Article
Immunology
Helio S. Sader, Rodrigo E. Mendes, John H. Kimbrough, Valerie Kantro, Mariana Castanheira
Summary: The CLSI lowered the breakpoints for amikacin, gentamicin, and tobramycin, which are commonly used to treat multidrug-resistant Enterobacterales infections. These changes resulted in a reduction in the susceptibility rates of Enterobacterales, particularly against resistant subsets. Plazomicin demonstrated potent activity against antimicrobial-resistant Enterobacterales, including CRE and MDR strains.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Claudine Fournier, Laurent Poirel, Sarah Despont, Julie Kessler, Patrice Nordmann
Summary: The study analyzed carbapenem- and aminoglycoside-resistant clinical isolates in Switzerland, finding a high diversity in terms of genetic backgrounds and plasmid associations, highlighting heterogeneous importations rather than clonal dissemination.
Article
Agronomy
Zhaobin Xia, Xinuo Lai, Xing Zhao, Lu Wang, A. Gayuebumo, Xiangyu Yin, Zhihua Ren, Chaoxi Chen
Summary: This study evaluated the effects of three antibiotics on Nicandra physalodes and its rhizobacterial community. The results showed that the antibiotics influenced the growth behavior, biomass, soil enzyme activity, and bacterial diversity of Nicandra physalodes. This research provides a scientific basis for the rational use of antibiotics in animal husbandry and veterinary science.
Article
Infectious Diseases
Aswin Thacharodi, Iain L. Lamont
Summary: This research aimed to understand the genetic basis of aminoglycoside resistance in Pseudomonas aeruginosa. The study identified mutations in resistance-associated genes in clinical isolates, with fusA1 mutation having the biggest impact on reducing aminoglycoside susceptibility. Mutations in amgS and mexZ also influenced resistance, and all mutations increased the expression of the mexXY efflux pump. The findings demonstrate the complex interplay between mutations, efflux pump expression, and other mechanisms in reducing P. aeruginosa's susceptibility to aminoglycosides.
Article
Microbiology
Roger Vargas, Luca Freschi, Andrea Spitaleri, Sabira Tahseen, Ivan Barilar, Stefan Niemann, Paolo Miotto, Daniela Maria Cirillo, Claudio U. Koser, Maha R. Farhat
Summary: Antibiotic resistance among bacterial pathogens is a major global health threat, with Mycobacterium tuberculosis complex having the highest resistance rates globally. By analyzing over 31,000 MTBC genomes, it was demonstrated that certain mutations may not confer resistance independently and might require multiple mutations to act together. Understanding the association between specific mutations and resistance through genome analysis can help improve drug susceptibility testing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Environmental Sciences
Zhibo Zeng, Wen Yue, Cermon Kined, PengPeng Wang, Ran Liu, Jing Liu, Xinzhu Chen
Summary: This study found that Bacillus licheniformis could effectively restore gut microbial dysbiosis and inflammation levels induced by ceftriaxone sodium treatment, which is important for maintaining intestinal health.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biology
Abigail Ferreira, Helena Martins, Jose Carlos Oliveira, Rui Lapa, Nuno Vale
Summary: Closely observing patients receiving antibiotic therapy, performing therapeutic drug monitoring, and adjusting dosing regimens are important. Antibiotic resistance is a dangerous issue, optimizing antibiotic use is crucial for treatment efficacy, preventing toxicity, and combating resistant strains.
Article
Microbiology
Teck-Phui Chua, Jennifer Danielewski, Kaveesha Bodiyabadu, Catriona S. Bradshaw, Dorothy A. Machalek, Suzanne M. Garland, Erica L. Plummer, Lenka A. Vodstrcil, Gerald L. Murray
Summary: This study investigates the association between single nucleotide polymorphisms (SNPs) in the 16S rRNA gene of Mycoplasma genitalium and change in organism load. Though doxycycline is not highly effective at eradicating M. genitalium infections, it can reduce organism load. The study concludes that the low efficacy of doxycycline against M. genitalium is not due to variation in the 16S rRNA gene.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Orthopedics
Viktor Labmayr, Markus H. Lerchbaumer, Klaus-Dieter Kuehn, Clemens Kittinger, Florian Amerstorfer, Andreas Leithner, Mathias Glehr
Summary: The study found that superficial vancomycin coating (SVC) enhances the antibiotic effect of antibiotic-loaded bone cements (ALBCs) and meets mechanical requirements.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2021)
Article
Infectious Diseases
Wenpei Shi, Yi Hu, Zhu Ning, Fan Xia, Meiying Wu, Yue O. O. Hu, Cheng Chen, Stefanie Prast-Nielsen, Biao Xu
Summary: There were significant differences in gut microbiota composition and metabolic pathways between tuberculosis patients and healthy controls. Antibiotic exposure was found to further reduce diversity and deplete beneficial bacteria in the gut microbiota of TB patients. Microbial functional analysis showed lower biosynthesis capacity of amino acids and fatty acids in TB patients compared to healthy controls.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Javier E. Fernandez, Helena M. B. Seth-Smith, Patrice Nordmann, Adrian Egli, Andrea Endimiani, Vincent Perreten
Summary: This study discovered a novel multidrug resistance plasmid pJEF1-OXA-181, which carries carbapenemase and aminoglycoside resistance genes. It highlights the risk of multidrug resistance plasmids spreading in the healthcare system and calls for continuous monitoring of multidrug-resistant bacteria in high-risk patients.
MICROBIOLOGY SPECTRUM
(2022)
Article
Environmental Sciences
Marcela Franca Dias, Deborah Leroy-Freitas, Elayne Cristina Machado, Leticia da Silva Santos, Cintia Dutra Leal, Gabriel da Rocha Fernandes, Juliana Calabria de Araujo
Summary: Wastewater tertiary treatment is an effective method to reduce the concentration of antibiotic resistant bacteria and genes. Activated sludge and UV irradiation can significantly decrease the abundance of antibiotic resistance determinants. However, some genes, including intI1, remain in the treated effluents, suggesting the need for further investigation on ways to mitigate their release into the environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Sergio Dias Costa-Junior, Adriana Maria Costa Marques da Silva, Jussyegles Niedja da Paz Pereira, Jailton Lobo da Costa Lima, Isabella Macario Ferro Cavalcanti, Maria Amelia Vieira Maciel
Summary: This study described a collection of aminoglycoside- or carbapenem-resistant Pseudomonas aeruginosa isolates in a hospital in Recife City, Brazil between 2018 and 2019, focusing on antimicrobial resistance markers and clonal diversity. The findings revealed the presence of cross-transmission of pathogenic clones among patients in the hospital, highlighting the importance of local molecular epidemiology studies to monitor measures for preventing nosocomial infections.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Frederic J. Baud, Pascal Houze, Pierre Carli, Lionel Lamhaut
Summary: This study aimed to investigate the elimination pathways of aminoglycosides in continuous renal replacement therapy through in vitro experiments, identifying the different factors influencing drug clearance and providing valuable insights for clinical treatment.
Article
Microbiology
Samuel Campista-Leon, Jose Uriel Lopez-Espinoza, Joel Tohevaris Garcia-Guerrero, Cecilia Alfonso-Corrado, Ricardo Clark-Tapia, Luz Isela Peinado-Guevaraa
Summary: This study investigated the contamination of drug-resistant bacteria on the human palmar surface and touchscreen cell phones in an urban community. The results showed that the predominant bacterial genera in both types of samples were Staphylococcus, Bacillus, Atlantibacter, and Microbacterium. Resistance to certain antibiotics was observed. The findings suggest that the presence of drug-resistant bacteria in the community could pose a risk to human health, and hygiene measures are recommended.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
Otavio Hallal Ferreira Raro, Patrice Nordmann, Manuel Dominguez Pino, Jacqueline Findlay, Laurent Poirel
Summary: There is an increasing occurrence of multidrug-resistant (MDR) and hypervirulent (hv) Klebsiella pneumoniae (MDR-hvKp) convergent clones. These strains can cause difficult-to-treat infections and have a higher mortality rate in healthy adults. This study in Switzerland identified a rate of 9.0% K. pneumoniae with a virulence genotype, producing carbapenemase and recovered from rectal swabs, urine, and blood. The presence of alarming MDR-hvKp and MDR nonhypervirulent K. pneumoniae (MDR-nhv-Kp) isolates highlights the need for surveillance networks to track and monitor their spread.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Jacqueline Findlay, Laurent Poirel, Maxime Bouvier, Valeria Gaia, Patrice Nordmann
Summary: Carbapenem-resistant Enterobacterales, including KPC-producing Klebsiella pneumoniae, pose a major threat to public health due to their rapid spread. Ceftazidime-avibactam, a beta-lactam/beta-lactamase inhibitor combination, has shown excellent activity against multidrug-resistant KPC-producing Enterobacterales strains. However, there is an increasing occurrence of CAZ-AVI-resistant K. pneumoniae isolates, mainly due to the emergence of KPC variants that confer resistance to CAZ-AVI but retain carbapenem resistance.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Microbiology
Samanta Freire, Teresa Grilo, Bruna Rodrigues, Rui Oliveira, Carla Esteves, Antonio Marques, Laurent Poirel, Marta Aires-de-Sousa
Summary: This study aimed to analyze the occurrence and characteristics of ESBL- and carbapenemase-producing E. coli among bivalves. Out of 522 collected bivalve samples, E. coli growth was observed in 39% of the samples. Nine samples (4.4%) were contaminated with ESBL producers and one sample (0.5%) was contaminated with a carbapenemase-producing K. pneumoniae. The presence of ESBL- and carbapenemase-producing Enterobacteriaceae in bivalves indicates that the marine environment could be a reservoir of critical bacterial pathogens, posing a potential risk to human health.
Article
Infectious Diseases
Maxime Bouvier, Auriane Kerbol, Jacqueline Findlay, Samanta Freire, Laurent Poirel, Patrice Nordmann
Summary: Resist Acineto is a novel immunochromatographic test for detecting the major acquired carbapenemases (OXA-23, OXA-40, OXA-58, and NDM) in Acinetobacter spp. This test is rapid and easy to perform, and it has shown excellent specificity and sensitivity with 100% positive and negative predictive values in both cases.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Jacqueline Findlay, Patrice Nordmann, Maxime Bouvier, Auriane Kerbol, Laurent Poirel
Summary: This study investigated the spread and emergence of A. baumannii clones co-producing OXA-23 and ArmA in Switzerland. The majority of the isolates were obtained from infections and belonged to the high-risk GC-2 clone. Monitoring and control of these MDR A. baumannii strains are crucial to prevent further spread.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Otavio Hallal Ferreira Raro, Maxime Bouvier, Auriane Kerbol, Jean-Winoc Decousser, Laurent Poirel, Patrice Nordmann
Summary: The study developed a rapid test for the detection of Acinetobacter baumannii susceptibility to the antibiotic cefiderocol. The test showed high sensitivity and specificity and significantly reduced the time required compared to current methods.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Patrice Nordmann, Maxime Bouvier, Laurent Poirel
Summary: Carbapenemase-producing Enterobacterales (CPE) are a major health concern globally, with limited therapeutic options in Switzerland. This study evaluated the susceptibility of CPE isolates recovered in Switzerland from 2018 to 2020 to novel β-lactam/β-lactamase inhibitor combinations, including ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam. The majority of clinical CPE isolates were Klebsiella pneumoniae and Escherichia coli, and the distribution of carbapenemases varied. The study found that meropenem-vaborbactam had the highest susceptibility among the three combinations, followed by ceftazidime-avibactam and imipenem-relebactam. These findings can help optimize first-line therapy for CPE infections.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Christophe Le Terrier, Patrice Nordmann, Chloe Buchs, Doris Yoong Wen Di, Gian Maria Rossolini, Roger Stephan, Mariana Castanheira, Laurent Poirel
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Otavio Hallal Ferreira Raro, Laurent Poirel, Maurine Tocco, Patrice Nordmann
Summary: The study aimed to evaluate whether subdosages of antibiotics administered in veterinary medicine could enhance plasmid transfer and resistance gene exchange in gut microbiota. The results showed that antibiotics in veterinary medicine may induce the transfer of plasmid-encoded resistance and contribute to the global spread of antibiotic resistance genes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Niklas Kroemer, Lisa F. Amann, Aneeq Farooq, Christoph Pfaffendorf, Miklas Martens, Jean-Winoc Decousser, Nicolas Gregoire, Patrice Nordmann, Sebastian G. Wicha
Summary: Rational combination therapy can increase efficacy and prevent the emergence of resistance. This study found that the combination of ceftazidime/avibactam and fosfomycin showed strong synergy in suppressing bacterial count and preventing resistance. Clinical evaluations are needed to explore dose reductions and the use of this combination for highly resistant strains.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Jacqueline Findlay, Roberto Sierra, Otavio Hallal Ferreira Raro, Marta Aires-de-Sousa, Diego O. Andrey, Patrice Nordmann
Summary: This study analysed a collection of E. coli strains harbouring acquired fosA genes and found high-level resistance to fosfomycin. The strains also carried other antibiotic resistance genes and were capable of transmission through conjugation.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Valentina Dona, Patrice Nordmann, Sonja Kittl, Simone Schuller, Maxime Bouvier, Laurent Poirel, Andrea Endimiani, Vincent Perreten
Summary: A study in Switzerland found that Enterobacter hormaechei producing the carbapenemase OXA-48 was identified in companion animals and human patients. The study analyzed the genetic relatedness of these strains and their mobile genetic elements and found a connection between antimicrobial resistance in E. hormaechei and animals and humans in the same environment.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
