Review
Dermatology
Maryam Khalili, Rezvan Amiri, Behzad Iranmanesh, Hamed Zartab, Mahin Aflatoonian
Summary: Mesotherapy is a popular novel therapeutic modality in aesthetic dermatology, suitable for patients with melasma who are refractory to first-line therapy, have low compliance with topical treatment, or have contraindications to oral tranexamic acid therapy. Further studies with larger sample sizes are needed to determine the optimal concentration and injection intervals of mesotherapy substances, evaluate the efficacy of different substances, and compare them with other treatment modalities.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Dermatology
Xiaowei Feng, Hong Su, Jinwei Xie
Summary: Microneedling with topical tranexamic acid (TXA) is found to be effective in treating melasma, but more well-designed studies are needed to confirm its efficacy and safety.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Yasmina El Attar, Noha Doghaim, Nashwa El Far, Samar El Hedody, Soha Abdalla Hawwam
Summary: The use of topical tranexamic acid or vitamin C after microneedling is an effective and safe technique for melasma treatment, with significant improvements in pigmented lesions and vascular components.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Dermatology
Adrian Joseph Michel Bailey, Heidi Oi-Yee Li, Marcus G. Tan, Wei Cheng, Jeffrey S. Dover
Summary: This study conducted a systematic review and meta-analysis on the efficacy of microneedling as an adjuvant to topical therapies for the treatment of melasma. The results showed that microneedling as an adjuvant therapy improved melasma severity significantly, with better results compared to topical therapy alone. Microneedling was well tolerated with no serious adverse events reported.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Dermatology
Amal T. Abdel-Rahman, Fatma G. Abdel-Hakeem, Maha H. Ragaie
Summary: This study compared the efficacy of microneedling with vitamin C and PRP in treating mixed melasma, with vitamin C showing more significant results. Vitamin C was more effective in reducing melanin and melanophages, as well as MART-1 positive cells, compared to PRP.
DERMATOLOGIC THERAPY
(2022)
Review
Dermatology
Gabriela Correia, Sofia Magina
Summary: This systematic review evaluates the effectiveness of topical vitamin C in treating photoaging and melasma, and finds that vitamin C can improve uneven and wrinkled skin, has depigmenting properties, but long-term use may be needed for noticeable changes. Q-switched Nd:YAG laser-associated protocols enhance the effects of vitamin C. Topical vitamin C may be a suitable alternative for melasma and photoaging, but more studies are needed to confirm these results and assess the ideal vitamin C concentration.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Ozlem Karadag Kose, Murat Borlu
Summary: The study demonstrates that the combination of Q-switched neodymium-doped yttrium aluminum garnet laser and microneedling with mesotherapy products containing biomimetic peptides is an effective and synergistic approach to treat melasma.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Aleksa Kojcinovic, Blaz Likozar, Miha Grilc
Summary: This study provides guidelines for the utilization of advanced technology in the century-old yet inadequately described reaction system of Kolbe-Schmitt and Marasse carboxylation of phenol. It systematically investigates and thoroughly explains the preparation procedures and analytical methods, offering valuable insights into this promising route in carbon capture and utilization practices.
Review
Nutrition & Dietetics
Anitra C. C. Carr, Masuma Zawari
Summary: The global healthcare burden of an aging population is increasing, with a significant portion of diseases attributed to older individuals. Micronutrient deficiencies, including vitamin C, are common among older people and can contribute to chronic illnesses. While there is limited evidence suggesting that healthy aging is associated with lower vitamin C levels or increased requirements, institutionalized elderly individuals tend to have lower vitamin C status and enhanced requirements due to poor intake and chronic illness. Appropriate nutritional interventions are necessary to support healthy aging in this vulnerable population.
Article
Dermatology
Maryam Karrabi, Mohammad Ali Mansournia, Ehsan Sharestanaki, Yeganeh Abdollahnejad, Mohammad Sahebkar
Summary: The study shows that while there is no significant advantage of cysteamine over Tranexamic Acid (TA) mesotherapy in the treatment of melasma, complications are less in the cysteamine group compared to the TA group.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Plant Sciences
Huixia Dong, Wei Zhang, Yongxia Li, Yuqian Feng, Xuan Wang, Zhenkai Liu, Dongzhen Li, Xiaojian Wen, Shuai Ma, Xingyao Zhang
Summary: In this study, the function of SAMT in poplar plants was investigated, and it was found to play a crucial role in the defense mechanism against pathogens. Overexpression of SAMT increased the content of MeSA and decreased the content of SA. Additionally, SAMT overexpression led to higher expression of pathogenesis-related genes, but did not confer resistance against the fungal pathogen.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xinru You, Liying Wang, Li Wang, Jun Wu
Summary: Researchers successfully polymerized salicylic acid, a functional component of aspirin, into poly (salicylic acid) to create prickly nanoparticles that are non-toxic to normal and cancer cells, and inhibit tumor growth. Drug-loaded prickly nanoparticles exhibit high blood vessel penetration, tumor penetration, and tumor accumulation, achieving significant tumor inhibition without side effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: In this study, the relationship between vitamin C status and demographic and lifestyle factors was investigated using NHANES 2017-2018 datasets. It was found that gender, smoking, and body weight have significant impacts on vitamin C requirements. Males and smokers require higher vitamin C intakes to achieve adequate serum concentrations. Overall, the general population should consume around 110 mg/day of vitamin C, smokers require approximately 165 mg/day, and heavier individuals (100+ kg) require about 155 mg/day to reach comparable vitamin C concentrations.
Article
Nutrition & Dietetics
Stephen P. Juraschek, J. Michael Gaziano, Robert J. Glynn, Natalya Gomelskaya, Vadim Y. Bubes, Julie E. Buring, Robert H. Shmerling, Howard D. Sesso
Summary: The study showed that a daily dose of 500 mg vitamin C reduced the risk of gout in middle-aged male physicians, while vitamin E did not have a significant effect.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)