Review
Dermatology
Jonwei Hwang, Alyssa Thompson, Joanna Jaros, Paul Blackcloud, Jennifer Hsiao, Vivian Y. Shi
Summary: Atopic dermatitis is a common inflammatory skin disease with contributing factors including genetics, immunology, and environment. Staphylococcus aureus is associated with exacerbation of atopic dermatitis, producing virulence factors that interact with the skin and immune system. Advances in genome sequencing have increased understanding of the interaction between Staphylococcus aureus and the cutaneous environment in atopic dermatitis hosts.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Maria Pia Ferraz
Summary: The human microbiome plays a crucial role in human health, particularly in understanding the pathogenesis and treatment of atopic dermatitis.
APPLIED SCIENCES-BASEL
(2023)
Article
Virology
Yuzuki Shimamori, Shoichi Mitsunaka, Hirotaka Yamashita, Tohru Suzuki, Tomoe Kitao, Tomoko Kubori, Hiroki Nagai, Shigeki Takeda, Hiroki Ando
Summary: Atopic dermatitis is often associated with the overgrowth of Staphylococcus aureus, and phage therapy shows promising clinical applications in treating skin infections by reducing the bacterial load and disease exacerbation. Typical commensal bacteria in healthy skin can also help reduce S. aureus resistance to phage therapy.
Article
Allergy
Laura Cau, Michael R. Williams, Anna M. Butcher, Teruaki Nakatsuji, Jeffrey S. Kavanaugh, Joyce Y. Cheng, Faiza Shafiq, Kyle Higbee, Tissa R. Hata, Alexander R. Horswill, Richard L. Gallo
Summary: Staphylococcus epidermidis may damage the skin by producing a protease, EcpA, which degrades barrier proteins and induces inflammation. The abundance of S epidermidis and expression of ecpA mRNA on the skin of some atopic patients may be related to disease severity, while another commensal bacterium, Staphylococcus hominis, can inhibit EcpA production.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Editorial Material
Oncology
Chia-Yu Chu
Summary: Although direct causation between S. aureus and AD is still lacking, there is evidence of its association with disease flares and therapeutic responses. Treatment with ATx201 OINTMENT 2% twice-daily resulted in a significant reduction in S. aureus abundance and increased diversity of the skin microbiome, making it a potential alternative for AD treatment.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Dermatology
Minke M. F. Van Mierlo, Suzanne G. M. A. Pasmans, Joan E. E. Totte, Jill De Wit, Bjorn L. Herpers, Margreet C. Vos, Corne H. W. Klaassen, Luba M. Pardo
Summary: The study found that Staphylococcus aureus strains in AD patients are highly heterogeneous, with most patients carrying the same spa-type in the nose and skin without temporal variation. Disease severity is not associated with specific spa-types or temporal variation in spa-type.
Review
Infectious Diseases
John Hulme
Summary: Atopic dermatitis skin is prone to Staphylococcus aureus infection, exposing it to various toxins and virulent determinants. Treatment options depend on the degree of infection and may include topical solutions and oral/IV antibiotics. Severe skin trauma can lead to rapid SA infection, impairing the immune system and causing local and systemic AD presentations. The desensitization of systemic AD is a lengthy process with potential relapses, necessitating careful monitoring of triggers and flare severity to modify targeted treatments for rapid resolution of symptoms.
Article
Biochemistry & Molecular Biology
Amedeo De Tomassi, Anna Reiter, Matthias Reiger, Luise Rauer, Robin Rohayem, Avidan U. CK CARE Study Grp, Claudia Traidl-Hoffmann, Avidan Neumann, Claudia Huelpuesch
Summary: Atopic dermatitis (AD) is an inflammatory skin disease characterized by dysbiosis of the microbiome, particularly with an overgrowth of Staphylococcus aureus. This study aimed to investigate the bacterial load on the skin of AD patients using both next-generation sequencing and quantitative PCR methods. The results showed that AD patients had a higher total bacterial load, as well as increased abundance and cell numbers of S. aureus, in both lesional and non-lesional skin compared to healthy controls. The severity of AD was also associated with higher S. aureus cell numbers and total bacterial load.
Article
Immunology
Leslie Landemaine, Gregory Da Costa, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Romain Briandet, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Cecile Clavaud, Mathias L. Richard
Summary: This study demonstrates that Staphylococcus epidermidis strains originating from healthy skin and atopic skin have different effects. Strains from atopic skin alter the structure of a 3D reconstructed skin model, while strains from healthy skin do not. The metabolites produced by strains from healthy skin can activate the aryl hydrocarbon receptor pathway, while strains from atopic skin cannot.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Eric L. Simpson, Patrick M. Schlievert, Takeshi Yoshida, Stephanie Lussier, Mark Boguniewicz, Tissa Hata, Zelma Fuxench, Anna De Benedetto, Peck Y. Ong, Justin Ko, Agustin Calatroni, Amanda K. Rudman Spergel, Marshall Plaut, Sally A. Quataert, Samuel H. Kilgore, Liam Peterson, Ann L. Gill, Gloria David, Tim Mosmann, Steven R. Gill, Donald Y. M. Leung, Lisa A. Beck
Summary: This study found that blocking IL-4 and IL-13 signaling can rapidly reduce the abundance of Staphylococcus aureus in patients with atopic dermatitis (AD), and this reduction is correlated with decreases in the inflammatory marker CCL17 and AD severity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Yoshihiro Ito, Takashi Sasaki, Youxian Li, Takeshi Tanoue, Yuki Sugiura, Ashwin N. Skelly, Wataru Suda, Yusuke Kawashima, Nobuyuki Okahashi, Eiichiro Watanabe, Hiroto Horikawa, Aiko Shiohama, Rina Kurokawa, Eiryo Kawakami, Hachiro Iseki, Hiroshi Kawasaki, Yoichiro Iwakura, Atsushi Shiota, Liansheng Yu, Junzo Hisatsune, Haruhiko Koseki, Motoyuki Sugai, Makoto Arita, Osamu Ohara, Takeshi Matsui, Makoto Suematsu, Masahira Hattori, Koji Atarashi, Masayuki Amagai, Kenya Honda
Summary: The research shows that Staphylococcus cohnii can beneficially inhibit skin inflammation, potentially offering a new therapeutic approach for chronic inflammatory skin conditions.
Article
Cell Biology
Leszek Blicharz, Maciej Zochowski, Ksenia Szymanek-Majchrzak, Joanna Czuwara, Mohamad Goldust, Krzysztof Skowronski, Grazyna Mlynarczyk, Malgorzata Olszewska, Zbigniew Samochocki, Lidia Rudnicka
Summary: This study found that Staphylococcus aureus superantigens (SAgs) are associated with the severity of atopic dermatitis. The anterior nares and nonlesional skin may serve as reservoirs of SAg-positive S. aureus. Restoring the physiological microbiome can reduce the burden of SAgs and alleviate symptoms of atopic dermatitis.
Article
Immunology
Chia-Hui Luo, Alan Chuan-Ying Lai, Ya-Jen Chang
Summary: Atopic dermatitis (AD) is an inflammatory skin disease caused by a disrupted skin barrier and dominated by type 2 immune responses. Staphylococcus aureus (S. aureus) infection poses a high risk to patients with AD. Interleukin-33 (IL-33) and butyrate have been implicated in the pathophysiology of AD, but their effects on AD aggravated by S. aureus infection are not well understood. In this study, we established an AD-like mouse model with epidermal barrier disruption and examined the effects of S. aureus and butyrate on IL-33 expression and immune response. We found that S. aureus infection exacerbated IL-33 release and skin inflammation, while butyrate attenuated S. aureus-aggravated skin inflammation through histone deacetylase 3 (HDAC3) inhibition. These findings suggest that butyrate may have a positive effect on controlling inflammatory skin conditions in AD aggravated by S. aureus infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Aaroh Anand Joshi, Marc Vocanson, Jean-Francois Nicolas, Peter Wolf, Vijaykumar Patra
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. Disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components of AD pathogenesis. Decreased expression of AMPs in AD patients leads to increased colonization by Staphylococcus aureus. AMPs derived from the host and skin microbiome play a crucial role in defining the skin microbial landscape and maintaining immune homeostasis, making them potential therapeutics for AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Allergy
Li Fang Koh, Ruo Yan Ong, John E. Common
Summary: The skin microbiome plays a crucial role in the development of atopic dermatitis (AD). AD patients have an imbalanced skin microbiome with reduced microbial diversity and an overgrowth of pathogenic Staphylococcus aureus (S. aureus). Recent studies have highlighted the importance of establishing a proper immune response to microbes early in life and have uncovered new mechanisms of microbial community dynamics in modulating the skin microbiome. Several microbes, including S. aureus and Malassezia, are associated with AD pathogenesis. The complex relationships within the skin microbiome consortia involve various species such as Staphylococcal, Roseomonas, and Cutibacterium strains, which can inhibit S. aureus and have the potential to be probiotics for AD skin. Additionally, numerous microbes have been found to modulate the host response, improving the health and barrier function of the skin through communication with keratinocytes, specialized immune cells, and adipocytes. This increased understanding of the bioactives of skin microbiota has led to new biotherapeutic approaches targeting the skin microenvironment for AD treatment.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Allergy
K. Iwamoto, T. J. Nuemm, S. Koch, N. Herrmann, N. Leib, T. Bieber
Letter
Allergy
Yoshimi Matsuo, Yuhki Yanase, Reiko Irifuku, Shunsuke Takahagi, Shoji Mihara, Kaori Ishii, Tomoko Kawaguchi, Akio Tanaka, Kazumasa Iwamoto, Haruka Watanuki, Kazuyuki Furuta, Satoshi Tanaka, Asuka Inoue, Junken Aoki, Michihiro Hide
Letter
Dermatology
Ryo Saito, Kazumasa Iwamoto, Yurie Tanaka, Mikio Kawai, Michihiro Hide
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2018)
Article
Allergy
Yuhki Yanase, Satoshi Morioke, Kazumasa Iwamoto, Shunsuke Takahagi, Kazue Uchida, Tomoko Kawaguchi, Kaori Ishii, Izumi Hide, Michihiro Hide
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Letter
Dermatology
Masaya Moriwaki, Kazumasa Iwamoto, Kaori Ishii, Shunsuke Takahagi, Michihiro Hide
JOURNAL OF DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yuhki Yanase, Yoshimi Matsuo, Tomoko Kawaguchi, Kaori Ishii, Akio Tanaka, Kazumasa Iwamoto, Shunsuke Takahagi, Michihiro Hide
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Allergy
Kazumasa Iwamoto, Masaya Moriwaki, Ryu Miyake, Michihiro Hide
ALLERGOLOGY INTERNATIONAL
(2019)
Letter
Dermatology
Ryo Saito, Akio Tanaka, Takaaki Hiragun, Kazumasa Iwamoto, Shunsuke Takahagi, Masakazu Takahashi, Michihiro Hide
JOURNAL OF DERMATOLOGY
(2019)
Letter
Allergy
Risa Otsuka, Akio Tanaka, Masakazu Takahashi, Ryo Saito, Kazumasa Iwamoto, Shunsuke Takahagi, Takanobu Kan, Satoshi Morioke, Michihiro Hide
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Allergy
Kazumasa Iwamoto, Beverley Yamamoto, Isao Ohsawa, Daisuke Honda, Takahiko Horiuchi, Akira Tanaka, Atsushi Fukunaga, Junichi Maehara, Kouhei Yamashita, Tomoyuki Akita, Michihiro Hide
Summary: The survey in Japan revealed a long delay between first symptom appearance and HAE diagnosis, with an average of 15.6 years and 4.6 different departments visited before diagnosis. Patients reported an average of 15.7 attacks per year, with only 53.1% receiving treatment.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Dermatology
Akio Tanaka, Satoshi Morioke, Yukihiro Ohya, Naoki Shimojo, Masakazu Takahashi, Maiko Tanaka, Shunsuke Takahagi, Takanobu Kan, Kazumasa Iwamoto, Ryo Saito, Michihiro Hide
Summary: A study of 3090 Japanese adult subjects diagnosed with AD revealed variations in the time course of disease severity from birth to 19 years old. Patients in their 20s and 30s tended to show improvement by the age of 12, while those in their 40s or older showed aggravation between the ages of 12 and 19. The survey suggested that acquired factors affecting the natural history of AD have changed over the past 50 years in Japan.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Ryu Miyake, Kazumasa Iwamoto, Norio Sakai, Kyoka Matsunae, Fatkhanuddin Aziz, Motoyuki Sugai, Shunsuke Takahagi, Akio Tanaka, Michihiro Hide
Summary: The study found that Staphylococcus aureus strains from atopic dermatitis patients are more easily internalized by keratinocytes, with internalization largely mediated by the IFN-gamma-fibronectin pathway and partially regulated by filaggrin expression.
JOURNAL OF DERMATOLOGY
(2022)
Article
Allergy
Marie-Sophie Philipp, Tim J. Nuemm, Yuxuan Deng, Kazumasa Iwamoto, Nadine Herrmann, Thomas Bieber
Article
Dermatology
S. Takahagi, A. Tanaka, K. Iwamoto, K. Ishii, M. Hide
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2017)
