Article
Multidisciplinary Sciences
Tiberiu S. Mihaila, Carina Bate, Lynn M. Ostersehlt, Jasmin K. Pape, Jan Keller-Findeisen, Steffen J. Sahl, Stefan W. Hell
Summary: With the recent advancements in fluorescence nanoscopes, the ability to dissect nanoscopic biological structures is limited by the size of protein labels. Bioorthogonal chemical groups provide a powerful tool for specific detection of biomolecules. In this study, we introduced an engineered aminoacyl-tRNA synthetase/tRNA pair to allow for the site-specific introduction of amino acids with clickable side chains into proteins. This enhanced genetic code expansion machinery was then used to label beta-actin in cells for high-resolution imaging. Our findings highlight the need for further improvements in labeling methods to fully exploit the potential of molecular-scale optical three-dimensional resolution.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Marcel Streit, Mareike Hemberger, Stephanie Haefner, Felix Knote, Tobias Langenhan, Gerti Beliu
Summary: The introduction of an engineered aminoacyl-tRNA synthetase/tRNA pair allows for the site-specific incorporation of unnatural amino acids into proteins. This method, called Genetic Code Expansion (GCE), can also be used to control the temporal incorporation of genetically encoded elements into proteins. In this study, an optimized GCE system (GCEXpress) was developed for efficient and fast incorporation of unnatural amino acids. The GCEXpress system was used to alter the subcellular localization of proteins and to study protein-protein interactions involved in immune functions and oncological processes. The results suggest that GCE, combined with biophysical measurements, is a valuable approach for analyzing the properties of proteins and their interactions with ligands.
Article
Chemistry, Multidisciplinary
Alex Gibney, Raphael E. F. de Paiva, Vandana Singh, Robert Fox, Damien Thompson, Joseph Hennessy, Creina Slator, Christine J. McKenzie, Pegah Johansson, Vickie McKee, Fredrik Westerlund, Andrew Kellett
Summary: In this study, a Cu-catalysed azide-alkyne cycloaddition reaction produced a 1,2,3-triazole linker that was used to create Cu-binding artificial metallo-nucleases (AMNs). A bioactive C-3-symmetric ligand called TC-Thio was developed using biologically inert reaction partners. The ligand formed Cu-II and Cu-I complexes through Cu coordination, and showed potent DNA binding and cleaving abilities. Mechanistic studies revealed that DNA recognition occurred at the minor groove, leading to oxidative damage through a pathway dependent on superoxide and peroxide. Single molecule imaging demonstrated that the complex caused DNA damage recognized by base excision repair enzymes, comparable to the clinical drug temozolomide.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ruijia Huang, Ying Xu, Jihui Du, Qiong Guan, Xiaoqing Cai, Feng Li, Jidong Wang, Wenwen Chen
Summary: Copper is an essential element in the human body and its excessive presence is associated with various diseases. A chemical sensor based on the Cu-catalyzed click reaction and fluorescence-enhanced substrate has been developed for selective detection of Cu2+. This sensor can detect Cu2+ as low as 3.87 nM within 10 minutes and has potential applications in disease diagnosis and antibiotic susceptibility testing.
Article
Chemistry, Multidisciplinary
Anandi Kugele, Sophie Ketter, Bjarne Silkenath, Valentin Wittmann, Benesh Joseph, Malte Drescher
Summary: This study successfully conducts spin labelling on cellular surfaces through Diels-Alder chemistry, providing new methods for the study of membrane proteins.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Niloofar Savadkouhi, Zeinab Mazarei, Maryam Esmaeelzadeh, Peyman Salehi, Hasan Rafati
Summary: In this study, new PEGylated derivatives of alpha-tocopherol were synthesized, with TPGT1000 showing lower CMC value, higher stability in FBS environment, and higher cytotoxicity against MCF-7 breast cancer cells compared to lower molecular weight PEGylated derivatives. Increasing PEG chain length had a positive effect on the polymeric micelle properties and improved the cytotoxicity effect of the new PEGylated vitamin E derivatives.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Polymer Science
Lu Lian, Jiaman Hu, Yong Lin, Youliang Zhao
Summary: The rational design of architecture-transformable polymers can optimize their physicochemical properties. In this study, a couplable and self-immolative ATRP initiator was used for one-shot copolymerization, resulting in polymers with different block numbers and connection modes. The incorporation of anthracene dimerization and thiolactone groups enabled the construction of graft copolymers with complex structures. Heating the polymers resulted in the cleavage of anthracene dimers and ester groups, generating mixtures of polymers with different block compositions. This approach provides a promising platform for achieving a wide range of complex macromolecular architectures through topological transformation.
Article
Polymer Science
Lu Lian, Jiaman Hu, Yong Lin, Youliang Zhao
Summary: The rational design and synthesis of architecture-transformable polymers allows for the optimization of physicochemical properties. Through a cascade synthesis involving multiple steps, diverse macromolecular architectures can be achieved. These polymers have tunable compositions and functions and serve as a promising platform for the generation of complex macromolecular structures.
Article
Multidisciplinary Sciences
Yawen You, Qingqing Deng, Yibo Wang, Yanjuan Sang, Guangming Li, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: This study reports on a DNA-based biocompatible, highly efficient, and precisely targeted copper nanocatalyst, which exhibits excellent catalytic activity and achieves efficient prodrug activation and antitumor effects in cancer cells.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Junfeng Chen, Aoon Rizvi, Joseph P. Patterson, Craig J. Hawker
Summary: This study reports a method to prepare libraries of discrete PEG analogues with a branched, nonlinear structure, which can achieve efficient nanoparticle assembly while reducing antibody recognition. The results illustrate the advantages of discrete macromolecules in terms of improved properties and reduced antibody responses.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Chunwei Dong, Ren-Wu Huang, Arunachalam Sagadevan, Peng Yuan, Luis Gutierrez-Arzaluz, Atanu Ghosh, Saidkhodzha Nematulloev, Badriah Alamer, Omar F. Mohammed, Irshad Hussain, Magnus Rueping, Osman M. Bakr
Summary: In this study, a synthesis method for obtaining an atomically precise nanoparticle with a surface-defective analogue is reported. The loss of a single surface atom drastically alters the reactivity of the nanoparticle, showing promising activity for click chemistry, especially photoinduced azide-alkyne cycloaddition. This study not only uncovers the effect of single-surface atom modification on nanoparticle properties but also demonstrates the potential of single-atom surface modification as a means for designing nanoparticle catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Max Roemer, Ian Luck, Nicholas Proschogo
Summary: This paper investigates the synthesis of aryl amines from halobenzenes via copper mediated reactions using sodium azide under mild conditions. The reaction proceeds stepwise through the formation of aryl azides, which are then reduced to amines. The methodology allows for the synthesis of amines from different positions of halobenzenes with electron withdrawing groups. The use of modified stirring bars as heterogeneous catalysts is also demonstrated.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Youxin Fu, Hugo Helbert, Nadja A. Simeth, Stefano Crespi, Gerbren B. Spoelstra, Jan Maarten van Dijl, Marleen van Oosten, Luiza Reali Nazario, Dion van der Born, Gert Luurtsema, Wiktor Szymanski, Philip H. Elsinga, Ben L. Feringa
Summary: The study developed an ultrafast photoclick method based on photocycloaddition reaction for the synthesis of short-lived F-18-PET tracers. The reaction can be completed in 60 seconds using a flow photo-microreactor, demonstrating practicality by preparing clinically relevant tracers for prostate cancer and bacterial infection imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Anurag Noonikara-Poyil, Alvaro Munoz-Castro, H. V. Rasika Dias
Summary: This study describes the isolation and full characterization of a thermally stable, copper(I) acetylene complex using a highly fluorinated bis(pyrazolyl)borate ligand support, as well as the details of a related copper(I) complex. Raman data show significant red-shifts in C equivalent to C stretch of different alkynes bound to copper(I), with computational analysis indicating that the interaction is primarily of the electrostatic character. The study also highlights the catalytic activity of a mononuclear copper complex in [3 + 2] cycloadditions and compares its effectiveness with a trinuclear copper catalyst.
Article
Chemistry, Organic
Hiroto Kimura, Kohsuke Aikawa, Takuya Hashimoto
Summary: CuAAC and SuFEx reactions are two important methods for connecting molecules in click chemistry. This study presents a copper-catalyzed aminoazidation reaction using NFC, which attaches both an azide and a fluorosulfonyl group to an alkene in one step. The derivatization of the product through consecutive CuAAC and SuFEx reactions allows rapid diversification of molecular structure.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yingying Chen, Xinchen Wang, Yinbiao Zhu, Longlong Si, Bo Zhang, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao
MOLECULAR PHARMACEUTICS
(2020)
Article
Rheumatology
Bo Zhang, Yan Wang, Yeshuang Yuan, Jiaqi Sun, Lulu Liu, Dan Huang, Jin Hu, Min Wang, Shengjie Li, Wei Song, Hua Chen, Demin Zhou, Xuan Zhang
Summary: Autoreactive B cells play a crucial role in the pathogenesis of rheumatoid arthritis (RA), and targeting these cells using FITC-labelled antigenic peptide epitopes with universal CAR-T cells shows promise for precise and customized treatment of RA and potentially other systemic autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Oncology
Ling Wu, Joanna Brzostek, Shvetha Sankaran, Qianru Wei, Jiawei Yap, Triscilla Y. Y. Tan, Junyun Lai, Paul A. MacAry, Nicholas R. J. Gascoigne
Summary: Chimeric antigen receptors (CARs) redirect T cells effectively in combating cancers and have achieved great success in clinical practice. However, the mechanisms underlying CAR signaling and function are not fully understood. Research findings suggest that CAR and TCR exhibit distinct signaling characteristics, providing new insights for clinical behavior of CAR-T therapy and technology optimization.
Meeting Abstract
Hematology
Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn Hart, Aijun Liao, Stacey M. Fernandes, Tinisha McDonald, Lucy Ghoda, Daniel Roeth, Markus Kalkum, Raju Pillai, Jianjun Chen, Jennifer R. Brown, Alexey V. Danilov, Steven T. Rosen, Tanya Siddiqi, Lili Wang
Article
Biochemistry & Molecular Biology
Xinyu Ling, Liying Chang, Heqi Chen, Xiaoqin Gao, Jianhang Yin, Yi Zuo, Yujia Huang, Bo Zhang, Jiazhi Hu, Tao Liu
Summary: Researchers have improved the genome editing efficiency of the Cas12a system by covalently linking CRISPR RNA and Cas12a, achieving high-efficiency gene editing and providing a new approach for engineering other low-efficiency Cas family members.
Article
Engineering, Biomedical
Bo Zhang, Jiaqi Sun, Yan Wang, Dezhong Ji, Yeshuang Yuan, Shengjie Li, Yeting Sun, Yingqin Hou, Pengchong Li, Lidan Zhao, Fei Yu, Wenxiao Ma, Boyang Cheng, Ling Wu, Jin Hu, Min Wang, Wei Song, Xiaogang Li, Hao Li, Yunyun Fei, Hua Chen, Lihe Zhang, George C. Tsokos, Demin Zhou, Xuan Zhang
Summary: Orthogonal conjugation of the cytokine interleukin-2 to poly(ethylene glycol) moieties at defined protein sites improves its pharmacokinetics and half-life as well as its therapeutic performance in mouse models of autoimmune diseases.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Wei Song, Zhibo Zhang, Ying Jiang, Yang Cao, Bo Zhang, Yujie Wang, Honghui Shi, Lan Zhu
Summary: This study is the first to describe the metabolic features of the adenomyosis uterus, identifying 106 differentially expressed metabolites related to inflammation, oxidative stress, cell proliferation and apoptosis, and energy metabolism.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yeshuang Yuan, Antonios G. A. Kolios, Yudong Liu, Bo Zhang, Hao Li, George C. Tsokos, Xuan Zhang
Summary: Autoimmune diseases can be treated by restoring immune balance, and low-dose interleukin-2 (IL-2) has immunoregulatory effects on regulatory T cells (T-reg cells). Recent advances have explored the therapeutic potential of IL-2 or IL-2-derived molecules in the treatment of autoimmune diseases.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Biology
Yeting Sun, Yeshuang Yuan, Bo Zhang, Xuan Zhang
Summary: The development of CAR-based therapeutic interventions has revolutionized cancer treatment and has also shown potential in treating autoimmune diseases. CAR-T cells can effectively deplete pathological immune cells, while CAR-Tregs have the ability to restore immune tolerance. The optimization of CAR structure and function has been influenced by previous experience in the field of cancer. This review discusses the potential application of CAR-T cells and CAR-Tregs in treating autoimmune diseases, as well as the strategies of gene editing and synthetic biological tools that have improved CAR-based therapies.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bo Zhang, Jiaqi Sun, Yeshuang Yuan, Dezhong Ji, Yeting Sun, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fei, Lihe Zhang, Demin Zhou, Xuan Zhang
Summary: In this study, a strategy was developed to selectively activate regulatory T cells (Tregs) using IL-2 variants that covalently bind to IL-2R alpha. The IL-2 variants, containing a bioreactive artificial amino acid, fluorosulfate-L-tyrosine (FSY), showed enhanced therapeutic efficacy in murine models of lupus and graft-versus-host disease (GvHD). Furthermore, N-terminal PEGylation of the IL-2 variants improved their circulatory retention and sustained effects. This proximity-enabled covalent binding strategy has the potential to accelerate the development of immunomodulatory therapies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Shuhua Yi, Yuting Yan, Meiling Jin, Supriyo Bhattacharya, Yi Wang, Yiming Wu, Lu Yang, Eva Gine, Guillem Clot, Lu Chen, Ying Yu, Dehui Zou, Jun Wang, An T. Phan, Rui Cui, Fei Li, Qi Sun, Qiongli Zhai, Tingyu Wang, Zhen Yu, Lanting Liu, Wei Liu, Rui Lyv, Weiwei Sui, Wenyang Huang, Wenjie Xiong, Huijun Wang, Chengwen Li, Zhijian Xiao, Mu Hao, Jianxiang Wang, Tao Cheng, Silvia Bea, Alex F. Herrera, Alexey Danilov, Elias Campo, Vu N. Ngo, Lugui Qiu, Lili Wang
Summary: This study identified four distinct genetic subsets of mantle cell lymphoma (MCL) and demonstrated the impact of clonal evolution on clinical outcomes. These findings provide valuable insights into the heterogeneity of MCL and its genetic determinants.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jin Hu, Jianquan Shi, Yeshuang Yuan, Bo Zhang, Shengjie Li, Haitao Dong
Summary: A simple and universal protein modification approach (SEC) was discovered to enhance the thermal stability and tumor retention of proteins. Concatenating self-fused proteins can significantly improve the bioactivity and stability of proteins.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bo Zhang, Yan Wang, Shenlong Huang, Jiaqi Sun, Min Wang, Wenxiao Ma, Yanbo You, Ling Wu, Jin Hu, Wei Song, Xudong Liu, Shengjie Li, Hua Chen, Guisheng Zhang, Lihe Zhang, Demin Zhou, Lingjun Li, Xuan Zhang
Summary: This study demonstrates a photoswitchable approach to regulate CAR-T cells, allowing rapid termination of cytotoxicity without compromising tumor therapy.
CELL CHEMICAL BIOLOGY
(2021)
Meeting Abstract
Hematology
Yiming Wu, Meiling Jin, Kevyn Hart, Aijun Liao, Stacey M. Fernandes, Tinisha McDonald, Lucy Brown, Daniel Roeth, Markus Kalkum, Raju Pillai, Jianjun Chen, Jennifer R. Brown, Steven T. Rosen, Tanya Siddiqi, Lili Wang
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
