期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 85, 期 1, 页码 20-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2016.09.019
关键词
Psoriasis; Palmoplantar psoriasis; Palmoplantar pustular psoriasis; IL-17; IL-23; Skin biopsies
类别
资金
- Novartis Pharmaceuticals
Background: Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis, which has significant negative impact on quality of life. The cellular and molecular inflammatory pathways involved in PPPP have not been well studied. Objective: Study the expression of cytokines and chemokines involved in the IL-17/IL-23 axis in palmoplantar pustular psoriasis and other difficult to treat psoriasis areas (palms, scalp, elbows and lower legs). Methods: Skin biopsies were performed on a total of 80 patients with PPPP, non-pustular palmoplantar psoriasis (NPPPP), or psoriasis located on elbows, knees and scalp as well as 10 healthy subjects. RT-PCR, immunohistochemistry and flow cytometry on cells extracted from skin biopsies were used to compare PPPP to other forms of psoriasis. Results: There was a significant (p < 0.05) increase in the expression of IL-113, IL-6, LL-37, IL-19, IL-17A, CXCL1 and CXCL2 in PPPP as compared to NPPPP. However, there was no significant difference in expression of IL-23 in PPPP as compared to NPPPP and other forms of psoriasis. The proportion of IL-22(+) but not IL-17A(+) mast cells was higher in PPPP as compared to NPPPP (p <0.05). Conclusion: These results suggest that the IL-17A pathway may play a more important role in PPPP than in NPPPP. (C) 2016 Published by Elsevier Ireland Ltd on behalf of Japanese Society for Investigative Dermatology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据