Article
Cell Biology
Feiyu Tang, Can Lu, Xiang He, Wei Lin, Bowen Xie, Xing Gao, Yang Peng, Desong Yang, Lunquan Sun, Liang Weng
Summary: The E3 ligase Trim35 is identified as an effective biomarker for predicting the prognosis of LSD1-targeted therapy and immunotherapy. It represses the activity of LSD1 by mediating its ubiquitination, leading to increased T cell infiltration and tumor immunogenicity.
Article
Chemistry, Medicinal
Jianshu Dong, Waqar Pervaiz, Bilal Tayyab, Die Li, Lei Kang, Huimin Zhang, Huimin Gong, Xinli Ma, Jian Li, Clement Agboyibor, Yuefeng Bi, Hongmin Liu
Summary: LSD1 is over-expressed in various cancer types and plays a crucial role in cancer initiation and progression. LSD1 inhibitors have shown effectiveness in attenuating tumor growth. However, personalized treatment remains a challenge in cancer therapies. This review provides fresh insights into LSD1 binding proteins and explores the role of LSD1 in different cancer types.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Smijin K. Soman, David Tingle, Raul Y. Dagda, Mariana Torres, Marisela Dagda, Ruben K. Dagda
Summary: Research shows that cPINK1 supports neuronal development by modulating the expression and release of BDNF, activating the PKA-CREB-BDNF signaling axis. cPINK1 plays a crucial role in neurons, but further studies are needed to understand its molecular mechanisms.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Shatrunjai Giri, Amit Ranjan, Awanish Kumar, Megha Amar, Birendra Nath Mallick
Summary: The study found that REM sleep deprivation leads to impaired neuronal plasticity, affecting neuronal branching and synaptic scaffold, which explains the underlying cellular basis of REMSD-associated patho-physio-behavioral changes.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Oncology
Qiqi Shi, Bo Yu, Yingwen Zhang, Yi Yang, Chenxin Xu, Mingda Zhang, Guoyu Chen, Fei Luo, Bowen Sun, Ru Yang, Yanxin Li, Haizhong Feng
Summary: TRIM24 is overexpressed in neuroblastoma and is associated with poor prognosis. Knockout of TRIM24 promotes cell differentiation, reduces stemness, and inhibits tumor growth. In addition, TRIM24 knockout activates the retinoic acid pathway. Therefore, TRIM24 may be a critical target in neuroblastoma differentiation therapy.
Article
Multidisciplinary Sciences
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T. Roodman, Fei Xavier Chen, Kaixiang Cao
Summary: This study reveals the catalytic-independent role of LSD1 in regulating gene expression and cellular differentiation, demonstrating that the loss of LSD1 protein globally de-represses enhancers and impairs cell fate transition. The researchers found that the increase of H3K27ac catalyzed by P300/CBP, rather than the loss of CoREST complex components from chromatin, contributes to the transcription de-repression of LSD1 targets and differentiation defects caused by LSD1 loss.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Silvia Ravera, Martina Bartolucci, Daniela Calzia, Alessandro M. Morelli, Isabella Panfoli
Summary: The study evaluated the aerobic metabolism of mitochondria and extra-mitochondrial structures in bovine isolated myelin, rod outer segments, and mitochondria-enriched fractions. It was found that myelin and outer segments were more efficient in oxygen consumption and ATP synthesis than mitochondria, suggesting ATP export is limited by extracellular ATP concentration. Additionally, myelin and outer segments were able to synthesize ATP at a later time compared to mitochondria after exposure to respiratory substrates, indicating a potential buffering effect of membrane phospholipids on the proton gradient produced by the electron transport chain.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Olga Bakina, Helmut Kettenmann, Christiane Nolte
Summary: This study analyzed the distribution of satellite microglia in different areas of the central nervous system of adult male mice. It was found that microglia form satellites with various neuronal subtypes without a preference for a specific subtype. The occurrence and frequency of satellite microglia depend on the histo-architectural organization of the brain area and the densities of neuronal somata therein.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Kati L. Healey, Sandra Kibble, Amelia Bell, Sierra Hodges, H. Scott Swartzwelder
Summary: Adolescent alcohol exposure has lasting effects on astrocyte function and interactions, with specific effects observed in different sexes and brain regions.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Yu Li, Yuanyuan Zhao, Xiaona Li, Liuqun Zhai, Hua Zheng, Ying Yan, Qiang Fu, Jinlian Ma, Haier Fu, Zhenqiang Zhang, Zhonghua Li
Summary: Alzheimer's disease is a common neurodegenerative disease with no cure. Lysine-specific demethylase 1 (LSD1) plays an important role in the pathogenesis of AD and has potential therapeutic benefits for treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
James M. Gahan, Ian U. Kouzel, Kamilla Ormevik Jansen, Pawel Burkhardt, Fabian Rentzsch
Summary: This study reveals the role of chromatin modifier Lsd1 in developmental regulation in cnidarians. The findings suggest that the integration of chromatin modifying proteins into developmental regulation predates the divergence of cnidarians and bilaterians, and is an ancient feature of animal development.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Alba Maiques-Diaz, Luciano Nicosia, Naseer J. Basma, Isabel Romero-Camarero, Francesco Camera, Gary J. Spencer, Fabio M. R. Amaral, Fabrizio Simeoni, Bettina Wingelhofer, Andrew J. K. Williamson, Andrew Pierce, Anthony D. Whetton, Tim C. P. Somervaille
Summary: Inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in AML patients with MLL gene translocations. The interaction of HMG20B with LSD1 is disrupted by LSD1 inhibition, and HMG20B is a critical component of the GFI1:LSD1 transcription repressor complex contributing to leukemia cell differentiation block.
Review
Chemistry, Medicinal
Yihui Song, Huiqing Zhang, Xiaoke Yang, Yuting Shi, Bin Yu
Summary: Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising epigenetic target for disease treatment. This review provides an update on LSD1 inhibitors, including natural products, synthetic compounds, and cyclic peptides reported in 2021. The design strategies, structure-activity relationships, binding model analysis, and modes of action are discussed. Highlights include the repurposing of FDA-approved drugs as reversible LSD1 inhibitors, the identification of clinical candidates for neuro-developmental disorders, and the enhanced anti-cancer effects of dual inhibitors targeting both LSD1 and HDAC6 or tubulin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rossella Fioravanti, Veronica Rodriguez, Jonatan Caroli, Ugo Chianese, Rosaria Benedetti, Elisabetta Di Bello, Beatrice Noce, Clemens Zwergel, Davide Corinti, Dolores Vina, Lucia Altucci, Andrea Mattevi, Sergio Valente, Antonello Mai
Summary: In this study, a series of (hetero)arylbenzoylamino TCP derivatives were synthesized and evaluated for their biological activity. The results showed that the meta derivatives were more effective than the para analogues in inhibiting LSD1-CoREST activity, with the meta thienyl analogs 4b and 5b being the most potent. In cell-based assays, selected compounds displayed cell growth arrest mainly in prostate cancer LNCaP cells, confirming the involvement of LSD1 inhibition.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Developmental Biology
Julien C. Habif, Chao Xie, Carlos de Celis, Kirill Ukhanov, Warren W. Green, Jordan C. Moretta, Lian Zhang, Robert J. Campbell, Jeffrey R. Martens
Summary: Olfactory sensory neurons (OSNs) mature by developing glomeruli with multiple cilia, and a GTPase called ARL13B plays a crucial role in this maturation process. Loss of ARL13B in immature OSNs causes dysregulation of cellular homeostasis and delays the timing of maturation. Additionally, ARL13B is essential for the proper structure and innervation of glomeruli, contributing to odor detection and perception.
Review
Neurosciences
James E. Schwob, Woochan Jang, Eric H. Holbrook, Brian Lin, Daniel B. Herrick, Jesse N. Peterson, Julie Hewitt Coleman
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Virology
Jesse N. Peterson, Brian Lin, Jong Shin, Paul J. Phelan, Philip Tsichlis, James E. Schwob, Peter A. Bullock
JOURNAL OF VIROLOGY
(2017)
Article
Multidisciplinary Sciences
Daniel B. Herrick, Brian Lin, Jesse Peterson, Nikolai Schnittke, James E. Schwob
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Cell & Tissue Engineering
Brian Lin, Priya Srikanth, Alison C. Castle, Sagar Nigwekar, Rajeev Malhotra, Jenna L. Galloway, David B. Sykes, Jayaraj Rajagopal
Article
Multidisciplinary Sciences
Daniel T. Montoro, Adam L. Haber, Moshe Biton, Vladimir Vinarsky, Brian Lin, Susan E. Birket, Feng Yuan, Sijia Chen, Hui Min Leung, Jorge Villoria, Noga Rogel, Grace Burgin, Alexander M. Tsankov, Avinash Waghray, Michal Slyper, Julia Waldman, Lan Nguyen, Danielle Dionne, Orit Rozenblatt-Rosen, Purushothama Rao Tata, Hongmei Mou, Manjunatha Shivaraju, Hermann Bihler, Martin Mense, Guillermo J. Tearney, Steven M. Rowe, John F. Engelhardt, Aviv Regev, Jayaraj Rajagopal
Article
Neurosciences
Julie H. Coleman, Brian Lin, Jonathan D. Louie, Jesse Peterson, Robert P. Lane, James E. Schwob
JOURNAL OF NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Richard C. Krolewski, Brian Lin, Samuel Stampfer, Adam Packard, James E. Schwob
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Carly G. K. Ziegler, Samuel J. Allon, Sarah K. Nyquist, Ian M. Mbano, Vincent N. Miao, Constantine N. Tzouanas, Yuming Cao, Ashraf S. Yousif, Julia Bals, Blake M. Hauser, Jared Feldman, Christoph Muus, Marc H. Wadsworth, Samuel W. Kazer, Travis K. Hughes, Benjamin Doran, G. James Gatter, Marko Vukovic, Faith Taliaferro, Benjamin E. Mead, Zhiru Guo, Jennifer P. Wang, Delphine Gras, Magali Plaisant, Meshal Ansari, Ilias Angelidis, Heiko Adler, Jennifer M. S. Sucre, Chase J. Taylor, Brian Lin, Avinash Waghray, Vanessa Mitsialis, Daniel F. Dwyer, Kathleen M. Buchheit, Joshua A. Boyce, Nora A. Barrett, Tanya M. Laidlaw, Shaina L. Carroll, Lucrezia Colonna, Victor Tkachev, Christopher W. Peterson, Alison Yu, Hengqi Betty Zheng, Hannah P. Gideon, Caylin G. Winchell, Philana Ling Lin, Colin D. Bingle, Scott B. Snapper, Jonathan A. Kropski, Fabian J. Theis, Herbert B. Schiller, Laure-Emmanuelle Zaragosi, Pascal Barbry, Alasdair Leslie, Hans-Peter Kiem, JoAnne L. Flynn, Sarah M. Fortune, Bonnie Berger, Robert W. Finberg, Leslie S. Kean, Manuel Garber, Aaron G. Schmidt, Daniel Lingwood, Alex K. Shalek, Jose Ordovas-Montanes
Article
Oncology
Derrick Lin, Brian Lin, Haymanti Bhanot, Rozenn Riou, Nicholas B. Abt, Jayaraj Rajagopal, Srinivas Vinod Saladi
Article
Biochemistry & Molecular Biology
Christoph Muus, Malte D. Luecken, Gokcen Eraslan, Lisa Sikkema, Avinash Waghray, Graham Heimberg, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smillie, Karthik A. Jagadeesh, Elizabeth Thu Duong, Evgenij Fiskin, Elena Torlai Triglia, Meshal Ansari, Peiwen Cai, Brian Lin, Justin Buchanan, Sijia Chen, Jian Shu, Adam L. Haber, Hattie Chung, Daniel T. Montoro, Taylor Adams, Hananeh Aliee, Samuel J. Allon, Zaneta Andrusivova, Ilias Angelidis, Orr Ashenberg, Kevin Bassler, Christophe Becavin, Inbal Benhar, Joseph Bergenstrahle, Ludvig Bergenstrahle, Liam Bolt, Emelie Braun, Linh T. Bui, Steven Callori, Mark Chaffin, Evgeny Chichelnitskiy, Joshua Chiou, Thomas M. Conlon, Michael S. Cuoco, Anna S. E. Cuomo, Marie Deprez, Grant Duclos, Denise Fine, David S. Fischer, Shila Ghazanfar, Astrid Gillich, Bruno Giotti, Joshua Gould, Minzhe Guo, Austin J. Gutierrez, Arun C. Habermann, Tyler Harvey, Peng He, Xiaomeng Hou, Lijuan Hu, Yan Hu, Alok Jaiswal, Lu Ji, Peiyong Jiang, Theodoros S. Kapellos, Christin S. Kuo, Ludvig Larsson, Michael A. Leney-Greene, Kyungtae Lim, Monika Litvinukova, Leif S. Ludwig, Soeren Lukassen, Wendy Luo, Henrike Maatz, Elo Madissoon, Lira Mamanova, Kasidet Manakongtreecheep, Sylvie Leroy, Christoph H. Mayr, Ian M. Mbano, Alexi M. McAdams, Ahmad N. Nabhan, Sarah K. Nyquist, Lolita Penland, Olivier B. Poirion, Sergio Poli, CanCan Qi, Rachel Queen, Daniel Reichart, Ivan Rosas, Jonas C. Schupp, Conor Shea, Xingyi Shi, Rahul Sinha, Rene Sit, Kamil Slowikowski, Michal Slyper, Neal P. Smith, Alex Sountoulidis, Maximilian Strunz, Travis B. Sullivan, Dawei Sun, Carlos Talavera-Lopez, Peng Tan, Jessica Tantivit, Kyle J. Travaglini, Nathan R. Tucker, Katherine A. Vernon, Marc H. Wadsworth, Julia Waldman, Xiuting Wang, Ke Xu, Wenjun Yan, William Zhao, Carly G. K. Ziegler
Summary: Our study reveals that cell-type-specific expression patterns of ACE2, TMPRSS2, and CTSL are associated with the pathogenesis of COVID-19. Factors such as age, sex, and smoking status are linked to the expression of viral entry genes in respiratory cell populations, suggesting potential therapeutic targets for intervention. The integrated analysis of single-cell and single-nucleus transcriptomics studies highlights coexpression patterns of SARS-CoV-2 viral entry genes across different human tissues.
Article
Neurosciences
Mira Fitzek, Parthkumar K. Patel, Peter D. Solomon, Brian Lin, Thomas Hummel, James E. Schwob, Eric H. Holbrook
Summary: Aging is associated with a gradual loss of olfactory sensory neurons, which results in a reduction in synaptic connections within the olfactory bulb. This loss of neurons and synapses occurs in a specific and uneven manner. Decreasing mitotically active olfactory epithelium basal cells may contribute to age-related decline in neurons and loss of smell perception in humans.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Cell Biology
Nana Chen, Gabriel Golczer, Subhoshree Ghose, Brian Lin, Adam Langenbucher, Jason Webb, Haymanti Bhanot, Nicholas B. Abt, Derrick Lin, Mark Varvares, Martin Sattler, Ann Marie Egloff, Richard Joh, Ravindra Uppaluri, Kevin S. Emerick, Michael S. Lawrence, Srinivas Vinod Saladi
Summary: Analysis of HNSCC data reveals frequent mutations in the FAT1 gene, which are associated with increased sensitivity to BRD4 inhibition by JQ1. This study uncovers the cooperative mechanism between YAP1 and BRD4 in HNSCC and suggests a specific therapeutic opportunity for a subset of head and neck cancer patients.
Article
Cell Biology
Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bank G. Fenyves, Nicole C. Charland, Anna L. K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloe Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg
Summary: This study analyzed thousands of plasma proteins longitudinally in COVID-19 patients, uncovering immune and non-immune proteins linked to the disease. Dynamic immune-cell-derived and tissue-associated proteins associated with survival were identified. The research proposed a model in which interactions among myeloid, epithelial, and T cells drive tissue damage in severe COVID-19 disease.
CELL REPORTS MEDICINE
(2021)
Article
Cell & Tissue Engineering
Brian Lin, Julie H. Coleman, Jesse N. Peterson, Matthew J. Zunitch, Woochan Jang, Daniel B. Herrick, James E. Schwob