Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Dermatology
Sayumi Tsuchiya, Suriadi, Hiromi Sanada, Junko Sugama, Makoto Oe
Summary: A monitoring tool named DMIST was developed for assessing the wound-healing process of diabetic foot ulcers (DFUs). This study analyzed the relationship between DMIST items and DFU healing, finding that depth, maceration, and size were associated with DFU healing at 4 weeks from baseline.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Chen-Hung Lee, Dong-Yi Chen, Ming-Jer Hsieh, Kuo-Chun Hung, Shu-Chun Huang, Chia-Jung Cho, Shih-Jung Liu
Summary: This study developed an advanced and encouraging vehicle to improve clinically applicable diabetic wound care. Nanofibrous insulin/vildagliptin core-shell biodegradable (PLGA) scaffolds were prepared to deliver vildagliptin and insulin for the repair of diabetic wounds. The core-shell nanofibrous scaffolds released vildagliptin and insulin effectively and accelerated wound healing. The insulin/vildagliptin-loaded core-shell nanofibers extended drug delivery and enhanced wound repair associated with diabetes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
David J. Margolis, Nandita Mitra, D. Scott Malay, Ziad K. Mirza, John C. Lantis, Hadar A. Lev-Tov, Robert S. Kirsner, Stephan R. Thom
Summary: Predicting the healing likelihood of diabetic foot ulcers can be done using simple wound characteristics like wound area and wound duration. This is important for comparing study results, center-based outcomes, and designing clinical trials.
WOUND REPAIR AND REGENERATION
(2022)
Article
Nutrition & Dietetics
Elham Alipoor, Shima Jazayeri, Mostafa Dahmardehei, Shiva Salehi, Mehdi Yaseri, Mohammad Reza Emami, Seyed Mahdi Rezayat, Mohammad Javad Hosseinzadeh-Attar
Summary: This study investigated the effects of collagen hydrolysate and omega-3 fatty acids on wound healing, metabolic disorders, and adipose-derived peptides in patients with major burns. The study found that adding collagen hydrolysate as part of adjunctive therapy can improve wound healing rate and quality. The efficacy of collagen hydrolysate and omega-3 fatty acids needs to be further confirmed in larger populations.
CLINICAL NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Yingzheng Zhao, Lanzi Luo, Lantian Huang, Yingying Zhang, Mengqi Tong, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
Summary: This study developed a new method, PNO gel, for treating diabetic foot ulcer. The results demonstrated that PNO can accelerate wound healing, reduce inflammation, and promote angiogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Genetics & Heredity
Lei Yu, Jianxin Qin, Jiajun Xing, Zihao Dai, Tingting Zhang, Feng Wang, Jin Zhou, Xiaobai Zhang, Xia Chen, Yunjuan Gu
Summary: The morbidity of diabetes mellitus is increasing, leading to a growing economic burden of diabetic foot ulcers as a common complication. However, there is currently no standardized clinical treatment for this complication, and the efficacy of current treatments is unsatisfactory. Recent studies have shown that exosomes, which have low immunogenicity, high stability, and easy storage, promote diabetic wound healing through various pathways, such as promoting angiogenesis, collagen fiber deposition, and inhibiting inflammation. This article reviews the specific roles and mechanisms of different cell- or tissue-derived exosomes in wound healing and discusses the potential obstacles and solutions for future research on exosomes in the management of diabetic foot ulcers, aiming to provide novel insights and approaches for treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Chemistry, Medicinal
Mehrdad Mokhtari, Reza Razzaghi, Mansooreh Momen-Heravi
Summary: The intake of nanocurcumin significantly improved glycemic control and cholesterol levels in patients with diabetic foot ulcers, but did not have a significant impact on wound healing parameters.
PHYTOTHERAPY RESEARCH
(2021)
Review
Multidisciplinary Sciences
Suriadi Jais, Kharisma Pratama
Summary: Indonesia is facing challenges in controlling the burden of diabetic foot ulcers, and a nursing care management approach is needed to accurately monitor wound healing progress. This literature review identified five assessment tools for chronic wounds, with the DMIST tool receiving sufficient rating for its predictive validity and responsiveness.
Review
Biotechnology & Applied Microbiology
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Zahra Sadat Razavi, Mohamad Mahjoor, Hamed Afkhami
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus (DM) that can lead to amputation. The wound-healing process is impaired in diabetic patients, making conventional treatments ineffective. Mesenchymal stem cells (MSCs) have gained attention for their potential in improving wound healing. MSC therapy improves healing in DFU through immunomodulation, differentiation, and angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Chi Wang, Hsiao-Chen Lee, Chien-Lin Chen, Ming-Chun Kuo, Savitha Ramachandran, Rong-Fu Chen, Yur-Ren Kuo
Summary: The study found that silver-releasing foam dressings were more effective in promoting wound healing of diabetic foot ulcers compared to silver-containing cream, particularly in the initial three weeks of treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jitao Chen, Penghui Ye, Rifang Gu, Huan Zhu, Wenjie He, Xingrui Mu, Xingqian Wu, Huiwen Pang, Felicity Han, Xuqiang Nie
Summary: This paper reviews the regulatory characteristics of neuropeptide substance P (SP) in normal and diabetic wound healing. SP actively regulates wound healing-related cells, exhibiting strong inflammatory properties, promoting cell proliferation and migration, and restoring skin cell activity and paracrine ability under diabetic conditions. Additionally, SP not only regulates healing-related cells but also orchestrates the immune environment, presenting unique and promising application prospects in wound intervention, particularly for diabetic foot ulcers (DFU) treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Imelda Ontoria-Oviedo, Elena Amaro-Prellezo, Delia Castellano, Elena Venegas-Venegas, Fernando Gonzalez-Santos, Amparo Ruiz-Sauri, Beatriz Pelacho, Felipe Prosper, Maria Dolores Perez del Caz, Pilar Sepulveda
Summary: Impaired wound healing in patients with type 2 diabetes is characterized by chronic inflammation. Specialized pro-resolving lipid mediators (SPMs) are bioactive molecules that regulate inflammation. This study found that LIPINOVA(R), a nutritional supplement rich in SPMs and EPA, promotes wound healing by reducing inflammation and inducing angiogenesis and macrophage polarization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Zunira Areeba Bhuiyan, Oluwasemilore Adebayo, Zubair Ahmed
Summary: This study aimed to explore the efficacy and safety of localised insulin administration on wound healing in non-diabetic adults. The findings showed a significant improvement in wound healing rate in the insulin treated group, but other parameters were not statistically significant. Therefore, larger prospective studies are needed to fully investigate the effects of insulin on different wounds.
WOUND REPAIR AND REGENERATION
(2023)
Article
Obstetrics & Gynecology
Elaheh Mesdaghinia, Fatemeh Naderi, Fereshteh Bahmani, Maryam Chamani, Amir Ghaderi, Zatollah Asemi
Summary: The study found that zinc supplementation in pregnant women at risk for IUGR had beneficial effects on total antioxidant capacity, plasma malondialdehyde, high-sensitivity C-reactive protein, and insulin metabolism. However, it did not significantly impact pulsatility index and other metabolic profiles.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Rheumatology
Kamal Esalatmanesh, Amirhossein Loghman, Roozbeh Esalatmanesh, Zahra Soleimani, Alireza Khabbazi, Aida Malek Mahdavi, Seyed Gholam Abbas Mousavi
Summary: Melatonin supplementation showed beneficial effects in reducing serum MDA and LDL-C levels in RA patients, but did not significantly impact disease activity or other metabolic parameters. Further research is needed to fully understand the effects of melatonin in RA treatment.
CLINICAL RHEUMATOLOGY
(2021)
Article
Chemistry, Medicinal
Naheed Aryaeian, Fatemehsadat Amiri, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Afsaneh Gholamrezayi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Elaheh Heshmati, Shahnaz Rimaz
Summary: The study suggests that C. mas extract may decrease BAP, PTH, and hsCRP levels in postmenopausal women, but has no beneficial effect on OC and TC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kamal Esalatmanesh, Alireza Jamali, Roozbeh Esalatmanesh, Zahra Soleimani, Alireza Khabbazi, Aida Malek Mahdavi
Summary: This study evaluated the effect of N-acetylcysteine (NAC) supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis (RA) patients. The results showed that NAC did not improve RA disease activity, but reduced nitric oxide (NO) and fasting blood sugar (FBS), and increased high-density lipoprotein cholesterol (HDL-C) levels. NAC should not be used as a replacement for routine medications in RA therapy but can be used as an adjunctive therapy.
Review
Pharmacology & Pharmacy
Amirhossein Davoodvandi, Farzaneh Fallahi, Omid Reza Tamtaji, Vida Tajiknia, Zarrin Banikazemi, Hadis Fathizadeh, Mohammad Abbasi-Kolli, Michael Aschner, Maryam Ghandali, Amirhossein Sahebkar, Mohsen Taghizadeh, Hamed Mirzaei
Summary: As the prevalence of gastrointestinal cancers increases, they are considered a major global health challenge. Imbalance of gut microbiota has been linked to susceptibility to various chronic diseases, including obesity and cancer. Probiotics have shown potential in preventing cancer development and reducing postoperative inflammation in cancer patients, but further clinical studies are needed for a better understanding of their mechanisms of action.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Zarrin Banikazemi, Seyed Mohammad Mirazimi, Fatemeh Dashti, Mohammad Reza Mazandaranian, Maryam Akbari, Korosh Morshedi, Fatemeh Aslanbeigi, Amir Rashidian, Mohsen Chamanara, Michael R. Hamblin, Mohsen Taghizadeh, Hamed Mirzaei
Summary: Coumarin and its derivatives have significant antitumor activity, with researchers exploring their potential mechanisms in combating gastrointestinal cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Marzieh Salimian, Alireza Soleimani, Fereshteh Bahmani, Seyed Mohammad Hossein Tabatabaei, Zatollah Asemi, Hamid Reza Talari
Summary: This study demonstrates the beneficial effects of selenium supplementation on insulin metabolism, cholesterol levels, and inflammation markers in diabetic hemodialysis patients.
CLINICAL NUTRITION ESPEN
(2022)
Article
Nutrition & Dietetics
Elaheh Amirani, Zatollah Asemi, Mohsen Taghizadeh
Summary: The objective of this study was to determine the effects of probiotic plus selenium supplementation on glycemic control and lipid profiles in patients with gestational diabetes mellitus (GDM). The results showed that probiotic plus selenium supplementation significantly improved fasting glucose, insulin concentrations, insulin sensitivity, and lipid profiles in GDM patients.
CLINICAL NUTRITION ESPEN
(2022)
Article
Nutrition & Dietetics
Mohsen Taghizadeh, Azam Mohammad Zadeh, Zatollah Asemi, Amir Hosein Farrokhnezhad, Mohammad Reza Memarzadeh, Zarin Banikazemi, Mohammad Shariat, Rana Shafabakhsh
Summary: This study showed that the administration of Morus Alba extract had beneficial effects on HDL-cholesterol, insulin, and MDA levels in patients with T2DM but did not affect other metabolic profiles.
CLINICAL NUTRITION ESPEN
(2022)
Article
Rheumatology
Kamal Esalatmanesh, Javid Azadbakht, Mehrzad Hajialilo, Mohsen Soroush, Roozbeh Esalatmanesh, Zahra Soleimani, Alireza Khabbazi
Summary: This study assessed the clinical manifestations, imaging findings, and outcomes of COVID-19 in patients with rheumatic diseases. The findings suggest that treatment methods, diabetes, and pulmonary disease are risk factors for moderate to severe pneumonia and hospitalization.
EGYPTIAN RHEUMATOLOGIST
(2022)
Article
Medicine, General & Internal
Nikan Zargarzadeh, Kiana Tadbir Vajargah, Armin Ebrahimzadeh, Seyed Mohammad Mousavi, Hamidreza Khodaveisi, Camellia Akhgarjand, Fernando M. P. Toyos, Henrique S. Cerqueira, Heitor O. Santos, Mohsen Taghizadeh, Alireza Milajerdi
Summary: This study aims to examine the association between adherence to the Mediterranean diet pattern and COVID-19 severity and symptoms in Iranian hospitalized patients. The results showed that patients who adhered more closely to the Mediterranean diet had better outcomes in terms of COVID-19 severity, symptoms, and inflammatory biomarkers.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Armin Ebrahimzadeh, Mohsen Taghizadeh, Alireza Milajerdi
Summary: This study examined the association between major dietary patterns before COVID-19 diagnosis in recovered patients and the risk of disease severity and symptoms after the disease begins. The results showed that a higher adherence to a healthy dietary pattern was associated with lower CRP and ESR levels, as well as a lower risk of severe COVID-19, hospitalization, and convalescence duration. On the other hand, a higher adherence to unhealthy or traditional dietary patterns was associated with higher CRP and ESR levels, and a higher risk of severe COVID-19 and hospitalization duration. There was a direct association between unhealthy and traditional patterns and the risk of certain COVID-19 symptoms, while an inverse association was found for a healthy dietary pattern.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Shahnaz Rimaz, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Sanaz Jamshidi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Afsaneh Gholamrezayi, Naheed Aryaeian
Summary: This study aims to evaluate the effect of Cornus mas fruit on menopausal symptoms and sex hormones in postmenopausal women. The findings indicate that the extract of C mas fruit can significantly reduce menopausal symptoms, decrease the frequency and duration of hot flushes, and improve sex hormone levels.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Peripheral Vascular Disease
Virginia Boccardi, Mohsen Taghizadeh, Mina Salek, Sadegh Jafarnejad
Summary: The meta-analysis showed that alpha-lipoic acid (ALA) supplementation significantly reduced systolic and diastolic blood pressure, especially in subjects with higher blood pressure.
ARTERIAL HYPERTENSION
(2021)
Article
Urology & Nephrology
Mahbobeh Satari, Fereshteh Bahmani, Zeljko Reiner, Alireza Soleimani, Esmat Aghadavod, Nejat Kheinpour, Zatollah Asemi
Summary: This study showed that 12 weeks of melatonin administration in patients with diabetic nephropathy had beneficial effects on glycemic control, HDL-cholesterol, total antioxidant capacity, glutathione levels, and gene expression of PPAR-gamma, but did not affect other metabolic parameters.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2021)