Review
Chemistry, Multidisciplinary
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao
Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.
Review
Pharmacology & Pharmacy
Ya-Nan Pi, Bai-Rong Xia, Ming-Zhu Jin, Wei-Lin Jin, Ge Lou
Summary: Cancer immunotherapy targeting the tumor immune microenvironment is considered revolutionary, with exosomes playing a crucial role in mediating intercellular communication and possibly serving as an adjuvant therapeutic strategy for immune-based combination therapy.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Noor Essa, Fiona O'Connell, Adriele Prina-Mello, Jacintha O'Sullivan, Simone Marcone
Summary: The relationship between obesity and cancer has been well characterized, but the biological mechanisms in obese cancer patients are still unclear. The obese tumor microenvironment provides additional benefits to tumor cells against anticancer therapies by altering the extracellular matrix composition and immune cell profile, while nanotechnology, particularly gold nanoparticles, is being researched for cancer treatment due to their sensitizing abilities for cancer cells and enhancement of drug delivery.
Review
Medicine, Research & Experimental
Maria Urbanova, Marina Cihova, Verona Buocikova, Jan Slopovsky, Peter Dubovan, Daniel Pindak, Miroslav Tomas, Laura Garcia-Bermejo, Mercedes Rodriguez-Garrote, Julie Earl, Yvonne Kohl, Agapi Kataki, Maria Dusinska, Bruno Sainz, Bozena Smolkova, Alena Gabelova
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer due to its desmoplastic stroma and immunosuppressive tumor microenvironment (TME). Remodeling the TME and targeting epigenetic pathways have become key therapeutic strategies. Nanotechnology offers new opportunities for enhancing drug efficacy through nano-based drug delivery systems (NDDSs), which provide advantages such as improved drug pharmacokinetics and enhanced tumor penetration.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Yujin Lee, Peter Graham, Yong Li
Summary: Breast cancer lacks effective management approaches for metastasis and therapy-resistant disease. Extracellular vesicles (EVs) play an important role in intercellular communication and are associated with pathological conditions. Cancer cells secrete EVs and communicate with neighboring cells in the tumor microenvironment, which contributes to BC metastasis, immune escape, and chemo-resistance. EVs have emerged as potential therapeutic targets and carriers for BC treatment, stimulating angiogenesis, inhibiting the immune response, and promoting cancer metastasis.
Article
Chemistry, Multidisciplinary
Qi-Song Tong, Wei-Min Miao, Hua Huang, Jia-Qi Luo, Rong Liu, Yong-Cong Huang, Dong-Kun Zhao, Song Shen, Jin-Zhi Du, Jun Wang
Summary: A newly developed tumor-penetrating nanoparticle can modulate the deep microenvironment of PDAC, facilitating the effectiveness of chemoimmunotherapy.
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Article
Chemistry, Multidisciplinary
Yongzhuo Huang
Summary: There is a close relationship between cancer metabolism and immunity. Targeting cancer metabolism shows promise as a therapeutic approach for cancer immunotherapy. The Warburg effect, characterized by abnormal glucose metabolism, can modify cancer cells and create a suppressive immune microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Summary: Multidrug resistance (MDR) reduces the efficacy of chemotherapy by inducing drug efflux pumps and altering the tumor microenvironment (TME) composition, limiting drug delivery. Multidrug-resistant tumors displayed a more mesenchymal phenotype, increased collagen production, enriched TME, and enhanced vascular perfusion. Drug carriers accumulated more efficiently in resistant tumors but had a limited ability to penetrate the interstitium. Microenvironmental drug resistance affected liposomal doxorubicin performance more than free doxorubicin.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Nanoscience & Nanotechnology
Mengbin Ding, Yijing Zhang, Jingchao Li, Kanyi Pu
Summary: Bioenzyme-based nanomedicines have shown great potential in improving the efficacy of cancer therapies by modulating the tumor microenvironment and increasing the penetration and retention of nanoparticles in deep tumors. These nanomedicines can enhance chemotherapy, phototherapy, and immunotherapy for cancer treatment.
Article
Engineering, Biomedical
Mohammad Souri, M. Soltani, Farshad Moradi Kashkooli, Mohammad Kiani Shahvandi, Mohsen Chiani, Fatemeh Sadat Shariati, Mohammad Reza Mehrabi, Lance L. Munn
Summary: Nanotechnology has shown promising results in medical applications, particularly in oncology as drug delivery systems. However, the clinical translation of this technology is challenging. To optimize drug delivery systems for clinical translation, the physicochemical characteristics of nanoparticles can be specified. Researchers have focused on producing biocompatible materials, production technologies, or new formulations to improve efficiency and stability. The effects of design parameters can be studied using various methods. This review summarizes the advances and technologies in cancer nanomedicines for clinical translation and commercialization, as well as the existing challenges and opportunities in the field.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Physical
Chenming Zou, Yuepeng Tang, Ping Zeng, Derong Cui, Majdi Al Amili, Ya Chang, Zhu Jin, Yuanyuan Shen, Songwei Tan, Shengrong Guo
Summary: Targeted co-delivery and co-release of multiple drugs using cRGD-modified nanoparticles (cRGD-TDA) provides an integrative collaborative effect on treating cancer. In this study, the cRGD-TDA nanoparticles containing doxorubicin, adjudin, and TPGS were combined with a PD-L1 antagonist to treat triple-negative breast cancer. The co-delivery and pH-sensitive co-release of triple agents by cRGD-TDA NPs resulted in significantly inhibited tumor growth and metastasis. Moreover, TPGS elicited powerful immunogenic cell death and PD-L1 antagonist mitigated the immunosuppressive environment, further enhancing the therapeutic effect of cRGD-TDA NPs. This study offers a new strategy for integrative and collaborative treatment of refractory cancer.
NANOSCALE HORIZONS
(2023)
Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Article
Chemistry, Multidisciplinary
Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Summary: Nano-immunotherapy has shown potential in improving outcomes for triple negative breast cancer patients, but mechanisms of resistance need to be understood. By decompressing compressed blood vessels in lung metastases, perfusion can be restored and hypoxia alleviated, leading to more efficient delivery of nanomedicines and enhancement of anti-tumor immunity. Mechanotherapeutics in combination with nano-immunotherapy may offer synergistic effects on efficacy in breast cancer treatment.
Review
Oncology
Lili Zhou, Manshu Zou, Yilin Xu, Peng Lin, Chang Lei, Xinhua Xia
Summary: Tumor immunotherapy is a powerful strategy for treating cancer by stimulating the immune system. However, the heterogeneity of tumors and immunosuppressive microenvironment make it difficult for immunotherapy to be effective. With the advancements in materials science and nanotechnology, innovative biomaterials and drug delivery systems can enhance the effectiveness of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maria Kalli, Ruxuan Li, Gordon B. Mills, Triantafyllos Stylianopoulos, Ioannis K. Zervantonakis
Summary: Mechanical stress plays an important role in pancreatic cancer cell migration, and targeting aberrant signaling in cancer cells that have adapted to mechanical stress could be an effective approach to limit pancreatic cancer cell migration.
MOLECULAR CANCER RESEARCH
(2022)
Review
Oncology
Ilias P. Nikas, Giannis Mountzios, Guy I. Sydney, Kalliopi J. Ioakim, Jae-Kyung Won, Panagiotis Papageorgis
Summary: Summary: Pancreatic cancer and cholangiocarcinoma are aggressive diseases that are often diagnosed at an advanced and inoperable stage. This review discusses the use of next-generation sequencing (NGS) on small biopsies, such as fine-needle aspiration/biopsy samples, brushings, pancreatic juice and bile, and blood, in the field of pancreatobiliary neoplasia. NGS has been shown to be a valuable tool for diagnosing and stratifying pancreatic and biliary lesions, as well as for monitoring the disease and assessing prognosis in cancer patients. However, standardization of the pre-analytical and analytical assay parameters is necessary for the routine implementation of NGS in clinical practice.
Article
Infectious Diseases
Pavlina Lena, Spyridon A. Karageorgos, Panayiota Loutsiou, Annita Poupazi, Demetris Lamnisos, Panagiotis Papageorgis, Constantinos Tsioutis
Summary: This study aimed to evaluate the presence of multidrug-resistant bacteria (MDRB) on healthcare worker (HCW) uniforms in Cyprus. The study found that HCW uniforms harbored MDRB, and identified long-term care facilities as an important area for interventions. Factors associated with HCW practices, characteristics, and attire laundering practices were also identified as areas for improvement.
Review
Cell Biology
Anastasios Birmpilis, Antonios Paschalis, Apostolis Mourkakis, Panayiota Christodoulou, Ioannis Kostopoulos, Elina Antimissari, Georgia Terzoudi, Alexandros G. Georgakilas, Christina Armpilia, Panagiotis Papageorgis, Efstathios Kastritis, Evangelos Terpos, Meletios A. Dimopoulos, Hubert Kalbacher, Evangelia Livaniou, Maria-Ioanna Christodoulou, Ourania E. Tsitsilonis
Summary: Studies have shown that immunogenic cell death (ICD) is a widely studied concept, revealing the immunogenic properties of different regulated cell death modalities and emphasizing the importance of danger-associated molecular patterns (DAMPs) released by dying or dead cells. Experimental results suggest that human proT alpha and its immunoreactive fragment may have potential clinical applications in ICD.
Article
Engineering, Biomedical
Andreas Stylianou, Fotios Mpekris, Chrysovalantis Voutouri, Antonia Papoui, Anastasia Constantinidou, Evros Kitiris, Michalis Kailides, Triantafyllos Stylianopoulos
Summary: Tumors undergo mechanical property changes during cancer progression, and targeting components of the tumor microenvironment to normalize tumor mechanical properties can enhance drug delivery. Atomic Force Microscopy (AFM) was used to assess nanomechanical properties of tumor biopsies, showing sensitivity to changes in tumor mechanical properties during treatment. This has the potential to develop biomarkers for treatment prediction and monitoring.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Petri Ch Papaphilippou, Oana Maria Marinica, Eugenia Tanasa, Fotios Mpekris, Triantafyllos Stylianopoulos, Vlad Socoliuc, Theodora Krasia-Christoforou
Summary: Functionalized electrospun polymer microfibrous membranes were prepared and further surface-functionalized with magnetic iron oxide nanoparticles to fabricate magnetoactive nanocomposite fibrous adsorbents. These magnetic-functionalized fibrous adsorbents exhibited significantly improved adsorption efficacy and could be recovered and regenerated magnetically.
Review
Biochemistry & Molecular Biology
Vasilia Tamamouna, Evangelia Pavlou, Christiana M. Neophytou, Panagiotis Papageorgis, Paul Costeas
Summary: Cancer recurrence and metastasis pose a significant threat in clinical oncology, and metastatic tumor dormancy is a crucial stage during cancer progression. Dormant cancer cells enter a state of cell cycle arrest and survival to adapt to new microenvironments, making them resistant to treatment and immune surveillance. Understanding the mechanisms of dormancy induction and escape is important for developing innovative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Chrysovalantis Voutouri, Fotios Mpekris, Myrofora Panagi, Connor Krolak, Christina Michael, John D. Martin, Michalakis A. Averkiou, Triantafyllos Stylianopoulos
Summary: Immunotherapy has transformed cancer treatment, but many patients do not benefit and may experience severe toxicities. This study shows that ultrasound imaging can be used to predict the response to immunotherapy by assessing tumor stiffness and perfusion. The researchers found correlations between ultrasound-derived measures of tumor stiffness and perfusion and the efficacy of immune checkpoint inhibition. These findings suggest that ultrasound biomarkers can be used in combination with mechanotherapeutics for more effective cancer treatment.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Summary: This study developed an experimental and computational approach to calculate growth-induced, residual stresses in solid tumors and applied it to breast, pancreatic, and fibrosarcoma tumor models. The average magnitude of residual stresses ranged from 3.31 to 10.88 kPa and they were non-uniformly distributed within the tumor tissue. The mechanical properties of the tumors were found to be associated with the spatial profile of stress, providing insights into the mechanical behavior of tumors.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Engineering, Biomedical
Konstantinos Tzirakis, Christos Panagiotis Papanikas, Vangelis Sakkalis, Eleftheria Tzamali, Yannis Papaharilaou, Alfonso Caiazzo, Triantafyllos Stylianopoulos, Vasileios Vavourakis
Summary: This paper presents a continuum-based finite element framework built on high performance computing and open-source libraries for simulating glioblastoma progression in both 2D and 3D brain models. The framework accurately and efficiently evaluates the impact of vascular density, cancer cell invasiveness and aggressiveness, phenotypic transition potential, and tumor-induced angiogenesis on the evolution of glioblastoma. Individualized simulations using magnetic resonance imaging data are also conducted to study the complex dynamics of the disease.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Ioannis G. Theodorou, Fotios Mpekris, Paris Papagiorgis, Myrofora Panagi, Maria Kalli, Louiza Potamiti, Kyriacos Kyriacou, Grigorios Itskos, Triantafyllos Stylianopoulos
Summary: Gold nanoparticles with a bipyramidal shape were developed for enhanced fluorescence imaging and targeted drug delivery to triple-negative breast tumors. The nanoparticles demonstrated the ability to be combined with various therapeutics and targeting agents, showing great potential for clinical applications in cancer treatment. Furthermore, cell-targeted multifunctional nanomaterials can provide precise early-stage diagnosis and local therapeutic delivery to specific cell types, making them promising tools for the diagnosis and treatment of aggressive triple-negative breast cancer.
Review
Medicine, Research & Experimental
Myrofora Panagi, Pampina Pilavaki, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Summary: Sarcomas are rare malignancies that can arise throughout the human lifespan. Surgery is the best treatment option, while traditional treatments like chemotherapy and radiation have limited effectiveness. Immunotherapy has emerged as a novel approach, but its efficacy in sarcomas is limited by the tumor microenvironment. Understanding the immunological properties of the sarcoma microenvironment and their impact on immunotherapy can help overcome these barriers.
Proceedings Paper
Materials Science, Biomaterials
Andreas Stylianou, Chrysovalantis Voutouri, Fotios Mpekris, Antonia Papoui, Katerina Polemidiotou, Triantafyllos Stylianopoulos
Summary: Cancer progression is associated with changes in the mechanical properties of the tumor microenvironment, including tumor stiffening, which hinders drug delivery. This study aimed to develop novel biomarkers to characterize the mechanical state of tumors and support the development of targeted therapies. Polarized microscopy and atomic force microscopy were used to assess collagen-based optical signatures and nanomechanical properties of tumor samples. FDA-approved anti-fibrotic and chemotherapy drugs were repurposed to alleviate tumor stiffness. The results showed that solid tumors have unique collagen-based signatures that can be used as biomarkers for cancer prognosis and treatment monitoring.
TISSUE OPTICS AND PHOTONICS II
(2022)
Meeting Abstract
Critical Care Medicine
C. C. Hardin, S. Subudhi, C. Voutouri, M. Nikmaneshi, A. Patel, A. Verma, M. Khandekar, S. Dutta, T. Stylianopoulos, R. Jain, L. Munn
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)