongming Pan, Huiying Fu, Qing Kong, Yin Xiao, Qiyang Shou, Hongqiang Chen, Yuehai Ke, Minli Chen
JOURNAL OF ETHNOPHARMACOLOGY
(2014)
Correction
Biochemistry & Molecular Biology
Ping Jin, Yongming Pan, Zhiyong Pan, Jianqin Xu, Min Lin, Zhichao Sun, Maosheng Xu, Minli Chen
LIPIDS IN HEALTH AND DISEASE
(2018)
Article
Endocrinology & Metabolism
Yongming Pan, Yili Rong, Junjie Huang, Keyan Zhu, Jiaojiao Chen, Chen Yu, Minli Chen
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2019)
Correction
Biotechnology & Applied Microbiology
Zhaowei Cai, Xiaoling Jiang, Yongming Pan, Liang Chen, Lifan Zhang, Keyan Zhu, Yueqin Cai, Yun Ling, Fangming Chen, Xiaoping Xu, Minli Chen