期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 501, 期 -, 页码 282-293出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2017.04.073
关键词
Drug-loaded microbubbles; Coaxial electrohydrodynamic atomization; Ischemic stroke; Doppler ultrasound; Theranostic agent
资金
- A*STAR
- National University of Singapore [APG2013/40A]
- A*STAR BMRC Strategic Positioning Fund
- A*STAR-PG Collaboration [R279-000-487-305]
- NUS FOE 3D Printing Initiatives [R261-509-001-646]
A single-step fabrication method, coaxial electrohydrodynamic atomization (CEHDA), was developed to synthesize drug-loaded microbubbles (MBs) for combination treatment of ischemic stroke. The bioactivity of therapeutic agent (tPA, tissue plasminogen activator) after preparation was evaluated, showing that CEHDA could be very promising method for producing MBs with therapeutic functions. The bubble performance and tPA release profiles were also examined by exposing the bubbles to 2 MHz ultrasound of various intensities. The results showed that the mean diameter of tPA-loaded MBs was found to fluctuate about its original diameter when exposed to ultrasound and higher intensity ultrasound was more effective in triggering the burst of CEHDA MBs. High ultrasound-triggered bubble disintegration effectiveness in a short period (first 5 min) fits well with the requirement of short ultrasound exposure time for human brain. Moreover, a numerical model was also applied to investigate the stability of the fabricated MBs in the bloodstream. It was found that MB dissolution time increased with initial radius, decreased with initial surface tension and increased with initial shell resistance but it was barely affected by the average excessive bloodstream pressure. (C) 2017 Elsevier Inc. All rights reserved.
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