Article
Clinical Neurology
Gustavo C. Leal, Breno Souza-Marques, Rodrigo P. Mello, Igor D. Bandeira, Ana Teresa Caliman-Fontes, Beatriz A. Carneiro, Daniela Faria-Guimaraes, Livia N. F. Guerreiro-Costa, Ana Paula Jesus-Nunes, Samantha S. Silva, Daniel H. Lins-Silva, Mariana A. Fontes, Raiza Alves-Pereira, Vivian Cordeiro, Sidelcina Rugieri-Pacheco, Cassio Santos-Lima, Fernanda S. Correia-Melo, Flavia Vieira, Gerard Sanacora, Acioly L. T. Lacerda, Lucas C. Quarantini
Summary: This study aimed to explore the feasibility of using (R)-ketamine (arketamine) for treatment-resistant depression (TRD) and assess its efficacy and safety compared to placebo. The results showed that arketamine was not significantly different from placebo in treating depression. The findings highlight the importance of conducting further clinical trials.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Chiara Fabbri, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Marco Andrea Riva, Cathryn M. Lewis, Alessandro Serretti
Summary: This study aimed to identify new potential treatments for treatment-resistant depression (TRD) by analyzing genes and drug databases, discovering some promising drug targets including known drugs for TRD, as well as novel molecules and antioxidant polyphenols nutraceuticals.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Geography, Physical
Pirmin Philipp Ebner, Franziska Koch, Valentina Premier, Carlo Marin, Florian Hanzer, Carlo Maria Carmagnola, Hugues Francois, Daniel Gunther, Fabiano Monti, Olivier Hargoaa, Ulrich Strasser, Samuel Morin, Michael Lehning
Summary: The study evaluated the performance of snowpack models that consider snow management in European Alps ski resorts, showing high accuracy in simulated results but highlighting the importance of detailed representation of real-world snow management practices for future refinement.
Article
Clinical Neurology
Markku Lahteenvuo, Heidi Taipale, Antti Tanskanen, Saara Rannanpaa, Jari Tiihonen
Summary: This study investigated the incidence, risk factors, and courses of treatment for treatment-resistant depression (TRD). The findings suggest that antidepressant monotherapies are still the most common fifth line of depression treatment. Factors such as severe depression, hospitalization due to depression, young age, and male gender may predispose individuals to TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Walter Paganin
Summary: The STAR*D study examined the efficacy of treatments for major depression and found that only 30% of participants achieved complete remission. There is a recent distinction emerging between treatment-resistant depression (TRD) and difficult-to-treat depression (DTD), with TRD characterized by inadequate response to multiple antidepressant treatments and DTD describing a clinical category where patients cannot achieve full symptom control. This shift in perspective proposes a more integrated approach for DTD, encompassing psychosocial, biological, and interactive factors.
EUROPEAN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Anish Mitra, Marcus E. Raichle, Andrew D. Geoly, Ian H. Kratter, Nolan R. Williams
Summary: This study investigates the relationship between directed brain activity, major depressive disorder (MDD), and the response to neurostimulation therapy. The findings suggest that directed signaling patterns in the anterior cingulate cortex (ACC) are potential biomarkers of MDD, as changes in ACC signaling predict improvement in depression symptoms and treatment response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Psychiatry
Laura A. Hannah, Cathy M. Walsh, Louise Jopling, Jesus Perez, Rudolf N. Cardinal, Rory A. Cameron
Summary: This article systematically reviews the literature on economic evaluation in treatment-resistant depression (TRD) to inform future studies. The study finds considerable heterogeneity in the definition of TRD, as well as inconsistencies in study design and evidence quality. Key considerations and challenges for future economic evaluations are identified, along with recommendations for research and suggestions for good practice.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Chemistry, Medicinal
Courtney M. Vecera, Alan C. Courtes, Gregory Jones, Jair C. Soares, Rodrigo Machado-Vieira
Summary: Treatment-resistant depression (TRD) is a specific type of major depressive disorder (MDD) characterized by failures of antidepressant therapies. Imbalance between L-glutamate and gamma-aminobutyric acid (GABA) neurotransmitters in the central nervous system has been found to play a key role in TRD. This review evaluates investigational antidepressants targeting these systems, assessing their evidence, mechanisms, and safety profiles. Some of these drugs have obtained FDA approval, but concerns exist for certain drugs.
Review
Clinical Neurology
Filippo Cantu, Valentina Ciappolino, Paolo Enrico, Chiara Moltrasio, Giuseppe Delvecchio, Paolo Brambilla
Summary: Studies have shown that aripiprazole and quetiapine may be beneficial in the treatment of TRD. RCTs on these drugs support their use in TRD, especially when comorbid anxiety or insomnia are present. However, larger and more homogenous RCTs are needed to improve the therapeutic outcome for patients with TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geography, Physical
Kai Xu, Min Chen, Albert J. Kettner, C. Michael Barton, Barry F. W. Croke, Anthony J. Jakeman, Daniel P. Ames, Hsiao-Hsuan Wang, Susan M. Cuddy, Songshan Yue, Yongning Wen, Fengyuan Zhang, Yixuan Zhang, Guonian Lu
Summary: In this study, a method for evaluating the academic impact of geographic simulation models is proposed. Five indices are designed and the weights of the indices are calculated using the analytic hierarchy process. The weighted sum method is used to quantify the academic impacts of the models. The results show that the proposed method can quantify the academic impact of a model and identify the major research areas impacted by the models.
INTERNATIONAL JOURNAL OF DIGITAL EARTH
(2022)
Article
Nursing
Marie Crowe, Jenni Manuel, Dave Carlyle, Cameron Lacey
Summary: This perspective paper discusses the selection of psychotherapy for psilocybin-assisted psychotherapy in treating treatment-resistant depression. Evidence supports the use of certain psychotherapies for treatment-resistant depression, as well as the efficacy of psilocybin. The paper aims to identify psychotherapies that align with the psilocybin experience and examines their congruence through qualitative analysis. The findings suggest that interpersonal psychotherapy and intensive short-term dynamic psychotherapy are compatible with the psilocybin experience.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
(2023)
Review
Clinical Neurology
Michal Sobstyl, Anna Kupryjaniuk, Marek Prokopienko, Marcin Rylski
Summary: DBS is a relatively new and experimental treatment for depression, which may have antidepressant effects by stimulating brain areas related to the disease. Current studies suggest that SCC DBS could be a promising treatment for TRD, but more research is needed due to the limited number of patients studied.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Robert F. Dougherty, Patrick Clarke, Merve Atli, Joanna Kuc, Danielle Schlosser, Boadie W. Dunlop, David J. Hellerstein, Scott T. Aaronson, Sidney Zisook, Allan H. Young, Robin Carhart-Harris, Guy M. Goodwin, Gregory A. Ryslik
Summary: A machine learning algorithm using NLP and EBI accurately predicts long-term patient response to psilocybin treatment, providing insights for personalized treatment and therapeutic model optimization.
PSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alice Caldiroli, Enrico Capuzzi, Ilaria Tagliabue, Martina Capellazzi, Matteo Marcatili, Francesco Mucci, Fabrizia Colmegna, Massimo Clerici, Massimiliano Buoli, Antonios Dakanalis
Summary: Aripiprazole and lithium may be potential effective augmentative strategies in TRD, while further research is needed to draw reliable conclusions about the efficacy of other molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychiatry
Emiliana Mancuso, Gaia Sampogna, Alessia Boiano, Bianca Della Rocca, Matteo Di Vincenzo, Maria Vita Lapadula, Flavia Martinelli, Federico Lucci, Mario Luciano
Summary: This article reviews studies on various biomarkers in TRD patients in order to improve its diagnosis, treatment, and prognosis. Some studies have found biological alterations in TRD patients, with TNF-alpha being the most relevant biomarker.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Marcelo B. Generoso, Ivan Taiar, Quirino Cordeiro, Pedro Shiozawa, Siegfried Kasper
Summary: Early treatment of psychotic illness is important for better outcomes, and cariprazine, a promising antipsychotic drug, may be beneficial in treating psychosis regardless of the diagnosis of schizophrenia or bipolar disorder.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Editorial Material
Neurosciences
Dekel Taliaz, Alessandro Serretti
Summary: The validity of clinical trials in psychiatry has been under discussion in the past two decades. The commonly used method of randomized controlled trials (RCTs) faces challenges when applied in the psychiatric field due to strict participant criteria and inconsistency in endpoint parameters. This has led to problematic clinical practice in psychiatry.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Psychiatry
Miquel Roca, Annalisa Bonelli, Agnese Cattaneo, Alessandro Comandini, Giorgio Di Dato, Franca Heiman, Valeria Pegoraro, Siegfried Kasper, Hans-Peter Volz, Diego Palao
Summary: This study explores the impact of pharmacological approaches in treating MDD patients and identifies factors associated with longer sick leave duration. Combination/switch/add-on treatments are associated with a higher risk of longer sick leave periods, while timely and careful selection of antidepressant treatment approach may help reduce sick leave.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Review
Psychiatry
Hans-Peter Volz, Johanna Stirnweiss, Siegfried Kasper, Hans-Juergen Moeller, Erich Seifritz
Summary: This paper reviews the research on subthreshold depression (SD) based on a scoping review. The results show that the operationalisation criteria used are highly heterogeneous, leading to inconsistent epidemiological data. The impact of SD on quality of life and related parameters is similar to that of major depression, and therapeutic approaches can be helpful in both preventing and treating SD.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Vincenzo Oliva, Giuseppe Fanelli, Manuel Zamparini, Cristina Zarbo, Matteo Rocchetti, Letizia Casiraghi, Fabrizio Starace, Alessandra Martinelli, Alessandro Serretti, Giovanni de Girolamo, DiAPASon Consortium
Summary: Antipsychotic polypharmacy (APP) is commonly used in patients with schizophrenia spectrum disorders (SSDs) despite recommendations against it. This study found high rates of APP and lower levels of physical activity in both residential and outpatient patients. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity compared to those on monopharmacy.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Kristina Mozuraityte, Agne Stanyte, Naomi A. Fineberg, Alessandro Serretti, Julija Gecaite-Stonciene, Julius Burkauskas
Summary: This study conducted a scoping review of published literature to examine the relationship between mental fatigue and various psychiatric disorders. The findings suggest that mental fatigue is studied in mood disorders, anxiety disorders, obsessive-compulsive disorder, and obsessive-compulsive personality disorder. Cognitive factors such as unhelpful beliefs about sleep and symptom-focussed rumination, as well as personality risk factors, were found to be relevant in predicting mental fatigue symptoms. Further investigation is needed to explore mental fatigue in adult psychiatric samples.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Fabio Panariello, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Summary: This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients. Results showed that the severity of depressive symptoms was associated with total, psychic, and neurological side effects, while autonomic side effects were higher in patients with somatic comorbidities and lower in patients receiving trazodone. Multivariate analyses revealed that depressive symptom severity was associated with psychic and total side effects, generalized anxiety disorder (GAD) with neurological side effects, and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Letter
Clinical Neurology
Lucie Bartova, Markus Dold, Gernot Fugger, Ana Weidenauer, Dan Rujescu, Siegfried Kasper
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Paolo Olgiati, Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Peter Stohrmann, Godber Mathis Godbersen, Murray Bruce Reed, Jakob Unterholzner, Manfred Klobl, Pia Baldinger-Melich, Thomas Vanicek, Andreas Hahn, Rupert Lanzenberger, Siegfried Kasper, Georg S. Kranz
Summary: This longitudinal study investigated the effect of bilateral sequential theta-burst stimulation (TBS) on functional connectivity (FC) in treatment-resistant depression (TRD). Results showed that both active and sham stimulation groups exhibited reductions in depression scores, with no significant difference between the two groups. Baseline FC between the left dorsolateral prefrontal cortex (DLPFC) and the subgenual cingulate cortex (sgACC) was correlated with changes in depression severity. TBS significantly reduced FC between the left stimulation target and bilateral anterior insula, highlighting the effect on the salience network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Psychiatry
Siegfried Kasper
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Murray B. Reed, Patricia A. Handschuh, Manfred Kloebl, Melisande E. Konadu, Ulrike Kaufmann, Andreas Hahn, Georg S. Kranz, Marie Spies, Rupert Lanzenberger
Summary: This study investigated the effects of sex steroids on insular connectivity. The findings showed increased connectivity in transgender women receiving gender-affirming hormone therapy. Additionally, gender-affirming hormone therapy led to changes in alexithymia in transgender women.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Alexander Kautzky, Lucie Bartova, Gernot Fugger, Markus Dold, Daniel Souery, Stuart Montgomery, Joseph Zohar, Julien Mendlewicz, Chiara Fabbri, Alessandro Serretti, Dan Rujescu, Siegfried Kasper
Summary: This study investigates the differences in presentation and treatment outcomes of treatment-resistant depression (TRD) among different age groups. It finds that age has an impact on depressive symptoms and treatment outcomes. In TRD patients, symptom load and hospitalization time increase with age, while treatment responders do not show this trend. Older patients are more likely to have symptoms such as inner tension, reduced appetite, concentration difficulties, and lassitude.
EUROPEAN PSYCHIATRY
(2023)