Article
Hematology
Lionel Ades, Larisa Girshova, Vadim A. Doronin, Maria Diez-Campelo, David Valcarcel, Suman Kambhampati, Nora-Athina Viniou, Dariusz Woszczyk, Raquel De Paz Arias, Argiris Symeonidis, Achilles Anagnostopoulos, Eduardo Ciliao Munhoz, Uwe Platzbecker, Valeria Santini, Robert J. Fram, Ying Yuan, Sharon Friedlander, Douglas Faller, Mikkael A. Sekeres
Summary: The study compared the efficacy of pevonedistat+azacitidine to azacitidine monotherapy in patients with newly diagnosed higher-risk myelodysplastic syndromes and found that in certain patient populations, the new treatment may yield better clinical outcomes, while continued therapy could potentially improve survival.
Article
Oncology
David A. Sallman, Amy E. DeZern, Guillermo Garcia-Manero, David P. Steensma, Gail J. Roboz, Mikkael A. Sekeres, Thomas Cluzeau, Kendra L. Sweet, Amy McLemore, Kathy L. McGraw, John Puskas, Ling Zhang, Jiqiang Yao, Qianxing Mo, Lisa Nardelli, Najla H. Al Ali, Eric Padron, Greg Korbel, Eyal C. Attar, Hagop M. Kantarjian, Jeffrey E. Lancet, Pierre Fenaux, Alan F. List, Rami S. Komrokji
Summary: The combination treatment with eprenetapopt and azacitidine is well-tolerated and results in high rates of clinical response and molecular remissions in patients with TP53-mutant MDS and oligoblastic AML.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Alan F. List, Zhuoxin Sun, Amit Verma, John M. Bennett, Rami S. Komrokji, Kathy McGraw, Jaroslaw Maciejewski, Jessica K. Altman, Puneet S. Cheema, David F. Claxton, Selina M. Luger, Ryan J. Mattison, Timothy R. Wassenaar, Andrew S. Artz, Charles A. Schiffer, Mark R. Litzow, Martin S. Tallman
Summary: The combination of lenalidomide and epoetin alfa significantly improves major erythroid response in lower-risk, non-del(5q) MDS patients compared to lenalidomide alone, with a higher rate and longer duration of response.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli, Lucio Cocco, Matilde Y. Follo
Summary: This study found that high levels of miR-192-5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide. Moreover, miR-192-5p specifically targets and inhibits BCL2, possibly regulating proliferation and apoptosis and leading to the identification of new therapeutic targets.
CLINICAL EPIGENETICS
(2023)
Article
Oncology
Yue Wei, Hong Zheng, Pamela Pennington Lockyer, Faezeh Darbaniyan, Ziyi Li, Rashmi Kanagal-Shamanna, Kelly A. Soltysiak, Hui Yang, Irene Ganan-Gomez, Guillermo Montalban-Bravo, Kelly S. Chien, Kim-Anh Do, Naval Daver, Guillermo Garcia-Manero
Summary: Failure of hypomethylation agent (HMA) treatments is a significant issue in MDS and CMML. This study found that combining an MDM2 antagonist with AZA could potentially improve the treatment outcomes of TP53 wildtype MDS and CMML by down-regulating leukemia stem cell marker genes and activating TP53 function and stability pathways.
LEUKEMIA & LYMPHOMA
(2022)
Article
Medical Laboratory Technology
Yanli Yang, Jun Li, Yinghua Geng, Lin Liu, Dianming Li
Summary: This study revealed the down-regulation of GADD45γ in MDS, which inhibited apoptosis and promoted proliferation in MDS cells. Azacitidine restored the expression of GADD45γ and inhibited MDS cell proliferation by inducing apoptosis, suggesting a potential new target for MDS therapy and providing direction for the development of new clinical drugs and demethylation therapy for MDS.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Hematology
Amer M. Zeidan, Uma Borate, Daniel A. Pollyea, Andrew M. Brunner, Fernando Roncolato, Jacqueline S. Garcia, Robin Filshie, Olatoyosi Odenike, Anne Marie Watson, Ravitharan Krishnadasan, Ashish Bajel, Kiran Naqvi, Jiuhong Zha, Wei-Han Cheng, Ying Zhou, David Hoffman, Jason G. Harb, Jalaja Potluri, Guillermo Garcia-Manero
Summary: The combination of venetoclax and azacitidine shows promising safety and efficacy in patients with relapsed/refractory myelodysplastic syndromes (MDS) following hypomethylating agent (HMA) therapy failure, providing hematological responses and clinically meaningful benefits.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Pathology
Roya Shahidi, Muhajir Mohamed, Archana Sharma, Jessica Heenan, Julia Gardner, Sam Hitchins
Summary: This study aimed to evaluate the impact of azacitidine treatment on MDS patients with bone marrow fibrosis. The study found that patients with fibrotic marrow had shorter overall survival and event-free survival compared to patients without fibrosis. Bone marrow fibrosis was an independent factor affecting overall survival.
Article
Chemistry, Medicinal
Milad Baroud, Elise Lepeltier, Yolla El-Makhour, Nolwenn Lautram, Jerome Bejaud, Sylvain Thepot, Olivier Duval
Summary: The study aims to improve the cell diffusion of Azacitidine and protect it from metabolic degradation by synthesizing amphiphilic prodrugs and their potential self-assembly. The obtained prodrugs successfully formed stable self-assemblies with promising cytotoxicity on a leukemia human cell line.
Review
Oncology
Jan Philipp Bewersdorf, Amer M. Zeidan
Summary: MDS and CMML are two distinct blood cancers with variable symptoms and risks. Management decisions should be individualized and based on validated risk stratification tools. Supportive care is the mainstay for lower-risk patients, while bone marrow transplant is the only curative option for higher-risk patients.
Article
Hematology
Amer M. Zeidan, Isaac Boss, C. L. Beach, Wilbert B. Copeland, Ethan Thompson, Brian A. Fox, Vanessa E. Hasle, Ken Ogasawara, James Cavenagh, Lewis R. Silverman, Maria Teresa Voso, Andrzej Hellmann, Mar Tormo, Tim O'Connor, Alessandro Previtali, Shelonitda Rose, Guillermo Garcia-Manero
Summary: This study conducted a randomized phase 2 trial comparing the efficacy of Azacitidine plus Durvalumab with Azacitidine monotherapy in the treatment of higher-risk myelodysplastic syndromes. The results showed that the combination therapy did not significantly improve clinical outcomes and was associated with more toxicities.
Article
Hematology
Thomas Schroeder, Matthias Stelljes, Maximilian Christopeit, Eva Esseling, Christoph Scheid, Jan-Henrik Mikesch, Christina Rautenberg, Paul Jaeger, Ron-Patrick Cadeddu, Nadja Drusenheimer, Udo Holtick, Stefan Klein, Rudolf Trenschel, Rainer Haas, Ulrich Germing, Nicolaus Kroeger, Guido Kobbe
Summary: Azacitidine combined with donor lymphocyte infusions is an established treatment for relapse of myeloid malignancies after allogeneic transplantation. This study found that adding Lenalidomide to this combination therapy can safely and effectively improve outcomes for patients with post-transplant relapse of acute myeloid leukemia, myelodysplastic syndromes, and chronic myelomonocytic leukemia.
Article
Oncology
Uwe Platzbecker, Joerg Chromik, Jan Kroenke, Hiroshi Handa, Stephen Strickland, Yasushi Miyazaki, Martin Wermke, Wataru Sakamoto, Yoshifumi Tachibana, Tillmann Taube, Ulrich Germing
Summary: This report summarizes three phase I studies evaluating the efficacy of volasertib, a polo-like kinase inhibitor, plus azacitidine in adult patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. The studies showed that the combination treatment was well-tolerated and showed preliminary activity in patients with myelodysplastic syndromes.
Article
Hematology
Thibault Comont, Mathieu Meunier, Amina Cherait, Clemence Santana, Thomas Cluzeau, Bohrane Slama, Kamel Laribi, Jean-Thomas Giraud, Sophie Dimicoli, Ana Berceanu, Lenaig Le Clech, Pascale Cony-Makhoul, Berangere Gruson, Jose Torregrosa, Laurence Sanhes, Vincent Jachiet, Marie-Agnes Azerad, Ahmad Al Jijakli, Emmanuel Gyan, Clement Gaudin, Jonathan Broner, Claire Guerveno, Thierry Guillaume, Pr Lionel Ades, Odile Beyne-Rauzy, Pierre Fenaux
Summary: This study demonstrates the effectiveness and tolerability of eltrombopag in patients with MDS and CMML, showing significant platelet responses with a relatively long duration. Despite some patients experiencing thrombotic events, the majority responded well to the medication with good treatment tolerance.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Alexandre Bazinet, Faezeh Darbaniyan, Elias Jabbour, Guillermo Montalban-Bravo, Maro Ohanian, Kelly Chien, Tapan Kadia, Koichi Takahashi, Lucia Masarova, Nicholas Short, Yesid Alvarado, Musa Yilmaz, Farhad Ravandi, Michael Andreeff, Rashmi Kanagal-Shamanna, Irene Ganan-Gomez, Simona Colla, Wei Qiao, Xuelin Huang, Deborah McCue, Bailey Mirabella, Hagop Kantarjian, Guillermo Garcia-Manero
Summary: The combination of azacitidine and venetoclax shows promising results in terms of safety and activity in patients with high-risk myelodysplastic syndromes or chronic myelomonocytic leukaemia.
LANCET HAEMATOLOGY
(2022)
Article
Medical Laboratory Technology
Alexander Chan, Priyadarshini Kumar, Qi Gao, Jeeyeon Baik, Allison Sigler, Dory Londono, Ying Liu, Maria E. Arcila, Ahmet Dogan, Yanming Zhang, Mikhail Roshal, Wenbin Xiao
Summary: Lineage infidelity, characterized by abnormal immature B lineage output, is rare but detectable in patients with MDS and non-CML MPN. Most cases with abnormal B-lymphoblast populations remain stable or disappear, with only a small percentage progressing to B-ALL. Further investigation is needed to understand the underlying disease biology and its implications for patient management.
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2023)
Article
Business
Yanming Zhang, Minhao Gu, Baofeng Huo
Summary: This study investigates the impact of IT usage and employee multi-skilling on the agility of the supply chain. The findings suggest that internal agility is the foundation of supply chain agility and can improve supplier and customer agility. IT usage is more significant than employee multi-skilling in facilitating supply chain agility. Both internal and supplier agility positively affect supply chain performance, while customer agility has no significant impact.
JOURNAL OF BUSINESS & INDUSTRIAL MARKETING
(2023)
Article
Hematology
Maximilian Stahl, Andriy Derkach, Noushin Farnoud, Jan Philipp Bewersdorf, Troy Robinson, Christopher Famulare, Christina Cho, Sean Devlin, Kamal Menghrajani, Minal A. Patel, Sheng F. Cai, Linde A. Miles, Robert L. Bowman, Mark B. Geyer, Andrew Dunbar, Zachary D. Epstein-Peterson, Erin McGovern, Jessica Schulman, Jacob L. Glass, Justin Taylor, Aaron D. Viny, Eytan M. Stein, Bartlomiej Getta, Maria E. Arcila, Qi Gao, Juliet Barker, Brian C. Shaffer, Esperanza B. Papadopoulos, Boglarka Gyurkocza, Miguel-Angel Perales, Omar Abdel-Wahab, Ross L. Levine, Sergio A. Giralt, Yanming Zhang, Wenbin Xiao, Nidhi Pai, Elli Papaemmanuil, Martin S. Tallman, Mikhail Roshal, Aaron D. Goldberg
Summary: Measurable residual disease (MRD) is a powerful prognostic factor in acute myeloid leukemia (AML). This study aims to identify pre-treatment molecular predictors of immunophenotypic MRD clearance in AML patients. The results showed that induction chemotherapy led to different MRD responses, with 35% achieving MRD- remission, 27% achieving MRD+ remission, and 38% having persistent disease. Subsequent therapy resulted in MRD conversion in 34% of MRD+ patients and 26% of patients with persistent disease. Specific gene mutations and karyotypic abnormalities were found to be associated with high or low rates of MRD- remission. Patients with fewer individual clones were more likely to achieve MRD- remission. Furthermore, the study demonstrated that achieving MRD- prior to allogeneic stem cell transplant (allo-SCT) was associated with favorable outcomes. Therefore, the inclusion of patients with specific baseline mutational patterns and high clone numbers in clinical trials should be considered.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Urology & Nephrology
Bryan Kestenbaum, Alexander G. Bick, Caitlyn Vlasschaert, Michael J. Rauh, Matthew B. Lanktree, Nora Franceschini, Moore B. Shoemaker, Raymond C. Harris Jr, Bruce M. Psaty, Anna Koettgen, Pradeep Natarajan, Cassianne Robinson-Cohen
Summary: This study found an association between clonal hematopoiesis and kidney function decline in the general population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Letter
Hematology
Ying Liu, Andriy Derkach, Natasha Lewis, Menglei Zhu, Yanming Zhang, Maria Arcila, Gilles Salles, Ahmet Dogan, Wenbin Xiao
Article
Engineering, Electrical & Electronic
Gaojing Zhang, Ming Su, Yanming Zhang, Anna Wang, Chengkang Pan
Summary: This article presents the design process of a beam-steering partially reflective surface (PRS) made up of C-shaped split-ring resonators (CSRRs). By analyzing the transmission characteristics of CSRRs with variable opening angles and orientations, spatially abrupt phase and magnitude are introduced over the PRS to reshape the wavefronts of linear polarization waves. Four arrangements of 5 x 5 CSRRs are fabricated to validate the design methodology of beam steering based on the designed two distributions and the two control methods. Furthermore, two reconfigurable Fabry-Perot (FP) antennas are proposed based on liquid-metal and mechanically rotating reconfiguration, demonstrating higher aperture efficiency, desirable radiation patterns, and excellent reconfiguration reliability. Moreover, an eight-element phased array combined with a liquid-metal PRS is fabricated and shows improved scanning performance and stable gain fluctuation.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Editorial Material
Hematology
Michael J. Rauh
Summary: In this article, a new model of Tet2-mutant clonal hematopoiesis (CH) that does not require irradiation or transplantation is presented. The study demonstrates that age-associated interleukin-1 (IL-1)/IL-1 receptor (IL-1R) signaling is a therapeutically targetable driver of clonal expansion.
Article
Multidisciplinary Sciences
Manqing Liu, Shiting Ding, Qintian Pan, Yanming Zhang, Jingru Zhang, Qiong Yang, Tongtong Fang
Summary: The macro policy of the stock market is an important piece of market information aimed at improving market effectiveness. Empirical data is needed to verify whether this goal has been achieved. The utility of this information is closely linked to the effectiveness of the stock market.
Article
Immunology
Qiong Wu, Yanjun Wu, Ye Zhao, Yanming Zhang, Junjie Cao, Depei Wu, Juying Zhou, Feng Chen
Summary: This study aims to observe and analyze the clinical characteristics and prognosis of adenovirus (ADV) infection diagnosed by metagenomic next-generation sequencing (mNGS) after haploidentical hematopoietic stem cell transplantation (Haplo-HSCT). The results showed that mNGS can provide screening for ADV and information on ADV subtypes, helpful for diagnosing patients at high risk for ADV infection. ADV infection can involve multiple organs, has difficulty in early diagnosis, and has a poor prognosis. Currently, effective treatments are inadequate.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Microbiology
Liang Zhang, Yanyan Yi, Tao Wang, Mengzhao Song, Kangkang Guo, Yanming Zhang
Summary: Classical swine fever virus (CSFV) utilizes cellular lipids and manipulates host lipid metabolism to ensure its replication. In this study, we screened the anti-CSFV activity of 12 compounds targeting lipid metabolism pathways. 25-hydroxycholesterol (25HC) exhibited potent anti-CSFV activity by inhibiting virus entry into cells.
VETERINARY MICROBIOLOGY
(2023)
Letter
Oncology
Zhenzhen Yao, Bin Gu, Jia Chen, Yang Xu, Feng Chen, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Lei Yu, Yanming Zhang, Depei Wu, Ying Wang
BLOOD CANCER JOURNAL
(2023)
Article
Business, Finance
Minhao Gu, Yanming Zhang, Dan Li, Baofeng Huo
Summary: This study explores the impact of high-involvement human resource management practices on supply chain resilience and the relationship between the dimensions of supply chain resilience and operational performance. The findings suggest that employee participation plays a crucial role in improving supplier, customer, and internal resilience. However, employee skills only facilitate internal and customer resilience, while employee incentives do not influence supply chain resilience. Additionally, internal and customer resilience have positive effects on operational performance, but supplier resilience does not significantly affect it. These findings contribute to both academia and practice.
JOURNAL OF MANAGEMENT SCIENCE AND ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Shiting Ding, Qintian Pan, Yanming Zhang, Jingru Zhang, Qiong Yang, Jingdong Luan
Summary: The Chinese economy has undergone a long-term transition reform, but there is still financial repression in the financial sector. China's actual interest rate has remained higher than the CPI for most years since 1999, which is inconsistent with financial repression. This is due to the calculation methods of China's CPI, which does not fully consider the rise in housing prices.
Meeting Abstract
Oncology
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla Heavican-Foral, Huiyun Liu, Geoffrey Nelson, Lu Yang, Renee Chen, Katherine Donovan, Marcus Jones, Mikhail Roshal, Yanming Zhang, Ran Xu, Ajit Nirmal, Salvia Jain, Catharine Leahy, Kristen Jones, Kristen Stevenson, Natasha Galasso, Nivetha Ganesan, Tiffany Chang, Wen-Chao Wu, Abner Louissaint, Lydie Debaize, Hojong Yoon, Paola Dal Cin, Wing Chan Chan, Shannan Ho Ho Sui Sui, Samuel Ng, Andrew Feldman, Steven M. Horwitz, Mathew Meyerson, Karen Adelman, Eric Fischer, Chun-Wei Chen, David Weinstock, Myles Brown
Meeting Abstract
Medicine, Research & Experimental
Dianne Torrence, Josephine Dermawan, Yanming Zhang, Chad Vanderbilt, Kerry Mullaney, Achim Jungbluth, Purvil Sukhadia, Narasimhan Agaram, Meera Hameed
LABORATORY INVESTIGATION
(2023)