Article
Infectious Diseases
Parnrada Nulsopapon, Manat Pongchaidecha, Worapong Nasomsong, Pitimon Polwichai, Sirilada Suphankong, Pantip Sirichote, Siriwan Chaisomboonpan, Wichai Santimaleeworagun
Summary: The spread of carbapenem-resistant Enterobacterales (CRE) is a global health burden, with variations in antimicrobial susceptibility and carbapenemase types among different geographic regions. This study collected clinical CRE isolates from hospitals in western Thailand and found high proportions of CRKP and regional hospitals reporting higher rates of resistance. The isolates were resistant to most antibiotics but susceptible to aminoglycosides. High-dose tigecycline was identified as the optimal regimen against CRE isolates.
Article
Infectious Diseases
Seung Hye Lee, Chan Hee Kim, Hee Young Lee, Kun Hee Park, Su Ha Han
Summary: This study examines the trends and epidemiological characteristics of carbapenem-resistant Enterobacteriaceae (CRE) occurrence in Gyeonggi Province over the past four years. The study finds that CRE infections are endemic in Gyeonggi Province, particularly in areas with a high number of healthcare facilities. Older adults constitute the majority of patients with CRE bacteremia, and antibiotic use does not significantly affect mortality risk.
Article
Public, Environmental & Occupational Health
Neveen A. Abdelaziz
Summary: This study characterized carbapenem resistance among Enterobacterales isolates in Egypt and found a high prevalence of carbapenem non-susceptibility. The most common carbapenemase encoding gene was bla(NDM), followed by bla(VIM). More than half of the isolates co-harbored multiple carbapenemase-encoding genes. Different genotypes had a significant impact on meropenem MIC values.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Microbiology
Victor Band, Sarah W. Satola, Richard D. Smith, David A. Hufnagel, Chris Bower, Andrew B. Conley, Lavanya Rishishwar, Suzanne E. Dale, Dwight J. Hardy, Roberto L. Vargas, Ghinwa Dumyati, Marion A. Kainer, Erin C. Phipps, Rebecca Pierce, Lucy E. Wilson, Matthew Sorensen, Erik Nilsson, I. King Jordan, Eileen M. Burd, Monica M. Farley, Jesse T. Jacob, Robert K. Ernst, David S. Weiss
Summary: The study revealed varying levels of colistin heteroresistance among highly drug-resistant carbapenem-resistant Enterobacterales (CRE), with most heteroresistant isolates being misclassified as colistin susceptible by clinical diagnostic testing. The findings from the 2015 study suggest a high frequency of colistin heteroresistance in CRE.
Article
Microbiology
Dee Shortridge, Valerie Kantro, Mariana Castanheira
Summary: Carbapenems are commonly used for Gram-negative infections, but carbapenem-resistant Enterobacterales (CRE) is a major concern. Klebsiella pneumoniae serine carbapenemases (KPCs) and metallo-beta-lactamases (MBLs) are prevalent globally. Meropenem-vaborbactam, an inhibitor of serine carbapenemases, showed high susceptibility in U.S. MDR Enterobacterales isolates. KPC was the most common carbapenemase, while MBL and OXA-48-like carbapenemases were less common.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Parnrada Nulsopapon, Worapong Nasomsong, Manat Pongchaidecha, Dhitiwat Changpradub, Piraporn Juntanawiwat, Wichai Santimaleeworagun
Summary: The study on antibiotic sensitivity and pharmacokinetic/pharmacodynamic data of CRKP and CoRKP suggests that increasing antibiotic treatment doses and combination therapy may be effective strategies against these bacteria.
Review
Microbiology
Deepak Balasubramanian, Sebastian Murcia, C. Brandon Ogbunugafor, Ronnie Gavilan, Salvador Almagro-Moreno
Summary: This study compared the risk factors and clinical outcomes between CRE infection and colonization. It showed that infected patients were more likely to have higher body weight, previous exposure to specific antibiotics, and blood as the common source of infection.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Xue Zhang, Fen Qu, Wei Jia, Bin Huang, Bin Shan, Hua Yu, Yiwei Tang, Liang Chen, Hong Du
Summary: This study found that despite the lack of exposure to polymyxins, 3.8% of CRE were resistant to polymyxins in China. Both chromosomal and plasmid-encoded mechanisms of resistance were identified in resistant isolates.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Fakhur Uddin, Syed Hadi Imam, Saeed Khan, Taseer Ahmed Khan, Zulfiqar Ahmed, Muhammad Sohail, Ashraf Y. Elnaggar, Ahmed M. Fallatah, Zeinhom M. El-Bahy
Summary: The worldwide spread and increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is of utmost concern and a problem for public health, as determined by this study that aimed to determine the dominance of NDM-producing Enterobacteriaceae at a teaching hospital in Karachi.
Article
Environmental Sciences
Congcong Gu, Xuewen Li, Huiyun Zou, Ling Zhao, Chen Meng, Chengxia Yang, Hui Zhang, Bjorn Berglund
Summary: The emergence and dissemination of carbapenem-resistant Enterobacteriaceae (CRE) is a major global health problem. This study investigates the occurrence and environmental transmission of CRE in groundwater in large animal breeding areas in northern China, suggesting that groundwater may be an underappreciated reservoir and source of CRE dissemination.
ENVIRONMENTAL POLLUTION
(2022)
Article
Microbiology
Min Yi Lau, Fui Enn Teng, Kek Heng Chua, Sasheela Ponnampalavanar, Chun Wie Chong, Kartini Abdul Jabar, Cindy Shuan Ju Teh
Summary: The study reported the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a Malaysian teaching hospital, with bla(OXA-48) identified as the predominant carbapenemase gene. Infection or colonization by CRKP, especially NDM-producers, central venous catheter usage, and stoma were associated with higher in-hospital mortality. Early detection of CRKP isolates was crucial due to the potential high mortality rate associated with infection.
Article
Infectious Diseases
Hongling Li, Mao Zhou, Xia Chen, Yawen Zhang, Zijuan Jian, Qun Yan, Wen-En Liu
Summary: This study evaluated the accuracy of different methods for detecting the susceptibility of CRE to tigecycline and found that ADM, MicroScan, and BD Phoenix 100 methods were accurate for determining the tigecycline susceptibility of CRE, with MicroScan demonstrating better performance.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Fatma Ben Abid, Clement K. M. Tsui, Yohei Doi, Anand Deshmukh, Christi L. McElheny, William C. Bachman, Erin L. Fowler, Ahmed Albishawi, Kamran Mushtaq, Emad B. Ibrahim, Sanjay H. Doiphode, Manal M. Hamed, Muna A. Almaslmani, Abdullatif Alkhal, Adeel A. Butt, Ali S. Omrani
Summary: The study conducted whole genome sequencing and multi-locus sequence typing on 149 carbapenem-resistant Enterobacterales obtained from clinical samples between April 2014 and November 2017. The most common species were Klebsiella pneumoniae and Escherichia coli, with genes encoding metallo-beta-lactamases and OXA-48-like enzymes being frequently detected in the isolates.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Hannah Panlilio, Anh K. Lam, Neda Heydarian, Tristan Haight, Cassandra L. Wouters, Erika L. Moen, Charles Rice
Summary: The rise of life-threatening carbapenem-resistant Enterobacteriaceae (CRE) infections has become a critical medical threat. Some of the most dangerous CRE bacteria can produce enzymes that degrade a wide range of antibiotics, including carbapenems and beta-lactams. Infections by CRE have a high mortality rate, and survivors can have severe morbidity from treatment with toxic antibiotics. The potential of low-molecular weight branched polyethylenimine (600 Da BPEI) and its poly(ethylene glycol) (PEG)ylated derivative (PEG-BPEI) to potentiate meropenem and imipenem against CRE is demonstrated, showing the ability to improve antibiotic efficacy and increase susceptibility to certain antibiotics.
ACS INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Hassan Al Mana, Sathyavathi Sundararaju, Clement K. M. Tsui, Andres Perez-Lopez, Hadi Yassine, Asmaa Al Thani, Khalid Al-Ansari, Nahla O. Eltai
Summary: Antibiotic resistance is a growing public health concern globally, with Gram-negative bacteria displaying the broadest resistance range. The main carbapenemases produced in CRE urinary tract infections in pediatric populations were OXA-48-like enzymes and NDM enzymes, highlighting differences in CRE epidemiology compared to adult populations in Qatar.
