4.7 Article

A method for the computational modeling of the physics of heart murmurs

期刊

JOURNAL OF COMPUTATIONAL PHYSICS
卷 336, 期 -, 页码 546-568

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcp.2017.02.018

关键词

Heart sound; Cardiovascular flow; Immersed boundary method; Hemodynamics; Elastic waves; Systolic murmur

资金

  1. NSF [IOS-1124804, IIS-1344772, CBET-1511200, TG-CTS100002]
  2. Direct For Computer & Info Scie & Enginr
  3. Div Of Information & Intelligent Systems [1344772] Funding Source: National Science Foundation
  4. Direct For Social, Behav & Economic Scie
  5. SBE Off Of Multidisciplinary Activities [1540916] Funding Source: National Science Foundation
  6. Div Of Chem, Bioeng, Env, & Transp Sys
  7. Directorate For Engineering [1511200] Funding Source: National Science Foundation

向作者/读者索取更多资源

A computational method for direct simulation of the generation and propagation of blood flow induced sounds is proposed. This computational hemoacoustic method is based on the immersed boundary approach and employs high-order finite difference methods to resolve wave propagation and scattering accurately. The current method employs a two-step, one-way coupled approach for the sound generation and its propagation through the tissue. The blood flow is simulated by solving the incompressible Navier Stokes equations using the sharp-interface immersed boundary method, and the equations corresponding to the generation and propagation of the three-dimensional elastic wave corresponding to the murmur are resolved with a high-order, immersed boundary based, finite-difference methods in the time-domain. The proposed method is applied to a model problem of aortic stenosis murmur and the simulation results are verified and validated by comparing with known solutions as well as experimental measurements. The murmur propagation in a realistic model of a human thorax is also simulated by using the computational method. The roles of hemodynamics and elastic wave propagation on the murmur are discussed based on the simulation results. (C) 2017 Elsevier Inc. All rights reserved.

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