Article
Radiology, Nuclear Medicine & Medical Imaging
Robert M. Kwee, Hugo J. A. Adams, Thomas C. Kwee
Summary: The frequency of PE in patients with COVID-19 is highest in the ICU, followed by general wards and the ED. PE in COVID-19 is more commonly located in peripheral than in central pulmonary arteries, which suggests local thrombosis to play a major role. D-dimer assessment may help to select patients with COVID-19 for CTPA, using D-dimer cutoff levels of at least 1000 mu g/L.
EUROPEAN RADIOLOGY
(2021)
Article
Hematology
Bente P. Van den Boom, Silke B. Bodewes, Bianca Lascaris, Jelle Adelmeijer, Robert J. Porte, Vincent E. de Meijer, Ton Lisman
Summary: Normothermic machine perfusion (NMP) of donor livers allows for new diagnostic and therapeutic strategies. However, high concentrations of heparin and low levels of fibrinogen may affect coagulation assays such as the International Normalised Ratio (INR) performed in perfusate.
THROMBOSIS RESEARCH
(2023)
Article
Medicine, General & Internal
Oscar Miro, Sonia Jimenez, Pere Llorens, Melanie Roussel, Judith Gorlicki, Eric Jorge Garcia-Lamberechts, Pierrick Le Borgne, Javier Jacob, Anthony Chauvin, Olivier Lucidarme, Guillermo Burillo-Putze, Alfons Aguirre, Fabien Brigant, Laura Lozano, Juan Gonzalez del Castillo, Yonathan Freund
Summary: The study aimed to compare the severity of pulmonary embolism (PE) between COVID-19 and non-COVID-19 patients and assess its association with in-hospital mortality. The results showed that COVID-19 patients had smaller PEs, less right ventricular dysfunction (RVD), and lower sPESI scores, but higher risk of in-hospital death. Severity of PE, assessed by RVD and sPESI, was independently associated with in-hospital mortality in COVID-19 patients, while PE size and sPESI were significantly associated with in-hospital mortality in non-COVID-19 patients. COVID-19 status showed a significant interaction with the association between PE size and outcome.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Yiyang Tang, Jing Sun, Zaixin Yu, Benhui Liang, Baohua Peng, Jing Ma, Xiaofang Zeng, Yilu Feng, Qin Chen, Lihuang Zha
Summary: This study found a positive correlation between prothrombin time-international normalized ratio (INR) and the risk of all-cause mortality in post-cardiac arrest (CA) patients. The findings suggest that an INR level exceeding 1.2 increases the risk of death in CA patients. High levels of INR are also associated with 30-day, 90-day, 1-year, and in-hospital mortalities. These results were consistent and validated in subgroup analyses, propensity score matching, and inverse probability of treatment analyses.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Raquel Morillo, David Jimenez, Behnood Bikdeli, Carmen Rodriguez, Andres Tenes, Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura, Gemma Vidal, Nuria Ruiz-Gimenez, Olivier Espitia, Manuel Monreal
Summary: The study evaluates the utility of a modified simplified Pulmonary Embolism Severity Index (sPESI) in elderly patients with acute symptomatic pulmonary embolism, and concludes that the new model has higher sensitivity for predicting short-term mortality in this population. Safe outpatient therapy may benefit a minority of these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Critical Care Medicine
Ana Jaureguizar, David Jimenez, Behnood Bikdeli, Pedro Ruiz-Artacho, Alfonso Muriel, Victor Tapson, Raquel Lopez-Reyes, Beatriz Valero, Gili Kenet, Manuel Monreal
Summary: This study investigated the association between heart rate and pulmonary embolism outcomes and found that a higher heart rate is associated with increased all-cause and PE-related mortality. Modifying the heart rate cutoff in the simplified Pulmonary Embolism Severity Index (sPESI) and the Bova score can improve the prognostication of patients with PE.
Article
Hematology
Marco Zuin, Gianluca Rigatelli, Claudio Bilato, Amedeo Bongarzoni, Franco Casazza, Pietro Zonzin, Loris Roncon
Summary: The persistence of RBBB, NTWs, and qR pattern in V1 lead at day 3 of hospitalization are independent prognostic factors of death within 30 days in high-risk acute PE patients. The prognostic power of any single ECG abnormality is lower compared to the combination of the three ECG variables.
THROMBOSIS RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Liwei Liu, Ming Ying, Shiqun Chen, Qiang Li, Guanzhong Chen, Huanqiang Li, Ziling Mai, Yibo He, Bo Wang, Danyuan Xu, Zhidong Huang, Xiaoming Yan, Ning Tan, Zhujun Chen, Jin Liu, Yong Liu
Summary: This study suggests that high levels of PT-INR are associated with an increased risk of long-term mortality in patients with coronary artery disease.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Cristina Rodriguez, Neus Luque, Isabel Blanco, Laura Sebastian, Joan Albert Barbera, Victor Peinado, Olga Tura-Ceide
Summary: SARS-CoV-2, causing COVID-19, poses a major threat to global public health with severe respiratory and multiorgan complications. The complications of COVID-19, including cytokine storm and thrombi formation, involve the pulmonary endothelium in regulating vascular homeostasis and coagulation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Konstantinos Bartziokas, Christos Kyriakopoulos, Dimitrios Potonos, Konstantinos Exarchos, Athena Gogali, Konstantinos Kostikas
Summary: This study investigated the potential value of the UA/Cr ratio as a diagnostic tool for the prognosis of patients with acute pulmonary embolism (PE) and its correlation with other parameters. The results showed that UA/Cr levels are associated with disease severity and risk stratification, and may serve as a useful biomarker for identifying patients at risk of adverse outcomes.
Article
Multidisciplinary Sciences
Noa Cahan, Eyal Klang, Edith M. Marom, Shelly Soffer, Yiftach Barash, Evyatar Burshtein, Eli Konen, Hayit Greenspan
Summary: Pulmonary embolism (PE) is a common and life-threatening cardiovascular emergency. Risk stratification is crucial in the management of acute PE, and this study explores the use of multimodal fusion models that combine volumetric pixel data with clinical patient data for automatic risk stratification. The best performing model incorporates bilinear attention and TabNet, providing a sensitivity of 90%, specificity of 94%, and an AUC of 0.96 in assessing PE severity, highlighting the value of multimodal data in automatic PE severity assessment.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Shuili Yu, Honglu Zhou, Yang Li, Jianfeng Song, Jinyan Shao, Xuanyi Wang, Zichen Xie, Chao Qiu, Keyu Sun
Summary: In CTPA-confirmed patients, the PERFORM score system is an objective, accurate, and simple tool for predicting the risk of 30-day mortality, performing as well as traditional PESI and sPESI methods in mortality prediction. Patients with low PERFORM scores had shorter recovery times, while those with high scores faced higher mortality rates.
Article
Immunology
Ting-Ting Wu, Ying Pan, Ying-Ying Zheng, Yi Yang, Xian-Geng Hou, Chang-Jiang Deng, Yi-Tong Ma, Xiang Xie
Summary: The ABIC score is a potential prognostic model for patients with CAD who have undergone PCI, as it predicts high long-term mortality and cardiac death risk.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Emergency Medicine
Jatin Narang, Amy S. Nowacki, Spencer S. Seballos, Philip R. Wang, Sharon E. Mace
Summary: This study aimed to determine whether D-dimer concentration can differentiate patients that require anti-coagulation from those who do not in the absence of imaging. Results showed that age-adjusted D-dimer cut-offs were effective in distinguishing these two groups of patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Karsten Keller, Lukas Hobohm, Mir A. Ostad, Susanne Karbach, Christine Espinola-Klein, Thomas Muenzel, Joel M. Gelfand, Stavros Konstantinides, Kerstin Steinbrink, Tommaso Gori
Summary: Psoriasis patients have an increased risk for venous thromboembolism (VTE) and are associated with an unfavorable cardiovascular-risk and VTE-risk profile. However, patients with psoriasis and PE have a lower in-hospital mortality rate, potentially due to their younger age.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ezgi Kalaycioglu, Mustafa Cetin, Goksel Cinier, Tuncay Kiris, Tayyar Gokdeniz, Ali Gokhan Ozyildiz, Ismet Durmus
Summary: Higher osteoprotegerin levels in hypertensive and diabetic patients were correlated with impaired left atrial function as assessed by 2D-STE. This suggests that serum osteoprotegerin can be used as a risk predictor for left atrial mechanical dysfunction in this high-risk patient population.
Article
Respiratory System
Ezgi Kalaycioglu, Mustafa Cetin, Goksel Cinier, Ali Gokhan Ozyildiz, Ismet Durmus, Tuncay Kiris, Tayyar Gokdeniz
Summary: This study found that EAT thickness in COPD patients is positively correlated with systolic pulmonary arterial pressure (PAPs) levels, and is independently associated with factors such as BMI, WBC, and FEV1 in linear regression analysis. This suggests that EAT may play a role in the development of PHT in COPD patients, regardless of the severity of COPD.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ersin C. Simsek, Tuncay Kiris
Summary: Early clinical outcomes following CAP, including cardiac tamponade and 30-day cardiovascular mortality, were significantly worse in patients with ACS compared to those with stable CAD. However, there was no significant difference in all-cause mortality between the two groups at the 3-year follow-up.
CORONARY ARTERY DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Ezgi Kalaycioglu, Mustafa Cetin, Ali Gokhan Ozyildiz, Tuncay Kiris
Summary: This study investigated the relationship between aortic root diameter (ARD) and left atrial (LA) mechanical functions in patients with hypertension and diabetes. The results showed that age, LA volume, expansion index, and strain rate were significantly associated with increased ARD, indicating a potential link between impaired LA mechanical functions and ARD.
Article
Medicine, General & Internal
Mehmet Baran Karatas, Nizamettin Selcuk Yelgec, Yigit canga, Ahmet Zengin, Ayse Emre
Summary: In this study, digoxin therapy was found to be independently associated with short-term and long-term mortality in patients with acute pulmonary embolism. Various clinical parameters such as PESI score, right ventricle diastolic diameter, systolic pulmonary arterial pressure, brain natriuretic peptide, troponin, and digoxin therapy were identified as predictors of short-term mortality. Similarly, systolic pulmonary arterial pressure, PESI score, right ventricle diastolic diameter, and digoxin therapy were determined as independent predictors of long-term mortality in this patient population.
WIENER KLINISCHE WOCHENSCHRIFT
(2021)
Article
Cardiac & Cardiovascular Systems
Ismet Durmus, Ezgi Kalaycioglu, Mustafa Cetin, Hanife Baykal Sahin, Tuncay Kiris
Summary: This study investigated the effect of exercise-based cardiac rehabilitation (CR) programs on mean platelet volume (MPV) in stable coronary artery disease (CAD) patients. The results showed a significant reduction in MPV in the CR group, with a strong correlation between MPV reduction and CR. The findings suggest that decreased platelet activation through exercise-based CR may play a role in reducing thrombotic risk in patients with CAD.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Mustafa Cetin, Turan Erdogan, Ali Gokhan Ozyildiz, Savas Ozer, Ahmet Cagri Ayhan, Tuncay Kiris
Summary: Elevation of blood urea nitrogen (BUN) is associated with increased mortality in patients with stable angina pectoris (SAP). BUN concentration above 16.1 mg/dl has a high sensitivity for predicting mortality in these patients.
Article
Respiratory System
Ezgi Kalaycioglu, Mustafa Cetin, Tuncay Kiris, Ali Gokhan Ozyildiz, Turhan Turan, Ahmet Seyda Yilmaz
Summary: FEV1 is independently associated with impaired left atrial strain in COPD patients with preserved left ventricular systolic function, regardless of arterial blood gas and left ventricular diastolic dysfunction parameters.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Acoustics
Ezgi Kalaycioglu, Mustafa Cetin, Tuncay Kiris, Ali Gokhan Ozyildiz
Summary: In this study, researchers investigated the relationship between LDL-C levels and left atrial (LA) function in patients with hypertension and diabetes. Results showed a moderately but independently paradoxical association between LDL-C levels and impaired LA function assessed by 2D-STE. Lower LDL-C, higher BMI, lower LVEF, and higher E-wave velocity were found to be independently associated with impaired LA-strain in multivariate analysis.
JOURNAL OF CLINICAL ULTRASOUND
(2021)
Article
Cardiac & Cardiovascular Systems
Tuncay Kiris, Eyup Avci, Tuba Ekin, Didar Elif Akgun, Mucahit Tiryaki, Arafat Yidirim, Kutluhan Hazir, Bektas Murat, Mehtap Yeni, Rojhad Altindag, Sefa Gul, Baran Arik, Tuncay Guzel, Selda Murat, Ahmet Oz, Mustafa Karabacak, Zihni Aktas, Tarik Yildirim, Baris Kilicaslan, Asim Oktay Ergene
Summary: During the COVID-19 outbreak in Turkey, there was a significant decrease in ST-segment elevation myocardial infarction hospitalization rates and a delay in symptom onset to first medical contact. COVID-19 positive STEMI patients showed higher thrombus grade and mortality rates compared to COVID-19 negative patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Medicine, General & Internal
Tuncay Kiris, Eyup Avci, Tuba Ekin, Didar Elif Akgun, Mucahit Tiryaki, Arafat Yidirim, Kutluhan Hazir, Bektas Murat, Mehtap Yeni, Rojhad Altindag, Sefa Gul, Baran Arik, Tuncay Guzel, Selda Murat, Ahmet Oz, Mustafa Karabacak, Zihni Aktas, Tarik Yildirim, Baris Kilicaslan, Asim Oktay Ergene
Summary: The study aimed to compare the occurrence rates of MACCE in Turkish STEMI patients before and after COVID-19, showing no significant difference in MACCE rates between the two periods, but higher long-term MACCE and heart failure hospitalization rates in COVID-19 positive patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Peripheral Vascular Disease
Aykan Celik, Fatma Kayalti Esin, Sadik Volkan Emren, Tuncay Kiris, Mustafa Karaca
Summary: The PRECISE-DAPT score can be used to predict long-term outcomes in patients with acute coronary syndrome, specifically major adverse cardiovascular and cerebrovascular events and bleeding.
Article
Cardiac & Cardiovascular Systems
Ahmet Dolapoglu, Eyup Avci, Tuncay Kiris
Summary: This study investigated the predictive ability of the C-reactive protein-to-albumin ratio (CAR) for ascending aorta progression in patients with 40-50 mm diameter of ascending aortic dilatation. Hypertension, chronic obstructive pulmonary disease, positive family history, and CAR were identified as independent risk factors for ascending aorta growth > 1.00 mm/year. The AUC of CAR for predicting ascending aorta growth > 1.00 mm/year was 0.771(95% CI 0.689-0.854). CAR may be useful for predicting ascending aorta progression in patients with 40-50 mm ascending aneurysms.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmet Zengin, Mehmet Karaca, Emre Arugaslan, Ersin Yildirim, Mehmet Baran Karatas, Yigit Canga, Ayse Emre, Gulsah Tayyareci
Summary: The study found that high NLR values were significantly associated with recurrent angina and myocardial infarction, as well as younger age and smoking status. High NLR levels were correlated with increased levels of WBC, troponin I, and CRP, and were identified as independent predictors of recurrent myocardial infarction in long-term follow up.
JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
(2021)
Article
Medicine, General & Internal
Oguzhan Celik, Cem Cil, Ozcan Basaran, Erkan Demirci, Veysel Ozan Tanik, Emine Altuntas, Kadriye Memic Sancar, Ozcan Orscelik, Mucahit Yetim, Lutfu Bekar, Osman Karaarslan, Bulent Ozlek, Eda Ozlek, Aysel Gokcek, Tolga Dogan, Mubariz Murat Resulzade, Caglar Kaya, Emrah Kucuk, Tuncay Kiris, Abdullah Orhan Demirtas, Murat Civan, Ramazan Asoglu, Volkan Dogan, Murat Biteker
Summary: The study investigated the prescription patterns and appropriateness of aspirin use in Turkey, finding that inappropriate use of aspirin is common in real-world practice according to both ESC and USPTF guidelines. Independent predictors of inappropriate aspirin use included heart failure, oral anticoagulant use, and female sex.
BALKAN MEDICAL JOURNAL
(2021)
