Review
Oncology
Lin Yang, Kerri Winters-Stone, Benny Rana, Chao Cao, Linda E. Carlson, Kerry S. Courneya, Christine M. Friedenreich, Kathryn H. Schmitz
Summary: This systematic review found that supervised Tai Chi exercises for 8-12 weeks, three times a week, 40-60 minutes each time, could improve fatigue and sleep quality in cancer survivors. However, further confirmation in larger trials is needed, and more research is required to evaluate the effects of Tai Chi on other cancer-related outcomes.
Article
Sport Sciences
Danny J. Yu, Angus P. Yu, Shirley X. Li, Rachel N. Y. Chan, Daniel Y. Fong, Derwin K. C. Chan, Stanley S. Hui, Ka Fai Chung, Jean Woo, Chenchen Wang, Michael R. Irwin, Parco M. Siu
Summary: This study aims to compare the efficacy and long-term outcomes of Tai Chi and cognitive behavioral therapy for insomnia (CBT-I) in older adults. The participants will be randomly assigned to either the Tai Chi or CBT-I group, and the severity of insomnia will be assessed at 3 months and 15 months. This study is of clinical importance as it supports the use of Tai Chi as an alternative non-pharmacological approach for insomnia treatment.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Clinical Neurology
J. Todd Arnedt, Deirdre A. Conroy, Ann Mooney, Allison Furgal, Ananda Sen, Daniel Eisenberg
Summary: The study found that telemedicine delivery of CBT for insomnia is not inferior to face-to-face treatment in terms of insomnia severity, and yields similar improvements in sleep and daytime functioning outcomes. Additionally, telemedicine allows for more efficient treatment delivery without compromising therapeutic alliance.
Article
Cardiac & Cardiovascular Systems
Jie Zhao, Yuli Zang, Janita Pak Chun Chau, Rong He, David R. Thompson
Summary: This study explored the perceptions of Chinese stroke survivors on participation in exercise or sitting Tai Chi. The findings indicated that encouragement and support from healthcare professionals, family and peers, as well as motivation and perceived benefits were important facilitators for exercise participation. However, stroke survivors also faced barriers such as fear of falling, physical discomfort, and challenges in standing. Despite these challenges, most participants were willing to try sitting Tai Chi, which could be an appropriate alternative for stroke survivors without access to formal exercise programs.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Article
Oncology
Kerri M. Winters-Stone, Fay Horak, Nathan F. Dieckmann, Shiuh-Wen Luoh, Elizabeth Eckstrom, Sydnee A. Stoyles, Eric J. Roeland, Fuzhong Li
Summary: The purpose of this study was to compare the efficacy of tai ji quan and strength training in preventing falls in older, postmenopausal women after chemotherapy. The study found no significant difference in the incidence of falls between the tai ji quan, strength training, and stretching control groups after 6 months of training. However, there was a significant reduction in fall-related injuries within the tai ji quan group during the first 6 months.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Kim Mathiasen, Tonny E. Andersen, Mia Beck Lichtenstein, Lars Holger Ehlers, Heleen Riper, Annet Kleiboer, Kirsten K. Roessler
Summary: This study compared the clinical effectiveness of internet-based cognitive behavioral therapy (iCBT) combined with traditional face-to-face therapy (FtF-CBT) in a blended format (B-CBT) for adult major depressive disorder. The results showed no significant difference in treatment efficacy between B-CBT and FtF-CBT at 6 months' follow-up. These findings suggest that B-CBT may be capable of producing treatment effects similar to FtF-CBT.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Clinical Neurology
Josee Savard, Hans Ivers, Marie-Helene Savard, Charles M. Morin, Aude Caplette-Gingras, Stephane Bouchard, Guy Lacroix
Summary: The study compared the short and long-term efficacy of a stepped care CBT-I to standard face-to-face CBT-I for cancer patients with insomnia, finding that the stepped care approach was not inferior to standard care. This suggests that stepped care CBT-I is a valuable and cost-effective approach to improving accessibility of treatment for cancer patients.
Article
Oncology
Daniel L. Hall, Kimberly A. Arditte Hall, Mark J. Gorman, Amy Comander, Michael R. Goldstein, Tony J. Cunningham, Sarah Wieman, Helen R. Mizrach, Brooke C. Juhel, Raissa Li, Alexandros Markowitz, Michael Grandner, Elyse R. Park
Summary: The study adapted and assessed the feasibility, acceptability, and preliminary effects of synchronous, virtual CBT-I for cancer survivors. The Survivorship Sleep Program (SSP) showed large, clinically significant improvements in insomnia severity and positive effects on other sleep metrics, suggesting its efficacy in reducing insomnia severity among cancer survivors.
Article
Clinical Neurology
Josee Savard, Hans Ivers, Marie-Helene Savard, Charles M. Morin, Aude Caplette-Gingras, Stephane Bouchard, Guy Lacroix
Summary: The study aimed to compare the efficacy of stepped care CBT-I and standard face-to-face CBT-I for insomnia symptoms in cancer patients. Results showed that stepped care CBT-I was not inferior to standard face-to-face intervention, making it a valuable approach for improving treatment accessibility for cancer patients.
Article
Health Care Sciences & Services
Timothy J. Genovese, Philip Gehrman, MingXiao Yang, Yuelin Li, Sheila N. Garland, Irene Orlow, Jun J. Mao
Summary: This study explored genetic associations with insomnia treatment response in cancer survivors receiving cognitive behavioral therapy for insomnia (CBT-I) and acupuncture. Results suggest that specific variants in the COMT and NFKB2 genes may be associated with response to acupuncture but not to CBT-I. However, these associations did not remain statistically significant after adjustment for multiple testing.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Multidisciplinary Sciences
Lemeng Zhang, Xiaohong Liu, Fei Tong, Ran Zou, Wanglian Peng, Hui Yang, Feng Liu, Desong Yang, Xufen Huang, Lili Yi, Minni Wen, Ling Jiang
Summary: This study investigated the effects of cognitive behavioral therapy (CBT) on anxiety and depression in cancer survivors. The findings showed that CBT significantly improved the depression and anxiety scores of the cancer survivors, and this improvement was maintained until the 6-month follow-up.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Philip Gehrman, Paul Gunter, James Findley, Rosemarie Frasso, Aalim M. Weljie, Samuel T. Kuna, Matthew S. Kayser
Summary: The study aimed to compare the efficacy of CBT-I delivered by telehealth to in-person treatment and waitlist control for individuals with DSM-5 insomnia disorder. Results showed that telehealth CBT-I produced clinically significant improvements in insomnia severity that were noninferior to in-person treatment. This suggests that telehealth is a promising option for increasing access to treatment without compromising clinical gains.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Integrative & Complementary Medicine
Erica G. Soltero, Linda K. Larkey, Wonsun Sunny Kim, Jose B. Rosales Chavez, Rebecca E. Lee
Summary: This study developed and tested two non-traditional physical activity interventions, Latin dance and Qigong/Tai Chi, among breast cancer survivors, showing promising effects on increasing physical activity and reducing body fat. Further research is needed to explore how these interventions can improve outcomes associated with recurrence.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2022)
Article
Pharmacology & Pharmacy
S. A. Moawd, G. Nambi, S. M. Alrawaili, W. K. Abdelbasset, F. Aboelmagd, S. H. Elsayed
Summary: This study evaluated the efficacy of a combination of MIRE exposure and Tai Chi exercise on balance and fall risk in community-dwelling older adults with lower-extremity disease. The results showed that the intervention significantly improved balance and reduced fall risk.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Maria Ines Clara, Maria Cristina Canavarro, Mariana Miller-Mendes, Ana Allen Gomes
Summary: Insomnia is a common and distressing complaint among cancer survivors, with negative impacts on their functioning, quality of life, and health. Cognitive behavioral therapy is recommended as the first-line treatment, but its availability in European oncology care is limited. This paper analyzes the etiopathogenesis of cancer-related insomnia and reviews the latest developments in cognitive behavioral therapeutics. Opportunities to optimize insomnia treatment in cancer care are discussed, including adapting therapy for survivors and utilizing digital therapeutics.
EUROPEAN PSYCHOLOGIST
(2023)
Article
Psychology, Clinical
Dominique Piber, Richard Olmstead, Joshua H. Cho, Miguel Guzman, Michael R. Irwin
Summary: This study found that both poor sleep maintenance and higher levels of IFN-gamma were associated with depressed mood in older adults. Moreover, IFN-gamma moderated the relationship between poor sleep maintenance and depressed mood, indicating that older adults with higher IFN-gamma are at a heightened risk for depressive symptoms following sleep disturbance.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mark A. Straccia, Adam R. Teed, Perri L. Katzman, Kevin M. Tan, Michael H. Parrish, Michael R. Irwin, Naomi Eisenberger, Matthew D. Lieberman, Benjamin A. Tabak
Summary: Although there are theoretical grounds, this study fails to demonstrate the effects of oxytocin (OT) and vasopressin (AVP) on social cognition in healthy individuals, suggesting that the impact of these neuropeptides may be more limited than initially assumed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Eden R. Brauer, Elisa F. Long, Laura Petersen, Patricia A. Ganz
Summary: Despite the availability of breast cancer-specific survivorship care guidelines, adherence to their recommendations in clinical practice is suboptimal. Survey results identified key gaps in survivorship care for breast cancer survivors, particularly related to subsequent primary cancers and psychosocial long-term and late effects.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Psychology, Clinical
Denise R. Purdie, Myke Federman, Alan Chin, Diana Winston, Brenda Bursch, Richard Olmstead, Yonca Bulut, Michael R. Irwin
Summary: Physicians are facing high levels of work-related stress and burnout. This study found that a hybrid mindfulness meditation intervention can help reduce perceived stress in pediatric residents.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2023)
Editorial Material
Oncology
Michael E. Roth, Susan K. Parsons, Patricia A. Ganz, Lynne Wagner, Pamela S. Hinds, Sarah Alexander, Kristin Bingen, Sharon L. Bober, Julienne Brackett, David Cella, N. Lynn Henry, Daniel J. Indelicato, Rebecca H. Johnson, Tamara P. Miller, Shoshana M. Rosenberg, Kathryn H. Schmitz, Gita Thanarajasingam, Bryce B. Reeve, John M. Salsman
Summary: Disparities in care, treatment-related toxicity, and health-related quality of life for adolescents and young adults with cancer are often disregarded due to limited collection of patient-reported outcomes in cancer clinical trials. Standardizing the assessment of HRQoL and treatment toxicity in AYA CCTs is crucial for improving patient outcomes. The National Cancer Institute's Clinical Trials Network AYA PRO Task Force has identified key considerations and selected appropriate measures to address this issue.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Julienne E. Bower, Ann H. Partridge, Antonio C. Wolff, Steve W. Cole, Michael R. Irwin, Elissa D. Thorner, Hadine Joffe, Laura Petersen, Catherine M. Crespi, Patricia A. Ganz
Summary: This study examined the effects of interventions on younger breast cancer survivors and found that mindful awareness practices (MAPs) had beneficial effects on psychological and immune outcomes, indicating its potential for enhancing biobehavioral health.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Anesthesiology
Michael R. Irwin, Richard Olmstead, Martin F. Bjurstrom, Patrick H. Finan, Michael T. Smith
Summary: Sleep loss increases pain sensitivity, and this study aimed to explore the mechanisms behind this association. By disrupting sleep and inducing inflammation and loss of slow wave, N3 sleep, the researchers found that sleep disruption led to decreased pain threshold. A causal mediation analysis revealed that the effect of sleep disruption on pain sensitivity was mediated by decreased N3 sleep and subsequent inflammation.
Article
Psychology, Clinical
Erica N. Grodin, Lindsay R. Meredith, Elizabeth M. Burnette, Karen Miotto, Michael R. Irwin, Lara A. Ray
Summary: This study investigated CRP as a predictor of treatment response to ibudilast and suggests that a baseline proinflammatory profile may enhance clinical efficacy.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)
Article
Clinical Neurology
Danny Rahal, Julienne E. Bower, Michael R. Irwin, Andrew J. Fuligni, Jessica J. Chiang
Summary: The study found that higher resting RSA can enhance the emotional response to social-evaluative stress in adolescents, possibly due to active engagement and active response to stimuli. Higher resting RSA may promote flexible emotional responses to the social environment, thereby improving mental health.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Oncology
Patricia A. Ganz
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Neurosciences
Emil F. Coccaro, Royce Lee, Elizabeth C. Breen, Michael R. Irwin
Summary: Growing evidence suggests that individuals with aggressive behavior have chronic, low-level inflammation indicated by elevated levels of acute phase reactant proteins and pro-inflammatory cytokines. While animal studies show that pro-inflammatory proteins in the brain increase aggression, there is no data on this relationship in humans. This study found that aggressive individuals with Intermittent Explosive Disorder (IED) have elevated plasma, but not cerebrospinal fluid, levels of proinflammatory markers, suggesting that proinflammatory proteins may influence brain-based behavior in a manner not reflected in lumbar cerebrospinal fluid.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Alejandro D. Meruelo, Matthew A. Timmins, Michael R. Irwin, Emil F. Coccaro
Summary: This study found that morning salivary cortisol levels were significantly lower in individuals with Intermittent Explosive Disorder (IED) compared with controls. Salivary cortisol levels were inversely correlated with trait anger, trait aggression, and plasma C-Reactive Protein (CRP), a marker of systemic inflammation. This suggests a complex interaction between chronic-low level inflammation, the hypothalamic-pituitary-adrenal (HPA) axis, and IED.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Judith E. Carroll, Richard Olmstead, Steve W. Cole, Elizabeth C. Breen, Jesusa M. Arevalo, Michael R. Irwin
Summary: Late life insomnia may increase the risk of biological aging. Treating insomnia with cognitive behavioral therapy (CBT-I) may reduce the expression of p16(INK4a), a marker of cellular senescence. This study found that CBT-I treatment reduced the increase in p16(INK4a) expression over 24 months, and sustained remission of insomnia led to a decrease in p16(INK4a) expression.
Article
Immunology
Michael R. Irwin, Chloe C. Boyle, Joshua H. Cho, Dominique Piber, Elizabeth C. Breen, Nina Sadeghi, Daisy Castillo, Michael Smith, Naomi I. Eisenberger, Richard Olmstead
Summary: Depression is a common disease in older adults, posing significant risks for morbidity and mortality. Due to the large population of older adults, the burden of late-life depression, and the limited effectiveness of current antidepressants, it is important to develop biologically plausible models that lead to selective depression prevention strategies. Insomnia is a predictor of depression recurrence and can be targeted to prevent depression in older adults. However, the mechanisms by which insomnia contributes to depression and the molecular targets for interventions are not yet understood.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Review
Rheumatology
Michael R. Irwin, Rainer H. Straub, Michael T. Smith
Summary: Sleep has a homeostatic role in immune system regulation and can help control inflammation and pain sensitivity. In rheumatoid arthritis (RA) patients, sleep-wake activity dysregulation due to a misaligned inflammatory profile leads to excessive inflammation and increased pain sensitivity. Understanding these risk mechanisms may offer prevention and treatment opportunities for insomnia in RA, potentially improving pain and disease outcomes.
NATURE REVIEWS RHEUMATOLOGY
(2023)